Full name : Soukup Ondrej
First name : Ondrej
Mail : Department of Toxicology\; Faculty of Military Health Science\; University of Defense\; Trebesska 1575\; 500 01 Hradec Kralove
Zip Code :
City :
Country : Czech Republic
Email : ondrej.soukup@fnhk.cz
Phone : +420603351801
Fax :
Website :
Directory :
| Title : Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease - Mezeiova_2024_Biomed.Pharmacother_173_116399 |
| Author(s) : Mezeiova E , Prchal L , Hrabinova M , Muckova L , Pulkrabkova L , Soukup O , Misiachna A , Janousek J , Fibigar J , Kucera T , Horak M , Makhaeva GF , Korabecny J |
| Ref : Biomed Pharmacother , 173 :116399 , 2024 |
| Abstract : Mezeiova_2024_Biomed.Pharmacother_173_116399 |
| ESTHER : Mezeiova_2024_Biomed.Pharmacother_173_116399 |
| PubMedSearch : Mezeiova_2024_Biomed.Pharmacother_173_116399 |
| PubMedID: 38492439 |
| Title : A-series agent A-234: initial in vitro and in vivo characterization - Hrabinova_2024_Arch.Toxicol__ |
| Author(s) : Hrabinova M , Pejchal J , Hepnarova V , Muckova L , Junova L , Opravil J , Zdarova Karasova J , Rozsypal T , Dlabkova A , Rehulkova H , Kucera T , Vecera Z , Caisberger F , Schmidt M , Soukup O , Jun D |
| Ref : Archives of Toxicology , : , 2024 |
| Abstract : Hrabinova_2024_Arch.Toxicol__ |
| ESTHER : Hrabinova_2024_Arch.Toxicol__ |
| PubMedSearch : Hrabinova_2024_Arch.Toxicol__ |
| PubMedID: 38446233 |
| Title : Carltonine-Derived Compounds for Targeted Butyrylcholinesterase Inhibition - Pidany_2024_RSC.Med.Chem__ |
| Author(s) : Pidany F , Kroustkova J , Jenco J , Breiterova K , Muckovab L , Novakova L , Kunes J , Fibigar J , Kucera T , Novak M , Sorf A , Hrabinova M , Pulkrabkova L , Janousek J , Soukup O , Jun D , Korabecny J , Cahlikova L |
| Ref : RSC Med Chem , : , 2024 |
| Abstract : Pidany_2024_RSC.Med.Chem__ |
| ESTHER : Pidany_2024_RSC.Med.Chem__ |
| PubMedSearch : Pidany_2024_RSC.Med.Chem__ |
| PubMedID: |
| Title : Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition - Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| Author(s) : Misiachna A , Svobodova B , Netolicky J , Chvojkova M , Kleteckova L , Prchal L , Novak M , Hrabinova M , Kucera T , Muckova L , Moravcova Z , Karasova JZ , Pejchal J , Blazek F , Malinak D , Hakenova K , Krausova BH , Kolcheva M , Ladislav M , Korabecny J , Pahnke J , Vales K , Horak M , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 266 :116130 , 2024 |
| Abstract : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| ESTHER : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| PubMedSearch : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| PubMedID: 38218127 |
| Title : Uncharged mono- and bisoximes: In search of a zwitterion to countermeasure organophosphorus intoxication - Gorecki_2024_Chem.Biol.Interact__110941 |
| Author(s) : Gorecki L , Markova A , Hepnarova V , Zivna N , Junova L , Hrabinova M , Janousek J , Kobrlova T , Prchal L , Jun D , Soukup O , Horn G , Worek F , Marek J , Korabecny J |
| Ref : Chemico-Biological Interactions , :110941 , 2024 |
| Abstract : Gorecki_2024_Chem.Biol.Interact__110941 |
| ESTHER : Gorecki_2024_Chem.Biol.Interact__110941 |
| PubMedSearch : Gorecki_2024_Chem.Biol.Interact__110941 |
| PubMedID: 38493910 |
| Title : A-agents, misleadingly known as Novichoks: a narrative review - Opravil_2023_Arch.Toxicol__ |
| Author(s) : Opravil J , Pejchal J , Finger V , Korabecny J , Rozsypal T , Hrabinova M , Muckova L , Hepnarova V , Konecny J , Soukup O , Jun D |
| Ref : Archives of Toxicology , : , 2023 |
| Abstract : Opravil_2023_Arch.Toxicol__ |
| ESTHER : Opravil_2023_Arch.Toxicol__ |
| PubMedSearch : Opravil_2023_Arch.Toxicol__ |
| PubMedID: 37612377 |
| Title : Highly selective butyrylcholinesterase inhibitors related to Amaryllidaceae alkaloids - Design, synthesis, and biological evaluation - Pidany_2023_Eur.J.Med.Chem_252_115301 |
| Author(s) : Pidany F , Kroustkova J , Al Mamun A , Suchankova D , Brazzolotto X , Nachon F , Chantegreil F , Dolezal R , Pulkrabkova L , Muckova L , Hrabinova M , Finger V , Kufa M , Soukup O , Jun D , Jenco J , Kunes J , Novakova L , Korabecny J , Cahlikova L |
| Ref : Eur Journal of Medicinal Chemistry , 252 :115301 , 2023 |
| Abstract : Pidany_2023_Eur.J.Med.Chem_252_115301 |
| ESTHER : Pidany_2023_Eur.J.Med.Chem_252_115301 |
| PubMedSearch : Pidany_2023_Eur.J.Med.Chem_252_115301 |
| PubMedID: 36996715 |
| Gene_locus related to this paper: human-BCHE |
| Title : The effect of single and repeated doses of rivastigmine on gastric myoelectric activity in experimental pigs - Tsianou_2023_PLoS.One_18_e0286386 |
| Author(s) : Tsianou CC , Kvetina J , Radochova V , Kohoutova D , Rejchrt S , Valis M , Karasova JZ , Tacheci I , Knoblochova V , Soukup O , Bures J |
| Ref : PLoS ONE , 18 :e0286386 , 2023 |
