Author Report for: Matsuda HNo contact information in database for Matsuda H
Matsuda H, Yokoyama K, Sato N, Ito K, Nemoto K, Oba H, Hanyu H, Kanetaka H, Mizumura S and Shigemori K <11 more author(s)> Matsuda H, Yokoyama K, Sato N, Ito K, Nemoto K, Oba H, Hanyu H, Kanetaka H, Mizumura S, Kitamura S, Shinotoh H, Shimada H, Suhara T, Terada H, Nakatsuka T, Kawakatsu S, Hayashi H, Asada T, Ono T, Goto T, Shigemori K (- 11) Ref: Neuropsychiatr Dis Treat, 15:2715, 2019 : PubMed ESTHER: Matsuda_2019_Neuropsychiatr.Dis.Treat_15_2715 PubMedSearch: Matsuda 2019 Neuropsychiatr.Dis.Treat 15 2715 PubMedID: 31571887 Abstract Background: The differential diagnosis of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD) is particularly important because DLB patients respond better to cholinesterase inhibitors but sometimes exhibit sensitivity to neuroleptics, which may cause worsening of clinical status. Antemortem voxel-based morphometry (VBM) using structural MRI has previously revealed that patients with DLB have normal hippocampal volume, but atrophy in the dorsal mesopontine area. Objectives: The aim of this multicenter study was to determine whether VBM of the brain stem in addition to that of medial temporal lobe structures improves the differential diagnosis of AD and DLB. Methods: We retrospectively chose 624 patients who were clinically diagnosed with either DLB (239 patients) or AD (385 patients) from 10 institutes using different MR scanners with different magnetic field strengths. In all cases, VBM was performed on 3D T1-weighted images. The degree of local atrophy was calculated using Z-score by comparison with a database of normal volumes of interest (VOIs) in medial temporal lobe (MTL) and the dorsal brain stem (DBS). The discrimination of DLB and AD was evaluated using Z-score values in these two VOIs. MRI data from 414 patients were used as the training data set to determine the classification criteria, with the MRI data from the remaining 210 patients used as the test data set. Results: The DLB and AD patients did not differ with respect to mean age or Mini-Mental State Examination scores. Z-index scores showed that there was significantly more atrophy in MTL of AD patients, compared to DLB patients and in DBS of DLB patients, compared to AD patients. The discrimination accuracies of VBM were 63.3% in the test data set and 73.4% in the training data set. Conclusion: VBM of DBS in addition to that of MTL improves the differentiation of DLB and AD. Title: Novel polyacetylene derivatives and their inhibitory activities on acetylcholinesterase obtained from Panax ginseng roots Murata K, Iida D, Ueno Y, Samukawa K, Ishizaka T, Kotake T, Matsuda H Ref: J Nat Med, 71:114, 2017 : PubMed ESTHER: Murata_2017_J.Nat.Med_71_114 PubMedSearch: Murata 2017 J.Nat.Med 71 114 PubMedID: 27568312 Abstract In our research program to identify cholinesterase and beta-secretase inhibitors, we investigated Ginseng (root of Panax ginseng), a crude drug described as a multifunctional drug in the ancient Chinese herbal book Shennong Ben Cao Jing. Results from hexane and methanol extracts showed moderate inhibitory activities. This suggests that ginseng roots may be effective for the prevention of and therapy for dementia. We then focused on hexane extracts of raw ginseng root and dried ginseng root since the determination of hexane extract constituents has not been studied extensively. Activity-guided fractionation and purification led to the isolation of 4 polyacetylene compounds; homopanaxynol, homopanaxydol, (9Z)-heptadeca-1, 9-diene-4,6-diyn-3-one, and (8E)-octadeca-1,8-diene-4,6-diyn-3,10-diol. The chemical structures of these compounds, including stereochemistry, were determined. This is the first study to identify the structure of homopanaxynol and homopanaxydol. Moreover, the modes of action of some compounds were characterized as competitive inhibitors. This study showed, for the first time, that polyacetylene compounds possess acetylcholinesterase inhibitory activities. Title: Screening of beta-secretase and acetylcholinesterase