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| Title : Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening - Krieger_2024_ACS.Infect.Dis__ |
| Author(s) : Krieger IV , Yalamanchili S , Dickson P , Engelhart CA , Zimmerman MD , Wood J , Clary E , Nguyen J , Thornton N , Centrella PA , Chan B , Cuozzo JW , Gengenbacher M , Guie MA , Guilinger JP , Bienstock C , Hartl H , Hupp CD , Jetson R , Satoh T , Yeoman JTS , Zhang Y , Dartois V , Schnappinger D , Keefe AD , Sacchettini JC |
| Ref : ACS Infect Dis , : , 2024 |
| Abstract : Krieger_2024_ACS.Infect.Dis__ |
| ESTHER : Krieger_2024_ACS.Infect.Dis__ |
| PubMedSearch : Krieger_2024_ACS.Infect.Dis__ |
| PubMedID: 38577994 |
| Title : Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13\; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target - Wilson_2022_J.Med.Chem_65_409 |
| Author(s) : Wilson C , Ray P , Zuccotto F , Hernandez J , Aggarwal A , Mackenzie C , Caldwell N , Taylor M , Huggett M , Mathieson M , Murugesan D , Smith A , Davis S , Cocco M , Parai MK , Acharya A , Tamaki F , Scullion P , Epemolu O , Riley J , Stojanovski L , Lopez-Roman EM , Torres-Gomez PA , Toledo AM , Guijarro-Lopez L , Camino I , Engelhart CA , Schnappinger D , Massoudi LM , Lenaerts A , Robertson GT , Walpole C , Matthews D , Floyd D , Sacchettini JC , Read KD , Encinas L , Bates RH , Green SR , Wyatt PG |
| Ref : Journal of Medicinal Chemistry , 65 :409 , 2022 |
| Abstract : Wilson_2022_J.Med.Chem_65_409 |
| ESTHER : Wilson_2022_J.Med.Chem_65_409 |
| PubMedSearch : Wilson_2022_J.Med.Chem_65_409 |
| PubMedID: 34910486 |
| Gene_locus related to this paper: myctu-PKS13 |
| Title : An Antibacterial beta-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis - Lehmann_2018_Angew.Chem.Int.Ed.Engl_57_348 |
| Author(s) : Lehmann J , Cheng TY , Aggarwal A , Park AS , Zeiler E , Raju RM , Akopian T , Kandror O , Sacchettini JC , Moody DB , Rubin EJ , Sieber SA |
| Ref : Angew Chem Int Ed Engl , 57 :348 , 2018 |
| Abstract : Lehmann_2018_Angew.Chem.Int.Ed.Engl_57_348 |
| ESTHER : Lehmann_2018_Angew.Chem.Int.Ed.Engl_57_348 |
| PubMedSearch : Lehmann_2018_Angew.Chem.Int.Ed.Engl_57_348 |
| PubMedID: 29067779 |
| Title : Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13 - Aggarwal_2017_Cell_170_249 |
| Author(s) : Aggarwal A , Parai MK , Shetty N , Wallis D , Woolhiser L , Hastings C , Dutta NK , Galaviz S , Dhakal RC , Shrestha R , Wakabayashi S , Walpole C , Matthews D , Floyd D , Scullion P , Riley J , Epemolu O , Norval S , Snavely T , Robertson GT , Rubin EJ , Ioerger TR , Sirgel FA , van der Merwe R , van Helden PD , Keller P , Bottger EC , Karakousis PC , Lenaerts AJ , Sacchettini JC |
| Ref : Cell , 170 :249 , 2017 |
| Abstract : Aggarwal_2017_Cell_170_249 |
| ESTHER : Aggarwal_2017_Cell_170_249 |
| PubMedSearch : Aggarwal_2017_Cell_170_249 |
| PubMedID: 28669536 |
| Gene_locus related to this paper: myctu-PKS13 |
| Title : Mycobacterium tuberculosis antigen 85A and 85C structures confirm binding orientation and conserved substrate specificity - Ronning_2004_J.Biol.Chem_279_36771 |
| Author(s) : Ronning DR , Vissa V , Besra GS , Belisle JT , Sacchettini JC |
| Ref : Journal of Biological Chemistry , 279 :36771 , 2004 |
| Abstract : Ronning_2004_J.Biol.Chem_279_36771 |
| ESTHER : Ronning_2004_J.Biol.Chem_279_36771 |
| PubMedSearch : Ronning_2004_J.Biol.Chem_279_36771 |
| PubMedID: 15192106 |
| Gene_locus related to this paper: myctu-a85a , myctu-a85c |
| Title : The mycobacterial antigens 85 complex--from structure to function: response - |
| Author(s) : Sacchettini JC , Ronning DR |
| Ref : Trends Microbiol , 8 :441 , 2000 |
| PubMedID: 11203233 |
| Title : Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines - Ronning_2000_Nat.Struct.Biol_7_141 |
| Author(s) : Ronning DR , Klabunde T , Besra GS , Vissa VD , Belisle JT , Sacchettini JC |
| Ref : Nat Struct Biol , 7 :141 , 2000 |
| Abstract : Ronning_2000_Nat.Struct.Biol_7_141 |
| ESTHER : Ronning_2000_Nat.Struct.Biol_7_141 |
| PubMedSearch : Ronning_2000_Nat.Struct.Biol_7_141 |
| PubMedID: 10655617 |
| Gene_locus related to this paper: myctu-a85c |
| Title : A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase - Eads_1997_Structure_5_47 |
| Author(s) : Eads JC , Ozturk D , Wexler TB , Grubmeyer C , Sacchettini JC |
| Ref : Structure , 5 :47 , 1997 |
| Abstract : Eads_1997_Structure_5_47 |
| ESTHER : Eads_1997_Structure_5_47 |
| PubMedSearch : Eads_1997_Structure_5_47 |
| PubMedID: 9016724 |