Report for Sexton PM

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References (37)

Title : From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease - Brown_2021_Cell_184_5886
Author(s) : Brown AJH , Bradley SJ , Marshall FH , Brown GA , Bennett KA , Brown J , Cansfield JE , Cross DM , de Graaf C , Hudson BD , Dwomoh L , Dias JM , Errey JC , Hurrell E , Liptrot J , Mattedi G , Molloy C , Nathan PJ , Okrasa K , Osborne G , Patel JC , Pickworth M , Robertson N , Shahabi S , Bundgaard C , Phillips K , Broad LM , Goonawardena AV , Morairty SR , Browning M , Perini F , Dawson GR , Deakin JFW , Smith RT , Sexton PM , Warneck J , Vinson M , Tasker T , Tehan BG , Teobald B , Christopoulos A , Langmead CJ , Jazayeri A , Cooke RM , Rucktooa P , Congreve MS , Weir M , Tobin AB
Ref : Cell , 184 :5886 , 2021
Abstract : Brown_2021_Cell_184_5886
ESTHER : Brown_2021_Cell_184_5886
PubMedSearch : Brown_2021_Cell_184_5886
PubMedID: 34822784

Title : Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs - Bradley_2020_Nat.Chem.Biol_16_240
Author(s) : Bradley SJ , Molloy C , Valuskova P , Dwomoh L , Scarpa M , Rossi M , Finlayson L , Svensson KA , Chernet E , Barth VN , Gherbi K , Sykes DA , Wilson CA , Mistry R , Sexton PM , Christopoulos A , Mogg AJ , Rosethorne EM , Sakata S , John Challiss RA , Broad LM , Tobin AB
Ref : Nat Chemical Biology , 16 :240 , 2020
Abstract : Bradley_2020_Nat.Chem.Biol_16_240
ESTHER : Bradley_2020_Nat.Chem.Biol_16_240
PubMedSearch : Bradley_2020_Nat.Chem.Biol_16_240
PubMedID: 32080630

Title : M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss - Bradley_2017_J.Clin.Invest_127_487
Author(s) : Bradley SJ , Bourgognon JM , Sanger HE , Verity N , Mogg AJ , White DJ , Butcher AJ , Moreno JA , Molloy C , Macedo-Hatch T , Edwards JM , Wess J , Pawlak R , Read DJ , Sexton PM , Broad LM , Steinert JR , Mallucci GR , Christopoulos A , Felder CC , Tobin AB
Ref : J Clinical Investigation , 127 :487 , 2017
Abstract : Bradley_2017_J.Clin.Invest_127_487
ESTHER : Bradley_2017_J.Clin.Invest_127_487
PubMedSearch : Bradley_2017_J.Clin.Invest_127_487
PubMedID: 27991860

Title : Muscarinic acetylcholine receptors: novel opportunities for drug development - Kruse_2014_Nat.Rev.Drug.Discov_13_549
Author(s) : Kruse AC , Kobilka BK , Gautam D , Sexton PM , Christopoulos A , Wess J
Ref : Nat Rev Drug Discov , 13 :549 , 2014
Abstract : Kruse_2014_Nat.Rev.Drug.Discov_13_549
ESTHER : Kruse_2014_Nat.Rev.Drug.Discov_13_549
PubMedSearch : Kruse_2014_Nat.Rev.Drug.Discov_13_549
PubMedID: 24903776

Title : Molecular determinants of allosteric modulation at the m1 muscarinic acetylcholine receptor - Abdul-Ridha_2014_J.Biol.Chem_289_6067
Author(s) : Abdul-Ridha A , Lopez L , Keov P , Thal DM , Mistry SN , Sexton PM , Lane JR , Canals M , Christopoulos A
Ref : Journal of Biological Chemistry , 289 :6067 , 2014
Abstract : Abdul-Ridha_2014_J.Biol.Chem_289_6067
ESTHER : Abdul-Ridha_2014_J.Biol.Chem_289_6067
PubMedSearch : Abdul-Ridha_2014_J.Biol.Chem_289_6067
PubMedID: 24443568

