Full name : Sepsova Vendula
First name : Vendula
Mail : Faculty of Military Health Sciences\; Department of Toxicology\; Trebesska 1575\; Hradec Kralove\; 50001
Zip Code :
City :
Country : Czech Republic
Email : vendula.sepsova@unob.cz
Phone : +42097325517
Fax :
Website :
Directory :
| Title : Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy - Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| Author(s) : Dgachi Y , Martin H , Malek R , Jun D , Janockova J , Sepsova V , Soukup O , Iriepa I , Moraleda I , Maalej E , Carreiras MC , Refouvelet B , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : J Enzyme Inhib Med Chem , 34 :163 , 2019 |
| Abstract : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| ESTHER : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| PubMedSearch : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| PubMedID: 30482062 |
| Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K |
| Ref : Drug Des Devel Ther , 12 :505 , 2018 |
| Abstract : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| ESTHER : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| PubMedSearch : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| PubMedID: 29563775 |
| Title : Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier - Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
| Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Janockova J , Hrabinova M , Sepsova V , Kuca K |
| Ref : Curr Alzheimer Res , 15 :1096 , 2018 |
| Abstract : Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
| ESTHER : Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
| PubMedSearch : Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
| PubMedID: 29992880 |
| Title : Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents - Panek_2018_ACS.Chem.Neurosci_9_1074 |
| Author(s) : Panek D , Wieckowska A , Jonczyk J , Godyn J , Bajda M , Wichur T , Pasieka A , Knez D , Pislar A , Korabecny J , Soukup O , Sepsova V , Sabate R , Kos J , Gobec S , Malawska B |
| Ref : ACS Chem Neurosci , 9 :1074 , 2018 |
| Abstract : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| ESTHER : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| PubMedSearch : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| PubMedID: 29345897 |
| Title : Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment - Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| Author(s) : Gazova Z , Soukup O , Sepsova V , Siposova K , Drtinova L , Jost P , Spilovska K , Korabecny J , Nepovimova E , Fedunova D , Horak M , Kaniakova M , Wang ZJ , Hamouda AK , Kuca K |
| Ref : Biochimica & Biophysica Acta Mol Basis Dis , 1863 :607 , 2017 |
| Abstract : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| ESTHER : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| PubMedSearch : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| PubMedID: 27865910 |
| Title : Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation - Spilovska_2017_Molecules_22_ |
| Author(s) : Spilovska K , Korabecny J , Sepsova V , Jun D , Hrabinova M , Jost P , Muckova L , Soukup O , Janockova J , Kucera T , Dolezal R , Mezeiova E , Kaping D , Kuca K |
| Ref : Molecules , 22 : , 2017 |
| Abstract : Spilovska_2017_Molecules_22_ |
| ESTHER : Spilovska_2017_Molecules_22_ |
| PubMedSearch : Spilovska_2017_Molecules_22_ |
| PubMedID: 28621747 |
| Title : The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203 - Kassa_2017_Molecules_22_ |
| Author(s) : Kassa J , Misik J , Hatlapatkova J , Karasova JZ , Sepsova V , Caisberger F , Pejchal J |
| Ref : Molecules , 22 : , 2017 |