| Abstract : Tsianou_2023_PLoS.One_18_e0286386 |
| ESTHER : Tsianou_2023_PLoS.One_18_e0286386 |
| PubMedSearch : Tsianou_2023_PLoS.One_18_e0286386 |
| PubMedID: 37262057 |
| Title : Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators - Kapitanov_2023_Chem.Biol.Interact_14ChEPon_110735 |
| Author(s) : Kapitanov IV , Spulak M , Pour M , Soukup O , Marek J , Jun D , Novak M , Diz de Almeida JSF , Costa Franca TC , Gathergood N , Kuca K , Karpichev Y |
| Ref : Chemico-Biological Interactions , :110735 , 2023 |
| Abstract : Kapitanov_2023_Chem.Biol.Interact_14ChEPon_110735 |
| ESTHER : Kapitanov_2023_Chem.Biol.Interact_14ChEPon_110735 |
| PubMedSearch : Kapitanov_2023_Chem.Biol.Interact_14ChEPon_110735 |
| PubMedID: 37802409 |
| Title : Tacrine First-Phase Biotransformation and Associated Hepatotoxicity: A Possible Way to Avoid Quinone Methide Formation - Novak_2023_ACS.Chem.Biol_18_1993 |
| Author(s) : Novak M , Vajrychova M , Koutsilieri S , Sismanoglou DC , Kobrlova T , Prchal L , Svobodova B , Korabecny J , Zarybnicky T , Raisova-Stuchlikova L , Skalova L , Lauschke VM , Kucera R , Soukup O |
| Ref : ACS Chemical Biology , 18 :1993 , 2023 |
| Abstract : Novak_2023_ACS.Chem.Biol_18_1993 |
| ESTHER : Novak_2023_ACS.Chem.Biol_18_1993 |
| PubMedSearch : Novak_2023_ACS.Chem.Biol_18_1993 |
| PubMedID: 37622522 |
| Title : UHPLC-Orbitrap study of the first phase tacrine in vitro metabolites and related Alzheimer's drug candidates using human liver microsomes - Novak_2023_J.Pharm.Biomed.Anal_224_115154 |
| Author(s) : Novak M , Svobodova B , Konecny J , Kuratkova A , Nevosadova L , Prchal L , Korabecny J , Lauschke VM , Soukup O , Kucera R |
| Ref : J Pharm Biomed Anal , 224 :115154 , 2023 |
| Abstract : Novak_2023_J.Pharm.Biomed.Anal_224_115154 |
| ESTHER : Novak_2023_J.Pharm.Biomed.Anal_224_115154 |
| PubMedSearch : Novak_2023_J.Pharm.Biomed.Anal_224_115154 |
| PubMedID: 36442458 |
| Title : Differentiated SH-SY5Y neuroblastoma cells as a model for evaluation of nerve agent-associated neurotoxicity - Pulkrabkova_2023_Arch.Toxicol__ |
| Author(s) : Pulkrabkova L , Muckova L , Hrabinova M , Sorf A , Kobrlova T , Jost P , Bezdekova D , Korabecny J , Jun D , Soukup O |
| Ref : Archives of Toxicology , : , 2023 |
| Abstract : Pulkrabkova_2023_Arch.Toxicol__ |
| ESTHER : Pulkrabkova_2023_Arch.Toxicol__ |
| PubMedSearch : Pulkrabkova_2023_Arch.Toxicol__ |
| PubMedID: 37221426 |
| Title : Structure-Guided Design of N-Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease - Svobodova_2023_Int.J.Mol.Sci_24_ |
| Author(s) : Svobodova B , Pulkrabkova L , Panek D , Misiachna A , Kolcheva M , Andrys R , Handl J , Capek J , Nyvltova P , Rousar T , Prchal L , Hepnarova V , Hrabinova M , Muckova L , Tosnerova D , Karabanovich G , Finger V , Soukup O , Horak M , Korabecny J |
| Ref : Int J Mol Sci , 24 : , 2023 |
| Abstract : Svobodova_2023_Int.J.Mol.Sci_24_ |
| ESTHER : Svobodova_2023_Int.J.Mol.Sci_24_ |
| PubMedSearch : Svobodova_2023_Int.J.Mol.Sci_24_ |
| PubMedID: 37298087 |
| Title : Neurotoxicity evoked by organophosphates and available countermeasures - Pulkrabkova_2022_Arch.Toxicol__ |
| Author(s) : Pulkrabkova L , Svobodova B , Konecny J , Kobrlova T , Muckova L , Janousek J , Pejchal J , Korabecny J , Soukup O |
| Ref : Archives of Toxicology , : , 2022 |
| Abstract : Pulkrabkova_2022_Arch.Toxicol__ |
| ESTHER : Pulkrabkova_2022_Arch.Toxicol__ |
| PubMedSearch : Pulkrabkova_2022_Arch.Toxicol__ |
| PubMedID: 36335468 |
| Title : Countermeasures in organophosphorus intoxication: pitfalls and prospects - Gorecki_2022_Trends.Pharmacol.Sci__ |
| Author(s) : Gorecki L , Soukup O , Korabecny J |
| Ref : Trends in Pharmacological Sciences , : , 2022 |
| Abstract : Gorecki_2022_Trends.Pharmacol.Sci__ |
| ESTHER : Gorecki_2022_Trends.Pharmacol.Sci__ |
| PubMedSearch : Gorecki_2022_Trends.Pharmacol.Sci__ |
| PubMedID: 35643835 |
| Title : Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities - Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| Author(s) : Chrienova Z , Nepovimova E , Andrys R , Dolezal R , Janockova J , Muckova L , Fabova L , Soukup O , Oleksak P , Valis M , Korabecny J , Marco-Contelles J , Kuca K |
| Ref : J Enzyme Inhib Med Chem , 37 :2605 , 2022 |
| Abstract : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| ESTHER : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| PubMedSearch : Chrienova_2022_J.Enzyme.Inhib.Med.Chem_37_2605 |
| PubMedID: 36131624 |
| Title : N-substituted arylhydroxamic acids as acetylcholinesterase reactivators - Bondar_2022_Chem.Biol.Interact__110078 |
| Author(s) : Bondar D , Kapitanov I , Pulkrabkova L , Soukup O , Jun D , Diniz FB , Franca TCC , Kuca K , Karpichev Y |
| Ref : Chemico-Biological Interactions , :110078 , 2022 |
