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Author Report for: Pepeu G

Contact information:

Pepeu Giancarlo
Department of Pharmacology; University of Florence; Pharmacology; Viale Pieraccini 6; Florence
Italy
Phone :
Fax :
Prof. Giancarlo Pepeu passed away in November 2021 at 91. Born in Milan Pepeu graduated in medicine at the University of Florence in 1954, Full professor of Pharmacology in Cagliari in 1968, he returned to Florence in 1974 where he taught in the Faculty of Medicine until 2005. He has contributed substantially to the understanding of the mechanisms of cholinergic neurotransmission in the central nervous system and of the pathophysiology of Alzheimer's disease. His more than 300 articles have had international resonance and have earned him numerous awards.





    Title: Sex and Gender Differences in the Brain Cholinergic System and in the Response to Therapy of Alzheimer Disease with Cholinesterase Inhibitors
    Giacobini E, Pepeu G
    Ref: Curr Alzheimer Res, 15:1077, 2018 : PubMed

            

    Title: Do cholinesterase inhibitors act primarily on attention deficit? A naturalistic study in Alzheimer's disease patients
    Bracco L, Bessi V, Padiglioni S, Marini S, Pepeu G
    Ref: J Alzheimers Dis, 40:737, 2014 : PubMed

            

    Title: Effect of cholinesterase inhibitors on attention
    Pepeu G, Giovannini MG, Bracco L
    Ref: Chemico-Biological Interactions, 203:361, 2013 : PubMed

            

    Title: Cholinesterase inhibitors and memory
    Pepeu G, Giovannini MG
    Ref: Chemico-Biological Interactions, 187:403, 2010 : PubMed

            

    Title: Cholinesterase inhibitors and beyond
    Pepeu G, Giovannini MG
    Ref: Curr Alzheimer Res, 6:86, 2009 : PubMed

            

    Title: N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine
    Cerbai F, Giovannini MG, Melani C, Enz A, Pepeu G
    Ref: European Journal of Pharmacology, 572:142, 2007 : PubMed

            

    Title: Acetylcholine release from fetal tissue homotopically grafted to the motoneuron-depleted lumbar spinal cord. An in vivo microdialysis study in the awake rat
    Gulino R, Cataudella T, Casamenti F, Pepeu G, Stanzani S, Leanza G
    Ref: Experimental Neurology, 204:326, 2007 : PubMed

            

    Title: Cholinergic dysfunction, neuronal damage and axonal loss in TgCRND8 mice
    Bellucci A, Luccarini I, Scali C, Prosperi C, Giovannini MG, Pepeu G, Casamenti F
    Ref: Neurobiol Dis, 23:260, 2006 : PubMed

            

    Title: Inhibition of acetylcholine-induced activation of extracellular regulated protein kinase prevents the encoding of an inhibitory avoidance response in the rat
    Giovannini MG, Pazzagli M, Malmberg-Aiello P, Della Corte L, Rakovska AD, Cerbai F, Casamenti F, Pepeu G
    Ref: Neuroscience, 136:15, 2005 : PubMed

            

    Title: Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent
    Greig NH, Utsuki T, Ingram DK, Wang Y, Pepeu G, Scali C, Yu QS, Mamczarz J, Holloway HW and Lahiri DK <5 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 102:17213, 2005 : PubMed

            

    Title: Activation of the cholinergic system during cognitive processes.
    Giovannini MG, Passani MB, Pepeu G
    Ref: Cholinergic Mechanisms, CRC Press, :387, 2004 : PubMed

            

    Title: Changes in acetylcholine extracellular levels during cognitive processes
    Pepeu G, Giovannini MG
    Ref: Learn Mem, 11:21, 2004 : PubMed

            

    Title: S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat
    Rosi S, Giovannini MG, Lestage P, Munoz C, Corte LD, Pepeu G
    Ref: Neuroscience Letters, 361:120, 2004 : PubMed

            

    Title: Investigation on acetylcholine, aspartate, glutamate and GABA extracellular levels from ventral hippocampus during repeated exploratory activity in the rat
    Bianchi L, Ballini C, Colivicchi MA, Della Corte L, Giovannini MG, Pepeu G
    Ref: Neurochem Res, 28:565, 2003 : PubMed

            

    Title: The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo
    Scali C, Giovannini MG, Prosperi C, Bellucci A, Pepeu G, Casamenti F
    Ref: Neuroscience, 117:909, 2003 : PubMed

            

    Title: Rivastigmine antagonizes deficits in prepulse inhibition induced by selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis
    Ballmaier M, Casamenti F, Scali C, Mazzoncini R, Zoli M, Pepeu G, Spano PF
    Ref: Neuroscience, 114:91, 2002 : PubMed

            

    Title: Beta-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo: involvement of the p38MAPK pathway
    Giovannini MG, Scali C, Prosperi C, Bellucci A, Vannucchi MG, Rosi S, Pepeu G, Casamenti F
    Ref: Neurobiol Dis, 11:257, 2002 : PubMed

            

    Title: Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats
    Scali C, Casamenti F, Bellucci A, Costagli C, Schmidt B, Pepeu G
    Ref: J Neural Transm, 109:1067, 2002 : PubMed

            