| Abstract : Kassa_2017_Molecules_22_ |
| ESTHER : Kassa_2017_Molecules_22_ |
| PubMedSearch : Kassa_2017_Molecules_22_ |
| PubMedID: 28696367 |
| Title : Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy - Mezeiova_2017_Molecules_22_ |
| Author(s) : Mezeiova E , Korabecny J , Sepsova V , Hrabinova M , Jost P , Muckova L , Kucera T , Dolezal R , Misik J , Spilovska K , Pham NL , Pokrievkova L , Roh J , Jun D , Soukup O , Kaping D , Kuca K |
| Ref : Molecules , 22 : , 2017 |
| Abstract : Mezeiova_2017_Molecules_22_ |
| ESTHER : Mezeiova_2017_Molecules_22_ |
| PubMedSearch : Mezeiova_2017_Molecules_22_ |
| PubMedID: 28788095 |
| Title : Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease - Benek_2016_ChemMedChem_11_1264 |
| Author(s) : Benek O , Soukup O , Pasdiorova M , Hroch L , Sepsova V , Jost P , Hrabinova M , Jun D , Kuca K , Zala D , Ramsay RR , Marco-Contelles J , Musilek K |
| Ref : ChemMedChem , 11 :1264 , 2016 |
| Abstract : Benek_2016_ChemMedChem_11_1264 |
| ESTHER : Benek_2016_ChemMedChem_11_1264 |
| PubMedSearch : Benek_2016_ChemMedChem_11_1264 |
| PubMedID: 26427608 |
| Title : Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease - Jerabek_2016_Eur.J.Med.Chem_127_250 |
| Author(s) : Jerabek J , Uliassi E , Guidotti L , Korabecny J , Soukup O , Sepsova V , Hrabinova M , Kuca K , Bartolini M , Pena-Altamira LE , Petralla S , Monti B , Roberti M , Bolognesi ML |
| Ref : Eur Journal of Medicinal Chemistry , 127 :250 , 2016 |
| Abstract : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| ESTHER : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| PubMedSearch : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| PubMedID: 28064079 |
| Title : Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules - Hamulakova_2016_J.Inorg.Biochem_161_52 |
| Author(s) : Hamulakova S , Poprac P , Jomova K , Brezova V , Lauro P , Drostinova L , Jun D , Sepsova V , Hrabinova M , Soukup O , Kristian P , Gazova Z , Bednarikova Z , Kuca K , Valko M |
| Ref : J Inorg Biochem , 161 :52 , 2016 |
| Abstract : Hamulakova_2016_J.Inorg.Biochem_161_52 |
| ESTHER : Hamulakova_2016_J.Inorg.Biochem_161_52 |
| PubMedSearch : Hamulakova_2016_J.Inorg.Biochem_161_52 |
| PubMedID: 27230386 |
| Title : The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators - Benchekroun_2016_J.Med.Chem_59_9967 |
| Author(s) : Benchekroun M , Romero A , Egea J , Leon R , Michalska P , Buendia I , Jimeno ML , Jun D , Janockova J , Sepsova V , Soukup O , Bautista-Aguilera OM , Refouvelet B , Ouari O , Marco-Contelles J , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 59 :9967 , 2016 |
| Abstract : Benchekroun_2016_J.Med.Chem_59_9967 |
| ESTHER : Benchekroun_2016_J.Med.Chem_59_9967 |
| PubMedSearch : Benchekroun_2016_J.Med.Chem_59_9967 |
| PubMedID: 27736061 |
| Title : Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity - Nepovimova_2015_J.Med.Chem_58_8985 |
| Author(s) : Nepovimova E , Korabecny J , Dolezal R , Babkova K , Ondrejicek A , Jun D , Sepsova V , Horova A , Hrabinova M , Soukup O , Bukum N , Jost P , Muckova L , Kassa J , Malinak D , Andrs M , Kuca K |
| Ref : Journal of Medicinal Chemistry , 58 :8985 , 2015 |
| Abstract : Nepovimova_2015_J.Med.Chem_58_8985 |
| ESTHER : Nepovimova_2015_J.Med.Chem_58_8985 |
| PubMedSearch : Nepovimova_2015_J.Med.Chem_58_8985 |
| PubMedID: 26503905 |
| Title : 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment - Korabecny_2015_Molecules_20_22084 |
| Author(s) : Korabecny J , Andrs M , Nepovimova E , Dolezal R , Babkova K , Horova A , Malinak D , Mezeiova E , Gorecki L , Sepsova V , Hrabinova M , Soukup O , Jun D , Kuca K |