| Abstract : Bondar_2022_Chem.Biol.Interact__110078 |
| ESTHER : Bondar_2022_Chem.Biol.Interact__110078 |
| PubMedSearch : Bondar_2022_Chem.Biol.Interact__110078 |
| PubMedID: 35940282 |
| Title : Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer's Activity Profile - Makhaeva_2022_Molecules_27_ |
| Author(s) : Makhaeva GF , Kovaleva NV , Boltneva NP , Rudakova EV , Lushchekina SV , Astakhova TY , Serkov IV , Proshin AN , Radchenko EV , Palyulin VA , Korabecny J , Soukup O , Bachurin SO , Richardson RJ |
| Ref : Molecules , 27 : , 2022 |
| Abstract : Makhaeva_2022_Molecules_27_ |
| ESTHER : Makhaeva_2022_Molecules_27_ |
| PubMedSearch : Makhaeva_2022_Molecules_27_ |
| PubMedID: 35164325 |
| Title : (+\/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease - Ismaili_2021_ACS.Chem.Neurosci__ |
| Author(s) : Ismaili L , Monnin J , Etievant A , Arribas RL , Viejo L , Refouvelet B , Soukup O , Janockova J , Hepnarova V , Korabecny J , Kucera T , Jun D , Andrys R , Musilek K , Baguet A , Garcia-Frutos EM , De Simone A , Andrisano V , Bartolini M , de los Rios C , Marco-Contelles J , Haffen E |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : Ismaili_2021_ACS.Chem.Neurosci__ |
| ESTHER : Ismaili_2021_ACS.Chem.Neurosci__ |
| PubMedSearch : Ismaili_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33797877 |
| Title : Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors - Gorecki_2021_Eur.J.Med.Chem_219_113434 |
| Author(s) : Gorecki L , Misiachna A , Damborsky J , Dolezal R , Korabecny J , Cejkova L , Hakenova K , Chvojkova M , Karasova JZ , Prchal L , Novak M , Kolcheva M , Kortus S , Vales K , Horak M , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 219 :113434 , 2021 |
| Abstract : Gorecki_2021_Eur.J.Med.Chem_219_113434 |
| ESTHER : Gorecki_2021_Eur.J.Med.Chem_219_113434 |
| PubMedSearch : Gorecki_2021_Eur.J.Med.Chem_219_113434 |
| PubMedID: 33892271 |
| Title : Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease - Hamulakova_2021_Future.Med.Chem__ |
| Author(s) : Hamulakova S , Kudlickova Z , Janovec L , Mezencev R , Deckner ZJ , Chernoff YO , Janockova J , Ihnatova V , Bzonek P , Novakova N , Hepnarova V , Hrabinova M , Jun D , Korabecny J , Soukup O , Kuca K |
| Ref : Future Med Chem , : , 2021 |
| Abstract : Hamulakova_2021_Future.Med.Chem__ |
| ESTHER : Hamulakova_2021_Future.Med.Chem__ |
| PubMedSearch : Hamulakova_2021_Future.Med.Chem__ |
| PubMedID: 33829876 |
| Title : Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment - Makhaeva_2021_Bioorg.Chem_112_104974 |
| Author(s) : Makhaeva GF , Lushchekina SV , Kovaleva NV , Yu Astakhova T , Boltneva NP , Rudakova EV , Serebryakova OG , Proshin AN , Serkov IV , Trofimova TP , Tafeenko VA , Radchenko EV , Palyulin VA , Fisenko VP , Korabecny J , Soukup O , Richardson RJ |
| Ref : Bioorg Chem , 112 :104974 , 2021 |
| Abstract : Makhaeva_2021_Bioorg.Chem_112_104974 |
| ESTHER : Makhaeva_2021_Bioorg.Chem_112_104974 |
| PubMedSearch : Makhaeva_2021_Bioorg.Chem_112_104974 |
| PubMedID: 34029971 |
| Title : Synthesis and Decontamination Effect on Chemical and Biological Agents of Benzoxonium-Like Salts - Markova_2021_Toxics_9_ |
| Author(s) : Markova A , Hympanova M , Matula M , Prchal L , Sleha R , Benkova M , Pulkrabkova L , Soukup O , Krocova Z , Jun D , Marek J |
| Ref : Toxics , 9 : , 2021 |
| Abstract : Markova_2021_Toxics_9_ |
| ESTHER : Markova_2021_Toxics_9_ |
| PubMedSearch : Markova_2021_Toxics_9_ |
| PubMedID: 34564373 |
| Title : Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment - Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| Author(s) : Mezeiova E , Hrabinova M , Hepnarova V , Jun D , Janockova J , Muckova L , Prchal L , Kristofikova Z , Kucera T , Gorecki L , Chalupova K , Kunes J , Hroudova J , Soukup O , Korabecny J |
| Ref : Bioorganic & Medicinal Chemistry Lett , :128100 , 2021 |
| Abstract : Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| ESTHER : Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| PubMedSearch : Mezeiova_2021_Bioorg.Med.Chem.Lett__128100 |
| PubMedID: 33984470 |
| Title : Development of versatile and potent monoquaternary reactivators of acetylcholinesterase - Gorecki_2021_Arch.Toxicol__ |
| Author(s) : Gorecki L , Hepnarova V , Karasova JZ , Hrabinova M , Courageux C , Dias J , Kucera T , Kobrlova T , Muckova L , Prchal L , Malinak D , Jun D , Musilek K , Worek F , Nachon F , Soukup O , Korabecny J |
| Ref : Archives of Toxicology , : , 2021 |
| Abstract : Gorecki_2021_Arch.Toxicol__ |
| ESTHER : Gorecki_2021_Arch.Toxicol__ |
| PubMedSearch : Gorecki_2021_Arch.Toxicol__ |
| PubMedID: 33517499 |
| Title : Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease - Vrabec_2021_Phytochemistry_194_113017 |