    Title: Selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis impairs prepulse inhibition of acoustic startle
    Ballmaier M, Casamenti F, Zoli M, Pepeu G, Spano P
    Ref: Neuroscience, 108:299, 2001 : PubMed

            

    Title: Effects of novelty and habituation on acetylcholine, GABA, and glutamate release from the frontal cortex and hippocampus of freely moving rats
    Giovannini MG, Rakovska A, Benton RS, Pazzagli M, Bianchi L, Pepeu G
    Ref: Neuroscience, 106:43, 2001 : PubMed

            

    Title: NO synthesis inhibition decreases cortical ACh release and impairs retention of a conditioned response
    Kopf SR, Benton RS, Kalfin R, Giovannini MG, Pepeu G
    Ref: Brain Research, 894:141, 2001 : PubMed

            

    Title: Overview and perspective on the therapy of Alzheimer's disease from a preclinical viewpoint
    Pepeu G
    Ref: Prog Neuropsychopharmacol Biological Psychiatry, 25:193, 2001 : PubMed

            

    Title: Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti-inflammatory drug: implication in Alzheimer's disease
    Scali C, Prosperi C, Vannucchi MG, Pepeu G, Casamenti F
    Ref: European Journal of Neuroscience, 12:1900, 2000 : PubMed

            

    Title: Interleukin-1beta activates forebrain glial cells and increases nitric oxide production and cortical glutamate and GABA release in vivo: implications for Alzheimer's disease
    Casamenti F, Prosperi C, Scali C, Giovannelli L, Colivicchi MA, Faussone-Pellegrini MS, Pepeu G
    Ref: Neuroscience, 91:831, 1999 : PubMed

            

    Title: Effects of novelty and pain on behavior and hippocampal extracellular ACh levels in male and female rats
    Ceccarelli I, Casamenti F, Massafra C, Pepeu G, Scali C, Aloisi AM
    Ref: Brain Research, 815:169, 1999 : PubMed

            

    Title: Systemic chlorophenylpiperazine increases acetylcholine release from rat hippocampus-implication of 5-HT2C receptors
    Zhelyazkova-Savova M, Giovannini MG, Pepeu G
    Ref: Pharmacol Res, 40:165, 1999 : PubMed

            

    Title: Long-term changes in the aggregation state and toxic effects of beta-amyloid injected into the rat brain
    Giovannelli L, Scali C, Faussone-Pellegrini MS, Pepeu G, Casamenti F
    Ref: Neuroscience, 87:349, 1998 : PubMed

            

    Title: Effect of subchronic treatment with metrifonate and tacrine on brain cholinergic function in aged F344 rats
    Giovannini MG, Scali C, Bartolini L, Schmidt B, Pepeu G
    Ref: European Journal of Pharmacology, 354:17, 1998 : PubMed

            

    Title: Acetylcholine release from the frontal cortex during exploratory activity
    Giovannini MG, Bartolini L, Kopf SR, Pepeu G
    Ref: Brain Research, 784:218, 1998 : PubMed

            

    Title: Activation of non-NMDA receptors stimulates acetylcholine and GABA release from dorsal hippocampus: a microdialysis study in the rat
    Giovannini MG, Rakovska A, Della Corte L, Bianchi L, Pepeu G
    Ref: Neuroscience Letters, 243:152, 1998 : PubMed

            

    Title: The acetylcholine, GABA, glutamate triangle in the rat forebrain
    Pepeu G, Blandina P
    Ref: Journal de Physiologie (Paris), 92:351, 1998 : PubMed

            

    Title: Neurotensin modulation of acetylcholine and GABA release from the rat hippocampus: an in vivo microdialysis study
    Rakovska A, Giovannini MG, Della Corte L, Kalfin R, Bianchi L, Pepeu G
    Ref: Neurochem Int, 33:335, 1998 : PubMed

            

    Title: Effects of novelty, pain and stress on hippocampal extracellular acetylcholine levels in male rats
    Aloisi AM, Casamenti F, Scali C, Pepeu G, Carli G
    Ref: Brain Research, 748:219, 1997 : PubMed

            

    Title: Stereoselective increase in cholinergic transmission by R-(+)-hyoscyamine
    Ghelardini C, Gualtieri F, Romanelli MN, Angeli P, Pepeu G, Giovannini MG, Casamenti F, Malmberg-Aiello P, Giotti A, Bartolini A
    Ref: Neuropharmacology, 36:281, 1997 : PubMed

            

    Title: Glutamatergic modulation of cortical acetylcholine release in the rat: a combined in vivo microdialysis, retrograde tracing and immunohistochemical study
    Giovannini MG, Giovannelli L, Bianchi L, Kalfin R, Pepeu G
    Ref: European Journal of Neuroscience, 9:1678, 1997 : PubMed

            

    Title: Differential susceptibility of senile and lesion-induced astrogliosis to phosphatidylserine
    Jeglinski W, Pepeu G, Oderfeld-Nowak B
    Ref: Neurobiology of Aging, 18:81, 1997 : PubMed

            

    Title: Effect of metrifonate on extracellular brain acetylcholine and object recognition in aged rats
    Scali C, Giovannini MG, Bartolini L, Prosperi C, Hinz V, Schmidt B, Pepeu G
    Ref: European Journal of Pharmacology, 325:173, 1997 : PubMed