| Ref : Molecules , 20 :22084 , 2015 |
| Abstract : Korabecny_2015_Molecules_20_22084 |
| ESTHER : Korabecny_2015_Molecules_20_22084 |
| PubMedSearch : Korabecny_2015_Molecules_20_22084 |
| PubMedID: 26690394 |
| Title : A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K727, K733) with the oxime HI-6 and obidoxime in sarin-poisoned rats and mice - Kassa_2015_Toxicol.Mech.Methods_25_229 |
| Author(s) : Kassa J , Sepsova V , Matouskova L , Horova A , Musilek K |
| Ref : Toxicol Mech Methods , 25 :229 , 2015 |
| Abstract : Kassa_2015_Toxicol.Mech.Methods_25_229 |
| ESTHER : Kassa_2015_Toxicol.Mech.Methods_25_229 |
| PubMedSearch : Kassa_2015_Toxicol.Mech.Methods_25_229 |
| PubMedID: 25894563 |
| Title : Cholinergic properties of new 7-methoxytacrine-donepezil derivatives - Sepsova_2015_Gen.Physiol.Biophys_34_189 |
| Author(s) : Sepsova V , Karasova JZ , Tobin G , Jun D , Korabecny J , Cabelova P , Janska K , Krusek J , Skrenkova K , Kuca K , Soukup O |
| Ref : Gen Physiol Biophys , 34 :189 , 2015 |
| Abstract : Sepsova_2015_Gen.Physiol.Biophys_34_189 |
| ESTHER : Sepsova_2015_Gen.Physiol.Biophys_34_189 |
| PubMedSearch : Sepsova_2015_Gen.Physiol.Biophys_34_189 |
| PubMedID: 25504063 |
| Title : A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (K727 and K733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice - Kassa_2015_Basic.Clin.Pharmacol.Toxicol_116_367 |
| Author(s) : Kassa J , Sepsova V , Tumova M , Horova A , Musilek K |
| Ref : Basic Clin Pharmacol Toxicol , 116 :367 , 2015 |
| Abstract : Kassa_2015_Basic.Clin.Pharmacol.Toxicol_116_367 |
| ESTHER : Kassa_2015_Basic.Clin.Pharmacol.Toxicol_116_367 |
| PubMedSearch : Kassa_2015_Basic.Clin.Pharmacol.Toxicol_116_367 |
| PubMedID: 25225130 |
| Title : The Evaluation of Prophylactic Efficacy of Newly Developed Reversible Inhibitors of Acetylcholinesterase in Soman-Poisoned Mice - A Comparison with Commonly Used Pyridostigmine - Kassa_2014_Basic.Clin.Pharmacol.Toxicol_115_571 |
| Author(s) : Kassa J , Korabecny J , Sepsova V , Tumova M |
| Ref : Basic Clin Pharmacol Toxicol , 115 :571 , 2014 |
| Abstract : Kassa_2014_Basic.Clin.Pharmacol.Toxicol_115_571 |
| ESTHER : Kassa_2014_Basic.Clin.Pharmacol.Toxicol_115_571 |
| PubMedSearch : Kassa_2014_Basic.Clin.Pharmacol.Toxicol_115_571 |
| PubMedID: 24842281 |
| Title : Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine - Zemek_2014_Expert.Opin.Drug.Saf_13_759 |
| Author(s) : Zemek F , Drtinova L , Nepovimova E , Sepsova V , Korabecny J , Klimes J , Kuca K |
| Ref : Expert Opin Drug Safety , 13 :759 , 2014 |
| Abstract : Zemek_2014_Expert.Opin.Drug.Saf_13_759 |
| ESTHER : Zemek_2014_Expert.Opin.Drug.Saf_13_759 |
| PubMedSearch : Zemek_2014_Expert.Opin.Drug.Saf_13_759 |
| PubMedID: 24845946 |
| Title : 7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies - Korabecny_2014_Eur.J.Med.Chem_82C_426 |
| Author(s) : Korabecny J , Dolezal R , Cabelova P , Horova A , Hruba E , Ricny J , Sedlacek L , Nepovimova E , Spilovska K , Andrs M , Musilek K , Opletalova V , Sepsova V , Ripova D , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 82C :426 , 2014 |
| Abstract : Korabecny_2014_Eur.J.Med.Chem_82C_426 |
| ESTHER : Korabecny_2014_Eur.J.Med.Chem_82C_426 |
| PubMedSearch : Korabecny_2014_Eur.J.Med.Chem_82C_426 |
| PubMedID: 24929293 |
| Title : The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor - Sepsova_2014_Physiol.Res_63_771 |
| Author(s) : Sepsova V , Krusek J , Karasova JZ , Zemek F , Musilek K , Kuca K , Soukup O |
| Ref : Physiol Res , 63 :771 , 2014 |