| Author(s) : Vrabec R , Marikova J , Locarek M , Korabecny J , Hulcova D , Hosalkova A , Kunes J , Chlebek J , Kucera T , Hrabinova M , Jun D , Soukup O , Andrisano V , Jenco J , Safratova M , Novakova L , Opletal L , Cahlikova L |
| Ref : Phytochemistry , 194 :113017 , 2021 |
| Abstract : Vrabec_2021_Phytochemistry_194_113017 |
| ESTHER : Vrabec_2021_Phytochemistry_194_113017 |
| PubMedSearch : Vrabec_2021_Phytochemistry_194_113017 |
| PubMedID: 34798410 |
| Title : Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies - Al Mamun_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Al Mamun A , Pidany F , Hulcova D , Marikova J , Kucera T , Schmidt M , Catapano MC , Hrabinova M , Jun D , Muckova L , Kunes J , Janousek J , Andrys R , Novakova L , Perinova R , Maafi N , Soukup O , Korabecny J , Cahlikova L |
| Ref : Int J Mol Sci , 22 : , 2021 |
| Abstract : Al Mamun_2021_Int.J.Mol.Sci_22_ |
| ESTHER : Al Mamun_2021_Int.J.Mol.Sci_22_ |
| PubMedSearch : Al Mamun_2021_Int.J.Mol.Sci_22_ |
| PubMedID: 34361074 |
| Title : Cholinesterase Research - Korabecny_2021_Biomolecules_11_ |
| Author(s) : Korabecny J , Soukup O |
| Ref : Biomolecules , 11 : , 2021 |
| Abstract : Korabecny_2021_Biomolecules_11_ |
| ESTHER : Korabecny_2021_Biomolecules_11_ |
| PubMedSearch : Korabecny_2021_Biomolecules_11_ |
| PubMedID: 34439787 |
| Title : 7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo - Kaniakova_2021_Biochem.Pharmacol__114460 |
| Author(s) : Kaniakova M , Korabecny J , Holubova K , Kleteckova L , Chvojkova M , Hakenova K , Prchal L , Novak M , Dolezal R , Hepnarova V , Svobodova B , Kucera T , Lichnerova K , Krausova B , Horak M , Vales K , Soukup O |
| Ref : Biochemical Pharmacology , :114460 , 2021 |
| Abstract : Kaniakova_2021_Biochem.Pharmacol__114460 |
| ESTHER : Kaniakova_2021_Biochem.Pharmacol__114460 |
| PubMedSearch : Kaniakova_2021_Biochem.Pharmacol__114460 |
| PubMedID: 33571502 |
| Title : Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells - Hudacova_2021_Int.J.Mol.Sci_22_ |
| Author(s) : Hudacova M , Hamuakova S , Konkoova E , Jendzelovsky R , Vargova J , Sevc J , Fedorocko P , Soukup O , Janockova J , Ihnatova V , Kucera T , Bzonek P , Novakova N , Jun D , Junova L , Korabecny J , Kuca K , Kozurkova M |
| Ref : Int J Mol Sci , 22 : , 2021 |
| Abstract : Hudacova_2021_Int.J.Mol.Sci_22_ |
| ESTHER : Hudacova_2021_Int.J.Mol.Sci_22_ |
| PubMedSearch : Hudacova_2021_Int.J.Mol.Sci_22_ |
| PubMedID: 33917200 |
| Title : Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease - Rossi_2021_J.Med.Chem_64_4972 |
| Author(s) : Rossi M , Freschi M , de Camargo Nascente L , Salerno A , de Melo Viana Teixeira S , Nachon F , Chantegreil F , Soukup O , Prchal L , Malaguti M , Bergamini C , Bartolini M , Angeloni C , Hrelia S , Soares Romeiro LA , Bolognesi ML |
| Ref : Journal of Medicinal Chemistry , 64 :4972 , 2021 |
| Abstract : Rossi_2021_J.Med.Chem_64_4972 |
| ESTHER : Rossi_2021_J.Med.Chem_64_4972 |
| PubMedSearch : Rossi_2021_J.Med.Chem_64_4972 |
| PubMedID: 33829779 |
| Gene_locus related to this paper: human-BCHE |
| Title : Turning Donepezil into a Multi-Target-Directed Ligand through a Merging Strategy - Perone_2021_ChemMedChem_16_187 |
| Author(s) : Perone R , Albertini C , Uliassi E , Di Pietri F , de Sena Murteira Pinheiro P , Petralla S , Rizzardi N , Fato R , Pulkrabkova L , Soukup O , Tramarin A , Bartolini M , Bolognesi ML |
| Ref : ChemMedChem , 16 :187 , 2021 |
| Abstract : Perone_2021_ChemMedChem_16_187 |
| ESTHER : Perone_2021_ChemMedChem_16_187 |
| PubMedSearch : Perone_2021_ChemMedChem_16_187 |
| PubMedID: 32716144 |
| Title : Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease - Gorecki_2021_ACS.Chem.Neurosci__ |
| Author(s) : Gorecki L , Uliassi E , Bartolini M , Janockova J , Hrabinova M , Hepnarova V , Prchal L , Muckova L , Pejchal J , Karasova JZ , Mezeiova E , Benkova M , Kobrlova T , Soukup O , Petralla S , Monti B , Korabecny J , Bolognesi ML |
| Ref : ACS Chem Neurosci , : , 2021 |
| Abstract : Gorecki_2021_ACS.Chem.Neurosci__ |
| ESTHER : Gorecki_2021_ACS.Chem.Neurosci__ |
| PubMedSearch : Gorecki_2021_ACS.Chem.Neurosci__ |
| PubMedID: 33852284 |
| Title : Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties - de Andrade Ramos_2021_RSC.Med.Chem_12_1154 |
| Author(s) : de Andrade Ramos G , Souza de Oliveira A , Bartolini M , Naldi M , Liparulo I , Bergamini C , Uliassi E , Wu L , Fraser PE , Abreu M , Kiametis AS , Gargano R , Silveira ER , Brand GD , Prchal L , Soukup O , Korabecny J , Bolognesi ML , Soares Romeiro LA |
| Ref : RSC Med Chem , 12 :1154 , 2021 |
| Abstract : de Andrade Ramos_2021_RSC.Med.Chem_12_1154 |
| ESTHER : de Andrade Ramos_2021_RSC.Med.Chem_12_1154 |
| PubMedSearch : de Andrade Ramos_2021_RSC.Med.Chem_12_1154 |
| PubMedID: 34355181 |
