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| Title : A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice - Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
| Author(s) : Berger JP , SinhaRoy R , Pocai A , Kelly TM , Scapin G , Gao YD , Pryor KAD , Wu JK , Eiermann GJ , Xu SS , Zhang X , Tatosian DA , Weber AE , Thornberry NA , Carr RD |
| Ref : Endocrinol Diabetes Metab , 1 :e00002 , 2018 |
| Abstract : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
| ESTHER : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
| PubMedSearch : Berger_2018_Endocrinol.Diabetes.Metab_1_e00002 |
| PubMedID: 30815539 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors - Pissarnitski_2016_Bioorg.Med.Chem_24_5534 |
| Author(s) : Pissarnitski DA , Zhao Z , Cole D , Wu WL , Domalski M , Clader JW , Scapin G , Voigt J , Soriano A , Kelly T , Powles MA , Yao Z , Burnett DA |
| Ref : Bioorganic & Medicinal Chemistry , 24 :5534 , 2016 |
| Abstract : Pissarnitski_2016_Bioorg.Med.Chem_24_5534 |
| ESTHER : Pissarnitski_2016_Bioorg.Med.Chem_24_5534 |
| PubMedSearch : Pissarnitski_2016_Bioorg.Med.Chem_24_5534 |
| PubMedID: 27670099 |
| Gene_locus related to this paper: human-DPP4 |
| Title : The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors - Cox_2016_Bioorg.Med.Chem.Lett_26_2622 |
| Author(s) : Cox JM , Chu HD , Kuethe JT , Gao YD , Scapin G , Eiermann G , He H , Li X , Lyons KA , Metzger J , Petrov A , Wu JK , Xu S , Sinha-Roy R , Weber AE , Biftu T |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :2622 , 2016 |
| Abstract : Cox_2016_Bioorg.Med.Chem.Lett_26_2622 |
| ESTHER : Cox_2016_Bioorg.Med.Chem.Lett_26_2622 |
| PubMedSearch : Cox_2016_Bioorg.Med.Chem.Lett_26_2622 |
| PubMedID: 27106708 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes - Wu_2016_ACS.Med.Chem.Lett_7_498 |
| Author(s) : Wu WL , Hao J , Domalski M , Burnett DA , Pissarnitski D , Zhao Z , Stamford A , Scapin G , Gao YD , Soriano A , Kelly TM , Yao Z , Powles MA , Chen S , Mei H , Hwa J |
| Ref : ACS Med Chem Lett , 7 :498 , 2016 |
| Abstract : Wu_2016_ACS.Med.Chem.Lett_7_498 |
| ESTHER : Wu_2016_ACS.Med.Chem.Lett_7_498 |
| PubMedSearch : Wu_2016_ACS.Med.Chem.Lett_7_498 |
| PubMedID: 27190600 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes - Biftu_2014_J.Med.Chem_57_3205 |
| Author(s) : Biftu T , Sinha-Roy R , Chen P , Qian X , Feng D , Kuethe JT , Scapin G , Gao YD , Yan Y , Krueger D , Bak A , Eiermann G , He J , Cox J , Hicks J , Lyons K , He H , Salituro G , Tong S , Patel S , Doss G , Petrov A , Wu J , Xu SS , Sewall C , Zhang X , Zhang B , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 57 :3205 , 2014 |
| Abstract : Biftu_2014_J.Med.Chem_57_3205 |
| ESTHER : Biftu_2014_J.Med.Chem_57_3205 |
| PubMedSearch : Biftu_2014_J.Med.Chem_57_3205 |
| PubMedID: 24660890 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors - Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| Author(s) : Edmondson SD , Mastracchio A , Cox JM , Eiermann GJ , He H , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Xu S , Zhu B , Thornberry NA , Roy RS , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :4097 , 2009 |
| Abstract : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| ESTHER : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| PubMedSearch : Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097 |
| PubMedID: 19539471 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines - Kim_2008_J.Med.Chem_51_589 |
| Author(s) : Kim D , Kowalchick JE , Brockunier LL , Parmee ER , Eiermann GJ , Fisher MH , He H , Leiting B , Lyons K , Scapin G , Patel SB , Petrov A , Pryor KD , Roy RS , Wu JK , Zhang X , Wyvratt MJ , Zhang BB , Zhu L , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 51 :589 , 2008 |
| Abstract : Kim_2008_J.Med.Chem_51_589 |
| ESTHER : Kim_2008_J.Med.Chem_51_589 |
| PubMedSearch : Kim_2008_J.Med.Chem_51_589 |
| PubMedID: 18201067 |
| Title : Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors - Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409 |
| Author(s) : Edmondson SD , Wei L , Xu J , Shang J , Xu S , Pang J , Chaudhary A , Dean DC , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Scapin G , Wu JK , Beconi MG , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :2409 , 2008 |
| Abstract : Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409 |
| ESTHER : Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409 |
| PubMedSearch : Edmondson_2008_Bioorg.Med.Chem.Lett_18_2409 |
| PubMedID: 18331795 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design - Liang_2008_Bioorg.Med.Chem.Lett_18_3706 |
| Author(s) : Liang GB , Qian X , Biftu T , Singh S , Gao YD , Scapin G , Patel S , Leiting B , Patel R , Wu J , Zhang X , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :3706 , 2008 |
| Abstract : Liang_2008_Bioorg.Med.Chem.Lett_18_3706 |
| ESTHER : Liang_2008_Bioorg.Med.Chem.Lett_18_3706 |
| PubMedSearch : Liang_2008_Bioorg.Med.Chem.Lett_18_3706 |
| PubMedID: 18524582 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors - Gao_2007_Bioorg.Med.Chem.Lett_17_3877 |
