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Author Report for: Silman I

Contact information:

Silman Israel
Department of Neurobiology; Weizmann Institute of Science; Rehovot 76100
76100
Rehovot
Israel
Phone : +972-8-9343669
Fax : +972-8-947-1949
Send E-Mail to Silman Israel
Visit the web site of Silman I at : http://www.weizmann.ac.il/neurobiology/labs/silman/silman.html





    Title: Preface: Cholinergic mechanisms: This is the Preface for the special issue Cholinergic Mechanisms
    Anglister L, Silman I, Soreq H
    Ref: Journal of Neurochemistry, :, 2021 : PubMed

            

    Title: Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif
    Silman I, Shnyrov VL, Ashani Y, Roth E, Nicolas A, Sussman JL, Weiner L
    Ref: Protein Science, :, 2021 : PubMed

            

    Title: The multiple biological roles of the cholinesterases
    Silman I
    Ref: Prog Biophys Mol Biol, 162:41, 2021 : PubMed

            

    Title: Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
    Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A and Munoz-Torrero D <16 more author(s)>
    Ref: Journal of Medicinal Chemistry, 64:812, 2021 : PubMed

            

    Title: Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor
    Catto M, Pisani L, De la Mora E, Belviso BD, Mangiatordi GF, Pinto A, Palma A, Denora N, Caliandro R and Altomare CD <3 more author(s)>
    Ref: ACS Med Chem Lett, 11:869, 2020 : PubMed

            

    Title: A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides
    Nachon F, Rosenberry TL, Silman I, Sussman JL
    Ref: Molecules, 25:1198, 2020 : PubMed

            

    Title: Computational studies on cholinesterases: Strengthening our understanding of the integration of structure, dynamics and function
    Sussman JL, Silman I
    Ref: Neuropharmacology, :108265, 2020 : PubMed

            

    Title: Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers
    Toker L, Silman I, Zeev-Ben-Mordehai T, Sussman JL, Schopfer LM, Lockridge O
    Ref: Chemico-Biological Interactions, :109007, 2020 : PubMed

            

    Title: Molecular dynamics simulations of the interaction of Mouse and Torpedo acetylcholinesterase with covalent inhibitors explain their differential reactivity: Implications for drug design
    Chandar NB, Efremenko I, Silman I, Martin JML, Sussman JL
    Ref: Chemico-Biological Interactions, 310:108715, 2019 : PubMed

            

    Title: Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model.
    Dighe SN, De la Mora E, Chan S, Kantham S, McColl G, Miles JA, Veliyath SK, Sreenivas BY, Nassar ZD and Ross BP <6 more author(s)>
    Ref: Communications chemistry, 2:35, 2019 : PubMed

            

    Title: Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase
    Lalut J, Santoni G, Karila D, Lecoutey C, Davis A, Nachon F, Silman I, Sussman JL, Weik M and Rochais C <2 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 162:234, 2019 : PubMed

            

    Title: The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability
    Novichkova DA, Lushchekina SV, Dym O, Masson P, Silman I, Sussman JL
    Ref: Chemico-Biological Interactions, 309:108699, 2019 : PubMed

            

    Title: Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3
    Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M and Renard PY <9 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 168:58, 2019 : PubMed

            

    Title: Generation of Reactive Oxygen Species by Photosensitizers and their Modes of Action on Proteins
    Bilkis I, Silman I, Weiner L
    Ref: Curr Med Chem, 25:5528, 2018 : PubMed

            

    Title: Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis
    Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, Bartolini M, Perez B, Clos MV, Silman I, Jean L, Colletier JP and Munoz-Torrero D <1 more author(s)>
    Ref: Molecules, 23:, 2018 : PubMed

            

    Title: Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly
    Leung MR, van Bezouwen LS, Schopfer LM, Sussman JL, Silman I, Lockridge O, Zeev-Ben-Mordehai T
    Ref: Proc Natl Acad Sci U S A, 115:13270, 2018 : PubMed

            

    Title: Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
    Santoni G, de Sousa J, De la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD and Nachon F <2 more author(s)>
    Ref: Journal of Medicinal Chemistry, 61:7630, 2018 : PubMed

            

    Title: Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration
    Zorbaz T, Braiki A, Marakovic N, Renou J, De la Mora E, Macek Hrvat N, Katalinic M, Silman I, Sussman JL and Renard PY <9 more author(s)>
    Ref: Chemistry, 24:9675, 2018 : PubMed

            

    Title: Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse
    Haronen H, Zainul Z, Tu H, Naumenko N, Sormunen R, Miinalainen I, Shakirzyanova A, Oikarainen T, Abdullin A and Pihlajaniemi T <7 more author(s)>
    Ref: Hum Mol Genet, 26:2076, 2017 : PubMed

            

    Title: Preface: Cholinergic Mechanisms
    Prado MAM, Marchot P, Silman I
    Ref: Journal of Neurochemistry, 142 Suppl 2:3, 2017 : PubMed

            

    Title: Recent developments in structural studies on acetylcholinesterase
    Silman I, Sussman JL
    Ref: Journal of Neurochemistry, 142 Suppl 2:19, 2017 : PubMed

            

    Title: Alexander George Karczmar (1917-2017)
    Soreq H, Silman I
    Ref: Journal of Neurochemistry, 143:609, 2017 : PubMed

            

    Title: Computational Studies on Acetylcholinesterases
    Xu Y, Cheng S, Sussman JL, Silman I, Jiang H
    Ref: Molecules, 22:, 2017 : PubMed

            

    Title: In vitro evaluation of the catalytic activity of paraoxonases and phosphotriesterases predicts the enzyme circulatory levels required for in vivo protection against organophosphate intoxications
    Ashani Y, Leader H, Aggarwal N, Silman I, Worek F, Sussman JL, Goldsmith M
    Ref: Chemico-Biological Interactions, 259:252, 2016 : PubMed

            

    Title: The Impact of Crystallization Conditions on Structure-Based Drug Design: A Case Study on the Methylene Blue/Acetylcholinesterase Complex
    Dym O, Song W, Felder CE, Roth E, Shnyrov V, Ashani Y, Xu Y, Joosten RP, Weiner L and Silman I <1 more author(s)>
    Ref: Protein Science, 25:1096, 2016 : PubMed

            

    Title: Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability
    Goldenzweig A, Goldsmith M, Hill SE, Gertman O, Laurino P, Ashani Y, Dym O, Unger T, Albeck S and Fleishman SJ <6 more author(s)>
    Ref: Mol Cell, 63:337, 2016 : PubMed

            

    Title: Catalytic metal ion rearrangements underline promiscuity and evolvability of a metalloenzyme
    Ben-David M, Wieczorek G, Elias M, Silman I, Sussman JL, Tawfik DS
    Ref: Journal of Molecular Biology, 425:1028, 2013 : PubMed

            

    Title: The specific interaction of the photosensitizer methylene blue with acetylcholinesterase provides a model system for studying the molecular consequences of photodynamic therapy
    Silman I, Roth E, Paz A, Triquigneaux MM, Ehrenshaft M, Xu Y, Shnyrov VL, Sussman JL, Deterding LJ and Weiner L <2 more author(s)>
    Ref: Chemico-Biological Interactions, 203:63, 2013 : PubMed

            

    Title: Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1
    Ben-David M, Elias M, Filippi JJ, Dunach E, Silman I, Sussman JL, Tawfik DS
    Ref: Journal of Molecular Biology, 418:181, 2012 : PubMed

            

    Title: Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification
    Goldsmith M, Ashani Y, Simo Y, Ben-David M, Leader H, Silman I, Sussman JL, Tawfik DS
    Ref: Chemical Biology, 19:456, 2012 : PubMed

            

    Title: Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
    Khare SD, Kipnis Y, Greisen P, Jr., Takeuchi R, Ashani Y, Goldsmith M, Song Y, Gallaher JL, Silman I and Baker D <4 more author(s)>
    Ref: Nat Chemical Biology, 8:294, 2012 : PubMed

            

    Title: Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase
    Paz A, Roth E, Ashani Y, Xu Y, Shnyrov VL, Sussman JL, Silman I, Weiner L
    Ref: Protein Science, 21:1138, 2012 : PubMed

