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| Title : Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies - Panek_2023_Eur.J.Med.Chem_249_115135 |
| Author(s) : Panek D , Pasieka A , Latacz G , Zareba P , Szczech M , Godyn J , Chantegreil F , Nachon F , Brazzolotto X , Skrzypczak-Wiercioch A , Walczak M , Smolik M , Salat K , Hofner G , Wanner K , Wieckowska A , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 249 :115135 , 2023 |
| Abstract : Panek_2023_Eur.J.Med.Chem_249_115135 |
| ESTHER : Panek_2023_Eur.J.Med.Chem_249_115135 |
| PubMedSearch : Panek_2023_Eur.J.Med.Chem_249_115135 |
| PubMedID: 36696766 |
| Gene_locus related to this paper: human-BCHE |
| Title : Novel drug-like fluorenyl derivatives as selective butyrylcholinesterase and beta-amyloid inhibitors for the treatment of Alzheimer's disease - Pasieka_2023_Bioorg.Med.Chem_88-89_117333 |
| Author(s) : Pasieka A , Panek D , Zareba P , Slugocka E , Gucwa N , Espargaro A , Latacz G , Khan N , Bucki A , Sabate R , Wieckowska A , Malawska B |
| Ref : Bioorganic & Medicinal Chemistry , 88-89 :117333 , 2023 |
| Abstract : Pasieka_2023_Bioorg.Med.Chem_88-89_117333 |
| ESTHER : Pasieka_2023_Bioorg.Med.Chem_88-89_117333 |
| PubMedSearch : Pasieka_2023_Bioorg.Med.Chem_88-89_117333 |
| PubMedID: 37236021 |
| Title : Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, beta-secretase, and amyloid beta aggregation as potential treatment of Alzheimer's disease - Zareba_2023_Eur.J.Med.Chem_261_115832 |
| Author(s) : Zareba P , Latka K , Mazur G , Gryzlo B , Pasieka A , Godyn J , Panek D , Skrzypczak-Wiercioch A , Hofner GC , Latacz G , Maj M , Espargaro A , Sabate R , Jozwiak K , Wanner KT , Salat K , Malawska B , Kulig K , Bajda M |
| Ref : Eur Journal of Medicinal Chemistry , 261 :115832 , 2023 |
| Abstract : Zareba_2023_Eur.J.Med.Chem_261_115832 |
| ESTHER : Zareba_2023_Eur.J.Med.Chem_261_115832 |
| PubMedSearch : Zareba_2023_Eur.J.Med.Chem_261_115832 |
| PubMedID: 37837674 |
| Title : Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease - Svobodova_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Svobodova B , Pulkrabkova L , Panek D , Misiachna A , Kolcheva M , Andrys R , Handl J , Capek J , Nyvltova P , Rousar T , Prchal L , Hepnarova V , Hrabinova M , Muckova L , Tosnerova D , Karabanovich G , Finger V , Soukup O , Horak M , Korabecny J |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : Svobodova_2023_Int.J.Mol.Sci_24_ |
| ESTHER : Svobodova_2023_Int.J.Mol.Sci_24_ |
| PubMedSearch : Svobodova_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37298087 |
| Title : Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau - Wichur_2021_Eur.J.Med.Chem_225_113783 |
| Author(s) : Wichur T , Pasieka A , Godyn J , Panek D , Goral I , Latacz G , Honkisz-Orzechowska E , Bucki A , Siwek A , Gluch-Lutwin M , Knez D , Brazzolotto X , Gobec S , Kolaczkowski M , Sabate R , Malawska B , Wieckowska A |
| Ref : Eur Journal of Medicinal Chemistry , 225 :113783 , 2021 |
| Abstract : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| ESTHER : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| PubMedSearch : Wichur_2021_Eur.J.Med.Chem_225_113783 |
| PubMedID: 34461507 |
| Title : Discovery of multifunctional anti-Alzheimers agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters - Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| Author(s) : Pasieka A , Panek D , Jonczyk J , Godyn J , Szalaj N , Latacz G , Tabor J , Mezeiova E , Chantegreil F , Dias J , Knez D , Lu J , Pi R , Korabecny J , Brazzolotto X , Gobec S , Hofner G , Wanner K , Wieckowska Q , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 218 :113397 , 2021 |