Title : Development of a photoactivatable allosteric ligand for the m1 muscarinic acetylcholine receptor - Davie_2014_ACS.Chem.Neurosci_5_902
Author(s) : Davie BJ , Sexton PM , Capuano B , Christopoulos A , Scammells PJ
Ref : ACS Chem Neurosci , 5 :902 , 2014
Abstract : Davie_2014_ACS.Chem.Neurosci_5_902
ESTHER : Davie_2014_ACS.Chem.Neurosci_5_902
PubMedSearch : Davie_2014_ACS.Chem.Neurosci_5_902
PubMedID: 25188871

Title : Probing structural requirements of positive allosteric modulators of the m4 muscarinic receptor - Huynh_2013_J.Med.Chem_56_8196
Author(s) : Huynh T , Valant C , Crosby IT , Sexton PM , Christopoulos A , Capuano B
Ref : Journal of Medicinal Chemistry , 56 :8196 , 2013
Abstract : Huynh_2013_J.Med.Chem_56_8196
ESTHER : Huynh_2013_J.Med.Chem_56_8196
PubMedSearch : Huynh_2013_J.Med.Chem_56_8196
PubMedID: 24074052

Title : Reverse engineering of the selective agonist TBPB unveils both orthosteric and allosteric modes of action at the M(1) muscarinic acetylcholine receptor - Keov_2013_Mol.Pharmacol_84_425
Author(s) : Keov P , Valant C , Devine SM , Lane JR , Scammells PJ , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 84 :425 , 2013
Abstract : Keov_2013_Mol.Pharmacol_84_425
ESTHER : Keov_2013_Mol.Pharmacol_84_425
PubMedSearch : Keov_2013_Mol.Pharmacol_84_425
PubMedID: 23798605

Title : Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs - Dror_2013_Nature_503_295
Author(s) : Dror RO , Green HF , Valant C , Borhani DW , Valcourt JR , Pan AC , Arlow DH , Canals M , Lane JR , Rahmani R , Baell JB , Sexton PM , Christopoulos A , Shaw DE
Ref : Nature , 503 :295 , 2013
Abstract : Dror_2013_Nature_503_295
ESTHER : Dror_2013_Nature_503_295
PubMedSearch : Dror_2013_Nature_503_295
PubMedID: 24121438

Title : Activation and allosteric modulation of a muscarinic acetylcholine receptor - Kruse_2013_Nature_504_101
Author(s) : Kruse AC , Ring AM , Manglik A , Hu J , Hu K , Eitel K , Hubner H , Pardon E , Valant C , Sexton PM , Christopoulos A , Felder CC , Gmeiner P , Steyaert J , Weis WI , Garcia KC , Wess J , Kobilka BK
Ref : Nature , 504 :101 , 2013
Abstract : Kruse_2013_Nature_504_101
ESTHER : Kruse_2013_Nature_504_101
PubMedSearch : Kruse_2013_Nature_504_101
PubMedID: 24256733

Title : Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor - Mistry_2013_J.Med.Chem_56_5151
Author(s) : Mistry SN , Valant C , Sexton PM , Capuano B , Christopoulos A , Scammells PJ
Ref : Journal of Medicinal Chemistry , 56 :5151 , 2013
Abstract : Mistry_2013_J.Med.Chem_56_5151
ESTHER : Mistry_2013_J.Med.Chem_56_5151
PubMedSearch : Mistry_2013_J.Med.Chem_56_5151
PubMedID: 23718562

Title : Allosteric modulation of a chemogenetically modified G protein-coupled receptor - Abdul-Ridha_2013_Mol.Pharmacol_83_521
Author(s) : Abdul-Ridha A , Lane JR , Sexton PM , Canals M , Christopoulos A
Ref : Molecular Pharmacology , 83 :521 , 2013
Abstract : Abdul-Ridha_2013_Mol.Pharmacol_83_521
ESTHER : Abdul-Ridha_2013_Mol.Pharmacol_83_521
PubMedSearch : Abdul-Ridha_2013_Mol.Pharmacol_83_521
PubMedID: 23197649

Title : A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation - Canals_2012_J.Biol.Chem_287_650
Author(s) : Canals M , Lane JR , Wen A , Scammells PJ , Sexton PM , Christopoulos A
Ref : Journal of Biological Chemistry , 287 :650 , 2012
Abstract : Canals_2012_J.Biol.Chem_287_650
ESTHER : Canals_2012_J.Biol.Chem_287_650
PubMedSearch : Canals_2012_J.Biol.Chem_287_650
PubMedID: 22086918