| Title : Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile - Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| Author(s) : Sobolova K , Hrabinova M , Hepnarova V , Kucera T , Kobrlova T , Benkova M , Janockova J , Dolezal R , Prchal L , Benek O , Mezeiova E , Jun D , Soukup O , Korabecny J |
| Ref : Eur Journal of Medicinal Chemistry , 203 :112593 , 2020 |
| Abstract : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| ESTHER : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| PubMedSearch : Sobolova_2020_Eur.J.Med.Chem_203_112593 |
| PubMedID: 32688201 |
| Title : From orexin receptor agonist YNT-185 to novel antagonists with drug-like properties for the treatment of insomnia - Mezeiova_2020_Bioorg.Chem_103_104179 |
| Author(s) : Mezeiova E , Janockova J , Konecny J , Kobrlova T , Benkova M , Dolezal R , Prchal L , Karasova-Zdarova J , Soukup O , Korabecny J |
| Ref : Bioorg Chem , 103 :104179 , 2020 |
| Abstract : Mezeiova_2020_Bioorg.Chem_103_104179 |
| ESTHER : Mezeiova_2020_Bioorg.Chem_103_104179 |
| PubMedSearch : Mezeiova_2020_Bioorg.Chem_103_104179 |
| PubMedID: 32891860 |
| Title : Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems - Nepovimova_2020_Bioorg.Chem_107_104596 |
| Author(s) : Nepovimova E , Svobodova L , Dolezal R , Hepnarova V , Junova L , Jun D , Korabecny J , Kucera T , Gazova Z , Motykova K , Kubackova J , Bednarikova Z , Janockova J , Jesus C , Cortes L , Pina J , Rostohar D , Serpa C , Soukup O , Aitken L , Hughes RE , Musilek K , Muckova L , Jost P , Chvojkova M , Vales K , Valis M , Chrienova Z , Chalupova K , Kuca K |
| Ref : Bioorg Chem , 107 :104596 , 2020 |
| Abstract : Nepovimova_2020_Bioorg.Chem_107_104596 |
| ESTHER : Nepovimova_2020_Bioorg.Chem_107_104596 |
| PubMedSearch : Nepovimova_2020_Bioorg.Chem_107_104596 |
| PubMedID: 33421953 |
| Title : Pursuing the Complexity of Alzheimer's Disease: Discovery of Fluoren-9-Amines as Selective Butyrylcholinesterase Inhibitors and N-Methyl-d-Aspartate Receptor Antagonists - Konecny_2020_Biomolecules_11_ |
| Author(s) : Konecny J , Misiachna A , Hrabinova M , Pulkrabkova L , Benkova M , Prchal L , Kucera T , Kobrlova T , Finger V , Kolcheva M , Kortus S , Jun D , Valko M , Horak M , Soukup O , Korabecny J |
| Ref : Biomolecules , 11 : , 2020 |
| Abstract : Konecny_2020_Biomolecules_11_ |
| ESTHER : Konecny_2020_Biomolecules_11_ |
| PubMedSearch : Konecny_2020_Biomolecules_11_ |
| PubMedID: 33375115 |
| Title : Effect of P-glycoprotein on the availability of oxime reactivators in the brain - Kobrlova_2020_Toxicology__152541 |
| Author(s) : Kobrlova T , Soukup O |
| Ref : Toxicology , :152541 , 2020 |
| Abstract : Kobrlova_2020_Toxicology__152541 |
| ESTHER : Kobrlova_2020_Toxicology__152541 |
| PubMedSearch : Kobrlova_2020_Toxicology__152541 |
| PubMedID: 32835730 |
| Title : Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors - Svobodova_2019_Biomolecules_9_ |
| Author(s) : Svobodova B , Mezeiova E , Hepnarova V , Hrabinova M , Muckova L , Kobrlova T , Jun D , Soukup O , Jimeno ML , Marco-Contelles J , Korabecny J |
| Ref : Biomolecules , 9 : , 2019 |
| Abstract : Svobodova_2019_Biomolecules_9_ |
| ESTHER : Svobodova_2019_Biomolecules_9_ |
| PubMedSearch : Svobodova_2019_Biomolecules_9_ |
| PubMedID: 31430943 |
| Title : Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase - AlFadly_2019_Eur.J.Med.Chem_167_161 |
| Author(s) : AlFadly ED , Elzahhar PA , Tramarin A , Elkazaz S , Shaltout H , Abu-Serie MM , Janockova J , Soukup O , Ghareeb DA , El-Yazbi AF , Rafeh RW , Bakkar NZ , Kobeissy F , Iriepa I , Moraleda I , Saudi MNS , Bartolini M , Belal ASF |
| Ref : Eur Journal of Medicinal Chemistry , 167 :161 , 2019 |
| Abstract : AlFadly_2019_Eur.J.Med.Chem_167_161 |
| ESTHER : AlFadly_2019_Eur.J.Med.Chem_167_161 |
| PubMedSearch : AlFadly_2019_Eur.J.Med.Chem_167_161 |
| PubMedID: 30771604 |
| Title : A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer's Disease - Korabecny_2019_Curr.Med.Chem_26_5625 |
| Author(s) : Korabecny J , Spilovska K , Mezeiova E , Benek O , Juza R , Kaping D , Soukup O |
| Ref : Curr Med Chem , 26 :5625 , 2019 |
| Abstract : Korabecny_2019_Curr.Med.Chem_26_5625 |
| ESTHER : Korabecny_2019_Curr.Med.Chem_26_5625 |
| PubMedSearch : Korabecny_2019_Curr.Med.Chem_26_5625 |
| PubMedID: 29768996 |
| Title : N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy - Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| Author(s) : Nepovimova E , Korabecny J , Hepnarova V , Jun D , Dolezal R , Muckova L , Jost P , Soukup O , Janockova J , Pham NL , Nguyen TD , Valis M , Kuca K |
| Ref : Curr Alzheimer Res , 16 :333 , 2019 |
| Abstract : Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| ESTHER : Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| PubMedSearch : Nepovimova_2019_Curr.Alzheimer.Res_16_333 |