| Abstract : Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| ESTHER : Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| PubMedSearch : Pasieka_2021_Eur.J.Med.Chem_218_113397 |
| PubMedID: 33838585 |
| Title : Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease - Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944 |
| Author(s) : Szalaj N , Godyn J , Jonczyk J , Pasieka A , Panek D , Wichur T , Wieckowski K , Zareba P , Bajda M , Pislar A , Malawska B , Sabate R , Wieckowska A |
| Ref : J Enzyme Inhib Med Chem , 35 :1944 , 2020 |
| Abstract : Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944 |
| ESTHER : Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944 |
| PubMedSearch : Szalaj_2020_J.Enzyme.Inhib.Med.Chem_35_1944 |
| PubMedID: 33092411 |
| Title : New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition - Malek_2019_J.Med.Chem_62_11416 |
| Author(s) : Malek R , Arribas RL , Palomino-Antolin A , Totoson P , Demougeot C , Kobrlova T , Soukup O , Iriepa I , Moraleda I , Diez-Iriepa D , Godyn J , Panek D , Malawska B , Gluch-Lutwin M , Mordyl B , Siwek A , Chabchoub F , Marco-Contelles J , Kiec-Kononowicz K , Egea J , de los Rios C , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 62 :11416 , 2019 |
| Abstract : Malek_2019_J.Med.Chem_62_11416 |
| ESTHER : Malek_2019_J.Med.Chem_62_11416 |
| PubMedSearch : Malek_2019_J.Med.Chem_62_11416 |
| PubMedID: 31724859 |
| Title : 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease - Wichur_2019_Eur.J.Med.Chem_187_111916 |
| Author(s) : Wichur T , Wieckowska A , Wieckowski K , Godyn J , Jonczyk J , Valdivieso ADR , Panek D , Pasieka A , Sabate R , Knez D , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 187 :111916 , 2019 |
| Abstract : Wichur_2019_Eur.J.Med.Chem_187_111916 |
| ESTHER : Wichur_2019_Eur.J.Med.Chem_187_111916 |
| PubMedSearch : Wichur_2019_Eur.J.Med.Chem_187_111916 |
| PubMedID: 31812794 |
| Title : Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity - Marcinkowska_2019_Arch.Pharm.(Weinheim)__e1900041 |
| Author(s) : Marcinkowska M , Bucki A , Panek D , Siwek A , Fajkis N , Bednarski M , Zygmunt M , Godyn J , Del Rio Valdivieso A , Kotanska M , Kolaczkowski M , Wieckowska A |
| Ref : Arch Pharm (Weinheim) , :e1900041 , 2019 |
| Abstract : Marcinkowska_2019_Arch.Pharm.(Weinheim)__e1900041 |
| ESTHER : Marcinkowska_2019_Arch.Pharm.(Weinheim)__e1900041 |
| PubMedSearch : Marcinkowska_2019_Arch.Pharm.(Weinheim)__e1900041 |
| PubMedID: 31162703 |
| Title : Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents - Panek_2018_Molecules_23_ |
| Author(s) : Panek D , Wieckowska A , Pasieka A , Godyn J , Jonczyk J , Bajda M , Knez D , Gobec S , Malawska B |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Panek_2018_Molecules_23_ |
| ESTHER : Panek_2018_Molecules_23_ |
| PubMedSearch : Panek_2018_Molecules_23_ |
| PubMedID: 29414887 |
| Title : Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents - Panek_2018_ACS.Chem.Neurosci_9_1074 |
| Author(s) : Panek D , Wieckowska A , Jonczyk J , Godyn J , Bajda M , Wichur T , Pasieka A , Knez D , Pislar A , Korabecny J , Soukup O , Sepsova V , Sabate R , Kos J , Gobec S , Malawska B |
| Ref : ACS Chem Neurosci , 9 :1074 , 2018 |
| Abstract : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| ESTHER : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| PubMedSearch : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| PubMedID: 29345897 |
