Full name : Munoz-Torrero Diego
First name : Diego
Mail : Laboratori de Quemica Farmaceutica\; Facultat de Farmacia\; Av. Diagonal 643\; 8028 Barcelona
Zip Code :
City :
Country : Spain
Email : dmunoztorrero@ub.edu
Phone : +34934024533
Fax :
Website :
Directory :
| Title : Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets - Luque_2024_Acc.Chem.Res__ |
| Author(s) : Luque FJ , Munoz-Torrero D |
| Ref : Acc Chem Res , : , 2024 |
| Abstract : Luque_2024_Acc.Chem.Res__ |
| ESTHER : Luque_2024_Acc.Chem.Res__ |
| PubMedSearch : Luque_2024_Acc.Chem.Res__ |
| PubMedID: 38333993 |
| Title : A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer's disease exacerbated with high fat diet - Espinosa-Jimenez_2023_Cell.Biosci_13_52 |
| Author(s) : Espinosa-Jimenez T , Cano A , Sanchez-Lopez E , Olloquequi J , Folch J , Bullo M , Verdaguer E , Auladell C , Pont C , Munoz-Torrero D , Parcerisas A , Camins A , Ettcheto M |
| Ref : Cell Biosci , 13 :52 , 2023 |
| Abstract : Espinosa-Jimenez_2023_Cell.Biosci_13_52 |
| ESTHER : Espinosa-Jimenez_2023_Cell.Biosci_13_52 |
| PubMedSearch : Espinosa-Jimenez_2023_Cell.Biosci_13_52 |
| PubMedID: 36895036 |
| Title : Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis - Sampietro_2022_Pharmaceuticals.(Basel)_15_ |
| Author(s) : Sampietro A , Perez-Areales FJ , Martinez P , Arce EM , Galdeano C , Munoz-Torrero D |
| Ref : Pharmaceuticals (Basel) , 15 : , 2022 |
| Abstract : Sampietro_2022_Pharmaceuticals.(Basel)_15_ |
| ESTHER : Sampietro_2022_Pharmaceuticals.(Basel)_15_ |
| PubMedSearch : Sampietro_2022_Pharmaceuticals.(Basel)_15_ |
| PubMedID: 35631371 |
| Title : A Combined Chronic Low-Dose Soluble Epoxide Hydrolase and Acetylcholinesterase Pharmacological Inhibition Promotes Memory Reinstatement in Alzheimer's Disease Mice Models - Jarne-Ferrer_2022_Pharmaceuticals.(Basel)_15_ |
| Author(s) : Jarne-Ferrer J , Grinan-Ferre C , Bellver-Sanchis A , Vazquez S , Munoz-Torrero D , Pallas M |
| Ref : Pharmaceuticals (Basel) , 15 : , 2022 |
| Abstract : Jarne-Ferrer_2022_Pharmaceuticals.(Basel)_15_ |
| ESTHER : Jarne-Ferrer_2022_Pharmaceuticals.(Basel)_15_ |
| PubMedSearch : Jarne-Ferrer_2022_Pharmaceuticals.(Basel)_15_ |
| PubMedID: 35893732 |
| Title : Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease - Codony_2022_J.Med.Chem_65_4909 |
| Author(s) : Codony S , Pont C , Grinan-Ferre C , Di Pede-Mattatelli A , Calvo-Tusell C , Feixas F , Osuna S , Jarne-Ferrer J , Naldi M , Bartolini M , Loza MI , Brea J , Perez B , Bartra C , Sanfeliu C , Juarez-Jimenez J , Morisseau C , Hammock BD , Pallas M , Vazquez S , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 65 :4909 , 2022 |
| Abstract : Codony_2022_J.Med.Chem_65_4909 |
| ESTHER : Codony_2022_J.Med.Chem_65_4909 |
| PubMedSearch : Codony_2022_J.Med.Chem_65_4909 |
| PubMedID: 35271276 |
| Title : From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects - Pont_2021_Eur.J.Med.Chem_225_113779 |
| Author(s) : Pont C , Ginex T , Grinan-Ferre C , Scheiner M , Mattellone A , Martinez N , Arce EM , Soriano-Fernandez Y , Naldi M , De Simone A , Barenys M , Gomez-Catalan J , Perez B , Sabate R , Andrisano V , Loza MI , Brea J , Bartolini M , Bolognesi ML , Decker M , Pallas M , Luque FJ , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113779 , 2021 |
| Abstract : Pont_2021_Eur.J.Med.Chem_225_113779 |
| ESTHER : Pont_2021_Eur.J.Med.Chem_225_113779 |
| PubMedSearch : Pont_2021_Eur.J.Med.Chem_225_113779 |
| PubMedID: 34418785 |