            

    Title: Tacrine administration enhances extracellular acetylcholine in vivo and restores the cognitive impairment in aged rats
    Scali C, Giovannini MG, Prosperi C, Bartolini L, Pepeu G
    Ref: Pharmacol Res, 36:463, 1997 : PubMed

            

    Title: Selective muscarinic antagonists differentially affect in vivo acetylcholine release and memory performances of young and aged rats
    Vannucchi MG, Scali C, Kopf SR, Pepeu G, Casamenti F
    Ref: Neuroscience, 79:837, 1997 : PubMed

            

    Title: Increase of cortical acetylcholine release after systemic administration of chlorophenylpiperazine in the rat: an in vivo microdialysis study
    Zhelyazkova-Savova M, Giovannini MG, Pepeu G
    Ref: Neuroscience Letters, 236:151, 1997 : PubMed

            

    Title: Inhibition of cortical acetylcholine release and cognitive performance by histamine H3 receptor activation in rats
    Blandina P, Giorgetti M, Bartolini L, Cecchi M, Timmerman H, Leurs R, Pepeu G, Giovannini MG
    Ref: British Journal of Pharmacology, 119:1656, 1996 : PubMed

            

    Title: A2 adenosine receptors: their presence and neuromodulatory role in the central nervous system
    Latini S, Pazzagli M, Pepeu G, Pedata F
    Ref: General Pharmacology, 27:925, 1996 : PubMed

            

    Title: Enhanced acetylcholine release in the hippocampus and cortex during acquisition of an operant behavior
    Orsetti M, Casamenti F, Pepeu G
    Ref: Brain Research, 724:89, 1996 : PubMed

            

    Title: Amyloid beta-peptides injection into the cholinergic nuclei: morphological, neurochemical and behavioral effects
    Pepeu G, Giovannelli L, Casamenti F, Scali C, Bartolini L
    Ref: Prog Brain Res, 109:273, 1996 : PubMed

            

    Title: Chiral synthesis and pharmacological evaluation of the enantiomers of SM32, a new analgesic and cognition-enhancing agent
    Romanelli MN, Bartolini A, Bertucci C, Dei S, Ghelardini C, Giovannini MG, Gualtieri F, Pepeu G, Scapecchi S, Teodori E
    Ref: Chirality, 8:579, 1996 : PubMed

            

    Title: Synthesis and enantioselectivity of the enantiomers of PG9 and SM21, new potent analgesic and cognition-enhancing drugs
    Romanelli MN, Bartolini A, Bertucci C, Dei S, Ghelardini C, Giovannini MG, Gualtieri F, Pepeu G, Scapecchi S, Teodori E
    Ref: Chirality, 8:225, 1996 : PubMed

            

    Title: Differential effects of amyloid peptides beta-(1-40) and beta-(25-35) injections into the rat nucleus basalis
    Giovannelli L, Casamenti F, Scali C, Bartolini L, Pepeu G
    Ref: Neuroscience, 66:781, 1995 : PubMed

            

    Title: Differential regulation by N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors of acetylcholine release from the rat striatum in vivo
    Giovannini MG, Camilli F, Mundula A, Bianchi L, Colivicchi MA, Pepeu G
    Ref: Neuroscience, 65:409, 1995 : PubMed

            

    Title: Poster: alpha-Tropanyl esters that increase central ACh release: Enantioselectivity studies support a double mechanism of action
    Gualtieri F, Bartolini A, Bertucci C, Dei S, Ghelardini C, Giovannini MG, Giotti A, Pepeu G, Romanelli MN and Teodori E <1 more author(s)>
    Ref: Life Sciences, 56(11-12):1015, 1995 : PubMed

            

    Title: Peripherally injected scopolamine differentially modulates acetylcholine release in vivo in the young and aged rats
    Scali C, Vannucchi MG, Pepeu G, Casamenti F
    Ref: Neuroscience Letters, 197:171, 1995 : PubMed

            

    Title: Muscarinic receptor modulation of acetylcholine release from rat cerebral cortex and hippocampus
    Vannucchi MG, Pepeu G
    Ref: Neuroscience Letters, 190:53, 1995 : PubMed

            

    Title: Administration of amyloid beta-peptides into the medial septum of rats decreases acetylcholine release from hippocampus in vivo
    Abe E, Casamenti F, Giovannelli L, Scali C, Pepeu G
    Ref: Brain Research, 636:162, 1994 : PubMed

            

    Title: Glutamatergic regulation of acetylcholine output in different brain regions: a microdialysis study in the rat
    Giovannini MG, Camilli F, Mundula A, Pepeu G
    Ref: Neurochem Int, 25:23, 1994 : PubMed

            

    Title: NMDA receptor antagonists decrease GABA outflow from the septum and increase acetylcholine outflow from the hippocampus: a microdialysis study
    Giovannini MG, Mutolo D, Bianchi L, Michelassi A, Pepeu G
    Ref: Journal of Neuroscience, 14:1358, 1994 : PubMed

            

    Title: In vivo regulation of extracellular adenosine levels in the cerebral cortex by NMDA and muscarinic receptors
    Pazzagli M, Corsi C, Latini S, Pedata F, Pepeu G
    Ref: European Journal of Pharmacology, 254:277, 1994 : PubMed

