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Author Report for: Namgoong SK

Title: Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors
Moon SC, Shin JH, Jeong BH, Kim HS, Yu BS, Lee JS, Lee BS, Namgoong SK
Ref: Bioorganic & Medicinal Chemistry Lett, 10:1435, 2000 : PubMed
Abstract


ESTHER: Moon_2000_Bioorg.Med.Chem.Lett_10_1435
PubMedSearch: Moon 2000 Bioorg.Med.Chem.Lett 10 1435
PubMedID: 10888326

Abstract

New tetrakis(multifluoro-4-pyridyl)porphin derivatives (2-4) and water soluble porphyrin (5) were synthesized to investigate their interactions with acetylcholinesterase from electric eel. These compounds have been found to be the potent reversible inhibitors of the enzyme with Ki values of microM range. In addition, porphyrin (5) showed broad spectrum of anticancer activities.