| Author(s) : Gao YD , Feng D , Sheridan RP , Scapin G , Patel SB , Wu JK , Zhang X , Sinha-Roy R , Thornberry NA , Weber AE , Biftu T |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3877 , 2007 |
| Abstract : Gao_2007_Bioorg.Med.Chem.Lett_17_3877 |
| ESTHER : Gao_2007_Bioorg.Med.Chem.Lett_17_3877 |
| PubMedSearch : Gao_2007_Bioorg.Med.Chem.Lett_17_3877 |
| PubMedID: 17502141 |
| Title : Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors - Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934 |
| Author(s) : Kowalchick JE , Leiting B , Pryor KD , Marsilio F , Wu JK , He H , Lyons KA , Eiermann GJ , Petrov A , Scapin G , Patel RA , Thornberry NA , Weber AE , Kim D |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5934 , 2007 |
| Abstract : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934 |
| ESTHER : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934 |
| PubMedSearch : Kowalchick_2007_Bioorg.Med.Chem.Lett_17_5934 |
| PubMedID: 17827003 |
| Gene_locus related to this paper: human-DPP4 |
| Title : 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV - Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806 |
| Author(s) : Kaelin DE , Smenton AL , Eiermann GJ , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE , Duffy JL |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :5806 , 2007 |
| Abstract : Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806 |
| ESTHER : Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806 |
| PubMedSearch : Kaelin_2007_Bioorg.Med.Chem.Lett_17_5806 |
| PubMedID: 17851076 |
| Gene_locus related to this paper: human-DPP4 |
| Title : (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)- 1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| Author(s) : Biftu T , Feng D , Qian X , Liang GB , Kieczykowski G , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Scapin G , Patel S , Gao YD , Singh S , Wu J , Zhang X , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :49 , 2007 |
| Abstract : Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| ESTHER : Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| PubMedID: 17055272 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin - Biftu_2007_Bioorg.Med.Chem.Lett_17_3384 |
| Author(s) : Biftu T , Scapin G , Singh S , Feng D , Becker JW , Eiermann G , He H , Lyons K , Patel S , Petrov A , Sinha-Roy R , Zhang B , Wu J , Zhang X , Doss GA , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3384 , 2007 |
| Abstract : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384 |
| ESTHER : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384 |
| PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_3384 |
| PubMedID: 17433672 |
| Gene_locus related to this paper: human-DPP4 |
| Title : 4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV - Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| Author(s) : Duffy JL , Kirk BA , Wang L , Eiermann GJ , He H , Leiting B , Lyons KA , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :2879 , 2007 |
| Abstract : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| ESTHER : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| PubMedSearch : Duffy_2007_Bioorg.Med.Chem.Lett_17_2879 |
| PubMedID: 17350841 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors - Xu_2006_Bioorg.Med.Chem.Lett_16_5373 |
| Author(s) : Xu J , Wei L , Mathvink RJ , Edmondson SD , Eiermann GJ , He H , Leone JF , Leiting B , Lyons KA , Marsilio F , Patel RA , Patel SB , Petrov A , Scapin G , Wu JK , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 16 :5373 , 2006 |
| Abstract : Xu_2006_Bioorg.Med.Chem.Lett_16_5373 |
| ESTHER : Xu_2006_Bioorg.Med.Chem.Lett_16_5373 |
| PubMedSearch : Xu_2006_Bioorg.Med.Chem.Lett_16_5373 |
| PubMedID: 16919457 |
| Gene_locus related to this paper: human-DPP4 |
| Title : (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]tr iazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Edmondson_2006_J.Med.Chem_49_3614 |
| Author(s) : Edmondson SD , Mastracchio A , Mathvink RJ , He J , Harper B , Park YJ , Beconi M , Di Salvo J , Eiermann GJ , He H , Leiting B , Leone JF , Levorse DA , Lyons K , Patel RA , Patel SB , Petrov A , Scapin G , Shang J , Roy RS , Smith A , Wu JK , Xu S , Zhu B , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 49 :3614 , 2006 |
| Abstract : Edmondson_2006_J.Med.Chem_49_3614 |
| ESTHER : Edmondson_2006_J.Med.Chem_49_3614 |
| PubMedSearch : Edmondson_2006_J.Med.Chem_49_3614 |
| PubMedID: 16759103 |
| Gene_locus related to this paper: human-DPP4 |
| Title : (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)- yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Kim_2005_J.Med.Chem_48_141 |
| Author(s) : Kim D , Wang L , Beconi M , Eiermann GJ , Fisher MH , He H , Hickey GJ , Kowalchick JE , Leiting B , Lyons K , Marsilio F , McCann ME , Patel RA , Petrov A , Scapin G , Patel SB , Roy RS , Wu JK , Wyvratt MJ , Zhang BB , Zhu L , Thornberry NA , Weber AE |
| Ref : Journal of Medicinal Chemistry , 48 :141 , 2005 |
| Abstract : Kim_2005_J.Med.Chem_48_141 |
| ESTHER : Kim_2005_J.Med.Chem_48_141 |
| PubMedSearch : Kim_2005_J.Med.Chem_48_141 |
| PubMedID: 15634008 |
| Gene_locus related to this paper: human-DPP4 |