| Title : Protective Role of a Donepezil-Huprine Hybrid against the beta-Amyloid (1-42) Effect on Human Erythrocytes - Zambrano_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Zambrano P , Suwalsky M , Jemiola-Rzeminska M , Gallardo-Nelson MJ , Strzalka K , Munoz-Torrero D |
| Ref : Int J Mol Sci , 22 : , 2021 |
| Abstract : Zambrano_2021_Int.J.Mol.Sci_22_ |
| ESTHER : Zambrano_2021_Int.J.Mol.Sci_22_ |
| PubMedSearch : Zambrano_2021_Int.J.Mol.Sci_22_ |
| PubMedID: 34502472 |
| Title : Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP\/PS1 Mice - Viayna_2021_J.Med.Chem_64_812 |
| Author(s) : Viayna E , Coquelle N , Cieslikiewicz-Bouet M , Cisternas P , Oliva CA , Sanchez-Lopez E , Ettcheto M , Bartolini M , De Simone A , Ricchini M , Rendina M , Pons M , Firuzi O , Perez B , Saso L , Andrisano V , Nachon F , Brazzolotto X , Garcia ML , Camins A , Silman I , Jean L , Inestrosa NC , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 64 :812 , 2021 |
| Abstract : Viayna_2021_J.Med.Chem_64_812 |
| ESTHER : Viayna_2021_J.Med.Chem_64_812 |
| PubMedSearch : Viayna_2021_J.Med.Chem_64_812 |
| PubMedID: 33356266 |
| Gene_locus related to this paper: human-ACHE |
| Title : Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6 - Perez-Areales_2020_J.Med.Chem_63_9360 |
| Author(s) : Perez-Areales FJ , Garrido M , Aso E , Bartolini M , De Simone A , Espargaro A , Ginex T , Sabate R , Perez B , Andrisano V , Puigoriol-Illamola D , Pallas M , Luque FJ , Loza MI , Brea J , Ferrer I , Ciruela F , Messeguer A , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 63 :9360 , 2020 |
| Abstract : Perez-Areales_2020_J.Med.Chem_63_9360 |
| ESTHER : Perez-Areales_2020_J.Med.Chem_63_9360 |
| PubMedSearch : Perez-Areales_2020_J.Med.Chem_63_9360 |
| PubMedID: 32706255 |
| Title : A novel class of multitarget anti-Alzheimer benzohomoadamantanechlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors - Perez-Areales_2019_Eur.J.Med.Chem_180_613 |
| Author(s) : Perez-Areales FJ , Turcu AL , Barniol-Xicota M , Pont C , Pivetta D , Espargaro A , Bartolini M , De Simone A , Andrisano V , Perez B , Sabate R , Sureda FX , Vazquez S , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 180 :613 , 2019 |
| Abstract : Perez-Areales_2019_Eur.J.Med.Chem_180_613 |
| ESTHER : Perez-Areales_2019_Eur.J.Med.Chem_180_613 |
| PubMedSearch : Perez-Areales_2019_Eur.J.Med.Chem_180_613 |
| PubMedID: 31351393 |
| Title : Neuroprotective Effects of the Multitarget Agent AVCRI104P3 in Brain of Middle-Aged Mice - Relat_2018_Int.J.Mol.Sci_19_ |
| Author(s) : Relat J , Come J , Perez B , Camps P , Munoz-Torrero D , Badia A , Gimenez-Llort L , Clos MV |
| Ref : Int J Mol Sci , 19 : , 2018 |
| Abstract : Relat_2018_Int.J.Mol.Sci_19_ |
| ESTHER : Relat_2018_Int.J.Mol.Sci_19_ |
| PubMedSearch : Relat_2018_Int.J.Mol.Sci_19_ |
| PubMedID: 30181440 |
| Title : Huprine X Attenuates The Neurotoxicity Induced by Kainic Acid, Especially Brain Inflammation - Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| Author(s) : Relat J , Perez B , Camps P , Munoz-Torrero D , Badia A , Victoria Clos M |
| Ref : Basic Clin Pharmacol Toxicol , 122 :94 , 2018 |
| Abstract : Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| ESTHER : Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| PubMedSearch : Relat_2018_Basic.Clin.Pharmacol.Toxicol_122_94 |
| PubMedID: 28724203 |
| Title : Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis - Galdeano_2018_Molecules_23_ |
| Author(s) : Galdeano C , Coquelle N , Cieslikiewicz-Bouet M , Bartolini M , Perez B , Clos MV , Silman I , Jean L , Colletier JP , Renard PY , Munoz-Torrero D |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Galdeano_2018_Molecules_23_ |