            

    Title: Memory disorders: novel treatments, clinical perspective
    Pepeu G
    Ref: Life Sciences, 55:2189, 1994 : PubMed

            

    Title: Dysfunction of the brain cholinergic system during aging and after lesions of the nucleus basalis of Meynert
    Pepeu G, Marconcini Pepeu I
    Ref: J Neural Transm Suppl, 44:189, 1994 : PubMed

            

    Title: Nerve growth factor increases extracellular acetylcholine levels in the parietal cortex and hippocampus of aged rats and restores object recognition
    Scali C, Casamenti F, Pazzagli M, Bartolini L, Pepeu G
    Ref: Neuroscience Letters, 170:117, 1994 : PubMed

            

    Title: Long-term ethanol consumption by rats: effect on acetylcholine release in vivo, choline acetyltransferase activity, and behavior
    Casamenti F, Scali C, Vannucchi MG, Bartolini L, Pepeu G
    Ref: Neuroscience, 56:465, 1993 : PubMed

            

    Title: Overview and future directions of CNS cholinergic mechanisms
    Pepeu G
    Ref: Prog Brain Res, 98:455, 1993 : PubMed

            

    Title: The brain cholinergic system in ageing mammals
    Pepeu G, Casamenti F, Pepeu IM, Scali C
    Ref: J Reprod Fertil Suppl, 46:155, 1993 : PubMed

            

    Title: Aging of brain cholinergic neurons: pharmacological interventions
    Pepeu G, Casamenti F, Scali C, Jeglinski W
    Ref: Clinical Neuropharmacology, 15 Suppl 1 Pt A:31A, 1992 : PubMed

            

    Title: Phosphatidylserine reverses the age-dependent decrease in cortical acetylcholine release: a microdialysis study
    Casamenti F, Scali C, Pepeu G
    Ref: European Journal of Pharmacology, 194:11, 1991 : PubMed

            

    Title: Effect of thyrotropin releasing hormone (TRH) on acetylcholine release from different brain areas investigated by microdialysis
    Giovannini MG, Casamenti F, Nistri A, Paoli F, Pepeu G
    Ref: British Journal of Pharmacology, 102:363, 1991 : PubMed

            

    Title: A decrease in brain catecholamines prevents oxiracetam antagonism of the effects of scopolamine on memory and brain acetylcholine
    Giovannini MG, Spignoli G, Carla V, Pepeu G
    Ref: Pharmacol Res, 24:395, 1991 : PubMed

            

    Title: Principal aspects of the regulation of acetylcholine release in the brain
    Pepeu G, Casamenti F, Giovannini MG, Vannucchi MG, Pedata F
    Ref: Prog Brain Res, 84:273, 1990 : PubMed

            

    Title: Decrease of acetylcholine release from cortical slices in aged rats: investigations into its reversal by phosphatidylserine
    Vannucchi MG, Casamenti F, Pepeu G
    Ref: Journal of Neurochemistry, 55:819, 1990 : PubMed

            

    Title: Cholinergic and noradrenergic denervations decrease labelled purine release from electrically stimulated rat cortical slices
    Pedata F, Di Patre PL, Giovannini MG, Pazzagli M, Pepeu G
    Ref: Neuroscience, 32:629, 1989 : PubMed

            

    Title: Nootropic drugs and brain cholinergic mechanisms
    Pepeu G, Spignoli G
    Ref: Prog Neuropsychopharmacol Biological Psychiatry, 13 Suppl:S77, 1989 : PubMed

            

    Title: The relationship between the behavioral effects of cognition-enhancing drugs and brain acetylcholine. Nootropic drugs and brain acetylcholine
    Pepeu G, Spignoli G, Giovannini MG, Magnani M
    Ref: Pharmacopsychiatry, 22 Suppl 2:116, 1989 : PubMed

            

    Title: Purinergic modulation of cortical acetylcholine release is decreased in aging rats
    Giovannelli L, Giovannini MG, Pedata F, Pepeu G
    Ref: Experimental Gerontology, 23:175, 1988 : PubMed

            

    Title: Acetylcholine and brain aging
    Pepeu G
    Ref: Pharmacol Res Commun, 20:91, 1988 : PubMed

            

    Title: Cognitive deficits and cholinergic mechanisms in aging brain: investigations on potentially useful drugs
    Pepeu G, Vannucchi MG, Spignoli G
    Ref: Annali dell Istituto Superiore di Sanita, 24:411, 1988 : PubMed

            

    Title: Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis
    Wu CF, Bertorelli R, Sacconi M, Pepeu G, Consolo S
    Ref: Neurobiology of Aging, 9:357, 1988 : PubMed

            

    Title: Recovery of cortical acetylcholine output after ganglioside treatment in rats with lesion of the nucleus basalis
    Florian A, Casamenti F, Pepeu G
    Ref: Neuroscience Letters, 75:313, 1987 : PubMed

            

    Title: An analysis of cholecystokinin-induced increase in acetylcholine output from cerebral cortex of the rat
    Magnani M, Florian A, Casamenti F, Pepeu G
    Ref: Neuropharmacology, 26:1207, 1987 : PubMed

            

