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| Title : Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition - Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| Author(s) : Misiachna A , Svobodova B , Netolicky J , Chvojkova M , Kleteckova L , Prchal L , Novak M , Hrabinova M , Kucera T , Muckova L , Moravcova Z , Karasova JZ , Pejchal J , Blazek F , Malinak D , Hakenova K , Krausova BH , Kolcheva M , Ladislav M , Korabecny J , Pahnke J , Vales K , Horak M , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 266 :116130 , 2024 |
| Abstract : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| ESTHER : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| PubMedSearch : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| PubMedID: 38218127 |
| Title : Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication - Gorecki_2024_Chem.Biol.Interact__110941 |
| Author(s) : Gorecki L , Markova A , Hepnarova V , Zivna N , Junova L , Hrabinova M , Janousek J , Kobrlova T , Prchal L , Jun D , Soukup O , Horn G , Worek F , Marek J , Korabecny J |
| Ref : Chemico-Biological Interactions , :110941 , 2024 |
| Abstract : Gorecki_2024_Chem.Biol.Interact__110941 |
| ESTHER : Gorecki_2024_Chem.Biol.Interact__110941 |
| PubMedSearch : Gorecki_2024_Chem.Biol.Interact__110941 |
| PubMedID: 38493910 |
| Title : Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease - Mezeiova_2024_Biomed.Pharmacother_173_116399 |
| Author(s) : Mezeiova E , Prchal L , Hrabinova M , Muckova L , Pulkrabkova L , Soukup O , Misiachna A , Janousek J , Fibigar J , Kucera T , Horak M , Makhaeva GF , Korabecny J |
| Ref : Biomed Pharmacother , 173 :116399 , 2024 |
| Abstract : Mezeiova_2024_Biomed.Pharmacother_173_116399 |
| ESTHER : Mezeiova_2024_Biomed.Pharmacother_173_116399 |
| PubMedSearch : Mezeiova_2024_Biomed.Pharmacother_173_116399 |
| PubMedID: 38492439 |
| Title : BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS - Prchalova_2023_Biomed.Pharmacother_167_115490 |
| Author(s) : Prchalova E , Sukupova M , Malinak D , Andrys R , Sivak L , Pekarik V , Skarka A , Svobodova J , Prchal L , Fresser L , Heger Z , Musilek K |
| Ref : Biomed Pharmacother , 167 :115490 , 2023 |
| Abstract : Prchalova_2023_Biomed.Pharmacother_167_115490 |
| ESTHER : Prchalova_2023_Biomed.Pharmacother_167_115490 |
| PubMedSearch : Prchalova_2023_Biomed.Pharmacother_167_115490 |
| PubMedID: 37722189 |
| Title : Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation - Novak_2023_ACS.Chem.Biol_18_1993 |
| Author(s) : Novak M , Vajrychova M , Koutsilieri S , Sismanoglou DC , Kobrlova T , Prchal L , Svobodova B , Korabecny J , Zarybnicky T , Raisova-Stuchlikova L , Skalova L , Lauschke VM , Kucera R , Soukup O |
| Ref : ACS Chemical Biology , 18 :1993 , 2023 |
| Abstract : Novak_2023_ACS.Chem.Biol_18_1993 |
| ESTHER : Novak_2023_ACS.Chem.Biol_18_1993 |
| PubMedSearch : Novak_2023_ACS.Chem.Biol_18_1993 |
| PubMedID: 37622522 |
| Title : UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes - Novak_2023_J.Pharm.Biomed.Anal_224_115154 |
| Author(s) : Novak M , Svobodova B , Konecny J , Kuratkova A , Nevosadova L , Prchal L , Korabecny J , Lauschke VM , Soukup O , Kucera R |
| Ref : J Pharm Biomed Anal , 224 :115154 , 2023 |
| Abstract : Novak_2023_J.Pharm.Biomed.Anal_224_115154 |
| ESTHER : Novak_2023_J.Pharm.Biomed.Anal_224_115154 |
| PubMedSearch : Novak_2023_J.Pharm.Biomed.Anal_224_115154 |
| PubMedID: 36442458 |
| Title : Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease - Svobodova_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Svobodova B , Pulkrabkova L , Panek D , Misiachna A , Kolcheva M , Andrys R , Handl J , Capek J , Nyvltova P , Rousar T , Prchal L , Hepnarova V , Hrabinova M , Muckova L , Tosnerova D , Karabanovich G , Finger V , Soukup O , Horak M , Korabecny J |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : Svobodova_2023_Int.J.Mol.Sci_24_ |
| ESTHER : Svobodova_2023_Int.J.Mol.Sci_24_ |
| PubMedSearch : Svobodova_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37298087 |
| Title : Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents - Zorbaz_2022_Eur.J.Med.Chem_238_114377 |
| Author(s) : Zorbaz T , Malinak D , Hofmanova T , Marakovic N , Zunec S , Hrvat NM , Andrys R , Psotka M , Zandona A , Svobodova J , Prchal L , Fingler S , Katalinic M , Kovarik Z , Musilek K |
