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| Title : Restoration of nerve agent impaired neuromuscular transmission in rat diaphragm by bispyridinium non-oximes - Structure-activity relationships - Amend_2024_Toxicology__153741 |
| Author(s) : Amend N , Timperley CM , Bird M , Green AC , Worek F , Seeger T |
| Ref : Toxicology , :153741 , 2024 |
| Abstract : Amend_2024_Toxicology__153741 |
| ESTHER : Amend_2024_Toxicology__153741 |
| PubMedSearch : Amend_2024_Toxicology__153741 |
| PubMedID: 38311098 |
| Title : A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment - Kaiser_2022_Toxicol.Lett_373_160 |
| Author(s) : Kaiser J , Gertzen CGW , Bernauer T , Hofner G , Niessen KV , Seeger T , Paintner FF , Wanner KT , Worek F , Thiermann H , Gohlke H |
| Ref : Toxicol Lett , 373 :160 , 2022 |
| Abstract : Kaiser_2022_Toxicol.Lett_373_160 |
| ESTHER : Kaiser_2022_Toxicol.Lett_373_160 |
| PubMedSearch : Kaiser_2022_Toxicol.Lett_373_160 |
| PubMedID: 36503818 |
| Title : Diagnostics and treatment of nerve agent poisoning-current status and future developments - Amend_2020_Ann.N.Y.Acad.Sci__ |
| Author(s) : Amend N , Niessen KV , Seeger T , Wille T , Worek F , Thiermann H |
| Ref : Annals of the New York Academy of Sciences , : , 2020 |
| Abstract : Amend_2020_Ann.N.Y.Acad.Sci__ |
| ESTHER : Amend_2020_Ann.N.Y.Acad.Sci__ |
| PubMedSearch : Amend_2020_Ann.N.Y.Acad.Sci__ |
| PubMedID: 32198755 |
| Title : New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling - Wein_2019_Curr.Comput.Aided.Drug.Des_15_104 |
| Author(s) : Wein T , Wanner KT , Rappengluck S , Sichler S , Niessen KV , Seeger T , Worek F , Thiermann H |
| Ref : Curr Comput Aided Drug Des , 15 :104 , 2019 |
| Abstract : Wein_2019_Curr.Comput.Aided.Drug.Des_15_104 |
| ESTHER : Wein_2019_Curr.Comput.Aided.Drug.Des_15_104 |
| PubMedSearch : Wein_2019_Curr.Comput.Aided.Drug.Des_15_104 |
| PubMedID: 29968541 |
| Title : Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor - Rappengluck_2018_ChemMedChem_13_2653 |
| Author(s) : Rappengluck S , Sichler S , Hofner G , Wein T , Niessen KV , Seeger T , Paintner FF , Worek F , Thiermann H , Wanner KT |
| Ref : ChemMedChem , 13 :2653 , 2018 |
| Abstract : Rappengluck_2018_ChemMedChem_13_2653 |
| ESTHER : Rappengluck_2018_ChemMedChem_13_2653 |
| PubMedSearch : Rappengluck_2018_ChemMedChem_13_2653 |
| PubMedID: 30362667 |
| Title : Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor - Rappengluck_2018_ChemMedChem_13_1806 |
| Author(s) : Rappengluck S , Sichler S , Hofner G , Wein T , Niessen KV , Seeger T , Paintner FF , Worek F , Thiermann H , Wanner KT |
| Ref : ChemMedChem , 13 :1806 , 2018 |
| Abstract : Rappengluck_2018_ChemMedChem_13_1806 |
| ESTHER : Rappengluck_2018_ChemMedChem_13_1806 |
| PubMedSearch : Rappengluck_2018_ChemMedChem_13_1806 |
| PubMedID: 29974635 |
| Title : In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers - Niessen_2018_Toxicol.Lett_293_190 |
| Author(s) : Niessen KV , Seeger T , Rappengluck S , Wein T , Hofner G , Wanner KT , Thiermann H , Worek F |
| Ref : Toxicol Lett , 293 :190 , 2018 |
| Abstract : Niessen_2018_Toxicol.Lett_293_190 |