            

    Title: Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer Methylene Blue
    Triquigneaux MM, Ehrenshaft M, Roth E, Silman I, Ashani Y, Mason RP, Weiner L, Deterding LJ
    Ref: Biochemical Journal, 448:83, 2012 : PubMed

            

    Title: Backbone and side chain NMR assignments for the intrinsically disordered cytoplasmic domain of human neuroligin-3
    Wood K, Paz A, Dijkstra K, Scheek RM, Otten R, Silman I, Sussman JL, Mulder FA
    Ref: Biomol NMR Assign, 6:15, 2012 : PubMed

            

    Title: In vitro detoxification of cyclosarin in human blood pre-incubated ex vivo with recombinant serum paraoxonases
    Ashani Y, Goldsmith M, Leader H, Silman I, Sussman JL, Tawfik DS
    Ref: Toxicol Lett, 206:24, 2011 : PubMed

            

    Title: Directed evolution of hydrolases for prevention of G-type nerve agent intoxication
    Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R and Tawfik DS <2 more author(s)>
    Ref: Nat Chemical Biology, 7:120, 2011 : PubMed

            

    Title: Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations
    Sanson B, Colletier JP, Xu Y, Lang PT, Jiang H, Silman I, Sussman JL, Weik M
    Ref: Protein Science, 20:1114, 2011 : PubMed

            

    Title: Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen
    Weiner L, Roth E, Silman I
    Ref: Photochem Photobiol, 87:308, 2011 : PubMed

            

    Title: Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers
    Ashani Y, Gupta RD, Goldsmith M, Silman I, Sussman JL, Tawfik DS, Leader H
    Ref: Chemico-Biological Interactions, 187:362, 2010 : PubMed

            

    Title: Acetylcholinesterase: from 3D structure to function
    Dvir H, Silman I, Harel M, Rosenberry TL, Sussman JL
    Ref: Chemico-Biological Interactions, 187:10, 2010 : PubMed

            

    Title: Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase
    Xu Y, Colletier JP, Weik M, Qin G, Jiang H, Silman I, Sussman JL
    Ref: Biophysical Journal, 99:4003, 2010 : PubMed

            

    Title: Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its aged soman conjugate
    Gabel F, Masson P, Froment MT, Doctor BP, Saxena A, Silman I, Zaccai G, Weik M
    Ref: Biophysical Journal, 96:1489, 2009 : PubMed

            

    Title: Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization
    Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, Sussman JL, Aviram M, Tawfik DS
    Ref: Biochemistry, 48:6644, 2009 : PubMed

            

    Title: The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad
    Paz A, Xie Q, Greenblatt HM, Fu W, Tang Y, Silman I, Qiu Z, Sussman JL
    Ref: Journal of Medicinal Chemistry, 52:2543, 2009 : PubMed

            

    Title: Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime
    Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P and Weik M <1 more author(s)>
    Ref: Journal of Medicinal Chemistry, 52:7593, 2009 : PubMed

            

    Title: Stabilization of Torpedo californica acetylcholinesterase by reversible inhibitors
    Weiner L, Shnyrov VL, Konstantinovskii L, Roth E, Ashani Y, Silman I
    Ref: Biochemistry, 48:563, 2009 : PubMed

            

    Title: Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization
    Zeev-Ben-Mordehai T, Paz A, Peleg Y, Toker L, Wolf SG, Rydberg EH, Sussman JL, Silman I
    Ref: Protein Expr Purif, 63:147, 2009 : PubMed

            

    Title: The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties
    Zeev-Ben-Mordehai T, Mylonas E, Paz A, Peleg Y, Toker L, Silman I, Svergun DI, Sussman JL
    Ref: Biophysical Journal, 97:2316, 2009 : PubMed

            

    Title: Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography
    Colletier JP, Bourgeois D, Sanson B, Fournier D, Sussman JL, Silman I, Weik M
    Ref: Proc Natl Acad Sci U S A, 105:11742, 2008 : PubMed

            

    Title: Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site
    Harel M, Sonoda LK, Silman I, Sussman JL, Rosenberry TL
    Ref: Journal of the American Chemical Society, 130:7856, 2008 : PubMed

            

    Title: Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3
    Paz A, Zeev-Ben-Mordehai T, Lundqvist M, Sherman E, Mylonas E, Weiner L, Haran G, Svergun DI, Mulder FA and Silman I <1 more author(s)>
    Ref: Biophysical Journal, 95:1928, 2008 : PubMed

            

    Title: Acetylcholinesterase: how is structure related to function?
    Silman I, Sussman JL
    Ref: Chemico-Biological Interactions, 175:3, 2008 : PubMed

            

    Title: Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design
    Xu Y, Colletier JP, Jiang H, Silman I, Sussman JL, Weik M
    Ref: Protein Science, 17:601, 2008 : PubMed

            

    Title: Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics
    Xu Y, Colletier JP, Weik M, Jiang H, Moult J, Silman I, Sussman JL
    Ref: Biophysical Journal, 95:2500, 2008 : PubMed

            

    Title: Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography
    Colletier JP, Royant A, Specht A, Sanson B, Nachon F, Masson P, Zaccai G, Sussman JL, Goeldner M and Weik M <2 more author(s)>
    Ref: Acta Crystallographica D Biol Crystallogr, 63:1115, 2007 : PubMed

            

    Title: Bivalent ligands derived from Huperzine A as acetylcholinesterase inhibitors
    Haviv H, Wong DM, Silman I, Sussman JL
    Ref: Curr Top Med Chem, 7:375, 2007 : PubMed

            

    Title: Structural insights into substrate traffic and inhibition in acetylcholinesterase
    Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M
    Ref: EMBO Journal, 25:2746, 2006 : PubMed

            

    Title: Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge
    Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL
    Ref: Journal of Medicinal Chemistry, 49:5491, 2006 : PubMed

            

    Title: Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study
    Gabel F, Weik M, Masson P, Renault F, Fournier D, Brochier L, Doctor BP, Saxena A, Silman I, Zaccai G
    Ref: Biophysical Journal, 89:3303, 2005 : PubMed

            

    Title: The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action
    Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM
    Ref: Molecular Pharmacology, 67:1874, 2005 : PubMed

            

    Title: The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase
    Harel M, Hyatt JL, Brumshtein B, Morton CL, Wadkins RM, Silman I, Sussman JL, Potter PM
    Ref: Chemico-Biological Interactions, 157-158:153, 2005 : PubMed

            

    Title: Analysis of genetic polymorphisms in acetylcholinesterase as reflected in different populations
    Hasin Y, Avidan N, Bercovich D, Korczyn AD, Silman I, Beckmann JS, Sussman JL
    Ref: Curr Alzheimer Res, 2:207, 2005 : PubMed

            

    Title: Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase
    Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL
    Ref: Journal of the American Chemical Society, 127:11029, 2005 : PubMed

            

    Title: Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11
    Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM
    Ref: Chemico-Biological Interactions, 157-158:247, 2005 : PubMed

            

    Title: Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation
    Niu C, Xu Y, Luo X, Duan W, Silman I, Sussman JL, Zhu W, Chen K, Shen J, Jiang H
    Ref: J Phys Chem B, 109:23730, 2005 : PubMed

            

    Title: Depolarization initiates phasic acetylcholine release by relief of a tonic block imposed by presynaptic M2 muscarinic receptors
    Parnas H, Slutsky I, Rashkovan G, Silman I, Wess J, Parnas I
    Ref: Journal of Neurophysiology, 93:3257, 2005 : PubMed

            

    Title: Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology
    Silman I, Sussman JL
    Ref: Curr Opin Pharmacol, 5:293, 2005 : PubMed

            

    Title: Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization
    Aharoni A, Gaidukov L, Yagur S, Toker L, Silman I, Tawfik DS
    Ref: Proc Natl Acad Sci U S A, 101:482, 2004 : PubMed

            

    Title: Poster (74) Structural studies on torpedo californica acetylcholinesterase in complex with a substrate analogue
    Colletier JP, Fournier D, Greenblatt HM, Sussman JL, Zaccai G, Silman I, Weik M
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:359, 2004 : PubMed