| Title : Advances toward multifunctional cholinesterase and beta-amyloid aggregation inhibitors - Panek_2017_Future.Med.Chem_9_1835 |
| Author(s) : Panek D , Wichur T , Godyn J , Pasieka A , Malawska B |
| Ref : Future Med Chem , 9 :1835 , 2017 |
| Abstract : Panek_2017_Future.Med.Chem_9_1835 |
| ESTHER : Panek_2017_Future.Med.Chem_9_1835 |
| PubMedSearch : Panek_2017_Future.Med.Chem_9_1835 |
| PubMedID: 28925729 |
| Title : Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation - Panek_2016_Eur.J.Med.Chem_125_676 |
| Author(s) : Panek D , Wieckowska A , Wichur T , Bajda M , Godyn J , Jonczyk J , Mika K , Janockova J , Soukup O , Knez D , Korabecny J , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 125 :676 , 2016 |
| Abstract : Panek_2016_Eur.J.Med.Chem_125_676 |
| ESTHER : Panek_2016_Eur.J.Med.Chem_125_676 |
| PubMedSearch : Panek_2016_Eur.J.Med.Chem_125_676 |
| PubMedID: 27721153 |
| Title : Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy - Dgachi_2016_Eur.J.Med.Chem_126_576 |
| Author(s) : Dgachi Y , Sokolov O , Luzet V , Godyn J , Panek D , Bonet A , Martin H , Iriepa I , Moraleda I , Garcia-Iriepa C , Janockova J , Richert L , Soukup O , Malawska B , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Eur Journal of Medicinal Chemistry , 126 :576 , 2016 |
| Abstract : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| ESTHER : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| PubMedSearch : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| PubMedID: 27918993 |
| Title : Therapeutic strategies for Alzheimer's disease in clinical trials - Godyn_2016_Pharmacol.Rep_68_127 |
| Author(s) : Godyn J , Jonczyk J , Panek D , Malawska B |
| Ref : Pharmacol Rep , 68 :127 , 2016 |
| Abstract : Godyn_2016_Pharmacol.Rep_68_127 |
| ESTHER : Godyn_2016_Pharmacol.Rep_68_127 |
| PubMedSearch : Godyn_2016_Pharmacol.Rep_68_127 |
| PubMedID: 26721364 |
| Title : Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta - Hebda_2016_Molecules_21_ |
| Author(s) : Hebda M , Bajda M , Wieckowska A , Szalaj N , Pasieka A , Panek D , Godyn J , Wichur T , Knez D , Gobec S , Malawska B |
| Ref : Molecules , 21 : , 2016 |
| Abstract : Hebda_2016_Molecules_21_ |
| ESTHER : Hebda_2016_Molecules_21_ |
| PubMedSearch : Hebda_2016_Molecules_21_ |
| PubMedID: 27023510 |
| Title : Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands - Lazewska_2016_Bioorg.Med.Chem.Lett_26_4140 |
| Author(s) : Lazewska D , Jonczyk J , Bajda M , Szalaj N , Wieckowska A , Panek D , Moore C , Kuder K , Malawska B , Kiec-Kononowicz K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :4140 , 2016 |
| Abstract : Lazewska_2016_Bioorg.Med.Chem.Lett_26_4140 |
| ESTHER : Lazewska_2016_Bioorg.Med.Chem.Lett_26_4140 |
| PubMedSearch : Lazewska_2016_Bioorg.Med.Chem.Lett_26_4140 |
| PubMedID: 27445168 |
| Title : Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease - Guzior_2015_Curr.Med.Chem_22_373 |
| Author(s) : Guzior N , Wieckowska A , Panek D , Malawska B |
| Ref : Curr Med Chem , 22 :373 , 2015 |
| Abstract : Guzior_2015_Curr.Med.Chem_22_373 |
| ESTHER : Guzior_2015_Curr.Med.Chem_22_373 |
| PubMedSearch : Guzior_2015_Curr.Med.Chem_22_373 |
| PubMedID: 25386820 |
| Title : SEARCH FOR POTENTIAL CHOLINESTERASE INHIBITORS FROM THE ZINC DATABASE BY VIRTUAL SCREENING METHOD - Bajda_2015_Acta.Pol.Pharm_72_737 |
| Author(s) : Bajda M , Panek D , Hebda M , Wieckowska A , Guzior N , Malawska B |
| Ref : Acta Pol Pharm , 72 :737 , 2015 |
| Abstract : Bajda_2015_Acta.Pol.Pharm_72_737 |
| ESTHER : Bajda_2015_Acta.Pol.Pharm_72_737 |
| PubMedSearch : Bajda_2015_Acta.Pol.Pharm_72_737 |
| PubMedID: 26647631 |