inhibitors from plant resources Murata K, Matsumura S, Yoshioka Y, Ueno Y, Matsuda H Ref: J Nat Med, 69:123, 2015 : PubMed ESTHER: Murata_2015_J.Nat.Med_69_123 PubMedSearch: Murata 2015 J.Nat.Med 69 123 PubMedID: 25119528 Abstract The therapeutic agents for dementia are limited due to the complex system underlying the mechanisms. Taking a preventive point of view, we focused on the inhibition of beta-secretase and acetylcholinesterase (AChE). In addition, plant resources including herbs and spices have been widely consumed, and further, may be consumed for a long period over a lifetime. Considering this background, we screened beta-secretase and AChE inhibitors from curry spices. Amongst them, curry leaf, black pepper, and turmeric extracts were effective to inhibit beta-secretase. Furthermore, black pepper and turmeric extracts were also effective to inhibit AChE. Having these results in hand, we focused on the investigation of beta-secretase inhibitors since the inhibitor of this enzyme has not previously been well investigated. As a result, alpha- and beta-caryophyllene, beta-caryophyllene oxide (from curry leaf), piperine (from black pepper), curcumin, demethoxycurcumin, and bisdemethoxycurcumin (from turmeric) were successfully identified as low molecular inhibitors. This is the first report to determine alpha- and beta-caryophyllene, beta-caryophyllene oxide, and piperine as beta-secretase inhibitors. These compounds may pass through the blood brain barrier since their molecular weights are relatively low. Title: [Localized cerebral blood flow changes in response to ADL-related vitality in elderly patients with dementia using single photon emission computed tomography] Sonohara K, Toba K, Nakai R, Kobayashi Y, Moriya Y, Hasegawa H, Kozaki K, Matsuda H Ref: Nippon Ronen Igakkai Zasshi, 45:615, 2008 : PubMed ESTHER: Sonohara_2008_Nippon.Ronen.Igakkai.Zasshi_45_615 PubMedSearch: Sonohara 2008 Nippon.Ronen.Igakkai.Zasshi 45 615 PubMedID: 19179793 Abstract AIM: To clarify the area in the brain related to responsible for vitality and volition. Title: The transcriptional landscape of the mammalian genome Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B and Hayashizaki Y <184 more author(s)> Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y (- 184) Ref: Science, 309:1559, 2005 : PubMed ESTHER: Carninci_2005_Science_309_1559 PubMedSearch: Carninci 2005 Science 309 1559 PubMedID: 16141072 Gene_locus related to this paper: mouse-abhd1, mouse-abhd3, mouse-abhd4, mouse-acot4, mouse-adcl4, mouse-DGLB, mouse-ephx3, mouse-Kansl3, mouse-lipli, mouse-LIPN, mouse-Ppgb, mouse-q3uuq7, mouse-srac1, mouse-Tex30, mouse-tmco4, mouse-tmm53, mouse-f172a Abstract This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R and Hayashizaki Y <127 more author(s)> Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schonbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM, Kanapin A, Matsuda H, Batalov S, Beisel KW, Blake JA, Bradt D, Brusic V, Chothia C, Corbani LE, Cousins S, Dalla E, Dragani TA, Fletcher CF, Forrest A, Frazer KS, Gaasterland T, Gariboldi M, Gissi C, Godzik A, Gough J, Grimmond S, Gustincich S, Hirokawa N, Jackson IJ, Jarvis ED, Kanai A, Kawaji H, Kawasawa Y, Kedzierski RM, King BL, Konagaya A, Kurochkin IV, Lee Y, Lenhard B, Lyons PA, Maglott DR, Maltais L, Marchionni L, McKenzie L, Miki H, Nagashima T, Numata K, Okido T, Pavan WJ, Pertea G, Pesole G, Petrovsky N, Pillai R, Pontius JU, Qi D, Ramachandran S, Ravasi T, Reed JC, Reed DJ, Reid J, Ring BZ, Ringwald M, Sandelin A, Schneider C, Semple CA, Setou M, Shimada K, Sultana R, Takenaka Y, Taylor MS, Teasdale RD, Tomita M, Verardo R, Wagner L, Wahlestedt C, Wang Y, Watanabe Y, Wells C, Wilming LG, Wynshaw-Boris A, Yanagisawa M, Yang I, Yang L, Yuan Z, Zavolan M, Zhu Y, Zimmer A, Carninci P, Hayatsu N, Hirozane-Kishikawa T, Konno H, Nakamura M, Sakazume N, Sato K, Shiraki T, Waki K, Kawai J, Aizawa K, Arakawa T, Fukuda S, Hara A, Hashizume W, Imotani K, Ishii Y, Itoh M, Kagawa I, Miyazaki A, Sakai K, Sasaki D, Shibata K, Shinagawa A, Yasunishi A, Yoshino M, Waterston