| ESTHER : Galdeano_2018_Molecules_23_ |
| PubMedSearch : Galdeano_2018_Molecules_23_ |
| PubMedID: 29534488 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids - Perez-Areales_2017_Future.Med.Chem_9_965 |
| Author(s) : Perez-Areales FJ , Betari N , Viayna A , Pont C , Espargaro A , Bartolini M , De Simone A , Rinaldi Alvarenga JF , Perez B , Sabate R , Lamuela-Raventos RM , Andrisano V , Luque FJ , Munoz-Torrero D |
| Ref : Future Med Chem , 9 :965 , 2017 |
| Abstract : Perez-Areales_2017_Future.Med.Chem_9_965 |
| ESTHER : Perez-Areales_2017_Future.Med.Chem_9_965 |
| PubMedSearch : Perez-Areales_2017_Future.Med.Chem_9_965 |
| PubMedID: 28632395 |
| Title : Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease - Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| Author(s) : Gimenez-Llort L , Ratia M , Perez B , Camps P , Munoz-Torrero D , Badia A , Clos MV |
| Ref : Behav Pharmacol , 28 :124 , 2017 |
| Abstract : Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| ESTHER : Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| PubMedSearch : Gimenez-Llort_2017_Behav.Pharmacol_28_124 |
| PubMedID: 28125507 |
| Title : Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AbetaPPswe\/PS-1 Mice of Different Ages - Serrano_2016_Curr.Alzheimer.Res_13_1017 |
| Author(s) : Serrano FG , Tapia-Rojas C , Carvajal FJ , Cisternas P , Viayna E , Sola I , Munoz-Torrero D , Inestrosa NC |
| Ref : Curr Alzheimer Res , 13 :1017 , 2016 |
| Abstract : Serrano_2016_Curr.Alzheimer.Res_13_1017 |
| ESTHER : Serrano_2016_Curr.Alzheimer.Res_13_1017 |
| PubMedSearch : Serrano_2016_Curr.Alzheimer.Res_13_1017 |
| PubMedID: 26502813 |
| Title : Special Issue: Molecules against Alzheimer - Decker_2016_Molecules_21_ |
| Author(s) : Decker M , Munoz-Torrero D |
| Ref : Molecules , 21 : , 2016 |
| Abstract : Decker_2016_Molecules_21_ |
| ESTHER : Decker_2016_Molecules_21_ |
| PubMedSearch : Decker_2016_Molecules_21_ |
| PubMedID: 27999295 |
| Title : Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity - Di Pietro_2015_Eur.J.Med.Chem_105_120 |
| Author(s) : Di Pietro O , Vicente-Garcia E , Taylor MC , Berenguer D , Viayna E , Lanzoni A , Sola I , Sayago H , Riera C , Fisa R , Clos MV , Perez B , Kelly JM , Lavilla R , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 105 :120 , 2015 |
| Abstract : Di Pietro_2015_Eur.J.Med.Chem_105_120 |
| ESTHER : Di Pietro_2015_Eur.J.Med.Chem_105_120 |
| PubMedSearch : Di Pietro_2015_Eur.J.Med.Chem_105_120 |
| PubMedID: 26479031 |
| Title : Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases - Torrent_2015_Acta.Neuropathol.Commun_3_18 |
| Author(s) : Torrent J , Vilchez-Acosta A , Munoz-Torrero D , Trovaslet M , Nachon F , Chatonnet A , Grznarova K , Acquatella-Tran Van Ba I , Le Goffic R , Herzog L , Beringue V , Rezaei H |
| Ref : Acta Neuropathologica Commun , 3 :18 , 2015 |
| Abstract : Torrent_2015_Acta.Neuropathol.Commun_3_18 |
| ESTHER : Torrent_2015_Acta.Neuropathol.Commun_3_18 |
| PubMedSearch : Torrent_2015_Acta.Neuropathol.Commun_3_18 |
| PubMedID: 25853328 |
| Title : AVCRI104P3, a novel multitarget compound with cognition-enhancing and anxiolytic activities: Studies in cognitively poor middle-aged mice - Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| Author(s) : Gimenez-Llort L , Ratia M , Perez B , Camps P , Munoz-Torrero D , Badia A , Clos MV |
| Ref : Behavioural Brain Research , 286 :97 , 2015 |
