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Author Report for: Schopfer LM

Contact information:

Schopfer Lawrence M
University of Nebraska Medical Center; Eppley Institute; 985950 Nebraska Medical Center; Omaha; 68198
USA
Phone : +14025596305
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Send E-Mail to Schopfer Lawrence M





    Title: Butyrylcholinesterase in SH-SY5Y human neuroblastoma cells
    Onder S, Schopfer LM, Jiang W, Tacal O, Lockridge O
    Ref: Neurotoxicology, :, 2022 : PubMed

            

    Title: Chlorpyrifos oxon crosslinking of amyloid beta 42 peptides is a new route for generation of self-aggregating amyloidogenic oligomers that promote Alzheimer's disease
    Onder S, Biberoglu K, Tacal O, Schopfer LM
    Ref: Chemico-Biological Interactions, 363:110029, 2022 : PubMed

            

    Title: Organophosphorus Pesticides Promote Protein Cross-Linking
    Schopfer LM, Onder S, Lockridge O
    Ref: Chemical Research in Toxicology, :, 2022 : PubMed

            

    Title: Rabbit Antidiethoxyphosphotyrosine Antibody, Made by Single B Cell Cloning, Detects Chlorpyrifos Oxon-Modified Proteins in Cultured Cells and Immunopurifies Modified Peptides for Mass Spectrometry
    Onder S, van Grol M, Fidder A, Xiao G, Noort D, Yerramalla U, Tacal O, Schopfer LM, Lockridge O
    Ref: J Proteome Res, :, 2021 : PubMed

            

    Title: Evaluation of mass spectrometry MS/MS spectra for the presence of isopeptide crosslinked peptides
    Schopfer LM, Onder S, Lockridge O
    Ref: PLoS ONE, 16:e0254450, 2021 : PubMed

            

    Title: Chlorpyrifos Oxon-Induced Isopeptide Bond Formation in Human Butyrylcholinesterase
    Biberoglu K, Tacal O, Schopfer LM, Lockridge O
    Ref: Molecules, 25:, 2020 : PubMed

            

    Title: Characteristic fragment ions associated with dansyl cadaverine and biotin cadaverine adducts on glutamine
    Biberoglu K, Schopfer LM, Tacal O, Lockridge O
    Ref: Analytical Biochemistry, :113718, 2020 : PubMed

            

    Title: Signature Ions in MS/MS Spectra for Dansyl-Aminohexyl-QQIV Adducts on Lysine
    Schopfer LM, Lockridge O
    Ref: Molecules, 25:, 2020 : PubMed

            

    Title: Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers
    Toker L, Silman I, Zeev-Ben-Mordehai T, Sussman JL, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, :109007, 2020 : PubMed

            

    Title: Computer-designed active human butyrylcholinesterase double mutant with a new catalytic triad
    Grigorenko BL, Novichkova DA, Lushchekina SV, Zueva IV, Schopfer LM, Nemukhin AV, Varfolomeev SD, Lockridge O, Masson P
    Ref: Chemico-Biological Interactions, 306:138, 2019 : PubMed

            

    Title: Half-life of chlorpyrifos oxon and other organophosphorus esters in aqueous solution
    Lockridge O, Verdier L, Schopfer LM
    Ref: Chemico-Biological Interactions, :108788, 2019 : PubMed

            

    Title: Purification of human butyrylcholinesterase from frozen Cohn fraction IV-4 by ion exchange and Hupresin affinity chromatography
    Schopfer LM, Lockridge O, David E, Hinrichs SH
    Ref: PLoS ONE, 14:e0209795, 2019 : PubMed

            

    Title: Mass Spectrometry Identifies Isopeptide Cross-Links Promoted by Diethylphosphorylated Lysine in Proteins Treated with Chlorpyrifos Oxon
    Schopfer LM, Lockridge O
    Ref: Chemical Research in Toxicology, 32:762, 2019 : PubMed

            

    Title: Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly
    Leung MR, van Bezouwen LS, Schopfer LM, Sussman JL, Silman I, Lockridge O, Zeev-Ben-Mordehai T
    Ref: Proc Natl Acad Sci U S A, 115:13270, 2018 : PubMed

            