            

    Title: Poster (79) X-ray structures of TcAChE complexed with (+)-huperzine a and (-)-huperzine b: structural evidence for an active-site rearrangement
    Dvir H, Jiang H, Wong DM, Harel M, Chetrit M, He XC, Jin GY, Yu GL, Tang XC and Sussman JL <2 more author(s)>
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:362, 2004 : PubMed

            

    Title: The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix
    Dvir H, Harel M, Bon S, Liu WQ, Vidal M, Garbay C, Sussman JL, Massoulie J, Silman I
    Ref: EMBO Journal, 23:4394, 2004 : PubMed

            

    Title: The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study
    Gabel F, Weik M, Doctor BP, Saxena A, Fournier D, Brochier L, Renault F, Masson P, Silman I, Zaccai G
    Ref: Biophysical Journal, 86:3152, 2004 : PubMed

            

    Title: The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design
    Greenblatt HM, Guillou C, Guenard D, Argaman A, Botti SA, Badet B, Thal C, Silman I, Sussman JL
    Ref: Journal of the American Chemical Society, 126:15405, 2004 : PubMed

            

    Title: Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes
    Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A and Tawfik DS <3 more author(s)>
    Ref: Nat Struct Mol Biol, 11:412, 2004 : PubMed

            

    Title: Crystal structure of the tetramerization domain of acetylcholinesterase at 2.
    Harel M, Dvir H, Bon S, Liu WQ, Garbay C, Sussman JL, Massoulie J, Silman I
    Ref: Cholinergic Mechanisms, CRC Press, :183, 2004 : PubMed

            

    Title: Poster (48) Crystal structure of the tetramerization domain of acetylcholinesterase reveals a model of the AChE tetramer
    Harel M, Dvir H, Bon S, Liu WQ, Garbay C, Sussman JL, Massoulie J, Silman I
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:347, 2004 : PubMed

            

    Title: A paradigm for single nucleotide polymorphism analysis: the case of the acetylcholinesterase gene
    Hasin Y, Avidan N, Bercovich D, Korczyn A, Silman I, Beckmann JS, Sussman JL
    Ref: Hum Mutat, 24:408, 2004 : PubMed

            

    Title: Overexpression of the extracellular and cytoplasmic domains of the Drosophila adhesion protein, gliotactin.
    Rydberg EH, Macion R, Zeev-Ben-Mordehai T, Solomon A, Rees DM, Toker L, Botti SA, Auld VJ, Silman I, Sussman JL
    Ref: Cholinergic Mechanisms, CRC Press, :687, 2004 : PubMed

            

    Title: Poster (47) Conformational plasticity of acetylcholinesterase
    Silman I, Greenblatt HM, Zeev-Ben-Mordehai T, Sussman JL
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:346, 2004 : PubMed

            

    Title: Poster (31) Natively unstructured proteins: a case study of cholinesterase-like adhesion molecules (clams)
    Sussman JL, Zeev-Ben-Mordehai T, Rydberg EH, Solomon A, Toker L, Botti SA, Auld VJ, Silman I
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:337, 2004 : PubMed

            

    Title: New biosensors for improved detection of environmental and food contamination by anticholinesterase pesticides
    Toutant JP, Massoulie J, Fournier D, Marty JL, Schmid RD, Pfeiffer D, Selkirk ME, Sussman JL, Silman I and Magearu V <3 more author(s)>
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:233 , 2004 : PubMed

            

    Title: Poster (24) New biosensors for improved detection of environmental contamination by anticholinesterase pesticides
    Toutant JP, Massoulie J, Fournier D, Schmid RD, Pfeiffer D, Selkirk ME, Sussman JL, Silman I, Talesa V, Wodak SJ
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:333, 2004 : PubMed

            

    Title: Use of the morphing graphics technique to visualize conformational differences between acetylcholinesterases from different species and inhibitor-induced conformational changes.
    Zeev-Ben-Mordehai T, Silman I, Sussman JL
    Ref: Cholinergic Mechanisms, CRC Press, :747, 2004 : PubMed

            

    Title: Poster (104) Biophysical and bioinformatic analysis of the cytoplasmic portion of gliotactin
    Zeev-Ben-Mordehai T, Rydberg EH, Solomon A, Toker L, Silman I, Sussman JL
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:375, 2004 : PubMed

            

    Title: Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease
    Greenblatt HM, Dvir H, Silman I, Sussman JL
    Ref: Journal of Molecular Neuroscience, 20:369, 2003 : PubMed

            

    Title: Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones
    Millard CB, Shnyrov VL, Newstead S, Shin I, Roth E, Silman I, Weiner L
    Ref: Protein Science, 12:2337, 2003 : PubMed

            

    Title: Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
    Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL
    Ref: J Am Chem Soc, 125:363, 2003 : PubMed

            

    Title: How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations
    Xu Y, Shen J, Luo X, Silman I, Sussman JL, Chen K, Jiang H
    Ref: Journal of the American Chemical Society, 125:11340, 2003 : PubMed

            

    Title: The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded
    Zeev-Ben-Mordehai T, Rydberg EH, Solomon A, Toker L, Auld VJ, Silman I, Botti SA, Sussman JL
    Ref: Proteins, 53:758, 2003 : PubMed

            

    Title: Acetylcholinesterase in motion: visualizing conformational changes in crystal structures by a morphing procedure
    Zeev-Ben-Mordehai T, Silman I, Sussman JL
    Ref: Biopolymers, 68:395, 2003 : PubMed

            

    Title: Kinetic and structural studies on the interaction of cholinesterases with the anti-Alzheimer drug rivastigmine
    Bar-On P, Millard CB, Harel M, Dvir H, Enz A, Sussman JL, Silman I
    Ref: Biochemistry, 41:3555, 2002 : PubMed

            

    Title: 3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates
    Dvir H, Wong DM, Harel M, Barril X, Orozco M, Luque FJ, Munoz-Torrero D, Camps P, Rosenberry TL and Sussman JL <1 more author(s)>
    Ref: Biochemistry, 41:2970, 2002 : PubMed

            

    Title: X-ray Structures of Torpedo californica Acetylcholinesterase Complexed with (+)-Huperzine A and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement
    Dvir H, Jiang H, Wong DM, Harel M, Chetrit M, He XC, Jin GY, Yu GL, Tang XC and Sussman JL <2 more author(s)>
    Ref: Biochemistry, 41:10810, 2002 : PubMed

            

    Title: Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase
    Felder CE, Harel M, Silman I, Sussman JL
    Ref: Acta Crystallographica D Biol Crystallogr, 58:1765, 2002 : PubMed

            

    Title: A neutral molecule in a cation-binding site: specific binding of a PEG-SH to acetylcholinesterase from Torpedo californica
    Koellner G, Steiner T, Millard CB, Silman I, Sussman JL
    Ref: Journal of Molecular Biology, 320:721, 2002 : PubMed

            

    Title: Thermal denaturation of Bungarus fasciatus acetylcholinesterase: Is aggregation a driving force in protein unfolding?
    Shin I, Wachtel E, Roth E, Bon C, Silman I, Weiner L
    Ref: Protein Science, 11:2022, 2002 : PubMed

            

    Title: Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation
    Weik M, Berges J, Raves ML, Gros P, McSweeney S, Silman I, Sussman JL, Houee-Levin C, Ravelli RB
    Ref: J Synchrotron Radiat, 9:342, 2002 : PubMed

            

    Title: A Structural Motif of Acetylcholinesterase That Promotes Amyloid beta-Peptide Fibril Formation
    De Ferrari GV, Canales MA, Shin I, Weiner L, Silman I, Inestrosa NC
    Ref: Biochemistry, 40:10447, 2001 : PubMed

            

    Title: A structure-based design approach to the development of novel, reversible AChE inhibitors
    Doucet-Personeni C, Bentley PD, Fletcher RJ, Kinkaid A, Kryger G, Pirard B, Taylor A, Taylor R, Taylor J and Lewis T <4 more author(s)>
    Ref: Journal of Medicinal Chemistry, 44:3203, 2001 : PubMed