| Abstract : Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| ESTHER : Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| PubMedSearch : Gimenez-Llort_2015_Behav.Brain.Res_286_97 |
| PubMedID: 25732954 |
| Title : Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies - Sola_2015_J.Med.Chem_58_6018 |
| Author(s) : Sola I , Aso E , Frattini D , Lopez-Gonzalez I , Espargaro A , Sabate R , Di Pietro O , Luque FJ , Clos MV , Ferrer I , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 58 :6018 , 2015 |
| Abstract : Sola_2015_J.Med.Chem_58_6018 |
| ESTHER : Sola_2015_J.Med.Chem_58_6018 |
| PubMedSearch : Sola_2015_J.Med.Chem_58_6018 |
| PubMedID: 26181606 |
| Title : Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity - Sola_2015_Bioorg.Med.Chem_23_5156 |
| Author(s) : Sola I , Castella S , Viayna E , Galdeano C , Taylor MC , Gbedema SY , Perez B , Clos MV , Jones DC , Fairlamb AH , Wright CW , Kelly JM , Munoz-Torrero D |
| Ref : Bioorganic & Medicinal Chemistry , 23 :5156 , 2015 |
| Abstract : Sola_2015_Bioorg.Med.Chem_23_5156 |
| ESTHER : Sola_2015_Bioorg.Med.Chem_23_5156 |
| PubMedSearch : Sola_2015_Bioorg.Med.Chem_23_5156 |
| PubMedID: 25678015 |
| Title : Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting beta-amyloid, tau, and cholinesterase pathologies - Di Pietro_2014_Eur.J.Med.Chem_84C_107 |
| Author(s) : Di Pietro O , Perez-Areales FJ , Juarez-Jimenez J , Espargaro A , Clos MV , Perez B , Lavilla R , Sabate R , Luque FJ , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 84C :107 , 2014 |
| Abstract : Di Pietro_2014_Eur.J.Med.Chem_84C_107 |
| ESTHER : Di Pietro_2014_Eur.J.Med.Chem_84C_107 |
| PubMedSearch : Di Pietro_2014_Eur.J.Med.Chem_84C_107 |
| PubMedID: 25016233 |
| Title : Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines - Sola_2014_Bioorg.Med.Chem.Lett_24_5435 |
| Author(s) : Sola I , Artigas A , Taylor MC , Gbedema SY , Perez B , Clos MV , Wright CW , Kelly JM , Munoz-Torrero D |
| Ref : Bioorganic & Medicinal Chemistry Lett , 24 :5435 , 2014 |
| Abstract : Sola_2014_Bioorg.Med.Chem.Lett_24_5435 |
| ESTHER : Sola_2014_Bioorg.Med.Chem.Lett_24_5435 |
| PubMedSearch : Sola_2014_Bioorg.Med.Chem.Lett_24_5435 |
| PubMedID: 25454267 |
| Title : Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with beta-amyloid and tau anti-aggregating properties - Perez-Areales_2014_Bioorg.Med.Chem_22_5298 |
| Author(s) : Perez-Areales FJ , Di Pietro O , Espargaro A , Vallverdu-Queralt A , Galdeano C , Ragusa IM , Viayna E , Guillou C , Clos MV , Perez B , Sabate R , Lamuela-Raventos RM , Luque FJ , Munoz-Torrero D |
| Ref : Bioorganic & Medicinal Chemistry , 22 :5298 , 2014 |
| Abstract : Perez-Areales_2014_Bioorg.Med.Chem_22_5298 |
| ESTHER : Perez-Areales_2014_Bioorg.Med.Chem_22_5298 |
| PubMedSearch : Perez-Areales_2014_Bioorg.Med.Chem_22_5298 |
| PubMedID: 25156301 |
| Title : Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents - Viayna_2014_J.Med.Chem_57_2549 |
| Author(s) : Viayna E , Sola I , Bartolini M , De Simone A , Tapia-Rojas C , Serrano FG , Sabate R , Juarez-Jimenez J , Perez B , Luque FJ , Andrisano V , Clos MV , Inestrosa NC , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 57 :2549 , 2014 |
| Abstract : Viayna_2014_J.Med.Chem_57_2549 |
| ESTHER : Viayna_2014_J.Med.Chem_57_2549 |
| PubMedSearch : Viayna_2014_J.Med.Chem_57_2549 |
| PubMedID: 24568372 |
| Title : Huprine X and Huperzine A Improve Cognition and Regulate Some Neurochemical Processes Related with Alzheimer's Disease in Triple Transgenic Mice (3xTg-AD) - Ratia_2013_Neurodegener.Dis_11_129 |
