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| Title : High throughput functional assays for P2X receptors - Namovic_2012_Curr.Protoc.Pharmacol_Chapter 9_Unit 9 15 |
| Author(s) : Namovic MT , Jarvis MF , Donnelly-Roberts D |
| Ref : Curr Protoc Pharmacol , Chapter 9 :Unit 9 15 , 2012 |
| Abstract : Namovic_2012_Curr.Protoc.Pharmacol_Chapter 9_Unit 9 15 |
| ESTHER : Namovic_2012_Curr.Protoc.Pharmacol_Chapter 9_Unit 9 15 |
| PubMedSearch : Namovic_2012_Curr.Protoc.Pharmacol_Chapter 9_Unit 9 15 |
| PubMedID: 22684723 |
| Title : Synthesis and in vitro activity of N-benzyl-1-(2,3-dichlorophenyl)-1H-tetrazol-5-amine P2X(7) antagonists - Perez-Medrano_2011_Bioorg.Med.Chem.Lett_21_3297 |
| Author(s) : Perez-Medrano A , Donnelly-Roberts D , Florjancic AS , Nelson DW , Li T , Namovic MT , Peddi S , Faltynek CR , Jarvis MF , Carroll WA |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :3297 , 2011 |
| Abstract : Perez-Medrano_2011_Bioorg.Med.Chem.Lett_21_3297 |
| ESTHER : Perez-Medrano_2011_Bioorg.Med.Chem.Lett_21_3297 |
| PubMedSearch : Perez-Medrano_2011_Bioorg.Med.Chem.Lett_21_3297 |
| PubMedID: 21536435 |
| Title : Comparative analysis of inactivated-state block of N-type (Ca(v)2.2) calcium channels - Vortherms_2011_Inflamm.Res_60_683 |
| Author(s) : Vortherms TA , Swensen AM , Niforatos W , Limberis JT , Neelands TR , Janis RS , Thimmapaya R , Donnelly-Roberts D , Namovic MT , Zhang D , Brent Putman C , Martin RL , Surowy CS , Jarvis MF , Scott VE |
| Ref : Inflamm Res , 60 :683 , 2011 |
| Abstract : Vortherms_2011_Inflamm.Res_60_683 |
| ESTHER : Vortherms_2011_Inflamm.Res_60_683 |
| PubMedSearch : Vortherms_2011_Inflamm.Res_60_683 |
| PubMedID: 21394563 |
| Title : Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors - Donnelly-Roberts_2009_Br.J.Pharmacol_157_1203 |
| Author(s) : Donnelly-Roberts D , Namovic MT , Han P , Jarvis MF |
| Ref : British Journal of Pharmacology , 157 :1203 , 2009 |
| Abstract : Donnelly-Roberts_2009_Br.J.Pharmacol_157_1203 |
| ESTHER : Donnelly-Roberts_2009_Br.J.Pharmacol_157_1203 |
| PubMedSearch : Donnelly-Roberts_2009_Br.J.Pharmacol_157_1203 |
| PubMedID: 19558545 |
| Title : [3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors - Donnelly-Roberts_2009_Neuropharmacol_56_223 |
| Author(s) : Donnelly-Roberts D , Namovic MT , Surber B , Vaidyanathan SX , Perez-Medrano A , Wang Y , Carroll WA , Jarvis MF |
| Ref : Neuropharmacology , 56 :223 , 2009 |
| Abstract : Donnelly-Roberts_2009_Neuropharmacol_56_223 |
| ESTHER : Donnelly-Roberts_2009_Neuropharmacol_56_223 |
| PubMedSearch : Donnelly-Roberts_2009_Neuropharmacol_56_223 |
| PubMedID: 18602931 |
| Title : Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain - Perez-Medrano_2009_J.Med.Chem_52_3366 |
| Author(s) : Perez-Medrano A , Donnelly-Roberts D , Honore P , Hsieh GC , Namovic MT , Peddi S , Shuai Q , Wang Y , Faltynek CR , Jarvis MF , Carroll WA |
| Ref : Journal of Medicinal Chemistry , 52 :3366 , 2009 |
| Abstract : Perez-Medrano_2009_J.Med.Chem_52_3366 |
| ESTHER : Perez-Medrano_2009_J.Med.Chem_52_3366 |
| PubMedSearch : Perez-Medrano_2009_J.Med.Chem_52_3366 |
| PubMedID: 19397270 |