            

    Title: Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase
    Nicolas A, Ferron F, Toker L, Sussman JL, Silman I
    Ref: Acta Crystallographica D Biol Crystallogr, 57:1348, 2001 : PubMed

            

    Title: Presynaptic M(2) muscarinic receptors are involved in controlling the kinetics of ACh release at the frog neuromuscular junction
    Slutsky I, Silman I, Parnas I, Parnas H
    Ref: The Journal of Physiology, 536:717, 2001 : PubMed

            

    Title: Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes
    Weik M, Ravelli RB, Silman I, Sussman JL, Gros P, Kroon J
    Ref: Protein Science, 10:1953, 2001 : PubMed

            

    Title: Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors
    Harel M, Kryger G, Rosenberry TL, Mallender WD, Lewis T, Fletcher RJ, Guss JM, Silman I, Sussman JL
    Ref: Protein Science, 9:1063, 2000 : PubMed

            

    Title: Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica
    Koellner G, Kryger G, Millard CB, Silman I, Sussman JL, Steiner T
    Ref: Journal of Molecular Biology, 296:713, 2000 : PubMed

            

    Title: Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride
    Kraut D, Goff H, Pai RK, Hosea NA, Silman I, Sussman JL, Taylor P, Voet JG
    Ref: Molecular Pharmacology, 57:1243, 2000 : PubMed

            

    Title: Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II
    Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N and Sussman JL <2 more author(s)>
    Ref: Acta Crystallographica D Biol Crystallogr, 56:1385, 2000 : PubMed

            

    Title: Specific chemical and structural damage to proteins produced by synchrotron radiation
    Weik M, Ravelli RB, Kryger G, McSweeney S, Raves ML, Harel M, Gros P, Silman I, Kroon J, Sussman JL
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 97:623, 2000 : PubMed

            

    Title: Acetylcholinesterase of Schistosoma mansoni--functional correlates. Contributed in honor of Professor Hans Neurath's 90th birthday
    Arnon R, Silman I, Tarrab-Hazdai R
    Ref: Protein Science, 8:2553, 1999 : PubMed

            

    Title: A modular treatment of molecular traffic through the active site of cholinesterase
    Botti SA, Felder CE, Lifson S, Sussman JL, Silman I
    Ref: Biophysical Journal, 77:2430, 1999 : PubMed

            

    Title: Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution
    Greenblatt HM, Kryger G, Lewis T, Silman I, Sussman JL
    Ref: FEBS Letters, 463:321, 1999 : PubMed

            

    Title: Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs
    Kryger G, Silman I, Sussman JL
    Ref: Structure, 7:297, 1999 : PubMed

            

    Title: Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level
    Millard CB, Kryger G, Ordentlich A, Greenblatt HM, Harel M, Raves ML, Segall Y, Barak D, Shafferman A and Sussman JL <1 more author(s)>
    Ref: Biochemistry, 38:7032, 1999 : PubMed

            

    Title: Reaction Products of Acetylcholinesterase and Vx Reveal a Mobile Histidine in the Catalytic Triad
    Millard CB, Koellner G, Ordentlich A, Shafferman A, Silman I, Sussman JL
    Ref: Journal of the American Chemical Society, 121:9883, 1999 : PubMed

            

    Title: Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase
    Morel N, Bon S, Greenblatt HM, Van Belle D, Wodak SJ, Sussman JL, Massoulie J, Silman I
    Ref: Molecular Pharmacology, 55:982, 1999 : PubMed

            

    Title: A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase
    Silman I, Millard CB, Ordentlich A, Greenblatt HM, Harel M, Barak D, Shafferman A, Sussman JL
    Ref: Chemico-Biological Interactions, 119-120:43, 1999 : PubMed

            

    Title: Acetylcholinesterase from Schistosoma mansoni: interaction of globular species with heparin
    Tarrab-Hazdai R, Toker L, Silman I, Arnon R
    Ref: Biochemical Journal, 344 Pt 3:945, 1999 : PubMed

            

    Title: Targeted cross-linking of a molten globule form of acetylcholinesterase by the virucidal agent hypericin
    Weiner L, Roth E, Mazur Y, Silman I
    Ref: Biochemistry, 38:11401, 1999 : PubMed

            

    Title: Kinetic and structural studies on the interaction of the anti-Alzheimer drug, ENA-713, with Torpedo californica acetylcholinesterase
    Bar-On P, Harel M, Millard CB, Enz A, Sussman JL, Silman I
    Ref: Journal de Physiologie (Paris), 92:406, 1998 : PubMed

            

    Title: Kinetic and X-Ray Crystallographic Studies of the Binding of ENA-713 to Torpedo Californica Acetylcholinesterase
    Bar-On P, Harel M, Millard CB, Enz A, Sussman JL, Silman I
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:373, 1998 : PubMed

            

    Title: Electrotactins: a class of adhesion proteins with conserved electrostatic and structural motifs
    Botti SA, Felder CE, Sussman JL, Silman I
    Ref: Protein Engineering, 11:415, 1998 : PubMed

            

    Title: Electrostatic homology modelling of a set of ChE-like neural adhesion proteins identifies a shared annular motif with ChEs. Structural implications for a cell-recognition role of ChEs
    Botti SA, Felder CE, Sussman JL, Silman I
    Ref: Journal de Physiologie (Paris), 92:414, 1998 : PubMed

            

    Title: An Integrated Model for the Molecular Traffic through the Active Site of Cholinesterases
    Botti SA, Felder CE, Lifson S, Sussman JL, Silman I
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:227, 1998 : PubMed

            

    Title: The Conjunction of a Conserved Electrostatic Motif and a Common Cholinesterase Fold Defines a Class of Adhesion Proteins
    Botti SA, Felder CE, Sussman JL, Silman I
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:448, 1998 : PubMed

            

    Title: Assembly of Acetylcholinesterase Subunits in vitro
    Giles K, Ben-Yohanan R, Velan B, Shafferman A, Sussman JL, Silman I
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:442, 1998 : PubMed

            

    Title: Expression and Tissue Distribution of Cholinesterases Via EST Analysis
    Giles K, Silman I, Sussman JL
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:450, 1998 : PubMed

            

    Title: Crystal Structures of Complexes of E2020-Related Compounds with Torpedo Californica Acetylcholinesterase
    Greenblatt HM, Kryger G, Harel M, Lewis T, Taylor J, Silman I, Sussman JL
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:371-371, 1998 : PubMed

            

    Title: Three-dimensional structure of a complex of E2020 with acetylcholinesterase from Torpedo californica
    Kryger G, Silman I, Sussman JL
    Ref: Journal de Physiologie Paris, 92:191, 1998 : PubMed

            

    Title: 3D Structure at 2.7 Resolution of Native and E202Q Mutant Human Acetylcholinesterase Complexed with Fasciculin-II
    Kryger G, Giles K, Harel M, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N and Sussman JL <2 more author(s)>
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:323, 1998 : PubMed

            

    Title: 3D Structure of a Complex of Human Acetylcholinesterase with Fasciculin-II at 2.7 Resolution
    Kryger G, Giles K, Harel M, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N and Sussman JL <2 more author(s)>
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:370, 1998 : PubMed

            

    Title: 3D Structure of a Complex of the Anti-Alzheimer Drug, E2020, with Acetylcholinesterase at 2.5 Resolution
    Kryger G, Silman I, Sussman JL
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:469, 1998 : PubMed

            

    Title: Crystal structure of Aged phosphorylated and phosphonylated Torpedo Californica Acetylcholinesterase
    Millard CB, Kryger G, Ordentlich A, Harel M, Raves ML, Greenblatt HM, Segall Y, Barak D, Shafferman A and Sussman JL <1 more author(s)>
    Ref: In Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:425, 1998 : PubMed

            

    Title: Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase
    Millard CB, Kryger G, Ordentlich A, Harel M, Raves ML, Greenblatt HM, Segall Y, Barak D, Shafferman A and Sussman JL <1 more author(s)>
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:425, 1998 : PubMed

            