Title : Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor - Gregory_2012_J.Biol.Chem_287_37066
Author(s) : Gregory KJ , Sexton PM , Tobin AB , Christopoulos A
Ref : Journal of Biological Chemistry , 287 :37066 , 2012
Abstract : Gregory_2012_J.Biol.Chem_287_37066
ESTHER : Gregory_2012_J.Biol.Chem_287_37066
PubMedSearch : Gregory_2012_J.Biol.Chem_287_37066
PubMedID: 22965232

Title : Allosteric modulation of endogenous metabolites as an avenue for drug discovery - Wootten_2012_Mol.Pharmacol_82_281
Author(s) : Wootten D , Savage EE , Valant C , May LT , Sloop KW , Ficorilli J , Showalter AD , Willard FS , Christopoulos A , Sexton PM
Ref : Molecular Pharmacology , 82 :281 , 2012
Abstract : Wootten_2012_Mol.Pharmacol_82_281
ESTHER : Wootten_2012_Mol.Pharmacol_82_281
PubMedSearch : Wootten_2012_Mol.Pharmacol_82_281
PubMedID: 22576254

Title : Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects - Valant_2012_Mol.Pharmacol_81_41
Author(s) : Valant C , Felder CC , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 81 :41 , 2012
Abstract : Valant_2012_Mol.Pharmacol_81_41
ESTHER : Valant_2012_Mol.Pharmacol_81_41
PubMedSearch : Valant_2012_Mol.Pharmacol_81_41
PubMedID: 21989256

Title : Structure-function studies of muscarinic acetylcholine receptors - Leach_2012_Handb.Exp.Pharmacol_208_29
Author(s) : Leach K , Simms J , Sexton PM , Christopoulos A
Ref : Handbook of Experimental Pharmacology , :29 , 2012
Abstract : Leach_2012_Handb.Exp.Pharmacol_208_29
ESTHER : Leach_2012_Handb.Exp.Pharmacol_208_29
PubMedSearch : Leach_2012_Handb.Exp.Pharmacol_208_29
PubMedID: 22222693

Title : The role of transmembrane domain 3 in the actions of orthosteric, allosteric, and atypical agonists of the M4 muscarinic acetylcholine receptor - Leach_2011_Mol.Pharmacol_79_855
Author(s) : Leach K , Davey AE , Felder CC , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 79 :855 , 2011
Abstract : Leach_2011_Mol.Pharmacol_79_855
ESTHER : Leach_2011_Mol.Pharmacol_79_855
PubMedSearch : Leach_2011_Mol.Pharmacol_79_855
PubMedID: 21300722

Title : Structural determinants of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor: identification of ligand-specific and global activation mechanisms - Nawaratne_2010_J.Biol.Chem_285_19012
Author(s) : Nawaratne V , Leach K , Felder CC , Sexton PM , Christopoulos A
Ref : Journal of Biological Chemistry , 285 :19012 , 2010
Abstract : Nawaratne_2010_J.Biol.Chem_285_19012
ESTHER : Nawaratne_2010_J.Biol.Chem_285_19012
PubMedSearch : Nawaratne_2010_J.Biol.Chem_285_19012
PubMedID: 20406819

Title : Detection of novel functional selectivity at M3 muscarinic acetylcholine receptors using a Saccharomyces cerevisiae platform - Stewart_2010_ACS.Chem.Biol_5_365
Author(s) : Stewart GD , Sexton PM , Christopoulos A
Ref : ACS Chemical Biology , 5 :365 , 2010
Abstract : Stewart_2010_ACS.Chem.Biol_5_365
ESTHER : Stewart_2010_ACS.Chem.Biol_5_365
PubMedSearch : Stewart_2010_ACS.Chem.Biol_5_365
PubMedID: 20155933

Title : Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias - Gregory_2010_J.Biol.Chem_285_7459
Author(s) : Gregory KJ , Hall NE , Tobin AB , Sexton PM , Christopoulos A
Ref : Journal of Biological Chemistry , 285 :7459 , 2010
Abstract : Gregory_2010_J.Biol.Chem_285_7459
ESTHER : Gregory_2010_J.Biol.Chem_285_7459
PubMedSearch : Gregory_2010_J.Biol.Chem_285_7459
PubMedID: 20051519