| Title : Structure-activity relationship studies on N'-aryl carbohydrazide P2X7 antagonists - Nelson_2008_J.Med.Chem_51_3030 |
| Author(s) : Nelson DW , Sarris K , Kalvin DM , Namovic MT , Grayson G , Donnelly-Roberts D , Harris R , Honore P , Jarvis MF , Faltynek CR , Carroll WA |
| Ref : Journal of Medicinal Chemistry , 51 :3030 , 2008 |
| Abstract : Nelson_2008_J.Med.Chem_51_3030 |
| ESTHER : Nelson_2008_J.Med.Chem_51_3030 |
| PubMedSearch : Nelson_2008_J.Med.Chem_51_3030 |
| PubMedID: 18438986 |
| Title : Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists - Florjancic_2008_Bioorg.Med.Chem.Lett_18_2089 |
| Author(s) : Florjancic AS , Peddi S , Perez-Medrano A , Li B , Namovic MT , Grayson G , Donnelly-Roberts D , Jarvis MF , Carroll WA |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2089 , 2008 |
| Abstract : Florjancic_2008_Bioorg.Med.Chem.Lett_18_2089 |
| ESTHER : Florjancic_2008_Bioorg.Med.Chem.Lett_18_2089 |
| PubMedSearch : Florjancic_2008_Bioorg.Med.Chem.Lett_18_2089 |
| PubMedID: 18272366 |
| Title : Synthesis and in vitro activity of N'-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists - Morytko_2008_Bioorg.Med.Chem.Lett_18_2093 |
| Author(s) : Morytko MJ , Betschmann P , Woller K , Ericsson A , Chen H , Donnelly-Roberts D , Namovic MT , Jarvis MF , Carroll WA , Rafferty P |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2093 , 2008 |
| Abstract : Morytko_2008_Bioorg.Med.Chem.Lett_18_2093 |
| ESTHER : Morytko_2008_Bioorg.Med.Chem.Lett_18_2093 |
| PubMedSearch : Morytko_2008_Bioorg.Med.Chem.Lett_18_2093 |
| PubMedID: 18272365 |
| Title : Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists - Carroll_2007_Bioorg.Med.Chem.Lett_17_4044 |
| Author(s) : Carroll WA , Kalvin DM , Perez Medrano A , Florjancic AS , Wang Y , Donnelly-Roberts D , Namovic MT , Grayson G , Honore P , Jarvis MF |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :4044 , 2007 |
| Abstract : Carroll_2007_Bioorg.Med.Chem.Lett_17_4044 |
| ESTHER : Carroll_2007_Bioorg.Med.Chem.Lett_17_4044 |
| PubMedSearch : Carroll_2007_Bioorg.Med.Chem.Lett_17_4044 |
| PubMedID: 17482819 |
| Title : P2X7-related modulation of pathological nociception in rats - McGaraughty_2007_Neurosci_146_1817 |
| Author(s) : McGaraughty S , Chu KL , Namovic MT , Donnelly-Roberts D , Harris RR , Zhang XF , Shieh CC , Wismer CT , Zhu CZ , Gauvin DM , Fabiyi AC , Honore P , Gregg RJ , Kort ME , Nelson DW , Carroll WA , Marsh K , Faltynek CR , Jarvis MF |
| Ref : Neuroscience , 146 :1817 , 2007 |
| Abstract : McGaraughty_2007_Neurosci_146_1817 |
| ESTHER : McGaraughty_2007_Neurosci_146_1817 |
| PubMedSearch : McGaraughty_2007_Neurosci_146_1817 |
| PubMedID: 17478048 |
| Title : Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists - Nelson_2006_J.Med.Chem_49_3659 |
| Author(s) : Nelson DW , Gregg RJ , Kort ME , Perez-Medrano A , Voight EA , Wang Y , Grayson G , Namovic MT , Donnelly-Roberts D , Niforatos W , Honore P , Jarvis MF , Faltynek CR , Carroll WA |
| Ref : Journal of Medicinal Chemistry , 49 :3659 , 2006 |
| Abstract : Nelson_2006_J.Med.Chem_49_3659 |
| ESTHER : Nelson_2006_J.Med.Chem_49_3659 |
| PubMedSearch : Nelson_2006_J.Med.Chem_49_3659 |
| PubMedID: 16759108 |