| PubMedID: 30873921 |
| Title : New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition - Malek_2019_J.Med.Chem_62_11416 |
| Author(s) : Malek R , Arribas RL , Palomino-Antolin A , Totoson P , Demougeot C , Kobrlova T , Soukup O , Iriepa I , Moraleda I , Diez-Iriepa D , Godyn J , Panek D , Malawska B , Gluch-Lutwin M , Mordyl B , Siwek A , Chabchoub F , Marco-Contelles J , Kiec-Kononowicz K , Egea J , de los Rios C , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 62 :11416 , 2019 |
| Abstract : Malek_2019_J.Med.Chem_62_11416 |
| ESTHER : Malek_2019_J.Med.Chem_62_11416 |
| PubMedSearch : Malek_2019_J.Med.Chem_62_11416 |
| PubMedID: 31724859 |
| Title : Orexin supplementation in narcolepsy treatment: A review - Nepovimova_2019_Med.Res.Rev_39_961 |
| Author(s) : Nepovimova E , Janockova J , Misik J , Kubik S , Stuchlik A , Vales K , Korabecny J , Mezeiova E , Dolezal R , Soukup O , Kobrlova T , Pham NL , Nguyen TD , Konecny J , Kuca K |
| Ref : Med Res Rev , 39 :961 , 2019 |
| Abstract : Nepovimova_2019_Med.Res.Rev_39_961 |
| ESTHER : Nepovimova_2019_Med.Res.Rev_39_961 |
| PubMedSearch : Nepovimova_2019_Med.Res.Rev_39_961 |
| PubMedID: 30426515 |
| Title : Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease - Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| Author(s) : Mezeiova E , Chalupova K , Nepovimova E , Gorecki L , Prchal L , Malinak D , Kuca K , Soukup O , Korabecny J |
| Ref : Curr Alzheimer Res , 16 :772 , 2019 |
| Abstract : Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| ESTHER : Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| PubMedSearch : Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| PubMedID: 30819078 |
| Title : Current approaches to enhancing oxime reactivator delivery into the brain - Kobrlova_2019_Toxicology_423_75 |
| Author(s) : Kobrlova T , Korabecny J , Soukup O |
| Ref : Toxicology , 423 :75 , 2019 |
| Abstract : Kobrlova_2019_Toxicology_423_75 |
| ESTHER : Kobrlova_2019_Toxicology_423_75 |
| PubMedSearch : Kobrlova_2019_Toxicology_423_75 |
| PubMedID: 31112674 |
| Title : Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase - Gorecki_2019_Future.Med.Chem_11_2625 |
| Author(s) : Gorecki L , Junova L , Kucera T , Hepnarova V , Prchal L , Kobrlova T , Muckova L , Soukup O , Korabecny J |
| Ref : Future Med Chem , 11 :2625 , 2019 |
| Abstract : Gorecki_2019_Future.Med.Chem_11_2625 |
| ESTHER : Gorecki_2019_Future.Med.Chem_11_2625 |
| PubMedSearch : Gorecki_2019_Future.Med.Chem_11_2625 |
| PubMedID: 31556693 |
| Title : Tacrine and its 7-methoxy derivate\; time-change concentration in plasma and brain tissue and basic toxicological profile in rats - Karasova_2019_Drug.Chem.Toxicol__1 |
| Author(s) : Karasova JZ , Soukup O , Korabecny J , Hroch M , Krejciova M , Hrabinova M , Misik J , Novotny L , Hepnarova V , Kuca K |
| Ref : Drug & Chemical Toxicology , :1 , 2019 |
| Abstract : Karasova_2019_Drug.Chem.Toxicol__1 |
| ESTHER : Karasova_2019_Drug.Chem.Toxicol__1 |
| PubMedSearch : Karasova_2019_Drug.Chem.Toxicol__1 |
| PubMedID: 31257938 |
| Title : Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators - Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| Author(s) : Hepnarova V , Muckova L , Ring A , Pejchal J , Herman D , Misik J , Hrabinova M , Jun D , Soukup O |
| Ref : Toxicol Appl Pharmacol , :114776 , 2019 |
| Abstract : Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| ESTHER : Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| PubMedSearch : Hepnarova_2019_Toxicol.Appl.Pharmacol__114776 |
| PubMedID: 31629733 |
| Title : In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers - Janockova_2019_J.Enzyme.Inhib.Med.Chem_34_877 |
| Author(s) : Janockova J , Korabecny J , Plsikova J , Babkova K , Konkolova E , Kucerova D , Vargova J , Koval J , Jendzelovsky R , Fedorocko P , Kasparkova J , Brabec V , Rosocha J , Soukup O , Hamulakova S , Kuca K , Kozurkova M |
| Ref : J Enzyme Inhib Med Chem , 34 :877 , 2019 |
| Abstract : Janockova_2019_J.Enzyme.Inhib.Med.Chem_34_877 |
| ESTHER : Janockova_2019_J.Enzyme.Inhib.Med.Chem_34_877 |
| PubMedSearch : Janockova_2019_J.Enzyme.Inhib.Med.Chem_34_877 |
| PubMedID: 30938202 |
| Title : Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives - Jonczyk_2019_Bioorg.Chem_90_103084 |
| Author(s) : Jonczyk J , Lodarski K , Staszewski M , Godyn J , Zareba P , Soukup O , Janockova J , Korabecny J , Salat K , Malikowska-Racia N , Hebda M , Szalaj N , Filipek B , Walczynski K , Malawska B , Bajda M |
| Ref : Bioorg Chem , 90 :103084 , 2019 |
| Abstract : Jonczyk_2019_Bioorg.Chem_90_103084 |
| ESTHER : Jonczyk_2019_Bioorg.Chem_90_103084 |
| PubMedSearch : Jonczyk_2019_Bioorg.Chem_90_103084 |
| PubMedID: 31271942 |