    Title: Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase
    Millard CB, Kryger G, Ordentlich A, Harel M, Raves ML, Greenblatt HM, Segall Y, Barak D, Shafferman A and Sussman JL <1 more author(s)>
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:454, 1998 : PubMed

            

    Title: Surface Residues Near the Peripheral Site Affect the Stability of Torpedo Acetylcholinesterase
    Morel N, Bon S, Sussman JL, Massoulie J, Silman I
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:435, 1998 : PubMed

            

    Title: Activity of Torpedo Californica Acetylcholinesterase in the Crystalline State
    Nicolas A, Millard CB, Raves ML, Ravelli RB, Kroon J, Silman I, Sussman JL
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:230, 1998 : PubMed

            

    Title: Static laue diffraction studies on acetylcholinesterase
    Ravelli RB, Raves ML, Ren Z, Bourgeois D, Roth M, Kroon J, Silman I, Sussman JL
    Ref: Acta Crystallographica D Biol Crystallogr, 54:1359, 1998 : PubMed

            

    Title: Quaternary Structure of Tetrameric Acetylcholinesterase
    Raves ML, Giles K, Schrag JD, Schmid MF, Phillips JN, Jr., Chiu W, Howard AJ, Silman I, Sussman JL
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:351, 1998 : PubMed

            

    Title: Alternative Crystal Forms of Torpedo Californica Acetylcholinesterase
    Raves ML, Greenblatt HM, Kryger G, Nicolas A, Ravelli RB, Harel M, Kroon J, Silman I, Sussman JL
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:372, 1998 : PubMed

            

    Title: Membrane-Promoted Unfolding of Torpedo Californica and Bungarus Fasciatus Acetylcholinesterase
    Shin I, Silman I, Bon C, Weiner L
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:438, 1998 : PubMed

            

    Title: Liposome-catalyzed unfolding of acetylcholinesterase from Bungarus fasciatus
    Shin I, Silman I, Bon C, Weiner L
    Ref: Biochemistry, 37:4310, 1998 : PubMed

            

    Title: Irwin B. Wilson Plenary Lecture Structural and Functional Studies on Acetylcholinesterase
    Silman I, Sussman JL
    Ref: In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases, (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.:25, 1998 : PubMed

            

    Title: Acetylcholinesterase of S. mansoni (Trematode). Interaction of globular species with glycosaminoglycans
    Tarrab-Hazdai R, Silman I, Toker L, Schechtman D, Arnon R
    Ref: Journal de Physiologie (Paris), 92:501, 1998 : PubMed

            

    Title: External and internal electrostatic potentials of cholinesterase models
    Felder CE, Botti SA, Lifson S, Silman I, Sussman JL
    Ref: J Mol Graph Model, 15:318, 1997 : PubMed

            

    Title: Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A
    Raves ML, Harel M, Pang YP, Silman I, Kozikowski AP, Sussman JL
    Ref: Nat Struct Biol, 4:57, 1997 : PubMed

            

    Title: Membrane-promoted unfolding of acetylcholinesterase: a possible mechanism for insertion into the lipid bilayer
    Shin I, Kreimer DI, Silman I, Weiner L
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 94:2848, 1997 : PubMed

            

    Title: Site-directed mutants designed to test back-door hypotheses of acetylcholinesterase function
    Faerman C, Ripoll D, Bon S, Le Feuvre Y, Morel N, Massoulie J, Sussman JL, Silman I
    Ref: FEBS Letters, 386:65, 1996 : PubMed

            

    Title: The X-ray structure of a transition state analog complex reveals the molecular origins of the catalytic power and substrate specificity of acetylcholinesterase.
    Harel M, Quinn DM, Nair HK, Silman I, Sussman JL
    Ref: Journal of the American Chemical Society, 118:2340, 1996 : PubMed

            

    Title: Two partially unfolded states of Torpedo californica acetylcholinesterase
    Kreimer DI, Shin I, Shnyrov VL, Villar E, Silman I, Weiner L
    Ref: Protein Science, 5:1852, 1996 : PubMed

            

    Title: Biochemical evaluation of photolabile precursors of choline and of carbamylcholine for potential time-resolved crystallographic studies on cholinesterases
    Peng L, Silman I, Sussman JL, Goeldner M
    Ref: Biochemistry, 35:10854, 1996 : PubMed

            

    Title: Electrooptical measurements demonstrate a large permanent dipole moment associated with acetylcholinesterase
    Porschke D, Creminon C, Cousin X, Bon C, Sussman JL, Silman I
    Ref: Biophysical Journal, 70:1603, 1996 : PubMed

            

    Title: Interaction of partially unfolded forms of Torpedo acetylcholinesterase with liposomes
    Shin I, Silman I, Weiner L
    Ref: Protein Science, 5:42, 1996 : PubMed

            

    Title: The activity of an endoplasmic reticulum-localized pool of acetylcholinesterase is modulated by heat shock
    Eichler J, Silman I
    Ref: Journal of Biological Chemistry, 270:4466, 1995 : PubMed

            

    Title: Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target
    Harel M, Kleywegt GJ, Ravelli RB, Silman I, Sussman JL
    Ref: Structure, 3:1355, 1995 : PubMed

            

    Title: Irreversible thermal denaturation of Torpedo californica acetylcholinesterase
    Kreimer DI, Shnyrov VL, Villar E, Silman I, Weiner L
    Ref: Protein Science, 4:2349, 1995 : PubMed

            

    Title: Electrostatic Properties of Human Acetylcholinesterase
    Ripoll DR, Faerman CH, Gillilan R, Silman I, Sussman JL
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:67, 1995 : PubMed

            

    Title: Studies on Partially Unfolded States of Torpedo californica Acetylcholinesterase
    Silman I, Kreimer DI, Shin I, Dolginova EA, Roth E, Goldfarb D, Szosenfogel R, Raves ML, Sussman JL and Weiner L <1 more author(s)>
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:77, 1995 : PubMed

            

    Title: Structures of Complexes of Acetylcholinesterase with Covalently and Non-Covalently Bound Inhibitors
    Sussman JL, Harel M, Raves ML, Quinn DM, Nair HK, Silman I
    Ref: In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases, (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.:59, 1995 : PubMed

            

    Title: Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography
    Axelsen PH, Harel M, Silman I, Sussman JL
    Ref: Protein Science, 3:188, 1994 : PubMed

            

    Title: A molten globule of Torpedo acetylcholinesterase undergoes thiol-disulfide exchange
    Eichler J, Kreimer DI, Varon L, Silman I, Weiner L
    Ref: Journal of Biological Chemistry, 269:30093, 1994 : PubMed

            

    Title: Differential effects of peripheral site ligands on Torpedo and chicken acetylcholinesterase
    Eichler J, Anselmet A, Sussman JL, Massoulie J, Silman I
    Ref: Molecular Pharmacology, 45:335, 1994 : PubMed

            

    Title: Open back door in a molecular dynamics simulation of acetylcholinesterase
    Gilson MK, Straatsma TP, McCammon JA, Ripoll DR, Faerman CH, Axelsen PH, Silman I, Sussman JL
    Ref: Science, 263:1276, 1994 : PubMed

            

    Title: Two-state transition between molten globule and unfolded states of acetylcholinesterase as monitored by electron paramagnetic resonance spectroscopy
    Kreimer DI, Szosenfogel R, Goldfarb D, Silman I, Weiner L
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 91:12145, 1994 : PubMed

            

    Title: A metastable state of Torpedo californica acetylcholinesterase generated by modification with organomercurials
    Kreimer DI, Dolginova EA, Raves ML, Sussman JL, Silman I, Weiner L
    Ref: Biochemistry, 33:14407, 1994 : PubMed

            

    Title: Novel GPI structures of the membrane anchor of acetylcholinesterase from the electric organ of Torpedo californica
    Mehlert A, Varon L, Silman I, Homans SW, Ferguson MA
    Ref: Brazilian Journal of Medical & Biological Research, 27:243, 1994 : PubMed

            

    Title: Three-dimensional structures of acetylcholinesterase and of its complexes with anticholinesterase agents
    Silman I, Harel M, Axelsen PH, Raves ML, Sussman JL
    Ref: Biochemical Society Transactions, 22:745, 1994 : PubMed