| Title : Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzam ide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction - Patel_2006_J.Med.Chem_49_7450 |
| Author(s) : Patel MV , Kolasa T , Mortell K , Matulenko MA , Hakeem AA , Rohde JJ , Nelson SL , Cowart MD , Nakane M , Miller LN , Uchic ME , Terranova MA , El-Kouhen OF , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Chang R , Martino BR , Wetter JM , Marsh KC , Martin R , Darbyshire JF , Gintant G , Hsieh GC , Moreland RB , Sullivan JP , Brioni JD , Stewart AO |
| Ref : Journal of Medicinal Chemistry , 49 :7450 , 2006 |
| Abstract : Patel_2006_J.Med.Chem_49_7450 |
| ESTHER : Patel_2006_J.Med.Chem_49_7450 |
| PubMedSearch : Patel_2006_J.Med.Chem_49_7450 |
| PubMedID: 17149874 |
| Title : A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat - Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| Author(s) : Honore P , Donnelly-Roberts D , Namovic MT , Hsieh G , Zhu CZ , Mikusa JP , Hernandez G , Zhong C , Gauvin DM , Chandran P , Harris R , Medrano AP , Carroll W , Marsh K , Sullivan JP , Faltynek CR , Jarvis MF |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 319 :1376 , 2006 |
| Abstract : Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| ESTHER : Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| PubMedSearch : Honore_2006_J.Pharmacol.Exp.Ther_319_1376 |
| PubMedID: 16982702 |
| Title : 1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction - Kolasa_2006_J.Med.Chem_49_5093 |
| Author(s) : Kolasa T , Matulenko MA , Hakeem AA , Patel MV , Mortell K , Bhatia P , Henry R , Nakane M , Hsieh GC , Terranova MA , Uchic ME , Miller LN , Chang R , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Martino B , El Kouhen O , Marsh KC , Wetter JM , Moreland RB , Brioni JD , Stewart AO |
| Ref : Journal of Medicinal Chemistry , 49 :5093 , 2006 |
| Abstract : Kolasa_2006_J.Med.Chem_49_5093 |
| ESTHER : Kolasa_2006_J.Med.Chem_49_5093 |
| PubMedSearch : Kolasa_2006_J.Med.Chem_49_5093 |
| PubMedID: 16913699 |
| Title : Pharmacological characterization of P2X7 receptors in rat peritoneal cells - Chen_2005_Inflamm.Res_54_119 |
| Author(s) : Chen YW , Donnelly-Roberts D , Namovic MT , Gintant GA , Cox BF , Jarvis MF , Harris RR |
| Ref : Inflamm Res , 54 :119 , 2005 |
| Abstract : Chen_2005_Inflamm.Res_54_119 |
| ESTHER : Chen_2005_Inflamm.Res_54_119 |
| PubMedSearch : Chen_2005_Inflamm.Res_54_119 |
| PubMedID: 15883745 |
| Title : 2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist - Nakane_2005_Neuropharmacol_49_112 |
| Author(s) : Nakane M , Cowart MD , Hsieh GC , Miller L , Uchic ME , Chang R , Terranova MA , Donnelly-Roberts D , Namovic MT , Miller TR , Wetter JM , Marsh K , Stewart AO , Brioni JD , Moreland RB |
| Ref : Neuropharmacology , 49 :112 , 2005 |
| Abstract : Nakane_2005_Neuropharmacol_49_112 |
| ESTHER : Nakane_2005_Neuropharmacol_49_112 |
| PubMedSearch : Nakane_2005_Neuropharmacol_49_112 |
| PubMedID: 15992586 |
| Title : Mitogen-activated protein kinase and caspase signaling pathways are required for P2X7 receptor (P2X7R)-induced pore formation in human THP-1 cells - Donnelly-Roberts_2004_J.Pharmacol.Exp.Ther_308_1053 |
| Author(s) : Donnelly-Roberts D , Namovic MT , Faltynek CR , Jarvis MF |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 308 :1053 , 2004 |