    Title: Purification of recombinant human butyrylcholinesterase on Hupresin(R)
    Lockridge O, David E, Schopfer LM, Masson P, Brazzolotto X, Nachon F
    Ref: Journal of Chromatography B Analyt Technol Biomed Life Sciences, 1102-1103:109, 2018 : PubMed

            

    Title: Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents
    Lushchekina SV, Schopfer LM, Grigorenko BL, Nemukhin AV, Varfolomeev SD, Lockridge O, Masson P
    Ref: Front Pharmacol, 9:211, 2018 : PubMed

            

    Title: Use of Hupresin To Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure
    Onder S, Schopfer LM, Cashman JR, Tacal O, Johnson RC, Blake TA, Lockridge O
    Ref: Analytical Chemistry, 90:974, 2018 : PubMed

            

    Title: Tetramer organizing polyproline-rich peptides identified by mass spectrometry after release of the peptides from Hupresin-purified butyrylcholinesterase tetramers isolated from milk of domestic pig (Sus scrofa)
    Saxena A, Belinskaya T, Schopfer LM, Lockridge O
    Ref: Data Brief, 20:1607, 2018 : PubMed

            

    Title: Characterization of butyrylcholinesterase from porcine milk
    Saxena A, Belinskaya T, Schopfer LM, Lockridge O
    Ref: Archives of Biochemistry & Biophysics, 652:38, 2018 : PubMed

            

    Title: Chlorpyrifos oxon promotes tubulin aggregation via isopeptide cross-linking between diethoxyphospho-Lys and Glu or Asp: Implications for neurotoxicity
    Schopfer LM, Lockridge O
    Ref: Journal of Biological Chemistry, 293:13566, 2018 : PubMed

            

    Title: Characterization of butyrylcholinesterase in bovine serum
    Dafferner AJ, Lushchekina SV, Masson P, Xiao G, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, 266:17, 2017 : PubMed

            

    Title: Immunopurification of Acetylcholinesterase from Red Blood Cells for Detection of Nerve Agent Exposure
    Dafferner AJ, Schopfer LM, Xiao G, Cashman JR, Yerramalla U, Johnson RC, Blake TA, Lockridge O
    Ref: Chemical Research in Toxicology, 30:1897, 2017 : PubMed

            

    Title: Hupresin Retains Binding Capacity for Butyrylcholinesterase and Acetylcholinesterase after Sanitation with Sodium Hydroxide
    Onder S, David E, Tacal O, Schopfer LM, Lockridge O
    Ref: Front Pharmacol, 8:713, 2017 : PubMed

            

    Title: Monoclonal Antibody That Recognizes Diethoxyphosphotyrosine-Modified Proteins and Peptides Independent of Surrounding Amino Acids
    Onder S, Dafferner AJ, Schopfer LM, Xiao G, Yerramalla U, Tacal O, Blake TA, Johnson RC, Lockridge O
    Ref: Chemical Research in Toxicology, 30:2218, 2017 : PubMed

            

    Title: The C5 Variant of the Butyrylcholinesterase Tetramer Includes a Noncovalently Bound 60 kDa Lamellipodin Fragment
    Schopfer LM, Delacour H, Masson P, Leroy J, Krejci E, Lockridge O
    Ref: Molecules, 22:, 2017 : PubMed

            

    Title: Origin of polyproline-rich peptides in human butyrylcholinesterase tetramers
    Peng H, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, 259:63, 2016 : PubMed

            

    Title: Tetramer-organizing polyproline-rich peptides differ in CHO cell-expressed and plasma-derived human butyrylcholinesterase tetramers
    Schopfer LM, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1864:706, 2016 : PubMed

            

    Title: Pure human butyrylcholinesterase hydrolyzes octanoyl ghrelin to desacyl ghrelin
    Schopfer LM, Lockridge O, Brimijoin S
    Ref: General & Comparative Endocrinology, 224:61, 2015 : PubMed

            

    Title: Characterization of a Novel BCHE Silent Allele: Point Mutation (p.Val204Asp) Causes Loss of Activity and Prolonged Apnea with Suxamethonium
    Delacour H, Lushchekina SV, Mabboux I, Bousquet A, Ceppa F, Schopfer LM, Lockridge O, Masson P
    Ref: PLoS ONE, 9:e101552, 2014 : PubMed