Title : Prediction of functionally selective allosteric interactions at an M3 muscarinic acetylcholine receptor mutant using Saccharomyces cerevisiae - Stewart_2010_Mol.Pharmacol_78_205
Author(s) : Stewart GD , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 78 :205 , 2010
Abstract : Stewart_2010_Mol.Pharmacol_78_205
ESTHER : Stewart_2010_Mol.Pharmacol_78_205
PubMedSearch : Stewart_2010_Mol.Pharmacol_78_205
PubMedID: 20466821

Title : Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor - Avlani_2010_Mol.Pharmacol_78_94
Author(s) : Avlani VA , Langmead CJ , Guida E , Wood MD , Tehan BG , Herdon HJ , Watson JM , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 78 :94 , 2010
Abstract : Avlani_2010_Mol.Pharmacol_78_94
ESTHER : Avlani_2010_Mol.Pharmacol_78_94
PubMedSearch : Avlani_2010_Mol.Pharmacol_78_94
PubMedID: 20413650

Title : Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties - Leach_2010_Neuropsychopharmacology_35_855
Author(s) : Leach K , Loiacono RE , Felder CC , McKinzie DL , Mogg A , Shaw DB , Sexton PM , Christopoulos A
Ref : Neuropsychopharmacology , 35 :855 , 2010
Abstract : Leach_2010_Neuropsychopharmacology_35_855
ESTHER : Leach_2010_Neuropsychopharmacology_35_855
PubMedSearch : Leach_2010_Neuropsychopharmacology_35_855
PubMedID: 19940843

Title : The effect of social isolation on rat brain expression of genes associated with endocannabinoid signaling - Robinson_2010_Brain.Res_1343_153
Author(s) : Robinson SA , Loiacono RE , Christopoulos A , Sexton PM , Malone DT
Ref : Brain Research , 1343 :153 , 2010
Abstract : Robinson_2010_Brain.Res_1343_153
ESTHER : Robinson_2010_Brain.Res_1343_153
PubMedSearch : Robinson_2010_Brain.Res_1343_153
PubMedID: 20430015

Title : Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: implications for ligand screening and functional selectivity - Stewart_2009_J.Pharmacol.Exp.Ther_331_277
Author(s) : Stewart GD , Valant C , Dowell SJ , Mijaljica D , Devenish RJ , Scammells PJ , Sexton PM , Christopoulos A
Ref : Journal of Pharmacology & Experimental Therapeutics , 331 :277 , 2009
Abstract : Stewart_2009_J.Pharmacol.Exp.Ther_331_277
ESTHER : Stewart_2009_J.Pharmacol.Exp.Ther_331_277
PubMedSearch : Stewart_2009_J.Pharmacol.Exp.Ther_331_277
PubMedID: 19641164

Title : New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug) - Nawaratne_2008_Mol.Pharmacol_74_1119
Author(s) : Nawaratne V , Leach K , Suratman N , Loiacono RE , Felder CC , Armbruster BN , Roth BL , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 74 :1119 , 2008
Abstract : Nawaratne_2008_Mol.Pharmacol_74_1119
ESTHER : Nawaratne_2008_Mol.Pharmacol_74_1119
PubMedSearch : Nawaratne_2008_Mol.Pharmacol_74_1119
PubMedID: 18628403

Title : The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions - Avlani_2008_J.Pharmacol.Exp.Ther_325_927
Author(s) : Avlani VA , McLoughlin DJ , Sexton PM , Christopoulos A
Ref : Journal of Pharmacology & Experimental Therapeutics , 325 :927 , 2008
Abstract : Avlani_2008_J.Pharmacol.Exp.Ther_325_927
ESTHER : Avlani_2008_J.Pharmacol.Exp.Ther_325_927
PubMedSearch : Avlani_2008_J.Pharmacol.Exp.Ther_325_927
PubMedID: 18322151

Title : A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric\/allosteric ligand - Valant_2008_J.Biol.Chem_283_29312
Author(s) : Valant C , Gregory KJ , Hall NE , Scammells PJ , Lew MJ , Sexton PM , Christopoulos A
Ref : Journal of Biological Chemistry , 283 :29312 , 2008
Abstract : Valant_2008_J.Biol.Chem_283_29312
ESTHER : Valant_2008_J.Biol.Chem_283_29312
PubMedSearch : Valant_2008_J.Biol.Chem_283_29312
PubMedID: 18723515