| Title : Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease - Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| Author(s) : Kaniakova M , Nepovimova E , Kleteckova L , Skrenkova K , Holubova K , Chrienova Z , Hepnarova V , Kucera T , Kobrlova T , Vales K , Korabecny J , Soukup O , Horak M |
| Ref : Curr Alzheimer Res , 16 :821 , 2019 |
| Abstract : Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| ESTHER : Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| PubMedSearch : Kaniakova_2019_Curr.Alzheimer.Res_16_821 |
| PubMedID: 30819076 |
| Title : Oxime K203: a drug candidate for the treatment of tabun intoxication - Gorecki_2019_Arch.Toxicol_93_673 |
| Author(s) : Gorecki L , Soukup O , Kucera T , Malinak D , Jun D , Kuca K , Musilek K , Korabecny J |
| Ref : Archives of Toxicology , 93 :673 , 2019 |
| Abstract : Gorecki_2019_Arch.Toxicol_93_673 |
| ESTHER : Gorecki_2019_Arch.Toxicol_93_673 |
| PubMedSearch : Gorecki_2019_Arch.Toxicol_93_673 |
| PubMedID: 30564897 |
| Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease - Chalupova_2019_Eur.J.Med.Chem_168_491 |
| Author(s) : Chalupova K , Korabecny J , Bartolini M , Monti B , Lamba D , Caliandro R , Pesaresi A , Brazzolotto X , Gastellier AJ , Nachon F , Pejchal J , Jarosova M , Hepnarova V , Jun D , Hrabinova M , Dolezal R , Karasova JZ , Mzik M , Kristofikova Z , Misik J , Muckova L , Jost P , Soukup O , Benkova M , Setnicka V , Habartova L , Chvojkova M , Kleteckova L , Vales K , Mezeiova E , Uliassi E , Valis M , Nepovimova E , Bolognesi ML , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 168 :491 , 2019 |
| Abstract : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| ESTHER : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedSearch : Chalupova_2019_Eur.J.Med.Chem_168_491 |
| PubMedID: 30851693 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer's disease therapy - Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| Author(s) : Dgachi Y , Martin H , Malek R , Jun D , Janockova J , Sepsova V , Soukup O , Iriepa I , Moraleda I , Maalej E , Carreiras MC , Refouvelet B , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : J Enzyme Inhib Med Chem , 34 :163 , 2019 |
| Abstract : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| ESTHER : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| PubMedSearch : Dgachi_2019_J.Enzyme.Inhib.Med.Chem_34_163 |
| PubMedID: 30482062 |
| Title : Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents - Panek_2018_ACS.Chem.Neurosci_9_1074 |
| Author(s) : Panek D , Wieckowska A , Jonczyk J , Godyn J , Bajda M , Wichur T , Pasieka A , Knez D , Pislar A , Korabecny J , Soukup O , Sepsova V , Sabate R , Kos J , Gobec S , Malawska B |
| Ref : ACS Chem Neurosci , 9 :1074 , 2018 |
| Abstract : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| ESTHER : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| PubMedSearch : Panek_2018_ACS.Chem.Neurosci_9_1074 |
| PubMedID: 29345897 |
| Title : In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? - Soukup_2018_Med.Chem_14_281 |
| Author(s) : Soukup O , Korabecny J , Malinak D , Nepovimova E , Pham NL , Musilek K , Hrabinova M , Hepnarova V , Dolezal R , Pavek P , Jost P , Kobrlova T , Jankockova J , Gorecki L , Psotka M , Nguyen TD , Box K , Outhwaite B , Ceckova M , Sorf A , Jun D , Kuca K |
| Ref : Med Chem , 14 :281 , 2018 |
| Abstract : Soukup_2018_Med.Chem_14_281 |
| ESTHER : Soukup_2018_Med.Chem_14_281 |
| PubMedSearch : Soukup_2018_Med.Chem_14_281 |
| PubMedID: 29332594 |
| Title : Profiling donepezil template into multipotent hybrids with antioxidant properties - Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
| Author(s) : Mezeiova E , Spilovska K , Nepovimova E , Gorecki L , Soukup O , Dolezal R , Malinak D , Janockova J , Jun D , Kuca K , Korabecny J |
| Ref : J Enzyme Inhib Med Chem , 33 :583 , 2018 |
| Abstract : Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
| ESTHER : Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
| PubMedSearch : Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
| PubMedID: 29529892 |
| Title : A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase - Kuca_2018_BMC.Pharmacol.Toxicol_19_8 |
| Author(s) : Kuca K , Musilek K , Jun D , Karasova JZ , Nepovimova E , Soukup O , Hrabinova M , Mikler J , Franca TCC , da Cunha EFF , de Castro AA , Valis M , Ramalho TC |
| Ref : BMC Pharmacol Toxicol , 19 :8 , 2018 |
| Abstract : Kuca_2018_BMC.Pharmacol.Toxicol_19_8 |
| ESTHER : Kuca_2018_BMC.Pharmacol.Toxicol_19_8 |
| PubMedSearch : Kuca_2018_BMC.Pharmacol.Toxicol_19_8 |
| PubMedID: 29467029 |
| Title : Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease - Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| Author(s) : Wieckowska A , Wichur T , Godyn J , Bucki A , Marcinkowska M , Siwek A , Wieckowski K , Zareba P , Knez D , Gluch-Lutwin M , Kazek G , Latacz G , Mika K , Kolaczkowski M , Korabecny J , Soukup O , Benkova M , Kiec-Kononowicz K , Gobec S , Malawska B |