            

    Title: Oxidative stress transforms acetylcholinesterase to a molten-globule-like state
    Weiner L, Kreimer D, Roth E, Silman I
    Ref: Biochemical & Biophysical Research Communications, 198:915, 1994 : PubMed

            

    Title: Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins
    Cygler M, Schrag JD, Sussman JL, Harel M, Silman I, Gentry MK, Doctor BP
    Ref: Protein Science, 2:366, 1993 : PubMed

            

    Title: Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase
    Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 90:9031, 1993 : PubMed

            

    Title: Structure and functions of acetylcholinesterase and butyrylcholinesterase
    Massoulie J, Sussman JL, Bon S, Silman I
    Ref: Prog Brain Res, 98:139, 1993 : PubMed

            

    Title: The structure of the glycosylphosphatidylinositol anchor from Torpedo californica acetylcholinesterase
    Mehlert A, Silman I, Homans SW, Ferguson MA
    Ref: Biochemical Society Transactions, 21:, 1993 : PubMed

            

    Title: Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica
    Mehlert A, Varon L, Silman I, Homans SW, Ferguson MA
    Ref: Biochemical Journal, 296:473, 1993 : PubMed

            

    Title: An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase
    Ripoll DR, Faerman CH, Axelsen PH, Silman I, Sussman JL
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 90:5128, 1993 : PubMed

            

    Title: Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs
    Sussman JL, Harel M, Silman I
    Ref: Chemico-Biological Interactions, 87:187, 1993 : PubMed

            

    Title: Chemical modification of Torpedo acetylcholinesterase by disulfides: appearance of a molten globule state
    Dolginova EA, Roth E, Silman I, Weiner L
    Ref: Biochemistry, 31:12248, 1992 : PubMed

            

    Title: Site-directed mutagenesis of active-site-related residues in Torpedo acetylcholinesterase. Presence of a glutamic acid in the catalytic triad
    Duval N, Bon S, Silman I, Sussman JL, Massoulie J
    Ref: FEBS Letters, 309:421, 1992 : PubMed

            

    Title: G2-acetylcholinesterase is presynaptically localized in Torpedo electric organ
    Eichler J, Silman I, Anglister L
    Ref: Journal of Neurocytology, 21:707, 1992 : PubMed

            

    Title: Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis
    Harel M, Sussman JL, Krejci E, Bon S, Chanal P, Massoulie J, Silman I
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 89:10827, 1992 : PubMed

            

    Title: A Model of Butyrylcholinesterase Based on the X-Ray Structure of Acetylcholinesterase Indicates Differences in Specificity
    Harel M, Silman I, Sussman JL
    Ref: In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases, (Shafferman, A. and Velan, B., Eds) Plenum Press, New York:189, 1992 : PubMed

            

    Title: The alpha/beta hydrolase fold
    Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I and Goldman A <3 more author(s)>
    Ref: Protein Engineering, 5:197, 1992 : PubMed

            

    Title: Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding
    Shafferman A, Kronman C, Flashner Y, Leitner M, Grosfeld H, Ordentlich A, Gozes Y, Cohen S, Ariel N and Velan B <4 more author(s)>
    Ref: Journal of Biological Chemistry, 267:17640, 1992 : PubMed

            

    Title: Site-Directed Mutagenesis of Functional Residues in Torpedo Acetylcholinesterase
    Silman I, Krejci E, Duval N
    Ref: In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases, (Shafferman, A. and Velan, B., Eds) Plenum Press, New York:177, 1992 : PubMed

            

    Title: Three Dimensional Structure of Acetylcholinesterase
    Sussman JL, Harel M, Silman I
    Ref: In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases, (Shafferman, A. and Velan, B., Eds) Plenum Press, New York:95, 1992 : PubMed

            

    Title: Poster: Immunocytochemical localization of phosphatidylinositol-anchored acetylcholinesterase in excitable membranes of Torpedo ocellata
    Eichler J, Silman I, Gentry MK, Anglister L
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:49, 1991 : PubMed

            

    Title: Effect of heat shock on acetylcholinesterase activity in chick muscle cultures
    Eichler J, Toker L, Silman I
    Ref: FEBS Letters, 293:16, 1991 : PubMed

            

    Title: Poster: Effects of exposure to PIPL-C on AChE activity of Schistosoma mansoni
    Espinoza B, Silman I, Arnon R, Tarrab-Hazdai R
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:50, 1991 : PubMed

            

    Title: Phosphatidylinositol-specific phospholipase C induces biosynthesis of acetylcholinesterase via diacylglycerol in Schistosoma mansoni
    Espinoza B, Silman I, Arnon R, Tarrab-Hazdai R
    Ref: European Journal of Biochemistry, 195:863, 1991 : PubMed

            

    Title: Refined crystal structures of aged and non-aged organophosphoryl conjugates of gamma-chymotrypsin
    Harel M, Su CT, Frolow F, Ashani Y, Silman I, Sussman JL
    Ref: Journal of Molecular Biology, 221:909, 1991 : PubMed

            

    Title: Poster: Physicochemical and crystallographic studies on the stability and structure of aged and nonaged organophosphoryl conjugates of chymotrypsin
    Su CT, Steinberg N, Silman I, Harel M, Sussman JL, Grunwald J, Ashani Y
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:274, 1991 : PubMed

            

    Title: Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein
    Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Silman I
    Ref: Science, 253:872, 1991 : PubMed

            

    Title: Structural Studies on Acetylcholinesterase from Torpedo californica
    Sussman JL, Harel M, Frolow F, Oefner C, Toker L, Silman I
    Ref: In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology, (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC:7, 1991 : PubMed

            

    Title: Immunocytochemical localization of phosphatidylinositol-anchored acetylcholinesterase in excitable membranes of Torpedo ocellata
    Eichler J, Silman I, Gentry MK, Anglister L
    Ref: Brain Research Mol Brain Res, 8:213, 1990 : PubMed

            

    Title: Torpedo acetylcholinesterase is inactivated by thiol reagents
    Steinberg N, Roth E, Silman I
    Ref: Biochemistry International, 21:1043, 1990 : PubMed

            

    Title: Conformational differences between aged and non-aged organophosphoryl conjugates of chymotrypsin
    Steinberg N, Grunwald J, Roth E, August R, Haas E, Ashani Y, Silman I
    Ref: Prog Clin Biol Res, 289:293, 1989 : PubMed

            

    Title: Conformational differences between aged and nonaged pyrenebutyl-containing organophosphoryl conjugates of chymotrypsin as detected by optical spectroscopy
    Steinberg N, van der Drift AC, Grunwald J, Segall Y, Shirin E, Haas E, Ashani Y, Silman I
    Ref: Biochemistry, 28:1248, 1989 : PubMed

            

    Title: Visualization of collagenase-sensitive acetylcholinesterase in isolated cardiomyocytes and in heart tissue
    Eghbali M, Silman I, Robinson TF, Seifter S
    Ref: Cell & Tissue Research, 253:281, 1988 : PubMed

            

    Title: Acetylcholinesterase in Schistosoma mansoni is anchored to the membrane via covalently attached phosphatidylinositol
    Espinoza B, Tarrab-Hazdai R, Silman I, Arnon R
    Ref: Molecular & Biochemical Parasitology, 29:171, 1988 : PubMed

            

    Title: A membrane-associated dimer of acetylcholinesterase from Xenopus skeletal muscle is solubilized by phosphatidylinositol-specific phospholipase C
    Inestrosa NC, Fuentes ME, Anglister L, Futerman AH, Silman I
    Ref: Neuroscience Letters, 90:186, 1988 : PubMed

            

    Title: Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C
    Sussman JL, Harel M, Frolow F, Varon L, Toker L, Futerman AH, Silman I
    Ref: Journal of Molecular Biology, 203:821, 1988 : PubMed

            

    Title: Microtiter assay for acetylcholinesterase
    Doctor BP, Toker L, Roth E, Silman I
    Ref: Analytical Biochemistry, 166:399, 1987 : PubMed

            