| Author(s) : Ratia M , Gimenez-Llort L , Camps P , Munoz-Torrero D , Perez B , Clos MV , Badia A |
| Ref : Neurodegener Dis , 11 :129 , 2013 |
| Abstract : Ratia_2013_Neurodegener.Dis_11_129 |
| ESTHER : Ratia_2013_Neurodegener.Dis_11_129 |
| PubMedSearch : Ratia_2013_Neurodegener.Dis_11_129 |
| PubMedID: 22626981 |
| Title : Undifferentiated and Differentiated PC12 Cells Protected by Huprines Against Injury Induced by Hydrogen Peroxide - Pera_2013_PLoS.One_8_e74344 |
| Author(s) : Pera M , Camps P , Munoz-Torrero D , Perez B , Badia A , Clos Guillen MV |
| Ref : PLoS ONE , 8 :e74344 , 2013 |
| Abstract : Pera_2013_PLoS.One_8_e74344 |
| ESTHER : Pera_2013_PLoS.One_8_e74344 |
| PubMedSearch : Pera_2013_PLoS.One_8_e74344 |
| PubMedID: 24086337 |
| Title : 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: Synthesis, pharmacological evaluation and mechanistic studies - Di Pietro_2013_Eur.J.Med.Chem_73C_141 |
| Author(s) : Di Pietro O , Viayna E , Vicente-Garcia E , Bartolini M , Ramon R , Juarez-Jimenez J , Clos MV , Perez B , Andrisano V , Luque FJ , Lavilla R , Munoz-Torrero D |
| Ref : Eur Journal of Medicinal Chemistry , 73C :141 , 2013 |
| Abstract : Di Pietro_2013_Eur.J.Med.Chem_73C_141 |
| ESTHER : Di Pietro_2013_Eur.J.Med.Chem_73C_141 |
| PubMedSearch : Di Pietro_2013_Eur.J.Med.Chem_73C_141 |
| PubMedID: 24389509 |
| Title : Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases - Galdeano_2012_J.Med.Chem_55_661 |
| Author(s) : Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV , Relat J , Ratia M , Bartolini M , Mancini F , Andrisano V , Salmona M , Minguillon C , Gonzalez-Munoz GC , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Munoz-Torrero D |
| Ref : Journal of Medicinal Chemistry , 55 :661 , 2012 |
| Abstract : Galdeano_2012_J.Med.Chem_55_661 |
| ESTHER : Galdeano_2012_J.Med.Chem_55_661 |
| PubMedSearch : Galdeano_2012_J.Med.Chem_55_661 |
| PubMedID: 22185619 |
| Title : Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents - Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| Author(s) : Munoz-Torrero D , Pera M , Relat J , Ratia M , Galdeano C , Viayna E , Sola I , Formosa X , Camps P , Badia A , Clos MV |
| Ref : Neurodegener Dis , 10 :96 , 2012 |
| Abstract : Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| ESTHER : Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| PubMedSearch : Munoz-Torrero_2012_Neurodegener.Dis_10_96 |
| PubMedID: 22236498 |
| Title : Huprines as a new family of dual acting trypanocidal-antiplasmodial agents - Defaux_2011_Bioorg.Med.Chem_19_1702 |
| Author(s) : Defaux J , Sala M , Formosa X , Galdeano C , Taylor MC , Alobaid WA , Kelly JM , Wright CW , Camps P , Munoz-Torrero D |
| Ref : Bioorganic & Medicinal Chemistry , 19 :1702 , 2011 |
| Abstract : Defaux_2011_Bioorg.Med.Chem_19_1702 |
| ESTHER : Defaux_2011_Bioorg.Med.Chem_19_1702 |
| PubMedSearch : Defaux_2011_Bioorg.Med.Chem_19_1702 |
| PubMedID: 21315611 |
| Title : Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates - Camps_2010_Chem.Biol.Interact_187_411 |
| Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Ramirez L , Viayna E , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Bidon-Chanal A , Huertas O , Dafni T , Luque FJ |
| Ref : Chemico-Biological Interactions , 187 :411 , 2010 |
| Abstract : Camps_2010_Chem.Biol.Interact_187_411 |
| ESTHER : Camps_2010_Chem.Biol.Interact_187_411 |
| PubMedSearch : Camps_2010_Chem.Biol.Interact_187_411 |
| PubMedID: 20167211 |
| Title : Structural determinants of the multifunctional profile of dual binding site acetylcholinesterase inhibitors as anti-Alzheimer agents - Galdeano_2010_Curr.Pharm.Des_16_2818 |