            

    Title: Characterization of a novel butyrylcholinesterase point mutation (p.Ala34Val), silent with mivacurium
    Delacour H, Lushchekina SV, Mabboux I, Ceppa F, Masson P, Schopfer LM, Lockridge O
    Ref: Biochemical Pharmacology, 92:476, 2014 : PubMed

            

    Title: Detection of cresyl phosphate-modified butyrylcholinesterase in human plasma for chemical exposure associated with aerotoxic syndrome
    Schopfer LM, Masson P, Lamourette P, Simon S, Lockridge O
    Ref: Analytical Biochemistry, 461C:17, 2014 : PubMed

            

    Title: Healthy F-16 pilots show no evidence of exposure to tri-ortho-cresyl phosphate through the on-board oxygen generating system
    Tacal O, Schopfer LM
    Ref: Chemico-Biological Interactions, 215C:69, 2014 : PubMed

            

    Title: Polyproline tetramer organizing peptides in fetal bovine serum acetylcholinesterase
    Biberoglu K, Schopfer LM, Saxena A, Tacal O, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1834:745, 2013 : PubMed

            

    Title: Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry
    Carletti E, Colletier JP, Schopfer LM, Santoni G, Masson P, Lockridge O, Nachon F, Weik M
    Ref: Chemical Research in Toxicology, 26:280, 2013 : PubMed

            

    Title: Mass spectrometry method to identify aging pathways of Sp- and Rp-tabun adducts on human butyrylcholinesterase based on the acid labile P-N bond
    Jiang W, Cashman JR, Nachon F, Masson P, Schopfer LM, Lockridge O
    Ref: Toxicol Sci, 132:390, 2013 : PubMed

            

    Title: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of titanium oxide-enriched peptides for detection of aged organophosphorus adducts on human butyrylcholinesterase
    Jiang W, Murashko EA, Dubrovskii YA, Podolskaya EP, Babakov VN, Mikler J, Nachon F, Masson P, Schopfer LM, Lockridge O
    Ref: Analytical Biochemistry, 439:132, 2013 : PubMed

            

    Title: PHOS-Select Iron Affinity Beads Enrich Peptides for the Detection of Organophosphorus Adducts on Albumin
    Jiang W, Dubrovskii YA, Podolskaya EP, Murashko EA, Babakov VN, Nachon F, Masson P, Schopfer LM, Lockridge O
    Ref: Chemical Research in Toxicology, 26:1917, 2013 : PubMed

            

    Title: Polyclonal antibody to soman-tyrosine
    Li B, Duysen EG, Froment MT, Masson P, Nachon F, Jiang W, Schopfer LM, Thiele GM, Klassen LW and Lockridge O <2 more author(s)>
    Ref: Chemical Research in Toxicology, 26:584, 2013 : PubMed

            

    Title: Cresyl saligenin phosphate makes multiple adducts on free histidine, but does not form an adduct on histidine 438 of human butyrylcholinesterase
    Liyasova MS, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, 203:103, 2013 : PubMed

            

    Title: Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor
    Liyasova MS, Schopfer LM, Kodani S, Lantz SR, Casida JE, Lockridge O
    Ref: Chemical Research in Toxicology, 26:422, 2013 : PubMed

            

    Title: Effects of viscosity and osmotic stress on the reaction of human butyrylcholinesterase with cresyl saligenin phosphate, a toxicant related to aerotoxic syndrome: kinetic and molecular dynamics studies
    Masson P, Lushchekina SV, Schopfer LM, Lockridge O
    Ref: Biochemical Journal, 454:387, 2013 : PubMed

            

    Title: Resistance of human butyrylcholinesterase to methylene blue-catalyzed photoinactivation; mass spectrometry analysis of oxidation products
    Tacal O, Li B, Lockridge O, Schopfer LM
    Ref: Photochem Photobiol, 89:336, 2013 : PubMed

            

    Title: The proline-rich tetramerization peptides in equine serum butyrylcholinesterase
    Biberoglu K, Schopfer LM, Tacal O, Lockridge O
    Ref: Febs J, 279:3844, 2012 : PubMed