R, Lander ES, Rogers J, Birney E, Hayashizaki Y (- 127) Ref: Nature, 420:563, 2002 : PubMed ESTHER: Okazaki_2002_Nature_420_563 PubMedSearch: Okazaki 2002 Nature 420 563 PubMedID: 12466851 Gene_locus related to this paper: mouse-1lipg, mouse-1llip, mouse-1plrp, mouse-3neur, mouse-ABH15, mouse-abhd4, mouse-abhd5, mouse-Abhd8, mouse-Abhd11, mouse-abhda, mouse-acot4, mouse-adcl4, mouse-AI607300, mouse-BAAT, mouse-bphl, mouse-C87498, mouse-Ldah, mouse-Ces1d, mouse-Ces2e, mouse-CMBL, mouse-DGLB, mouse-dpp9, mouse-ES10, mouse-F135A, mouse-FASN, mouse-hslip, mouse-hyes, mouse-Kansl3, mouse-LIPH, mouse-LIPK, mouse-lipli, mouse-LIPM, mouse-lypla1, mouse-lypla2, mouse-MEST, mouse-MGLL, mouse-ndr4, mouse-OVCA2, mouse-pafa, mouse-pcp, mouse-ppce, mouse-Ppgb, mouse-PPME1, mouse-q3uuq7, mouse-Q8BLF1, mouse-ACOT6, mouse-Q8C1A9, mouse-Q9DAI6, mouse-Q80UX8, mouse-Q8BGG9, mouse-Q8C167, mouse-rbbp9, mouse-SERHL, mouse-tssp Abstract Only a small proportion of the mouse genome is transcribed into mature messenger RNA transcripts. There is an international collaborative effort to identify all full-length mRNA transcripts from the mouse, and to ensure that each is represented in a physical collection of clones. Here we report the manual annotation of 60,770 full-length mouse complementary DNA sequences. These are clustered into 33,409 'transcriptional units', contributing 90.1% of a newly established mouse transcriptome database. Of these transcriptional units, 4,258 are new protein-coding and 11,665 are new non-coding messages, indicating that non-coding RNA is a major component of the transcriptome. 41% of all transcriptional units showed evidence of alternative splicing. In protein-coding transcripts, 79% of splice variations altered the protein product. Whole-transcriptome analyses resulted in the identification of 2,431 sense-antisense pairs. The present work, completely supported by physical clones, provides the most comprehensive survey of a mammalian transcriptome so far, and is a valuable resource for functional genomics. Title: Functional annotation of a full-length mouse cDNA collection Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y and Hayashizaki Y <86 more author(s)> Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schonbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y (- 86) Ref: Nature, 409:685, 2001 : PubMed ESTHER: Kawai_2001_Nature_409_685 PubMedSearch: Kawai 2001 Nature 409 685 PubMedID: 11217851 Gene_locus related to this paper: mouse-1lipg, mouse-1plip, mouse-1plrp, mouse-ABH15, mouse-abhd5, mouse-ABHD6, mouse-Abhd8, mouse-aryla, mouse-bphl, mouse-cauxin, mouse-Ces1g, mouse-CPMac, mouse-dpp8, mouse-EPHX1, mouse-ES10, mouse-hslip, mouse-hyes, mouse-ABHD2, mouse-lcat, mouse-lipli, mouse-LIPN, mouse-lypla1, mouse-lypla2, mouse-OVCA2, mouse-pafa, mouse-pcp, mouse-Ppgb, mouse-PPME1, mouse-ppt, mouse-q3uuq7, mouse-Q9DAI6, mouse-Q80UX8, mouse-RISC, mouse-SERHL, mouse-SPG21, mouse-Tex30 Abstract The RIKEN Mouse Gene Encyclopaedia Project, a systematic approach to determining the full coding potential of the mouse genome, involves collection and sequencing of full-length complementary DNAs and physical mapping of the corresponding genes to the mouse genome. We organized an international functional annotation meeting (FANTOM) to annotate the first 21,076 cDNAs to be analysed in this project. Here we describe the first RIKEN clone collection, which is one of the largest described for any organism. Analysis of these cDNAs extends known gene families and identifies new ones. Title: Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease Nakano S, Asada T, Matsuda H, Uno M, Takasaki M Ref: J Nucl Med, 42:1441, 2001 : PubMed ESTHER: Nakano_2001_J.Nucl.Med_42_1441 PubMedSearch: Nakano 2001 J.Nucl.Med 42 1441 PubMedID: 11585854 Abstract The aim of this SPECT study was to investigate the effects of donepezil on regional cerebral blood flow (rCBF) in patients with mild to moderate Alzheimer's disease (AD) using statistical parametric mapping. METHODS: rCBF was noninvasively measured using (99m)Tc-ethyl cysteinate dimer in 35 