| Ref : Eur Journal of Medicinal Chemistry , 238 :114377 , 2022 |
| Abstract : Zorbaz_2022_Eur.J.Med.Chem_238_114377 |
| ESTHER : Zorbaz_2022_Eur.J.Med.Chem_238_114377 |
| PubMedSearch : Zorbaz_2022_Eur.J.Med.Chem_238_114377 |
| PubMedID: 35526478 |
| Title : Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides - Kohoutova_2022_J.Enzyme.Inhib.Med.Chem_37_760 |
| Author(s) : Kohoutova Z , Malinak D , Andrys R , Svobodova J , Psotka M , Schmidt M , Prchal L , Musilek K |
| Ref : J Enzyme Inhib Med Chem , 37 :760 , 2022 |
| Abstract : Kohoutova_2022_J.Enzyme.Inhib.Med.Chem_37_760 |
| ESTHER : Kohoutova_2022_J.Enzyme.Inhib.Med.Chem_37_760 |
| PubMedSearch : Kohoutova_2022_J.Enzyme.Inhib.Med.Chem_37_760 |
| PubMedID: 35193448 |
| Title : Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study - Maafi_2021_Bioorg.Med.Chem.Lett_51_128374 |
| Author(s) : Maafi N , Pidany F , Marikova J , Korabecny J , Hulcova D , Kucera T , Schmidt M , Shammari LA , Spulak M , Carmen Catapano M , Mecava M , Prchal L , Kunes J , Janousek J , Kohelova E , Jenco J , Novakova L , Cahlikova L |
| Ref : Bioorganic & Medicinal Chemistry Lett , 51 :128374 , 2021 |
| Abstract : Maafi_2021_Bioorg.Med.Chem.Lett_51_128374 |
| ESTHER : Maafi_2021_Bioorg.Med.Chem.Lett_51_128374 |
| PubMedSearch : Maafi_2021_Bioorg.Med.Chem.Lett_51_128374 |
| PubMedID: 34555506 |
| Title : Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts - Markova_2021_Toxics_9_ |
| Author(s) : Markova A , Hympanova M , Matula M , Prchal L , Sleha R , Benkova M , Pulkrabkova L , Soukup O , Krocova Z , Jun D , Marek J |
| Ref : Toxics , 9 : , 2021 |
| Abstract : Markova_2021_Toxics_9_ |
| ESTHER : Markova_2021_Toxics_9_ |
| PubMedSearch : Markova_2021_Toxics_9_ |
| PubMedID: 34564373 |
| Title : Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment - Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| Author(s) : Mezeiova E , Hrabinova M , Hepnarova V , Jun D , Janockova J , Muckova L , Prchal L , Kristofikova Z , Kucera T , Gorecki L , Chalupova K , Kunes J , Hroudova J , Soukup O , Korabecny J |
| Ref : Bioorganic & Medicinal Chemistry Lett , :128100 , 2021 |
| Abstract : Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| ESTHER : Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| PubMedSearch : Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| PubMedID: 33984470 |
| Title : Development of versatile and potent monoquaternary reactivators of acetylcholinesterase - Gorecki_2021_Arch.Toxicol__ |
| Author(s) : Gorecki L , Hepnarova V , Karasova JZ , Hrabinova M , Courageux C , Dias J , Kucera T , Kobrlova T , Muckova L , Prchal L , Malinak D , Jun D , Musilek K , Worek F , Nachon F , Soukup O , Korabecny J |
| Ref : Archives of Toxicology , : , 2021 |
| Abstract : Gorecki_2021_Arch.Toxicol__ |
| ESTHER : Gorecki_2021_Arch.Toxicol__ |
| PubMedSearch : Gorecki_2021_Arch.Toxicol__ |
| PubMedID: 33517499 |
| Title : 7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo - Kaniakova_2021_Biochem.Pharmacol__114460 |
| Author(s) : Kaniakova M , Korabecny J , Holubova K , Kleteckova L , Chvojkova M , Hakenova K , Prchal L , Novak M , Dolezal R , Hepnarova V , Svobodova B , Kucera T , Lichnerova K , Krausova B , Horak M , Vales K , Soukup O |
| Ref : Biochemical Pharmacology , :114460 , 2021 |
| Abstract : Kaniakova_2021_Biochem.Pharmacol__114460 |
| ESTHER : Kaniakova_2021_Biochem.Pharmacol__114460 |
| PubMedSearch : Kaniakova_2021_Biochem.Pharmacol__114460 |
| PubMedID: 33571502 |
| Title : Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease - Gorecki_2021_ACS.Chem.Neurosci__ |
| Author(s) : Gorecki L , Uliassi E , Bartolini M , Janockova J , Hrabinova M , Hepnarova V , Prchal L , Muckova L , Pejchal J , Karasova JZ , Mezeiova E , Benkova M , Kobrlova T , Soukup O , Petralla S , Monti B , Korabecny J , Bolognesi ML |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : Gorecki_2021_ACS.Chem.Neurosci__ |
| ESTHER : Gorecki_2021_ACS.Chem.Neurosci__ |
| PubMedSearch : Gorecki_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33852284 |
| Title : Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease - Rossi_2021_J.Med.Chem_64_4972 |