            

    Title: Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran
    Duysen EG, Cashman JR, Schopfer LM, Nachon F, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 195:189, 2012 : PubMed

            

    Title: Cresyl saligenin phosphate, an organophosphorus toxicant, makes covalent adducts with histidine, lysine, and tyrosine residues of human serum albumin
    Liyasova MS, Schopfer LM, Lockridge O
    Ref: Chemical Research in Toxicology, 25:1752, 2012 : PubMed

            

    Title: Analytical approaches for monitoring exposure to organophosphorus and carbamate agents through analysis of protein adducts
    Schopfer LM, Lockridge O
    Ref: Drug Test Anal, 4:246, 2012 : PubMed

            

    Title: Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis
    Carletti E, Schopfer LM, Colletier JP, Froment MT, Nachon F, Weik M, Lockridge O, Masson P
    Ref: Chemical Research in Toxicology, 24:797, 2011 : PubMed

            

    Title: Production of ES1 plasma carboxylesterase knockout mice for toxicity studies
    Duysen EG, Koentgen F, Williams GR, Timperley CM, Schopfer LM, Cerasoli DM, Lockridge O
    Ref: Chemical Research in Toxicology, 24:1891, 2011 : PubMed

            

    Title: Exposure to tri-o-cresyl phosphate detected in jet airplane passengers
    Liyasova M, Li B, Schopfer LM, Nachon F, Masson P, Furlong CE, Lockridge O
    Ref: Toxicol Appl Pharmacol, 256:337, 2011 : PubMed

            

    Title: Biomarkers of organophosphorus (OP) exposures in humans
    Marsillach J, Richter RJ, Kim JH, Stevens RC, Maccoss MJ, Tomazela D, Suzuki SM, Schopfer LM, Lockridge O, Furlong CE
    Ref: Neurotoxicology, 32:656, 2011 : PubMed

            

    Title: X-ray crystallographic snapshots of reaction intermediates in the G117H mutant of human butyrylcholinesterase, a nerve agent target engineered into a catalytic bioscavenger
    Nachon F, Carletti E, Wandhammer M, Nicolet Y, Schopfer LM, Masson P, Lockridge O
    Ref: Biochemical Journal, 434:73, 2011 : PubMed

            

    Title: Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents
    Jiang W, Duysen EG, Hansen H, Shlyakhtenko L, Schopfer LM, Lockridge O
    Ref: Toxicol Sci, 115:183, 2010 : PubMed

            

    Title: Dichlorvos, chlorpyrifos oxon and Aldicarb adducts of butyrylcholinesterase, detected by mass spectrometry in human plasma following deliberate overdose
    Li B, Ricordel I, Schopfer LM, Baud F, Megarbane B, Masson P, Lockridge O
    Ref: J Appl Toxicol, 30:559, 2010 : PubMed

            

    Title: Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos
    Li B, Ricordel I, Schopfer LM, Baud F, Megarbane B, Nachon F, Masson P, Lockridge O
    Ref: Toxicol Sci, 116:23, 2010 : PubMed

            

    Title: Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545
    Liyasova MS, Schopfer LM, Lockridge O
    Ref: Biochemical Pharmacology, 79:784, 2010 : PubMed

            

    Title: Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine
    Lockridge O, Schopfer LM
    Ref: Chemico-Biological Interactions, 187:344, 2010 : PubMed

            

    Title: Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates
    Schopfer LM, Grigoryan H, Li B, Nachon F, Masson P, Lockridge O
    Ref: Journal of Chromatography B Analyt Technol Biomed Life Sciences, 878:1297, 2010 : PubMed

            

    Title: Development of diagnostics in the search for an explanation of aerotoxic syndrome
    Schopfer LM, Furlong CE, Lockridge O
    Ref: Analytical Biochemistry, 404:64, 2010 : PubMed

            

    Title: Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase
    Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O
    Ref: Chemical Research in Toxicology, 22:1680, 2009 : PubMed

            

    Title: Mass spectral characterization of organophosphate-labeled lysine in peptides.
    Grigoryan H, Li B, Xue W, Grigoryan M, Schopfer LM, Lockridge O
    Ref: Analytical Biochemistry, 394:92, 2009 : PubMed