AD patients with a Mini-Mental State Examination score > 16 on initial evaluation. Baseline and follow-up SPECT studies with a mean interval of 12 mo were performed on these patients. We used the adjusted rCBF images in the relative flow distribution (normalization of global cerebral blood flow for each patient to 50 mL/100 g/min with proportional scaling) to compare these groups through statistical parametric mapping. RESULTS: In the follow-up study, the adjusted rCBF was significantly preserved in the right and left anterior cingulate gyri, right middle temporal gyrus, right inferior parietal lobules, and prefrontal cortex of donepezil-treated AD patients, compared with placebo-treated AD patients. CONCLUSION: Treatment with donepezil for 1 y appears to reduce the decline in rCBF, suggesting preservation of functional brain activity. Title: Changes in mRNA expression levels of synaptic- and target tissue-specific proteins after organophosphate exposure Matsuda H, Seo Y, Kakizaki E, Takahama K Ref: Leg Med (Tokyo), 2:55, 2000 : PubMed ESTHER: Matsuda_2000_Leg.Med.(Tokyo)_2_55 PubMedSearch: Matsuda 2000 Leg.Med.(Tokyo) 2 55 PubMedID: 12935443 Inhibitor(s) related to this paper: Disulfoton Abstract We examined the effects of organophosphate exposure on mRNA expression levels of synaptic- and target tissue-specific proteins in rats. We treated rats with a single dose of Disulfoton (O,O-diethyl S-2-ethylthioethyl phosphorodithioate) and used quantitative reverse transcription-polymerase chain reaction (RT-PCR) to measure the time course of changes in the levels of mRNAs encoding acetylcholinesterase (AChE), nicotinic acetylcholine receptor (nAChR), beta-enolase (MSE), and gamma-enolase (NSE) in soleus muscles and sciatic nerves. The expression levels of synaptic genes encoding AChE in both tissues were significantly decreased, with a nadir at 12h after the administration, and this down-regulation lasted for up to 30 days after administration. Similarly, the level of nAChR mRNA in soleus muscle also decreased, with a nadir at 48 h after administration and a return to 95% of that of the control levels by 30 days after administration. These results indicate that administration of organophosphate can decrease AChE and nAChR expression in the neuromuscular junction, and are suggestive of multiple mechanisms of down-regulation of both AChE and nAChR, some of which might involve alterations at the transcriptional level. The transcript level of the target tissue-specific gene encoding MSE in soleus muscle was slightly decreased, with a nadir at 48 h after administration, and was still lower than that of the control level after 30 days. In contrast, the level of the NSE transcript in sciatic nerve significantly increased within 2 h, and this up-regulation was sustained until 30 days after administration. Although the functions of either of these enolases are not completely established, up-regulation of NSE mRNA may be a marker for the nervous system abnormality following organophosphate exposure. All of these phenomena may contribute to the long-lasting neurotoxic effects observed after developmental exposure to organophosphates. Title: Predictive value of preoperative serum cholinesterase concentration in patients with liver dysfunction undergoing cardiac surgery Hirata N, Sawa Y, Matsuda H Ref: J Card Surg, 14:172, 1999 : PubMed ESTHER: Hirata_1999_J.Card.Surg_14_172 PubMedSearch: Hirata 1999 J.Card.Surg 14 172 PubMedID: 10789703 Abstract OBJECTIVE: There are an increasing number of patients with severe liver dysfunction subjected to open heart surgery. This retrospective study was designed to assess operative results and clarify the degree of liver injury in patients with liver dysfunction undergoing open heart surgery. In addition, determinants influencing their prognosis were assessed. Title: Ultrastructural localisation of cholinesterase activity in the nervous system of the rabbit iris dilator Matsuda H Ref: Japanese Journal of Ophthahmology, 14:21, 1970 : PubMed | |||||||
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