| Author(s) : Galdeano C , Viayna E , Arroyo P , Bidon-Chanal A , Blas JR , Munoz-Torrero D , Luque FJ |
| Ref : Curr Pharm Des , 16 :2818 , 2010 |
| Abstract : Galdeano_2010_Curr.Pharm.Des_16_2818 |
| ESTHER : Galdeano_2010_Curr.Pharm.Des_16_2818 |
| PubMedSearch : Galdeano_2010_Curr.Pharm.Des_16_2818 |
| PubMedID: 20698824 |
| Title : Effect of huprine X on beta-amyloid, synaptophysin and alpha7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice - Hedberg_2010_Neurodegener.Dis_7_379 |
| Author(s) : Hedberg MM , Clos MV , Ratia M , Gonzalez D , Lithner CU , Camps P , Munoz-Torrero D , Badia A , Gimenez-Llort L , Nordberg A |
| Ref : Neurodegener Dis , 7 :379 , 2010 |
| Abstract : Hedberg_2010_Neurodegener.Dis_7_379 |
| ESTHER : Hedberg_2010_Neurodegener.Dis_7_379 |
| PubMedSearch : Hedberg_2010_Neurodegener.Dis_7_379 |
| PubMedID: 20689242 |
| Title : Novel huprine derivatives with inhibitory activity toward beta-amyloid aggregation and formation as disease-modifying anti-Alzheimer drug candidates - Viayna_2010_ChemMedChem_5_1855 |
| Author(s) : Viayna E , Gomez T , Galdeano C , Ramirez L , Ratia M , Badia A , Clos MV , Verdaguer E , Junyent F , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Bidon-Chanal A , Luque FJ , Camps P , Munoz-Torrero D |
| Ref : ChemMedChem , 5 :1855 , 2010 |
| Abstract : Viayna_2010_ChemMedChem_5_1855 |
| ESTHER : Viayna_2010_ChemMedChem_5_1855 |
| PubMedSearch : Viayna_2010_ChemMedChem_5_1855 |
| PubMedID: 20859987 |
| Title : Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds - Camps_2009_J.Med.Chem_52_5365 |
| Author(s) : Camps P , Formosa X , Galdeano C , Munoz-Torrero D , Ramirez L , Gomez E , Isambert N , Lavilla R , Badia A , Clos MV , Bartolini M , Mancini F , Andrisano V , Arce MP , Rodriguez-Franco MI , Huertas O , Dafni T , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 52 :5365 , 2009 |
| Abstract : Camps_2009_J.Med.Chem_52_5365 |
| ESTHER : Camps_2009_J.Med.Chem_52_5365 |
| PubMedSearch : Camps_2009_J.Med.Chem_52_5365 |
| PubMedID: 19663388 |
| Title : Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease - Munoz-Torrero_2008_Curr.Med.Chem_15_2433 |
| Author(s) : Munoz-Torrero D |
| Ref : Curr Med Chem , 15 :2433 , 2008 |
| Abstract : Munoz-Torrero_2008_Curr.Med.Chem_15_2433 |
| ESTHER : Munoz-Torrero_2008_Curr.Med.Chem_15_2433 |
| PubMedSearch : Munoz-Torrero_2008_Curr.Med.Chem_15_2433 |
| PubMedID: 18855672 |
| Title : Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation - Camps_2008_J.Med.Chem_51_3588 |
| Author(s) : Camps P , Formosa X , Galdeano C , Gomez T , Munoz-Torrero D , Scarpellini M , Viayna E , Badia A , Clos MV , Camins A , Pallas M , Bartolini M , Mancini F , Andrisano V , Estelrich J , Lizondo M , Bidon-Chanal A , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 51 :3588 , 2008 |
| Abstract : Camps_2008_J.Med.Chem_51_3588 |
| ESTHER : Camps_2008_J.Med.Chem_51_3588 |
| PubMedSearch : Camps_2008_J.Med.Chem_51_3588 |
| PubMedID: 18517184 |
| Title : Acetylcholinesterase triggers the aggregation of PrP 106-126 - Pera_2006_Biochem.Biophys.Res.Commun_346_89 |
| Author(s) : Pera M , Roman S , Ratia M , Camps P , Munoz-Torrero D , Colombo L , Manzoni C , Salmona M , Badia A , Clos MV |
| Ref : Biochemical & Biophysical Research Communications , 346 :89 , 2006 |
| Abstract : Pera_2006_Biochem.Biophys.Res.Commun_346_89 |
| ESTHER : Pera_2006_Biochem.Biophys.Res.Commun_346_89 |
| PubMedSearch : Pera_2006_Biochem.Biophys.Res.Commun_346_89 |