| Author(s) : Rossi M , Freschi M , de Camargo Nascente L , Salerno A , de Melo Viana Teixeira S , Nachon F , Chantegreil F , Soukup O , Prchal L , Malaguti M , Bergamini C , Bartolini M , Angeloni C , Hrelia S , Soares Romeiro LA , Bolognesi ML |
| Ref : Journal of Medicinal Chemistry , 64 :4972 , 2021 |
| Abstract : Rossi_2021_J.Med.Chem_64_4972 |
| ESTHER : Rossi_2021_J.Med.Chem_64_4972 |
| PubMedSearch : Rossi_2021_J.Med.Chem_64_4972 |
| PubMedID: 33829779 |
| Gene_locus related to this paper: human-BCHE |
| Title : Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties - de Andrade Ramos_2021_RSC.Med.Chem_12_1154 |
| Author(s) : de Andrade Ramos G , Souza de Oliveira A , Bartolini M , Naldi M , Liparulo I , Bergamini C , Uliassi E , Wu L , Fraser PE , Abreu M , Kiametis AS , Gargano R , Silveira ER , Brand GD , Prchal L , Soukup O , Korabecny J , Bolognesi ML , Soares Romeiro LA |
| Ref : RSC Med Chem , 12 :1154 , 2021 |
| Abstract : de Andrade Ramos_2021_RSC.Med.Chem_12_1154 |
| ESTHER : de Andrade Ramos_2021_RSC.Med.Chem_12_1154 |
| PubMedSearch : de Andrade Ramos_2021_RSC.Med.Chem_12_1154 |
| PubMedID: 34355181 |
| Title : Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors - Gorecki_2021_Eur.J.Med.Chem_219_113434 |
| Author(s) : Gorecki L , Misiachna A , Damborsky J , Dolezal R , Korabecny J , Cejkova L , Hakenova K , Chvojkova M , Karasova JZ , Prchal L , Novak M , Kolcheva M , Kortus S , Vales K , Horak M , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 219 :113434 , 2021 |
| Abstract : Gorecki_2021_Eur.J.Med.Chem_219_113434 |
| ESTHER : Gorecki_2021_Eur.J.Med.Chem_219_113434 |
| PubMedSearch : Gorecki_2021_Eur.J.Med.Chem_219_113434 |
| PubMedID: 33892271 |
| Title : Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile - Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| Author(s) : Sobolova K , Hrabinova M , Hepnarova V , Kucera T , Kobrlova T , Benkova M , Janockova J , Dolezal R , Prchal L , Benek O , Mezeiova E , Jun D , Soukup O , Korabecny J |
| Ref : Eur Journal of Medicinal Chemistry , 203 :112593 , 2020 |
| Abstract : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| ESTHER : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| PubMedSearch : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| PubMedID: 32688201 |
| Title : From orexin receptor agonist YNT-185 to novel antagonists with drug-like properties for the treatment of insomnia - Mezeiova_2020_Bioorg.Chem_103_104179 |
| Author(s) : Mezeiova E , Janockova J , Konecny J , Kobrlova T , Benkova M , Dolezal R , Prchal L , Karasova-Zdarova J , Soukup O , Korabecny J |
| Ref : Bioorg Chem , 103 :104179 , 2020 |
| Abstract : Mezeiova_2020_Bioorg.Chem_103_104179 |
| ESTHER : Mezeiova_2020_Bioorg.Chem_103_104179 |
| PubMedSearch : Mezeiova_2020_Bioorg.Chem_103_104179 |
| PubMedID: 32891860 |
| Title : Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists - Konecny_2020_Biomolecules_11_ |
| Author(s) : Konecny J , Misiachna A , Hrabinova M , Pulkrabkova L , Benkova M , Prchal L , Kucera T , Kobrlova T , Finger V , Kolcheva M , Kortus S , Jun D , Valko M , Horak M , Soukup O , Korabecny J |
| Ref : Biomolecules , 11 : , 2020 |
| Abstract : Konecny_2020_Biomolecules_11_ |
| ESTHER : Konecny_2020_Biomolecules_11_ |
| PubMedSearch : Konecny_2020_Biomolecules_11_ |
| PubMedID: 33375115 |
| Title : Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease - Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| Author(s) : Mezeiova E , Chalupova K , Nepovimova E , Gorecki L , Prchal L , Malinak D , Kuca K , Soukup O , Korabecny J |
| Ref : Curr Alzheimer Res , 16 :772 , 2019 |
| Abstract : Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| ESTHER : Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| PubMedSearch : Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| PubMedID: 30819078 |
| Title : Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase - Gorecki_2019_Future.Med.Chem_11_2625 |
| Author(s) : Gorecki L , Junova L , Kucera T , Hepnarova V , Prchal L , Kobrlova T , Muckova L , Soukup O , Korabecny J |
| Ref : Future Med Chem , 11 :2625 , 2019 |
| Abstract : Gorecki_2019_Future.Med.Chem_11_2625 |
| ESTHER : Gorecki_2019_Future.Med.Chem_11_2625 |
| PubMedSearch : Gorecki_2019_Future.Med.Chem_11_2625 |
| PubMedID: 31556693 |