            

    Title: Mass spectrometry identifies multiple organophosphorylated sites on tubulin
    Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O
    Ref: Toxicol Appl Pharmacol, 240:149, 2009 : PubMed

            

    Title: Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine
    Grigoryan H, Li B, Anderson EK, Xue W, Nachon F, Lockridge O, Schopfer LM
    Ref: Chemico-Biological Interactions, 180:492, 2009 : PubMed

            

    Title: Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine
    Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O
    Ref: Toxicol Sci, 107:144, 2009 : PubMed

            

    Title: Carbofuran poisoning detected by mass spectrometry of butyrylcholinesterase adduct in human serum
    Li H, Ricordel I, Tong L, Schopfer LM, Baud F, Megarbane B, Maury E, Masson P, Lockridge O
    Ref: J Appl Toxicol, 29:149, 2009 : PubMed

            

    Title: Aging of cholinesterases phosphylated by tabun proceeds through O-dealkylation
    Carletti E, Li H, Li B, Ekstrom F, Nicolet Y, Loiodice M, Gillon E, Froment MT, Lockridge O and Nachon F <2 more author(s)>
    Ref: Journal of the American Chemical Society, 130:16011, 2008 : PubMed

            

    Title: Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin
    Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F and Lockridge O <4 more author(s)>
    Ref: Chemical Research in Toxicology, 21:1787, 2008 : PubMed

            

    Title: Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents
    Grigoryan H, Schopfer LM, Thompson CM, Terry AV, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 175:180, 2008 : PubMed

            

    Title: Binding and hydrolysis of soman by human serum albumin
    Li B, Nachon F, Froment MT, Verdier L, Debouzy JC, Brasme B, Gillon E, Schopfer LM, Lockridge O, Masson P
    Ref: Chemical Research in Toxicology, 21:421, 2008 : PubMed

            

    Title: Lamellipodin proline rich peptides associated with native plasma butyrylcholinesterase tetramers
    Li H, Schopfer LM, Masson P, Lockridge O
    Ref: Biochemical Journal, 411:425, 2008 : PubMed

            

    Title: Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase
    Li H, Tong L, Schopfer LM, Masson P, Lockridge O
    Ref: Chemico-Biological Interactions, 175:68, 2008 : PubMed

            

    Title: Pseudo-esterase activity of human albumin: slow turnover on tyrosine 411 and stable acetylation of 82 residues including 59 lysines
    Lockridge O, Xue W, Gaydess A, Grigoryan H, Ding SJ, Schopfer LM, Hinrichs SH, Masson P
    Ref: Journal of Biological Chemistry, 283:22582, 2008 : PubMed

            

    Title: A collaborative endeavor to design cholinesterase-based catalytic scavengers against toxic organophosphorus esters
    Masson P, Nachon F, Broomfield CA, Lenz DE, Verdier L, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, 175:273, 2008 : PubMed

            

    Title: Kinetic analysis of effector modulation of butyrylcholinesterase-catalysed hydrolysis of acetanilides and homologous esters
    Masson P, Froment MT, Gillon E, Nachon F, Lockridge O, Schopfer LM
    Ref: Febs J, 275:2617, 2008 : PubMed

            

    Title: Five new naturally occurring mutations of the BCHE gene and frequencies of 12 butyrylcholinesterase alleles in a Brazilian population
    Mikami LR, Wieseler S, Souza RL, Schopfer LM, Nachon F, Lockridge O, Chautard-Freire-Maia EA
    Ref: Pharmacogenet Genomics, 18:213, 2008 : PubMed

            

    Title: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411
    Li B, Schopfer LM, Hinrichs SH, Masson P, Lockridge O
    Ref: Analytical Biochemistry, 361:263, 2007 : PubMed

            

    Title: Aging pathways for organophosphate-inhibited human butyrylcholinesterase, including novel pathways for isomalathion, resolved by mass spectrometry
    Li H, Schopfer LM, Nachon F, Froment MT, Masson P, Lockridge O
    Ref: Toxicol Sci, 100:136, 2007 : PubMed

            

    Title: Aryl acylamidase activity of human serum albumin with o-nitrotrifluoroacetanilide as the substrate
    Masson P, Froment MT, Darvesh S, Schopfer LM, Lockridge O
    Ref: J Enzyme Inhib Med Chem, 22:463, 2007 : PubMed