| ESTHER : Niessen_2018_Toxicol.Lett_293_190 |
| PubMedSearch : Niessen_2018_Toxicol.Lett_293_190 |
| PubMedID: 29024789 |
| Title : Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor - Sichler_2018_Toxicol.Lett_293_172 |
| Author(s) : Sichler S , Hofner G , Rappengluck S , Wein T , Niessen KV , Seeger T , Worek F , Thiermann H , Paintner FF , Wanner KT |
| Ref : Toxicol Lett , 293 :172 , 2018 |
| Abstract : Sichler_2018_Toxicol.Lett_293_172 |
| ESTHER : Sichler_2018_Toxicol.Lett_293_172 |
| PubMedSearch : Sichler_2018_Toxicol.Lett_293_172 |
| PubMedID: 29146291 |
| Title : Counteracting desensitization of human alpha7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning - Scheffel_2018_Toxicol.Lett_293_149 |
| Author(s) : Scheffel C , Niessen KV , Rappengluck S , Wanner KT , Thiermann H , Worek F , Seeger T |
| Ref : Toxicol Lett , 293 :149 , 2018 |
| Abstract : Scheffel_2018_Toxicol.Lett_293_149 |
| ESTHER : Scheffel_2018_Toxicol.Lett_293_149 |
| PubMedSearch : Scheffel_2018_Toxicol.Lett_293_149 |
| PubMedID: 29248576 |
| Title : Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman - Drexler_2018_Toxicol.Lett_297_19 |
| Author(s) : Drexler B , Seeger T , Worek F , Thiermann H , Antkowiak B , Grasshoff C |
| Ref : Toxicol Lett , 297 :19 , 2018 |
| Abstract : Drexler_2018_Toxicol.Lett_297_19 |
| ESTHER : Drexler_2018_Toxicol.Lett_297_19 |
| PubMedSearch : Drexler_2018_Toxicol.Lett_297_19 |
| PubMedID: 30165091 |
| Title : Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human alpha7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis - Scheffel_2018_Toxicol.Lett_293_157 |
| Author(s) : Scheffel C , Niessen KV , Rappengluck S , Wanner KT , Thiermann H , Worek F , Seeger T |
| Ref : Toxicol Lett , 293 :157 , 2018 |
| Abstract : Scheffel_2018_Toxicol.Lett_293_157 |
| ESTHER : Scheffel_2018_Toxicol.Lett_293_157 |
| PubMedSearch : Scheffel_2018_Toxicol.Lett_293_157 |
| PubMedID: 29191791 |
| Title : Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor - Wein_2018_Toxicol.Lett_293_184 |
| Author(s) : Wein T , Hofner G , Rappengluck S , Sichler S , Niessen KV , Seeger T , Worek F , Thiermann H , Wanner KT |
| Ref : Toxicol Lett , 293 :184 , 2018 |
| Abstract : Wein_2018_Toxicol.Lett_293_184 |
| ESTHER : Wein_2018_Toxicol.Lett_293_184 |
| PubMedSearch : Wein_2018_Toxicol.Lett_293_184 |
| PubMedID: 29097222 |
| Title : Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology - Niessen_2016_Toxicol.Lett_247_1 |
| Author(s) : Niessen KV , Muschik S , Langguth F , Rappengluck S , Seeger T , Thiermann H , Worek F |
| Ref : Toxicol Lett , 247 :1 , 2016 |
| Abstract : Niessen_2016_Toxicol.Lett_247_1 |
| ESTHER : Niessen_2016_Toxicol.Lett_247_1 |
| PubMedSearch : Niessen_2016_Toxicol.Lett_247_1 |
| PubMedID: 26851639 |
| Title : Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study - Worek_2016_Toxicol.Lett_262_12 |
| Author(s) : Worek F , Seeger T , Neumaier K , Wille T , Thiermann H |
| Ref : Toxicol Lett , 262 :12 , 2016 |
| Abstract : Worek_2016_Toxicol.Lett_262_12 |
| ESTHER : Worek_2016_Toxicol.Lett_262_12 |
| PubMedSearch : Worek_2016_Toxicol.Lett_262_12 |