| Abstract : Sepsova_2014_Physiol.Res_63_771 |
| ESTHER : Sepsova_2014_Physiol.Res_63_771 |
| PubMedSearch : Sepsova_2014_Physiol.Res_63_771 |
| PubMedID: 25157661 |
| Title : The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice - Kassa_2014_Toxicol.Mech.Methods_24_173 |
| Author(s) : Kassa J , Sepsova V , Tumova M , Musilek K , Horova A |
| Ref : Toxicol Mech Methods , 24 :173 , 2014 |
| Abstract : Kassa_2014_Toxicol.Mech.Methods_24_173 |
| ESTHER : Kassa_2014_Toxicol.Mech.Methods_24_173 |
| PubMedSearch : Kassa_2014_Toxicol.Mech.Methods_24_173 |
| PubMedID: 24295433 |
| Title : The evaluation of the reactivating and therapeutic efficacy of three novel bispyridinium oximes (K454, K456, K458) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice - Kassa_2013_Toxicol.Mech.Methods_23_94 |
| Author(s) : Kassa J , Sepsova V , Musilek K , Horova A |
| Ref : Toxicol Mech Methods , 23 :94 , 2013 |
| Abstract : Kassa_2013_Toxicol.Mech.Methods_23_94 |
| ESTHER : Kassa_2013_Toxicol.Mech.Methods_23_94 |
| PubMedSearch : Kassa_2013_Toxicol.Mech.Methods_23_94 |
| PubMedID: 22901042 |
| Title : Oximes: Inhibitors of Human Recombinant Acetylcholinesterase. A Structure-Activity Relationship (SAR) Study - Sepsova_2013_Int.J.Mol.Sci_14_16882 |
| Author(s) : Sepsova V , Karasova JZ , Korabecny J , Dolezal R , Zemek F , Bennion BJ , Kuca K |
| Ref : Int J Mol Sci , 14 :16882 , 2013 |
| Abstract : Sepsova_2013_Int.J.Mol.Sci_14_16882 |
| ESTHER : Sepsova_2013_Int.J.Mol.Sci_14_16882 |
| PubMedSearch : Sepsova_2013_Int.J.Mol.Sci_14_16882 |
| PubMedID: 23959117 |
| Title : A Resurrection of 7-MEOTA: A Comparison with Tacrine - Soukup_2013_Curr.Alzheimer.Res_10_893 |
| Author(s) : Soukup O , Jun D , Karasova JZ , Patocka J , Musilek K , Korabecny J , Krusek J , Kaniakova M , Sepsova V , Mandikova J , Trejtnar F , Pohanka M , Drtinova L , Pavlik M , Tobin G , Kuca K |
| Ref : Curr Alzheimer Res , 10 :893 , 2013 |
| Abstract : Soukup_2013_Curr.Alzheimer.Res_10_893 |
| ESTHER : Soukup_2013_Curr.Alzheimer.Res_10_893 |
| PubMedSearch : Soukup_2013_Curr.Alzheimer.Res_10_893 |
| PubMedID: 24093535 |
| Title : Oximes as inhibitors of acetylholinesterase - a structure-activity relationship (SAR) study - Sepsova_2011_Mil.Med.Sci.Lett_80_178 |
| Author(s) : Sepsova V , Karasova JZ , Zemek F , Bennion BJ , Kuca K |
| Ref : Military Medical Science Letters , 80 :178 , 2011 |
| Abstract : Sepsova_2011_Mil.Med.Sci.Lett_80_178 |
| ESTHER : Sepsova_2011_Mil.Med.Sci.Lett_80_178 |
| PubMedSearch : Sepsova_2011_Mil.Med.Sci.Lett_80_178 |
| PubMedID: |
| Title : The benefit of combinations of oximes for the reactivating and therapeutic efficacy of antidotal treatment of sarin poisoning in rats and mice - Kassa_2011_Basic.Clin.Pharmacol.Toxicol_109_30 |
| Author(s) : Kassa J , Karasova JZ , Sepsova V , Caisberger F |
| Ref : Basic Clin Pharmacol Toxicol , 109 :30 , 2011 |
| Abstract : Kassa_2011_Basic.Clin.Pharmacol.Toxicol_109_30 |
| ESTHER : Kassa_2011_Basic.Clin.Pharmacol.Toxicol_109_30 |
| PubMedSearch : Kassa_2011_Basic.Clin.Pharmacol.Toxicol_109_30 |
| PubMedID: 21235715 |
| Title : A comparison of the reactivating and therapeutic efficacy of chosen combinations of oximes with individual oximes against VX in rats and mice - Kassa_2011_Int.J.Toxicol_30_562 |
| Author(s) : Kassa J , Karasova JZ , Sepsova V , Caisberger F , Bajgar J |
| Ref : Int J Toxicol , 30 :562 , 2011 |
| Abstract : Kassa_2011_Int.J.Toxicol_30_562 |
| ESTHER : Kassa_2011_Int.J.Toxicol_30_562 |
| PubMedSearch : Kassa_2011_Int.J.Toxicol_30_562 |
| PubMedID: 22013137 |