            

    Title: Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase
    Masson P, Froment MT, Gillon E, Nachon F, Lockridge O, Schopfer LM
    Ref: Biochimica & Biophysica Acta, 1774:16, 2007 : PubMed

            

    Title: Kinetic analysis of butyrylcholinesterase-catalyzed hydrolysis of acetanilides
    Masson P, Froment MT, Gillon E, Nachon F, Darvesh S, Schopfer LM
    Ref: Biochimica & Biophysica Acta, 1774:1139, 2007 : PubMed

            

    Title: Expression of three naturally occurring genetic variants (G75R, E90D, I99M) of the BCHE gene of human butyrylcholinesterase
    Mikami LR, Wieseler S, Souza RL, Schopfer LM, Lockridge O, Chautard-Freire-Maia EA
    Ref: Pharmacogenet Genomics, 17:681, 2007 : PubMed

            

    Title: Mutant of Bungarus fasciatus acetylcholinesterase with low affinity and low hydrolase activity toward organophosphorus esters
    Poyot T, Nachon F, Froment MT, Loiodice M, Wieseler S, Schopfer LM, Lockridge O, Masson P
    Ref: Biochimica & Biophysica Acta, 1764:1470, 2006 : PubMed

            

    Title: Markers of organophosphate exposure in human serum
    Wieseler S, Schopfer LM, Lockridge O
    Ref: Journal of Molecular Neuroscience, 30:93, 2006 : PubMed

            

    Title: Identification of organophosphate-reactive proteins by tandem mass spectrometry
    Li H, Schopfer LM, Spaulding R, Thompson CM, Lockridge O
    Ref: Chemico-Biological Interactions, 157-158:383, 2005 : PubMed

            

    Title: Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice
    Lockridge O, Duysen EG, Voelker T, Thompson CM, Schopfer LM
    Ref: Environ Toxicol Pharmacol, 19:463, 2005 : PubMed

            

    Title: Large scale purification of butyrylcholinesterase from human plasma suitable for injection into monkeys; A potential new therapeutic for protection against cocaine end nerve agent toxicity
    Lockridge O, Schopfer LM, Winger G, Woods JH
    Ref: Journal of Medicinal Chemistryical Biology Radiol Def, 3:nihms5095, 2005 : PubMed

            

    Title: Hysteresis of butyrylcholinesterase in the approach to steady-state kinetics
    Masson P, Schopfer LM, Froment MT, Debouzy JC, Nachon F, Gillon E, Lockridge O, Hrabovska A, Goldstein BN
    Ref: Chemico-Biological Interactions, 157-158:143, 2005 : PubMed

            

    Title: Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry
    Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O
    Ref: Toxicol Sci, 83:303, 2005 : PubMed

            

    Title: Characteristic mass spectral fragments of the organophosphorus agent FP-biotin and FP-biotinylated peptides from trypsin and bovine albumin (Tyr410)
    Schopfer LM, Champion MM, Tamblyn N, Thompson CM, Lockridge O
    Ref: Analytical Biochemistry, 345:122, 2005 : PubMed

            

    Title: Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase
    Schopfer LM, Voelker T, Bartels CF, Thompson CM, Lockridge O
    Ref: Chemical Research in Toxicology, 18:747, 2005 : PubMed

            

    Title: Damped oscillatory hysteretic behaviour of butyrylcholinesterase with benzoylcholine as substrate
    Masson P, Goldstein BN, Debouzy JC, Froment MT, Lockridge O, Schopfer LM
    Ref: European Journal of Biochemistry, 271:220, 2004 : PubMed

            

    Title: Hysteresis in butyrylcholinesterase catalysis.
    Masson P, Froment MT, Nachon F, Schopfer LM
    Ref: Cholinergic Mechanisms, CRC Press, :637, 2004 : PubMed

            

    Title: Hysteretic behavior of butyrylcholinesterase: Kinetic curiosity or catalytically and physiologicaly significant?
    Masson P, Froment MT, Nachon F, Lockridge O, Schopfer LM
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:191 , 2004 : PubMed

            