    Title: Differential susceptibility to phosphatidylinositol-specific phospholipase C of acetylcholinesterase in excitable tissues of embryonic and adult Torpedo ocellata
    Futerman AH, Raviv D, Michaelson DM, Silman I
    Ref: Brain Research, 388:105, 1987 : PubMed

            

    Title: Removal of covalently bound inositol from Torpedo acetylcholinesterase and mammalian alkaline phosphatases by deamination with nitrous acid. Evidence for a common membrane-anchoring structure
    Low MG, Futerman AH, Ackermann KE, Sherman WR, Silman I
    Ref: Biochemical Journal, 241:615, 1987 : PubMed

            

    Title: Posttranslational modification as a means of anchoring acetylcholinesterase to the cell surface
    Silman I, Futerman AH
    Ref: Biopolymers, 26:S241, 1987 : PubMed

            

    Title: Modes of attachment of acetylcholinesterase to the surface membrane.
    Silman I, Futerman AH
    Ref: European Journal of Biochemistry, 170:11, 1987 : PubMed

            

    Title: Acetylcholinesterase of Schistosoma mansoni: purification and characterization
    Goldlust A, Arnon R, Silman I, Tarrab-Hazdai R
    Ref: Journal of Neuroscience Research, 15:569, 1986 : PubMed

            

    Title: Arrhenius plots of acetylcholinesterase activity in mammalian erythrocytes and in Torpedo electric organ. Effect of solubilization by proteinases and by a phosphatidylinositol-specific phospholipase C
    Barton PL, Futerman AH, Silman I
    Ref: Biochemical Journal, 231:237, 1985 : PubMed

            

    Title: Physicochemical behaviour and structural characteristics of membrane-bound acetylcholinesterase from Torpedo electric organ. Effect of phosphatidylinositol-specific phospholipase C
    Futerman AH, Fiorini RM, Roth E, Low MG, Silman I
    Ref: Biochemical Journal, 226:369, 1985 : PubMed

            

    Title: Identification of covalently bound inositol in the hydrophobic membrane-anchoring domain of Torpedo acetylcholinesterase
    Futerman AH, Low MG, Ackermann KE, Sherman WR, Silman I
    Ref: Biochemical & Biophysical Research Communications, 129:312, 1985 : PubMed

            

    Title: Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C
    Futerman AH, Low MG, Michaelson DM, Silman I
    Ref: Journal of Neurochemistry, 45:1487, 1985 : PubMed

            

    Title: Butyrylcholinesterase: inhibition by arsenite, fluoride, and other ligands, cooperativity in binding
    Page JD, Wilson IB, Silman I
    Ref: Molecular Pharmacology, 27:437, 1985 : PubMed

            

    Title: Solubilization of membrane-bound acetylcholinesterase by a phosphatidylinositol-specific phospholipase C: enzymatic and physicochemical studies
    Futerman AH, Fiorini RM, Roth E, Michaelson DM, Low MG, Silman I
    Ref: In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases, (Brzin M, Barnard EA, Sket D, Eds) De Gruyter:99, 1984 : PubMed

            

    Title: Poster 9. Solubilisation of acetylchoinesterase from Torpedo electric organ by a phosphatidylinositol-specific phospholipase C
    Futerman AH, Low MG, Silman I
    Ref: In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases, (Brzin M, Barnard EA, Sket D, Eds) De Gruyter:, 1984 : PubMed

            

    Title: Poster 19. Molecular forms of the cholinesterases Inside and outside endplates in. slow-tonic chicken muscle fibers
    Jedrzejczyk J, Silman I, Barnard EA
    Ref: In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases, (Brzin M, Barnard EA, Sket D, Eds) De Gruyter:, 1984 : PubMed

            

    Title: Molecular forms of acetylcholinesterase in synaptic and extrasynaptic regions of avian tonic muscle
    Jedrzejczyk J, Silman I, Lai J, Barnard EA
    Ref: Neuroscience Letters, 46:283, 1984 : PubMed

            

    Title: Ontogenic and agranulation-induced alterations in cholinesterases and in cholinesterase mRNA in the rodent cerebellum
    Parvari R, Silman I, Soreq H
    Ref: In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases, (Brzin M, Barnard EA, Sket D, Eds) De Gruyter:219, 1984 : PubMed

            

    Title: Characterization of activities and forms of cholinesterases in human primary brain tumors
    Razon N, Soreq H, Roth E, Bartal A, Silman I
    Ref: Experimental Neurology, 84:681, 1984 : PubMed

            

    Title: A hydrophobic dimer of acetylcholinesterase from Torpedo californica electric organ is solubilized by phosphatidylinositol-specific phospholipase C
    Futerman AH, Low MG, Silman I
    Ref: Neuroscience Letters, 40:85, 1983 : PubMed

            

    Title: Biosynthesis of acetylcholinesterase in rat brain and Torpedo electric organ is directed by scarce mRNA species
    Soreq H, Parvari R, Silman I
    Ref: Progress in Brain Research, 58:107, 1983 : PubMed

            

    Title: Novel pyrene-containing organophosphates as fluorescent probes for studying aging-induced conformational changes in organophosphate-inhibited acetylcholinesterase
    Amitai G, Ashani Y, Gafni A, Silman I
    Ref: Biochemistry, 21:2060, 1982 : PubMed

            

    Title: Molecular forms of acetylcholinesterase and pseudocholinesterase in chicken skeletal muscles: their distribution and change with muscular dystrophy
    Barnard EA, Lyles JM, Silman I, Jedrzejczyk J, Barnard PJ
    Ref: Reproduction, Nutrition, Developpement, 22:261, 1982 : PubMed

            

    Title: Comparison of the molecular forms of the cholinesterases in tissues of normal and dystrophic chickens
    Lyles JM, Silman I, Di Giamberardino L, Couraud JY, Barnard EA
    Ref: Journal of Neurochemistry, 38:1007, 1982 : PubMed

            

    Title: Biosynthesis and secretion of catalytically active acetylcholinesterase in Xenopus oocytes microinjected with mRNA from rat brain and from Torpedo electric organ
    Soreq H, Parvari R, Silman I
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 79:830, 1982 : PubMed

            

    Title: In vivo modulation of the number of muscarinic receptors in rat brain by cholinergic ligands
    Ben-Barak J, Gazit H, Silman I, Dudai Y
    Ref: European Journal of Pharmacology, 74:73, 1981 : PubMed

            

    Title: Molecular forms of the cholinesterases inside and outside muscle endplates
    Jedrzejczyk J, Silman I, Lyles JM, Barnard EA
    Ref: Bioscience Reports, 1:45, 1981 : PubMed

            

    Title: New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase
    Amitai G, Ashani Y, Gafni A, Silman I
    Ref: Neurochem Int, 2C:199, 1980 : PubMed

            

    Title: Fluorescent organophosphates: novel probes for studying aging-induced conformational changes in inhibited acetylcholinesterase and for localization of cholinesterase in nervous tissue
    Amitai G, Ashani Y, Shahar A, Gafni A, Silman I
    Ref: Monographs in Neural Sciences, 7:70, 1980 : PubMed

            

    Title: The induction of ion channels through excitable membranes by acetylcholinesterase
    Kaufmann K, Silman I
    Ref: Naturwissenschaften, 67:608, 1980 : PubMed

            

    Title: Changes in the levels and forms of cholinesterases in the blood plasma of normal and dystrophic chickens
    Lyles JM, Barnard EA, Silman I
    Ref: Journal of Neurochemistry, 34:978, 1980 : PubMed

            

    Title: Electric eel acetylcholinesterase: a multisubunit enzyme containing a collagen tail
    Silman I, Anglister L
    Ref: Monographs in Neural Sciences, 7:55, 1980 : PubMed

            

    Title: Immunological cross-reactivity between electric-eel acetylcholinesterase and rat-tail-tendon collagen
    Anglister L, Tarrab-Hazdai R, Fuchs S, Silman I
    Ref: European Journal of Biochemistry, 94:25, 1979 : PubMed

            

    Title: Administration of an organophosphate causes a decrease in muscarinic receptor levels in rat brain
    Gazit H, Silman I, Dudai Y
    Ref: Brain Research, 174:351, 1979 : PubMed