| PubMedID: 16750169 |
| Title : Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole - Camps_2006_J.Med.Chem_49_6833 |
| Author(s) : Camps P , Gomez E , Munoz-Torrero D , Badia A , Clos MV , Curutchet C , Munoz-Muriedas J , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 49 :6833 , 2006 |
| Abstract : Camps_2006_J.Med.Chem_49_6833 |
| ESTHER : Camps_2006_J.Med.Chem_49_6833 |
| PubMedSearch : Camps_2006_J.Med.Chem_49_6833 |
| PubMedID: 17154513 |
| Title : Effect of acetylcholinesterase inhibitors on AChE-induced PrP106-126 aggregation - Clos_2006_J.Mol.Neurosci_30_89 |
| Author(s) : Clos MV , Pera M , Ratia M , Roman S , Camps P , Munoz-Torrero D , Colombo L , Salmona M , Badia A |
| Ref : Journal of Molecular Neuroscience , 30 :89 , 2006 |
| Abstract : Clos_2006_J.Mol.Neurosci_30_89 |
| ESTHER : Clos_2006_J.Mol.Neurosci_30_89 |
| PubMedSearch : Clos_2006_J.Mol.Neurosci_30_89 |
| PubMedID: 17192641 |
| Title : Dimeric and hybrid anti-Alzheimer drug candidates - Munoz-Torrero_2006_Curr.Med.Chem_13_399 |
| Author(s) : Munoz-Torrero D , Camps P |
| Ref : Curr Med Chem , 13 :399 , 2006 |
| Abstract : Munoz-Torrero_2006_Curr.Med.Chem_13_399 |
| ESTHER : Munoz-Torrero_2006_Curr.Med.Chem_13_399 |
| PubMedSearch : Munoz-Torrero_2006_Curr.Med.Chem_13_399 |
| PubMedID: 16475930 |
| Title : Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors - Roman_2005_Brain.Res_1061_73 |
| Author(s) : Roman S , Badia A , Camps P , Munoz-Torrero D , Clos MV |
| Ref : Brain Research , 1061 :73 , 2005 |
| Abstract : Roman_2005_Brain.Res_1061_73 |
| ESTHER : Roman_2005_Brain.Res_1061_73 |
| PubMedSearch : Roman_2005_Brain.Res_1061_73 |
| PubMedID: 16248990 |
| Title : Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors - Camps_2005_J.Med.Chem_48_1701 |
| Author(s) : Camps P , Formosa X , Munoz-Torrero D , Petrignet J , Badia A , Clos MV |
| Ref : Journal of Medicinal Chemistry , 48 :1701 , 2005 |
| Abstract : Camps_2005_J.Med.Chem_48_1701 |
| ESTHER : Camps_2005_J.Med.Chem_48_1701 |
| PubMedSearch : Camps_2005_J.Med.Chem_48_1701 |
| PubMedID: 15771413 |
| Title : (+\/-)-huprine Y, (-)-huperzine A and tacrine do not show neuroprotective properties in an apoptotic model of neuronal cytoskeletal alteration - Jorda_2004_J.Alzheimers.Dis_6_577 |
| Author(s) : Jorda EG , Verdaguer E , Jimenez A , Canudas AM , Rimbau V , Camps P , Munoz-Torrero D , Camins A , Pallas M |
| Ref : J Alzheimers Dis , 6 :577 , 2004 |
| Abstract : Jorda_2004_J.Alzheimers.Dis_6_577 |
| ESTHER : Jorda_2004_J.Alzheimers.Dis_6_577 |
| PubMedSearch : Jorda_2004_J.Alzheimers.Dis_6_577 |
| PubMedID: 15665397 |
| Title : Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids - Alcala_2003_Neuropharmacol_44_749 |
| Author(s) : Alcala Mdel M , Vivas NM , Hospital S , Camps P , Munoz-Torrero D , Badia A |
| Ref : Neuropharmacology , 44 :749 , 2003 |
| Abstract : Alcala_2003_Neuropharmacol_44_749 |
| ESTHER : Alcala_2003_Neuropharmacol_44_749 |
| PubMedSearch : Alcala_2003_Neuropharmacol_44_749 |
| PubMedID: 12681373 |
| Title : Cholinergic drugs in pharmacotherapy of Alzheimer's disease - Camps_2002_Mini.Rev.Med.Chem_2_11 |
| Author(s) : Camps P , Munoz-Torrero D |
| Ref : Mini Rev Med Chem , 2 :11 , 2002 |
| Abstract : Camps_2002_Mini.Rev.Med.Chem_2_11 |
| ESTHER : Camps_2002_Mini.Rev.Med.Chem_2_11 |
| PubMedSearch : Camps_2002_Mini.Rev.Med.Chem_2_11 |
| PubMedID: 12369954 |
| Title : 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates - Dvir_2002_Biochemistry_41_2970 |