    Title: Rate-determining step of butyrylcholinesterase-catalyzed hydrolysis of benzoylcholine and benzoylthiocholine. Volumetric study of wild-type and D70G mutant behavior
    Masson P, Bec N, Froment MT, Nachon F, Balny C, Lockridge O, Schopfer LM
    Ref: European Journal of Biochemistry, 271:1980, 2004 : PubMed

            

    Title: Poster (20) Hysteretic behavior of butyrylcholinesterase : kinetic curiosity or catalytically and physiologically significant?
    Masson P, Froment MT, Nachon F, Lockridge O, Schopfer LM
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:331, 2004 : PubMed

            

    Title: Mutants of human butyrylcholinesterase with organophosphate hydrolase activity; evidence that His117 is a general base catalyst for hydrolysis of echothiophate
    Schopfer LM, Boeck AT, Broomfield CA, Lockridge O
    Ref: Journal of Medicinal Chemistryical Biology Radiol Def, 2:1, 2004 : PubMed

            

    Title: Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants
    Wang Y, Schopfer LM, Duysen EG, Nachon F, Masson P, Lockridge O
    Ref: Analytical Biochemistry, 329:131, 2004 : PubMed

            

    Title: DNA sequence of butyrylcholinesterase from the rat: expression of the protein and characterization of the properties of rat butyrylcholinesterase
    Boeck AT, Schopfer LM, Lockridge O
    Ref: Biochemical Pharmacology, 63:2101, 2002 : PubMed

            

    Title: Butyrylcholinesterase-catalyzed hydrolysis of N-methylindoxyl acetate: analysis of volume changes upon reaction and hysteretic behavior
    Masson P, Froment MT, Fort S, Ribes F, Bec N, Balny C, Schopfer LM
    Ref: Biochimica & Biophysica Acta, 1597:229, 2002 : PubMed

            

    Title: Substrate activation in acetylcholinesterase induced by low pH or mutation in the pi-cation subsite
    Masson P, Schopfer LM, Bartels CF, Froment MT, Ribes F, Nachon F, Lockridge O
    Ref: Biochimica & Biophysica Acta, 1594:313, 2002 : PubMed

            

    Title: Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to vx lethality
    Duysen EG, Li B, Xie W, Schopfer LM, Anderson RS, Broomfield CA, Lockridge O
    Ref: Journal of Pharmacology & Experimental Therapeutics, 299:528, 2001 : PubMed

            

    Title: The active site of human paraoxonase (PON1)
    Josse D, Lockridge O, Xie W, Bartels CF, Schopfer LM, Masson P
    Ref: J Appl Toxicol, 21 Suppl 1:S7, 2001 : PubMed

            

    Title: Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.
    Sun H, El Yazal J, Lockridge O, Schopfer LM, Brimijoin S, Pang YP
    Ref: Journal of Biological Chemistry, 276:9330, 2001 : PubMed

            

    Title: Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma
    Bartels CF, Xie W, Miller-Lindholm AK, Schopfer LM, Lockridge O
    Ref: Biochemical Pharmacology, 60:479, 2000 : PubMed

            

    Title: Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
    Li B, Stribley JA, Ticu A, Xie W, Schopfer LM, Hammond P, Brimijoin S, Hinrichs SH, Lockridge O
    Ref: Journal of Neurochemistry, 75:1320, 2000 : PubMed

            

    Title: Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities
    Josse D, Xie W, Renault F, Rochu D, Schopfer LM, Masson P, Lockridge O
    Ref: Biochemistry, 38:2816, 1999 : PubMed

            

    Title: Tryptophan residue(s) as major components of the human serum paraoxonase active site
    Josse D, Xie W, Masson P, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, 119-120:79, 1999 : PubMed

            

    Title: Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase
    Masson P, Legrand P, Bartels CF, Froment MT, Schopfer LM, Lockridge O
    Ref: Biochemistry, 36:2266, 1997 : PubMed

            

    Title: Kinetics of heat inactivation of phenyl valerate hydrolases from hen and rat brain
    Reiner E, Davis CS, Schwab BW, Schopfer LM, Richardson RJ
    Ref: Biochemical Pharmacology, 36:3181, 1987 : PubMed

            


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