    Title: Effect of pyroglutamic acid stereoisomers on ECS and scopolamine-induced memory disruption and brain acetylcholine levels in the rat
    Spignoli G, Magnani M, Giovannini MG, Pepeu G
    Ref: Pharmacol Res Commun, 19:901, 1987 : PubMed

            

    Title: Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine
    Spignoli G, Pepeu G
    Ref: Pharmacol Biochem Behav, 27:491, 1987 : PubMed

            

    Title: Effect of phosphatidylserine on acetylcholine release and content in cortical slices from aging rats
    Vannucchi MG, Pepeu G
    Ref: Neurobiology of Aging, 8:403, 1987 : PubMed

            

    Title: Effect of BM-5, a presynaptic antagonist-postsynaptic agonist, on cortical acetylcholine release
    Casamenti F, Cosi C, Pepeu G
    Ref: European Journal of Pharmacology, 122:288, 1986 : PubMed

            

    Title: Changes in cortical acetylcholine output induced by modulation of the nucleus basalis
    Casamenti F, Deffenu G, Abbamondi AL, Pepeu G
    Ref: Brain Research Bulletin, 16:689, 1986 : PubMed

            

    Title: Biochemical and Behavioral Effects of Ethylcholine Mustard Aziridinium Ion
    Casamenti F, Bracco L, Pedata F, Pepeu G
    Ref: Advances in Behavioral Biology, 30:1137, 1986 : PubMed

            

    Title: Chronic caffeine treatment reduces caffeine but not adenosine effects on cortical acetylcholine release
    Corradetti R, Pedata F, Pepeu G, Vannucchi MG
    Ref: British Journal of Pharmacology, 88:671, 1986 : PubMed

            

    Title: Choline Fluxes to and from the Rat Cerebral Cortex Studied with the Cup Technique in Vivo
    Corradetti R, Brehm R, Loffelholz K, Pepeu G
    Ref: Advances in Behavioral Biology, 30:817, 1986 : PubMed

            

    Title: Effect of adenosine, adenosine derivatives, and caffeine on acetylcholine release from brain synaptosomes: interaction with muscarinic autoregulatory mechanisms
    Pedata F, Giovannelli L, De Sarno P, Pepeu G
    Ref: Journal of Neurochemistry, 46:1593, 1986 : PubMed

            

    Title: Neuroregulators and electrical activity: transmitter and modulator influence on the cortical cholinergic system
    Pepeu G, Pepeu IM
    Ref: Electroencephalography & Clinical Neurophysiology Suppl, 38:406, 1986 : PubMed

            

    Title: Neurotransmitters That Act on Cholinergic Magnocellular Forebrain Nuclei Influence Cortical Acetylcholine Output
    Pepeu G, Casamenti F, Mantovani P, Magnani M
    Ref: Advances in Behavioral Biology, 30:43, 1986 : PubMed

            

    Title: Effect of oxiracetam and piracetam on central cholinergic mechanisms and active-avoidance acquisition
    Spignoli G, Pedata F, Giovannelli L, Banfi S, Moroni F, Pepeu G
    Ref: Clinical Neuropharmacology, 9 Suppl 3:S39, 1986 : PubMed

            

    Title: Oxiracetam prevents electroshock-induced decrease in brain acetylcholine and amnesia
    Spignoli G, Pepeu G
    Ref: European Journal of Pharmacology, 126:253, 1986 : PubMed

            

    Title: Noradrenergic modulation of 4-aminopyridine-induced acetylcholine release from rat cerebral cortex
    Magnani M, Mantovani P, Pepeu G
    Ref: Pharmacol Res Commun, 17:653, 1985 : PubMed

            

    Title: Phosphatidylserine increases acetylcholine release from cortical slices in aged rats
    Pedata F, Giovannelli L, Spignoli G, Giovannini MG, Pepeu G
    Ref: Neurobiology of Aging, 6:337, 1985 : PubMed

            

    Title: Effect of ranitidine on ileal myenteric plexus preparation and on acetyl- and butyrylcholinesterase
    Galli A, Mantovani P, Pepeu G
    Ref: Biochemical Pharmacology, 33:1845, 1984 : PubMed

            

    Title: Effect of cholecystokinin octapeptide and ceruletide on release of acetylcholine from cerebral cortex of the rat in vivo
    Magnani M, Mantovani P, Pepeu G
    Ref: Neuropharmacology, 23:1305, 1984 : PubMed

            

    Title: Poster 64 Ranitidine is a rapidly reversible inhibitor of acetylcholineterase
    Mantovani P, Galli A, Pepeu G
    Ref: In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases, (Brzin M, Barnard EA, Sket D, Eds) De Gruyter:, 1984 : PubMed

            

    Title: Biphasic effect of methylxanthines on acetylcholine release from electrically-stimulated brain slices
    Pedata F, Pepeu G, Spignoli G
    Ref: British Journal of Pharmacology, 83:69, 1984 : PubMed

            

    Title: Effect of adenosine and caffeine on acetylcholine release from electrically stimulated brain slices
    Pedata F, Spignoli G, Pepeu G
    Ref: Annali dell Istituto Superiore di Sanita, 20:33, 1984 : PubMed

            