| Abstract : Donnelly-Roberts_2004_J.Pharmacol.Exp.Ther_308_1053 |
| ESTHER : Donnelly-Roberts_2004_J.Pharmacol.Exp.Ther_308_1053 |
| PubMedSearch : Donnelly-Roberts_2004_J.Pharmacol.Exp.Ther_308_1053 |
| PubMedID: 14634045 |
| Title : Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning - Stewart_2004_J.Med.Chem_47_2348 |
| Author(s) : Stewart AO , Cowart MD , Moreland RB , Latshaw SP , Matulenko MA , Bhatia PA , Wang X , Daanen JF , Nelson SL , Terranova MA , Namovic MT , Donnelly-Roberts D , Miller LN , Nakane M , Sullivan JP , Brioni JD |
| Ref : Journal of Medicinal Chemistry , 47 :2348 , 2004 |
| Abstract : Stewart_2004_J.Med.Chem_47_2348 |
| ESTHER : Stewart_2004_J.Med.Chem_47_2348 |
| PubMedSearch : Stewart_2004_J.Med.Chem_47_2348 |
| PubMedID: 15084133 |
| Title : Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists - Matulenko_2004_Bioorg.Med.Chem_12_3471 |
| Author(s) : Matulenko MA , Hakeem AA , Kolasa T , Nakane M , Terranova MA , Uchic ME , Miller LN , Chang R , Donnelly-Roberts D , Namovic MT , Moreland RB , Brioni JD , Stewart AO |
| Ref : Bioorganic & Medicinal Chemistry , 12 :3471 , 2004 |
| Abstract : Matulenko_2004_Bioorg.Med.Chem_12_3471 |
| ESTHER : Matulenko_2004_Bioorg.Med.Chem_12_3471 |
| PubMedSearch : Matulenko_2004_Bioorg.Med.Chem_12_3471 |
| PubMedID: 15186832 |
| Title : Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction - Cowart_2004_J.Med.Chem_47_3853 |
| Author(s) : Cowart M , Latshaw SP , Bhatia P , Daanen JF , Rohde J , Nelson SL , Patel M , Kolasa T , Nakane M , Uchic ME , Miller LN , Terranova MA , Chang R , Donnelly-Roberts D , Namovic MT , Hollingsworth PR , Martino BR , Lynch JJ, 3rd , Sullivan JP , Hsieh GC , Moreland RB , Brioni JD , Stewart AO |
| Ref : Journal of Medicinal Chemistry , 47 :3853 , 2004 |
| Abstract : Cowart_2004_J.Med.Chem_47_3853 |
| ESTHER : Cowart_2004_J.Med.Chem_47_3853 |
| PubMedSearch : Cowart_2004_J.Med.Chem_47_3853 |
| PubMedID: 15239663 |
| Title : Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand - Matulenko_2004_Bioorg.Med.Chem.Lett_14_5095 |
| Author(s) : Matulenko MA , Surber B , Fan L , Kolasa T , Nakane M , Terranova MA , Uchic ME , Miller LN , Chang R , Donnelly-Roberts D , Namovic MT , Moreland RB , Brioni JD , Stewart AO |
| Ref : Bioorganic & Medicinal Chemistry Lett , 14 :5095 , 2004 |
| Abstract : Matulenko_2004_Bioorg.Med.Chem.Lett_14_5095 |
| ESTHER : Matulenko_2004_Bioorg.Med.Chem.Lett_14_5095 |
| PubMedSearch : Matulenko_2004_Bioorg.Med.Chem.Lett_14_5095 |
| PubMedID: 15380206 |
| Title : Comparative pharmacology of human dopamine D(2)-like receptor stable cell lines coupled to calcium flux through Galpha(qo5) - Moreland_2004_Biochem.Pharmacol_68_761 |
| Author(s) : Moreland RB , Nakane M , Donnelly-Roberts D , Miller LN , Chang R , Uchic ME , Terranova MA , Gubbins EJ , Helfrich RJ , Namovic MT , El-Kouhen OF , Masters JN , Brioni JD |
| Ref : Biochemical Pharmacology , 68 :761 , 2004 |
| Abstract : Moreland_2004_Biochem.Pharmacol_68_761 |
| ESTHER : Moreland_2004_Biochem.Pharmacol_68_761 |
| PubMedSearch : Moreland_2004_Biochem.Pharmacol_68_761 |
| PubMedID: 15276084 |