| PubMedID: 27639501 |
| Title : Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro - Worek_2014_Arch.Toxicol_88_1257 |
| Author(s) : Worek F , Seeger T , Goldsmith M , Ashani Y , Leader H , Sussman JL , Tawfik DS , Thiermann H , Wille T |
| Ref : Archives of Toxicology , 88 :1257 , 2014 |
| Abstract : Worek_2014_Arch.Toxicol_88_1257 |
| ESTHER : Worek_2014_Arch.Toxicol_88_1257 |
| PubMedSearch : Worek_2014_Arch.Toxicol_88_1257 |
| PubMedID: 24477626 |
| Title : Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study - Worek_2014_Toxicol.Lett_231_45 |
| Author(s) : Worek F , Seeger T , Reiter G , Goldsmith M , Ashani Y , Leader H , Sussman JL , Aggarwal N , Thiermann H , Tawfik DS |
| Ref : Toxicol Lett , 231 :45 , 2014 |
| Abstract : Worek_2014_Toxicol.Lett_231_45 |
| ESTHER : Worek_2014_Toxicol.Lett_231_45 |
| PubMedSearch : Worek_2014_Toxicol.Lett_231_45 |
| PubMedID: 25195526 |
| Title : Effectiveness of a substituted beta-cyclodextrin to prevent cyclosarin toxicity in vivo - Worek_2014_Toxicol.Lett_226_222 |
| Author(s) : Worek F , Seeger T , Zengerle M , Kubik S , Thiermann H , Wille T |
| Ref : Toxicol Lett , 226 :222 , 2014 |
| Abstract : Worek_2014_Toxicol.Lett_226_222 |
| ESTHER : Worek_2014_Toxicol.Lett_226_222 |
| PubMedSearch : Worek_2014_Toxicol.Lett_226_222 |
| PubMedID: 24561299 |
| Title : Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length - Niessen_2013_Chem.Biol.Interact_206_545 |
| Author(s) : Niessen KV , Seeger T , Tattersall JE , Timperley CM , Bird M , Green C , Thiermann H , Worek F |
| Ref : Chemico-Biological Interactions , 206 :545 , 2013 |
| Abstract : Niessen_2013_Chem.Biol.Interact_206_545 |
| ESTHER : Niessen_2013_Chem.Biol.Interact_206_545 |
| PubMedSearch : Niessen_2013_Chem.Biol.Interact_206_545 |
| PubMedID: 24157926 |
| Title : Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro - Seeger_2012_Toxicology_294_80 |
| Author(s) : Seeger T , Eichhorn M , Lindner M , Niessen KV , Tattersall JE , Timperley CM , Bird M , Green AC , Thiermann H , Worek F |
| Ref : Toxicology , 294 :80 , 2012 |
| Abstract : Seeger_2012_Toxicology_294_80 |
| ESTHER : Seeger_2012_Toxicology_294_80 |
| PubMedSearch : Seeger_2012_Toxicology_294_80 |
| PubMedID: 22349640 |
| Title : Long-term evaluation of organophosphate toxicity and antidotal therapy in co-cultures of spinal cord and muscle tissue - Drexler_2011_Toxicol.Lett_206_89 |
| Author(s) : Drexler B , Seeger T , Grasshoff C , Thiermann H , Antkowiak B |
| Ref : Toxicol Lett , 206 :89 , 2011 |
| Abstract : Drexler_2011_Toxicol.Lett_206_89 |
| ESTHER : Drexler_2011_Toxicol.Lett_206_89 |
| PubMedSearch : Drexler_2011_Toxicol.Lett_206_89 |
| PubMedID: 21530620 |
| Title : Anaesthetic potency of diazepam is resistant to cholinergic overstimulation - Drexler_2011_Toxicol.Lett_206_84 |
| Author(s) : Drexler B , Zinser S , Seeger T , Thiermann H , Antkowiak B , Grasshoff C |
| Ref : Toxicol Lett , 206 :84 , 2011 |
| Abstract : Drexler_2011_Toxicol.Lett_206_84 |
| ESTHER : Drexler_2011_Toxicol.Lett_206_84 |
| PubMedSearch : Drexler_2011_Toxicol.Lett_206_84 |
| PubMedID: 21699965 |