    Title: A1 and A2 adenosine receptors modulate acetylcholine release from brain slices
    Spignoli G, Pedata F, Pepeu G
    Ref: European Journal of Pharmacology, 97:341, 1984 : PubMed

            

    Title: Effect of adenosine, adenosine triphosphate, adenosine deaminase, dipyridamole and aminophylline on acetylcholine release from electrically-stimulated brain slices
    Pedata F, Antonelli T, Lambertini L, Beani L, Pepeu G
    Ref: Neuropharmacology, 22:609, 1983 : PubMed

            

    Title: Acetylcholine release from rat cortical slices during postnatal development and aging
    Pedata F, Slavikova J, Kotas AM, Pepeu G
    Ref: Neurobiology of Aging, 4:31, 1983 : PubMed

            

    Title: Effects of 4-aminopyridine on acetylcholine output from the cerebral cortex of the rat in vivo
    Casamenti F, Corradetti R, Loffelholz K, Mantovani P, Pepeu G
    Ref: British Journal of Pharmacology, 76:439, 1982 : PubMed

            

    Title: Lesions of cholinergic forebrain nuclei: changes in avoidance behavior and scopolamine actions
    Lo Conte G, Bartolini L, Casamenti F, Marconcini-Pepeu I, Pepeu G
    Ref: Pharmacol Biochem Behav, 17:933, 1982 : PubMed

            

    Title: Effect of magnocellular forebrain nuclei lesions on acetylcholine output from the cerebral cortex, electrocorticogram and behaviour
    Lo Conte G, Casamenti F, Bigl V, Milaneschi E, Pepeu G
    Ref: Archives Italiennes de Biologie, 120:176, 1982 : PubMed

            

    Title: Effect of GABA-mimetic drugs on acetylcholine release in vitro
    Mantovani P, Santicioli P, Pepeu G
    Ref: Acta Physiol Pharmacol Bulg, 8:24, 1982 : PubMed

            

    Title: Changes in synaptosomal high affinity choline uptake following electrical stimulation of guinea-pig cortical slices: effect of atropine and physostigmine
    Antonelli T, Beani L, Bianchi C, Pedata F, Pepeu G
    Ref: British Journal of Pharmacology, 74:525, 1981 : PubMed

            

    Title: Interactions between ionophores, Mg2+ and Ca2+ on acetylcholine formation and release in brain slices
    Mantovani P, Pepeu G
    Ref: Pharmacol Res Commun, 13:175, 1981 : PubMed

            

    Title: Effect of haloperidol and pimozide on acetylcholine output from the cerebral cortex in rats and guinea pigs
    Casamenti F, Bianchi C, Beani L, Pepeu G
    Ref: European Journal of Pharmacology, 65:279, 1980 : PubMed

            

    Title: Acetylcholine input from the cerebral cortex, choline uptake and muscarinic receptors in morphine-dependent, freely-moving rats
    Casamenti F, Pedata F, Corradetti R, Pepeu G
    Ref: Neuropharmacology, 19:597, 1980 : PubMed

            

    Title: Stimulation of acetilcholine (ACh) output from isolated brain slices by anticholinergic drugs: influence of septal lesion, changes in ionic environment and GABA
    Mantovani P, Santicioli P, Lo Conte G, Pepeu G
    Ref: Pharmacol Res Commun, 12:605, 1980 : PubMed

            

    Title: Acetylcholine and amino acid neurotransmitters in epidural cups of freely moving rats: effect of acute and chronic treatment with antischizophrenic drugs
    Moroni F, Casamenti F, Caliari S, Pisani G, Moneti G, Pepeu G
    Ref: Adv Biochem Psychopharmacol, 24:245, 1980 : PubMed

            

    Title: Choline high-affinity uptake and metabolism and choline acetyltransferase activity in the striatum of rats chronically treated with neuroleptics
    Pedata F, Sorbi S, Pepeu G
    Ref: Journal of Neurochemistry, 35:606, 1980 : PubMed

            

    Title: Psychopharmacological prospectives in the treatment of dementia
    Antuono P, Amaducci L, Pazzagli A, Pepeu G
    Ref: Prog Neuropsychopharmacol, 3:75, 1979 : PubMed

            

    Title: Effect of phosphatidylserine on acetylcholine output from the cerebral cortex of the rat
    Casamenti F, Mantovani P, Amaducci L, Pepeu G
    Ref: Journal of Neurochemistry, 32:529, 1979 : PubMed

            

    Title: Stimulation of acetylcholine output from brain slices caused by the ionophores BrX-537A and A23187
    Casamenti F, Mantovani P, Pepeu G
    Ref: British Journal of Pharmacology, 63:259, 1978 : PubMed

            

    Title: Drug effect on cholinergic mechanisms in the cerebral cortex
    Pepeu G
    Ref: Annali dell Istituto Superiore di Sanita, 14:157, 1978 : PubMed

            

    Title: Effect of bromocriptine on acetylcholine output from the cerebral cortex
    Pepeu G, Mantovani P
    Ref: Pharmacology, 16 Suppl 1:204, 1978 : PubMed

            

    Title: Drug Stimulation of Acetylcholine Output from the Cerebral Cortex
    Pepeu G, Mantovani P, Pedata F
    Ref: Advances in Behavioral Biology, 24:605, 1978 : PubMed