            

    Title: Developmental changes in levels and forms of cholinesterases in muscles of normal and dystrophic chickens
    Lyles JM, Silman I, Barnard EA
    Ref: Journal of Neurochemistry, 33:727, 1979 : PubMed

            

    Title: Parallel regulation of acetylcholinesterase and pseudocholinesterase in normal, denervated and dystrophic chicken skeletal muscle
    Silman I, Di Giamberardino L, Lyles L, Couraud JY, Barnard EA
    Ref: Nature, 280:160, 1979 : PubMed

            

    Title: Molecular structure of elongated forms of electric eel acetylcholinesterase
    Anglister L, Silman I
    Ref: Journal of Molecular Biology, 125:293, 1978 : PubMed

            

    Title: Inactivation of electric eel acetylcholinesterase by acylation with N-hydroxysuccinimide esters of amino acid derivatives
    Blumberg S, Silman I
    Ref: Biochemistry, 17:1125, 1978 : PubMed

            

    Title: Intrinsic forms of acetylcholinesterase in skeletal muscle
    Silman I, Lyles JM, Barnard EA
    Ref: FEBS Letters, 94:166, 1978 : PubMed

            

    Title: Characterization of membranes obtained from electric organ of the electric eel by sucrose gradient fractionation and by microdissection
    Rosenberg P, Silman I, Ben-David E, De Vries A, Condrea E
    Ref: Journal of Neurochemistry, 29:561, 1977 : PubMed

            

    Title: Acetylcholinesterase: structure and activity of a membrane-bound enzyme
    Silman I, Dudai Y
    Ref: Advances in Biological & Medical Physics, 16:223, 1977 : PubMed

            

    Title: Effects of quaternary ligands on the inhibition of acetylcholinesterase by arsenite
    Wilson IB, Silman I
    Ref: Biochemistry, 16:2701, 1977 : PubMed

            

    Title: Detection of hydroxyproline in preparations of acetylcholinesterase from the electric organ of the electric eel
    Anglister L, Rogozinski S, Silman I
    Ref: FEBS Letters, 69:129, 1976 : PubMed

            

    Title: Appearance and disappearance of acetycholine receptor during differentiation of chick skeletal muscle in vitro
    Prives J, Silman I, Amsterdam A
    Ref: Cell, 7:543, 1976 : PubMed

            

    Title: Proceedings: Thymus, acetylcholine receptor and myasthenia gravis
    Aharonov A, Tarrab-Hazdai R, Abramsky O, Silman I, Fuchs S
    Ref: Isr J Med Sci, 11:1390, 1975 : PubMed

            

    Title: Proceedings: A water-soluble acetylcholine receptor fraction from electric organ tissue of the electric eel Electrophorus electricus
    Kalderon N, Silman I
    Ref: Isr J Med Sci, 11:1192, 1975 : PubMed

            

    Title: Proceedings: Appearance and disappearance of acetylcholine receptor during differentiation of embryonic chick skeletal muscle in vitro
    Prives J, Silman I, Amsterdam A
    Ref: Isr J Med Sci, 11:1192, 1975 : PubMed

            

    Title: General discussion on models for the ligand binding sites of cholinesterase
    Reiner E, Aldridge WN, Hopff WH, Taylor P, Krupka RM, Rosenberry TL, Augustinsson KB, Mooser G, O'Brien RD and Silman I <4 more author(s)>
    Ref: Croatica Chemica Acta, 47:499, 1975 : PubMed

            

    Title: Molecular structure and catalytic activity of membrane-bound acetylcholinesterase from Electric Organ Tissue of the Electric Eel
    Silman I, Dudai Y
    Ref: Croatica Chemica Acta, 47:181, 1975 : PubMed

            

    Title: Proceedings: Animal model for myasthenia gravis: acetylcholine receptor-induced myasthenia in rabbits, guinea pigs and monkeys
    Tarrab-Hazdai R, Aharonov A, Abramsky O, Silman I, Fuchs S
    Ref: Isr J Med Sci, 11:1390, 1975 : PubMed

            

    Title: Affinity chromatography of acetylcholinesterase
    Dudai Y, Silman I
    Ref: Methods Enzymol, 34:571, 1974 : PubMed

            

    Title: The effects of solubilization procedures on the release and molecular state of acetylcholinesterase from electric organ tissue
    Dudai Y, Silman I
    Ref: Journal of Neurochemistry, 23:1177, 1974 : PubMed

            

    Title: The molecular weight and subunit structure of acetylcholinesterase preparations from the electric organ of the electric eel
    Dudai Y, Silman I
    Ref: Biochemical & Biophysical Research Communications, 59:117, 1974 : PubMed

            

    Title: Chemical modification of electric eel acetylcholinesterase by tetranitromethane
    Fuchs S, Gurari D, Silman I
    Ref: Archives of Biochemistry & Biophysics, 165:90, 1974 : PubMed

            

    Title: Immunochemical and enzymic properties of the electric eel acetylcholinesterase-antiacetylcholinesterase system
    Gurari D, Silman I, Fuchs S
    Ref: European Journal of Biochemistry, 43:179, 1974 : PubMed

            

    Title: The effect of Ca(2+) on interaction of acetylcholinesterase with subcellular fractions of electric organ tissue from the electric eel
    Dudai Y, Silman I
    Ref: FEBS Letters, 30:49, 1973 : PubMed

            

    Title: Molecular structures of acetylcholinesterase from electric organ tissue of the electric eel
    Dudai Y, Herzberg M, Silman I
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 70:2473, 1973 : PubMed

            

    Title: Effect of cholinesterase inhibitors on active potassium influx in monkey erythrocytes
    Giberman E, Silman I, Edery H
    Ref: Biochemical Pharmacology, 22:271, 1973 : PubMed

            

    Title: Spectral evidence for the presence of tryptophan in the binding site of acetylcholinesterase
    Shinitzky M, Dudai Y, Silman I
    Ref: FEBS Letters, 30:125, 1973 : PubMed

            

    Title: Purification by affinity chromatography of acetylcholinesterase from electric organ tissue of the electric eel subsequent to tryptic treatment
    Dudai Y, Silman I, Kalderon N, Blumberg S
    Ref: Biochimica & Biophysica Acta, 268:138, 1972 : PubMed

            

    Title: Purification by affinity chromatography of the molecular forms of acetylcholinesterase present in fresh electric-organ tissue of electric eel
    Dudai Y, Silman I, Shinitzky M, Blumberg S
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 69:2400, 1972 : PubMed

            

    Title: The subunits of an acetylcholinesterase preparation purified from trypsin-treated electric eel tissue
    Dudai Y, Silman I
    Ref: FEBS Letters, 16:324, 1971 : PubMed

            

    Title: A method for the purification of acetylcholinesterase by affinity chromatography
    Kalderon N, Silman I, Blumberg S, Dudai Y
    Ref: Biochimica & Biophysica Acta, 207:560, 1970 : PubMed

            

    Title: Acetylcholine receptor: covalent attachment of depolarizing groups at the active site
    Silman I, Karlin A
    Ref: Science, 164:1420, 1969 : PubMed

            

    Title: Microenvironmental effects on enzyme activity
    Silman I
    Ref: Journal of General Physiology, 54:50, 1969 : PubMed

            

    Title: Papain-collodion membranes. I. Preparation and properties
    Goldman R, Kedem O, Silman I, Caplan SR, Katchalski E
    Ref: Biochemistry, 7:486, 1968 : PubMed

            

    Title: Effect of local pH change caused by substrate hydrolysis on the activity of membrane-bound acetylcholinesterase
    Silman I, Karlin A
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 58:1664, 1967 : PubMed

            

    Title: Water-insoluble derivatives of enzymes, antigens, and antibodies
    Silman I, Katchalski E
    Ref: Annual Review of Biochemistry, 35:873, 1966 : PubMed

            

    Title: Some water-insoluble papain derivatives
    Silman I, Albu-Weissenberg M, Katchalski E
    Ref: Biopolymers, 4:441, 1966 : PubMed

            


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