| Title : Interaction of bispyridinium compounds with the orthosteric binding site of human alpha7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs) - Niessen_2011_Toxicol.Lett_206_100 |
| Author(s) : Niessen KV , Tattersall JE , Timperley CM , Bird M , Green C , Seeger T , Thiermann H , Worek F |
| Ref : Toxicol Lett , 206 :100 , 2011 |
| Abstract : Niessen_2011_Toxicol.Lett_206_100 |
| ESTHER : Niessen_2011_Toxicol.Lett_206_100 |
| PubMedSearch : Niessen_2011_Toxicol.Lett_206_100 |
| PubMedID: 21703337 |
| Title : Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat - Klein-Rodewald_2011_Toxicol.Lett_206_94 |
| Author(s) : Klein-Rodewald T , Seeger T , Dutschmann M , Worek F , Morschel M |
| Ref : Toxicol Lett , 206 :94 , 2011 |
| Abstract : Klein-Rodewald_2011_Toxicol.Lett_206_94 |
| ESTHER : Klein-Rodewald_2011_Toxicol.Lett_206_94 |
| PubMedSearch : Klein-Rodewald_2011_Toxicol.Lett_206_94 |
| PubMedID: 21767620 |
| Title : Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6 - Seeger_2011_Toxicol.Lett_206_72 |
| Author(s) : Seeger T , Niessen KV , Langer P , Gerhardus J , Worek F , Friess H , Bumm R , Mihaljevic AL , Thiermann H |
| Ref : Toxicol Lett , 206 :72 , 2011 |
| Abstract : Seeger_2011_Toxicol.Lett_206_72 |
| ESTHER : Seeger_2011_Toxicol.Lett_206_72 |
| PubMedSearch : Seeger_2011_Toxicol.Lett_206_72 |
| PubMedID: 21803135 |
| Title : Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds - Thiermann_2010_Chem.Biol.Interact_187_265 |
| Author(s) : Thiermann H , Seeger T , Gonder S , Herkert N , Antkowiak B , Zilker T , Eyer F , Worek F |
| Ref : Chemico-Biological Interactions , 187 :265 , 2010 |
| Abstract : Thiermann_2010_Chem.Biol.Interact_187_265 |
| ESTHER : Thiermann_2010_Chem.Biol.Interact_187_265 |
| PubMedSearch : Thiermann_2010_Chem.Biol.Interact_187_265 |
| PubMedID: 20036651 |
| Title : Reevaluation of indirect field stimulation technique to demonstrate oxime effectiveness in OP-poisoning in muscles in vitro - Seeger_2007_Toxicology_233_209 |
| Author(s) : Seeger T , Worek F , Szinicz L , Thiermann H |
| Ref : Toxicology , 233 :209 , 2007 |
| Abstract : Seeger_2007_Toxicology_233_209 |
| ESTHER : Seeger_2007_Toxicology_233_209 |
| PubMedSearch : Seeger_2007_Toxicology_233_209 |
| PubMedID: 17250944 |
| Title : M1-M3 muscarinic acetylcholine receptor-deficient mice: novel phenotypes - Gautam_2006_J.Mol.Neurosci_30_157 |
| Author(s) : Gautam D , Duttaroy A , Cui Y , Han SJ , Deng C , Seeger T , Alzheimer C , Wess J |
| Ref : Journal of Molecular Neuroscience , 30 :157 , 2006 |
| Abstract : Gautam_2006_J.Mol.Neurosci_30_157 |
| ESTHER : Gautam_2006_J.Mol.Neurosci_30_157 |
| PubMedSearch : Gautam_2006_J.Mol.Neurosci_30_157 |
| PubMedID: 17192665 |
| Title : M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity - Seeger_2004_J.Neurosci_24_10117 |
| Author(s) : Seeger T , Fedorova I , Zheng F , Miyakawa T , Koustova E , Gomeza J , Basile AS , Alzheimer C , Wess J |
| Ref : Journal of Neuroscience , 24 :10117 , 2004 |
| Abstract : Seeger_2004_J.Neurosci_24_10117 |
| ESTHER : Seeger_2004_J.Neurosci_24_10117 |
| PubMedSearch : Seeger_2004_J.Neurosci_24_10117 |
| PubMedID: 15537882 |