Title : Allosteric modulation of muscarinic acetylcholine receptors - Gregory_2007_Curr.Neuropharmacol_5_157
Author(s) : Gregory KJ , Sexton PM , Christopoulos A
Ref : Curr Neuropharmacol , 5 :157 , 2007
Abstract : Gregory_2007_Curr.Neuropharmacol_5_157
ESTHER : Gregory_2007_Curr.Neuropharmacol_5_157
PubMedSearch : Gregory_2007_Curr.Neuropharmacol_5_157
PubMedID: 19305798

Title : Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors - May_2007_Mol.Pharmacol_72_463
Author(s) : May LT , Avlani VA , Langmead CJ , Herdon HJ , Wood MD , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 72 :463 , 2007
Abstract : May_2007_Mol.Pharmacol_72_463
ESTHER : May_2007_Mol.Pharmacol_72_463
PubMedSearch : May_2007_Mol.Pharmacol_72_463
PubMedID: 17525129

Title : Involvement of the sigma1 (sigma1) receptor in the anti-amnesic, but not antidepressant-like, effects of the aminotetrahydrofuran derivative ANAVEX1-41 - Espallergues_2007_Br.J.Pharmacol_152_267
Author(s) : Espallergues J , Lapalud P , Christopoulos A , Avlani VA , Sexton PM , Vamvakides A , Maurice T
Ref : British Journal of Pharmacology , 152 :267 , 2007
Abstract : Espallergues_2007_Br.J.Pharmacol_152_267
ESTHER : Espallergues_2007_Br.J.Pharmacol_152_267
PubMedSearch : Espallergues_2007_Br.J.Pharmacol_152_267
PubMedID: 17641675

Title : Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands - Avlani_2007_J.Biol.Chem_282_25677
Author(s) : Avlani VA , Gregory KJ , Morton CJ , Parker MW , Sexton PM , Christopoulos A
Ref : Journal of Biological Chemistry , 282 :25677 , 2007
Abstract : Avlani_2007_J.Biol.Chem_282_25677
ESTHER : Avlani_2007_J.Biol.Chem_282_25677
PubMedSearch : Avlani_2007_J.Biol.Chem_282_25677
PubMedID: 17591774

Title : Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors - Lanzafame_2006_Mol.Pharmacol_70_736
Author(s) : Lanzafame AA , Sexton PM , Christopoulos A
Ref : Molecular Pharmacology , 70 :736 , 2006
Abstract : Lanzafame_2006_Mol.Pharmacol_70_736
ESTHER : Lanzafame_2006_Mol.Pharmacol_70_736
PubMedSearch : Lanzafame_2006_Mol.Pharmacol_70_736
PubMedID: 16709648

Title : Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators - May_2005_J.Pharmacol.Exp.Ther_312_382
Author(s) : May LT , Lin Y , Sexton PM , Christopoulos A
Ref : Journal of Pharmacology & Experimental Therapeutics , 312 :382 , 2005
Abstract : May_2005_J.Pharmacol.Exp.Ther_312_382
ESTHER : May_2005_J.Pharmacol.Exp.Ther_312_382
PubMedSearch : May_2005_J.Pharmacol.Exp.Ther_312_382
PubMedID: 15333678

Title : Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors - Avlani_2004_J.Pharmacol.Exp.Ther_308_1062
Author(s) : Avlani V , May LT , Sexton PM , Christopoulos A
Ref : Journal of Pharmacology & Experimental Therapeutics , 308 :1062 , 2004
Abstract : Avlani_2004_J.Pharmacol.Exp.Ther_308_1062
ESTHER : Avlani_2004_J.Pharmacol.Exp.Ther_308_1062
PubMedSearch : Avlani_2004_J.Pharmacol.Exp.Ther_308_1062
PubMedID: 14711931

Title : G-protein-coupled receptor allosterism: the promise and the problem(s) - Christopoulos_2004_Biochem.Soc.Trans_32_873
Author(s) : Christopoulos A , May LT , Avlani VA , Sexton PM
Ref : Biochemical Society Transactions , 32 :873 , 2004
Abstract : Christopoulos_2004_Biochem.Soc.Trans_32_873
ESTHER : Christopoulos_2004_Biochem.Soc.Trans_32_873
PubMedSearch : Christopoulos_2004_Biochem.Soc.Trans_32_873
PubMedID: 15494038