| Author(s) : Dvir H , Wong DM , Harel M , Barril X , Orozco M , Luque FJ , Munoz-Torrero D , Camps P , Rosenberry TL , Silman I , Sussman JL |
| Ref : Biochemistry , 41 :2970 , 2002 |
| Abstract : Dvir_2002_Biochemistry_41_2970 |
| ESTHER : Dvir_2002_Biochemistry_41_2970 |
| PubMedSearch : Dvir_2002_Biochemistry_41_2970 |
| PubMedID: 11863435 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Tacrine-huperzine A hybrids (huprines): a new class of highly potent and selective acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease - Camps_2001_Mini.Rev.Med.Chem_1_163 |
| Author(s) : Camps P , Munoz-Torrero D |
| Ref : Mini Rev Med Chem , 1 :163 , 2001 |
| Abstract : Camps_2001_Mini.Rev.Med.Chem_1_163 |
| ESTHER : Camps_2001_Mini.Rev.Med.Chem_1_163 |
| PubMedSearch : Camps_2001_Mini.Rev.Med.Chem_1_163 |
| PubMedID: 12369981 |
| Title : Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors - Camps_2001_J.Med.Chem_44_4733 |
| Author(s) : Camps P , Gomez E , Munoz-Torrero D , Badia A , Vivas NM , Barril X , Orozco M , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 44 :4733 , 2001 |
| Abstract : Camps_2001_J.Med.Chem_44_4733 |
| ESTHER : Camps_2001_J.Med.Chem_44_4733 |
| PubMedSearch : Camps_2001_J.Med.Chem_44_4733 |
| PubMedID: 11741490 |
| Title : The pharmacology of novel acetylcholinesterase inhibitors, (+\/-)- huprines Y and X, on the Torpedo electric organ - Ros_2001_Eur.J.Pharmacol_421_77 |
| Author(s) : Ros E , Aleu J , Gomez de Aranda I , Munoz-Torrero D , Camps P , Badia A , Marsal J , Solsona C |
| Ref : European Journal of Pharmacology , 421 :77 , 2001 |
| Abstract : Ros_2001_Eur.J.Pharmacol_421_77 |
| ESTHER : Ros_2001_Eur.J.Pharmacol_421_77 |
| PubMedSearch : Ros_2001_Eur.J.Pharmacol_421_77 |
| PubMedID: 11399262 |
| Title : Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease - Camps_2000_Mol.Pharmacol_57_409 |
| Author(s) : Camps P , Cusack B , Mallender WD , Achab RE , Morral J , Munoz-Torrero D , Rosenberry TL |
| Ref : Molecular Pharmacology , 57 :409 , 2000 |
| Abstract : Camps_2000_Mol.Pharmacol_57_409 |
| ESTHER : Camps_2000_Mol.Pharmacol_57_409 |
| PubMedSearch : Camps_2000_Mol.Pharmacol_57_409 |
| PubMedID: 10648652 |
| Title : New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease - Camps_2000_J.Med.Chem_43_4657 |
| Author(s) : Camps P , El Achab R , Morral J , Munoz-Torrero D , Badia A , Banos JE , Vivas NM , Barril X , Orozco M , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 43 :4657 , 2000 |
| Abstract : Camps_2000_J.Med.Chem_43_4657 |
| ESTHER : Camps_2000_J.Med.Chem_43_4657 |
| PubMedSearch : Camps_2000_J.Med.Chem_43_4657 |
| PubMedID: 11101357 |
| Title : Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Camps_1999_J.Med.Chem_42_3227 |
| Author(s) : Camps P , El Achab R , Gorbig DM , Morral J , Munoz-Torrero D , Badia A , Eladi Banos J , Vivas NM , Barril X , Orozco M , Luque FJ |
| Ref : Journal of Medicinal Chemistry , 42 :3227 , 1999 |
| Abstract : Camps_1999_J.Med.Chem_42_3227 |
| ESTHER : Camps_1999_J.Med.Chem_42_3227 |
| PubMedSearch : Camps_1999_J.Med.Chem_42_3227 |
| PubMedID: 10464010 |
| Title : Synthesis and evaluation of tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease - Badia_1998_Bioorg.Med.Chem_6_427 |
| Author(s) : Badia A , Banos JE , Camps P , Contreras J , Gorbig DM , Munoz-Torrero D , Simon M , Vivas NM |
| Ref : Bioorganic & Medicinal Chemistry , 6 :427 , 1998 |
| Abstract : Badia_1998_Bioorg.Med.Chem_6_427 |
| ESTHER : Badia_1998_Bioorg.Med.Chem_6_427 |
| PubMedSearch : Badia_1998_Bioorg.Med.Chem_6_427 |
| PubMedID: 9597187 |