            

    Title: Interelationships between dopaminergic and cholinergic systems in the cerebral cortex
    Mantovani P, Bartolini A, Pepeu G
    Ref: Adv Biochem Psychopharmacol, 16:423, 1977 : PubMed

            

    Title: Effect of choline, phosphorylcholine and dimethylaminoethanol on brain acetylcholine level in the rat
    Pedata F, Wieraszko A, Pepeu G
    Ref: Pharmacol Res Commun, 9:755, 1977 : PubMed

            

    Title: Proceedings: Effect of some phospholipids on acetyl-choline output from the cerebral cortex in the rat
    Amaducci L, Mantovani P, Pepeu G
    Ref: British Journal of Pharmacology, 56:379P, 1976 : PubMed

            

    Title: Effect of single and repeated electroshock applications on brain acetylcholine levels and choline acetyltransferase activity in the rat
    Longoni R, Mulas A, Novak BO, Pepeu IM, Pepeu G
    Ref: Neuropharmacology, 15:283, 1976 : PubMed

            

    Title: Investigations into the relationship between phospholipids and brain acetylcholine
    Mantovani P, Pepeu G, Amaducci L
    Ref: Advances in Experimental Medicine & Biology, 72:285, 1976 : PubMed

            

    Title: Changes in regional brain acetylcholine levels during drug-induced convulsions
    Pedata F, Mulas A, Pepeu IM, Pepeu G
    Ref: European Journal of Pharmacology, 40:329, 1976 : PubMed

            

    Title: The influence of raphe lesions on the effect of morphine on nociception and cortical ACh output
    Garau L, Mulas ML, Pepeu G
    Ref: Neuropharmacology, 14:259, 1975 : PubMed

            

    Title: Stimulation by morphine of acetylcholine output from the cerebral cortex of septal rats
    Pepeu G, Garau L, Mulas ML, Marconcini-Pepeu I
    Ref: Brain Research, 100:677, 1975 : PubMed

            

    Title: [Synthesis of acetylcholine; metabolic and pharmacological factors]
    Amaducci L, Gaiti A, Longoni R, Pepeu G, Porcellati G
    Ref: Riv Patol Nerv Ment, 95:196, 1974 : PubMed

            

    Title: Proceedings: Drug effect on acetylcholine level in discrete brain regions of rats killed by microwave irradiation
    Longoni R, Mulas A, Pepeu G
    Ref: British Journal of Pharmacology, 52:429P, 1974 : PubMed

            

    Title: Effect of limbic system lesions on acetylcholine release from the cerebral cortex of the rat
    Mulas A, Mulas ML, Pepeu G
    Ref: Psychopharmacologia, 39:223, 1974 : PubMed

            

    Title: Acetylcholine levels in the frog spinal cord following the administration of different convulsants
    Nistri A, Pepeu G
    Ref: European Journal of Pharmacology, 27:281, 1974 : PubMed

            

    Title: Proceedings: Brain acetylcholine levels and nociceptive threshold in frogs after the administration of morphine, nalorphine and naloxone
    Nistri A, Pepeu G
    Ref: The Journal of Physiology, 241:51P, 1974 : PubMed

            

    Title: Effects of morphine on brain and spinal acetylcholine levels and nociceptive threshold in the frog
    Nistri A, Pepeu G, Cammelli E, Spina L, de Bellis AM
    Ref: Brain Research, 80:199, 1974 : PubMed

            

    Title: Does 5-hydroxytryptamine influence cholinergic mechanisms in the central nervous system?
    Pepeu G, Garau L, Mulas ML
    Ref: Adv Biochem Psychopharmacol, 10:247, 1974 : PubMed

            

    Title: Increase in brain and spinal acetylcholine levels without antinociceptive actions following morphine administration in the frog
    Nistri A, Pepeu G
    Ref: British Journal of Pharmacology, 47:650P, 1973 : PubMed

            

    Title: The release of acetylcholine from the brain: an approach to the study of the central cholinergic mechanisms
    Pepeu G
    Ref: Prog Neurobiol, 2:259, 1973 : PubMed

            

    Title: Changes in the acetylcholine content in the rat brain after lesions of the septum, fimbria and hippocampus
    Pepeu G, Mulas A, Mulas ML
    Ref: Brain Research, 57:153, 1973 : PubMed

            

    Title: Investigations into the release of acetylcholine from the cerebral cortex of the cat: effects of amphetamine, of scopolamine and of septal lesions
    Nistri A, Bartolini A, Deffenu G, Pepeu G
    Ref: Neuropharmacology, 11:665, 1972 : PubMed

            

    Title: Effect of bicuculline and strychnine on the acetylcholine content of the amphibian spinal cord
    Nistri A, Pepeu G
    Ref: British Journal of Pharmacology, 45:173P, 1972 : PubMed

            

    Title: Cholinergic neurotransmission in the central nervous system
    Pepeu G
    Ref: Archives Internationales de Pharmacodynamie et de Therapie, 196:Suppl 196:229, 1972 : PubMed

            

    Title: Effect of septal lesions on acetylcholine output from the cerebral cortex in the cat
    Bartolini A, Defenu G, Nistri A, Pepeu G
    Ref: British Journal of Pharmacology, 41:399P, 1971 : PubMed

