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Title : Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors - O'Connor_2010_Bioorg.Med.Chem.Lett_20_6273 |
Author(s) : O'Connor SP , Wang Y , Simpkins LM , Brigance RP , Meng W , Wang A , Kirby MS , Weigelt CA , Hamann LG |
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :6273 , 2010 |
Abstract : O'Connor_2010_Bioorg.Med.Chem.Lett_20_6273 |
ESTHER : O'Connor_2010_Bioorg.Med.Chem.Lett_20_6273 |
PubMedSearch : O'Connor_2010_Bioorg.Med.Chem.Lett_20_6273 |
PubMedID: 20833042 |
Title : Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors - Simpkins_2007_Bioorg.Med.Chem.Lett_17_6476 |
Author(s) : Simpkins LM , Bolton S , Pi Z , Sutton JC , Kwon C , Zhao G , Magnin DR , Augeri DJ , Gungor T , Rotella DP , Sun Z , Liu Y , Slusarchyk WS , Marcinkeviciene J , Robertson JG , Wang A , Robl JA , Atwal KS , Zahler RL , Parker RA , Kirby MS , Hamann LG |
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :6476 , 2007 |
Abstract : Simpkins_2007_Bioorg.Med.Chem.Lett_17_6476 |
ESTHER : Simpkins_2007_Bioorg.Med.Chem.Lett_17_6476 |
PubMedSearch : Simpkins_2007_Bioorg.Med.Chem.Lett_17_6476 |
PubMedID: 17937986 |
Title : Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Augeri_2005_J.Med.Chem_48_5025 |
Author(s) : Augeri DJ , Robl JA , Betebenner DA , Magnin DR , Khanna A , Robertson JG , Wang A , Simpkins LM , Taunk P , Huang Q , Han SP , Abboa-Offei B , Cap M , Xin L , Tao L , Tozzo E , Welzel GE , Egan DM , Marcinkeviciene J , Chang SY , Biller SA , Kirby MS , Parker RA , Hamann LG |
Ref : Journal of Medicinal Chemistry , 48 :5025 , 2005 |
Abstract : Augeri_2005_J.Med.Chem_48_5025 |
ESTHER : Augeri_2005_J.Med.Chem_48_5025 |
PubMedSearch : Augeri_2005_J.Med.Chem_48_5025 |
PubMedID: 16033281 |
Title : Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors - Zhao_2005_Bioorg.Med.Chem.Lett_15_3992 |
Author(s) : Zhao G , Taunk PC , Magnin DR , Simpkins LM , Robl JA , Wang A , Robertson JG , Marcinkeviciene J , Sitkoff DF , Parker RA , Kirby MS , Hamann LG |
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :3992 , 2005 |
Abstract : Zhao_2005_Bioorg.Med.Chem.Lett_15_3992 |
ESTHER : Zhao_2005_Bioorg.Med.Chem.Lett_15_3992 |
PubMedSearch : Zhao_2005_Bioorg.Med.Chem.Lett_15_3992 |
PubMedID: 16046120 |
Title : Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors - Magnin_2004_J.Med.Chem_47_2587 |
Author(s) : Magnin DR , Robl JA , Sulsky RB , Augeri DJ , Huang Y , Simpkins LM , Taunk PC , Betebenner DA , Robertson JG , Abboa-Offei BE , Wang A , Cap M , Xin L , Tao L , Sitkoff DF , Malley MF , Gougoutas JZ , Khanna A , Huang Q , Han SP , Parker RA , Hamann LG |
Ref : Journal of Medicinal Chemistry , 47 :2587 , 2004 |
Abstract : Magnin_2004_J.Med.Chem_47_2587 |
ESTHER : Magnin_2004_J.Med.Chem_47_2587 |
PubMedSearch : Magnin_2004_J.Med.Chem_47_2587 |
PubMedID: 15115400 |