            

    Title: Brain acetylcholine levels in rats with septal lesions
    Pepeu G, Mulas A, Ruffi A, Sotgiu P
    Ref: Life Sciences I, 10:181, 1971 : PubMed

            

    Title: The effect of oxotremorine on the acetylcholine content of different parts of cat brain
    Bartolini A, Bartolini R, Pepeu G
    Ref: J Pharm Pharmacol, 22:59, 1970 : PubMed

            

    Title: Investigations into the increase of acetylcholine output from the cerebral cortex of the cat caused by amphetamine
    Pepeu G, Bartolini A, Deffenu G
    Ref: Drugs and Cholinergic Mechanisms in the CNS, :387, 1970 : PubMed

            

    Title: Effect of psychoactive drugs on the output of acetylcholine from the cerebral cortex of the cat
    Pepeu G, Bartolini A
    Ref: European Journal of Pharmacology, 4:254, 1968 : PubMed

            

    Title: Investigations into the acetylcholine output from the cerebral cortex of the cat in the presence of hyoscine
    Bartolini A, Pepeu G
    Ref: British Journal of Pharmacology and Chemotherapy, 31:66, 1967 : PubMed

            

    Title: Acetylcholine and 5-hydroxytryptamine levels of the lateral geniculate bodies and superior colliculus of cats after visual deafferentation
    Deffenu G, Bertaccini G, Pepeu G
    Ref: Experimental Neurology, 17:203, 1967 : PubMed

            

    Title: [Effect of some psychopharmacological agents on acetylcholine release from cerebral cortex in cats]
    Pepeu G, Bartolini A
    Ref: Bollettino Societa Italiana Biologia Sperimentale, 43:1409, 1967 : PubMed

            

    Title: Scopolamine induced changes of brain acetylcholine and EEG pattern in cats with complete pontine transection
    Deffenu G, Mantegazzini P, Pepeu G
    Ref: Archives Italiennes de Biologie, 104:141, 1966 : PubMed

            

    Title: [Amnesic action of some anti-depressive drugs and their effect on cerebral acetylcholine in the rat]
    Pacini S, Gliozzi E, Pepeu G
    Ref: Bollettino Societa Italiana Biologia Sperimentale, 42:1078, 1966 : PubMed

            

    Title: Amnesic properties of scopolamine and brain acetylcholine in the rat
    Pazzagli A, Pepeu G
    Ref: International Journal of Neuropharmacology, 4:291, 1965 : PubMed

            

    Title: [Nicotine and cerebral acetylcholine]
    Pepeu G
    Ref: Arch Ital Sci Farmacol, 15:93, 1965 : PubMed

            

    Title: [Incorporation of P32 into the cat brain with pretrigeminal section and mesencephalic hemi-section]
    Amaducci L, Deffenu G, Pazzagli A, Pepeu G
    Ref: Bollettino Societa Italiana Biologia Sperimentale, 40:Suppl:2065, 1964 : PubMed

            

    Title: THE INFLUENCE OF CENTRALLY ACTING CHOLINOLYTIC DRUGS ON BRAIN ACETYLCHOLINE LEVELS
    Giarman NJ, Pepeu G
    Ref: British Journal of Pharmacology and Chemotherapy, 23:123, 1964 : PubMed

            

    Title: [Correlations between the modifications of behavior induced by scopolamine and cerbral acetylcholine contents in the rat]
    Pazzagli A, Pepeu G
    Ref: Rass Studi Psichiatr, 53:261, 1964 : PubMed

            

    Title: Midbrain hemisection: effect on cortical acetylcholine in the cat
    Pepeu G, Mantegazzini P
    Ref: Science, 145:1069, 1964 : PubMed

            

    Title: Effect of tremorine and some anti-parkinson's disease drugs on acetylcholine in the rat's brain
    Pepeu G
    Ref: Nature, 200:895, 1963 : PubMed

            

    Title: [ACTION OF ANTICHOLINERGIC DRUGS ON CEREBRAL ACETYLCHOLINE]
    Pepeu G, Giarman NJ
    Ref: Arch Ital Sci Farmacol, 13:240, 1963 : PubMed

            

    Title: Drug-induced changes in brain acetylcholine
    Giarman NJ, Pepeu G
    Ref: British Journal of Pharmacology and Chemotherapy, 19:226, 1962 : PubMed

            

    Title: [Variations of the intracellular distribution of cerebral acetylcholine caused by drugs]
    Giarman NJ, Pepeu G
    Ref: Bollettino Societa Italiana Biologia Sperimentale, 37:128, 1961 : PubMed

            

    Title: [Variations in the total acetylcholine content of the guinea pig small intestine induced by various drugs]
    Pepeu G
    Ref: Arch Ital Sci Farmacol, 11:382, 1961 : PubMed

            

    Title: [Action of atropine on the cerebral acetylcholine level]
    Pepeu G, Giarman NJ
    Ref: Bollettino Societa Italiana Biologia Sperimentale, 37:131, 1961 : PubMed

            

    Title: Effect of methylpentynol on acetylcholine in the rat's brain
    Pepeu G, Giarman NJ
    Ref: Nature, 186:638, 1960 : PubMed

            


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