| Ref : ACS Chem Neurosci , 9 :1195 , 2018 |
| Abstract : Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| ESTHER : Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| PubMedSearch : Wieckowska_2018_ACS.Chem.Neurosci_9_1195 |
| PubMedID: 29384656 |
| Title : Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings - Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| Author(s) : Kuca K , Karasova JZ , Soukup O , Kassa J , Novotna E , Sepsova V , Horova A , Pejchal J , Hrabinova M , Vodakova E , Jun D , Nepovimova E , Valis M , Musilek K |
| Ref : Drug Des Devel Ther , 12 :505 , 2018 |
| Abstract : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| ESTHER : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| PubMedSearch : Kuca_2018_Drug.Des.Devel.Ther_12_505 |
| PubMedID: 29563775 |
| Title : Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier - Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
| Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Janockova J , Hrabinova M , Sepsova V , Kuca K |
| Ref : Curr Alzheimer Res , 15 :1096 , 2018 |
| Abstract : Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
| ESTHER : Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
| PubMedSearch : Hamulakova_2018_Curr.Alzheimer.Res_15_1096 |
| PubMedID: 29992880 |
| Title : Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods - Janockova_2018_Molecules_23_ |
| Author(s) : Janockova J , Dolezal R , Nepovimova E , Kobrlova T , Benkova M , Kuca K , Konecny J , Mezeiova E , Melikova M , Hepnarova V , Ring A , Soukup O , Korabecny J |
| Ref : Molecules , 23 : , 2018 |
| Abstract : Janockova_2018_Molecules_23_ |
| ESTHER : Janockova_2018_Molecules_23_ |
| PubMedSearch : Janockova_2018_Molecules_23_ |
| PubMedID: 30423961 |
| Title : Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents - Zorbaz_2018_J.Med.Chem_61_10753 |
| Author(s) : Zorbaz T , Malinak D , Marakovic N , Macek Hrvat N , Zandona A , Novotny M , Skarka A , Andrys R , Benkova M , Soukup O , Katalinic M , Kuca K , Kovarik Z , Musilek K |
| Ref : Journal of Medicinal Chemistry , 61 :10753 , 2018 |
| Abstract : Zorbaz_2018_J.Med.Chem_61_10753 |
| ESTHER : Zorbaz_2018_J.Med.Chem_61_10753 |
| PubMedSearch : Zorbaz_2018_J.Med.Chem_61_10753 |
| PubMedID: 30383374 |
| Title : Cholinesterase inhibitor 6-chlorotacrine - in vivo toxicological profile and behavioural effects - Misik_2018_Curr.Alzheimer.Res_15_552 |
| Author(s) : Misik J , Nepovimova E , Pejchal J , Kassa J , Korabecny J , Soukup O |
| Ref : Curr Alzheimer Res , 15 :552 , 2018 |
| Abstract : Misik_2018_Curr.Alzheimer.Res_15_552 |
| ESTHER : Misik_2018_Curr.Alzheimer.Res_15_552 |
| PubMedSearch : Misik_2018_Curr.Alzheimer.Res_15_552 |
| PubMedID: 29231138 |
| Title : A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators - Tsai_2021_J.Food.Drug.Anal_29_153 |
| Author(s) : Malinak D , Korabecny J , Soukup O , Gorecki L , Nepovimova E , Psotka M , Dolezal R , Nguyen TD , Mezeiova E , Musilek K , Kuca K |
| Ref : Current Organic Chemistry , 22\ :1619 , 2018 |
| Abstract : Tsai_2021_J.Food.Drug.Anal_29_153 |
| ESTHER : Tsai_2021_J.Food.Drug.Anal_29_153 |
| PubMedSearch : Tsai_2021_J.Food.Drug.Anal_29_153 |
| PubMedID: |
| Title : The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease - Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| Author(s) : Hepnarova V , Korabecny J , Matouskova L , Jost P , Muckova L , Hrabinova M , Vykoukalova N , Kerhartova M , Kucera T , Dolezal R , Nepovimova E , Spilovska K , Mezeiova E , Pham NL , Jun D , Staud F , Kaping D , Kuca K , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 150 :292 , 2018 |
| Abstract : Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| ESTHER : Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| PubMedSearch : Hepnarova_2018_Eur.J.Med.Chem_150_292 |
| PubMedID: 29533874 |
| Title : The pharmacology of tacrine at N-methyl-d-aspartate receptors - Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54 |
| Author(s) : Horak M , Holubova K , Nepovimova E , Krusek J , Kaniakova M , Korabecny J , Vyklicky L , Kuca K , Stuchlik A , Ricny J , Vales K , Soukup O |
| Ref : Prog Neuropsychopharmacol Biological Psychiatry , 75 :54 , 2017 |
| Abstract : Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54 |
| ESTHER : Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54 |
| PubMedSearch : Horak_2017_Prog.Neuropsychopharmacol.Biol.Psychiatry_75_54 |
| PubMedID: 28089695 |
| Title : HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication - Psotka_2017_Mil.Med.Sci.Lett_86_70 |
| Author(s) : Psotka M , Malinak D , Gorecki L , Nguyen TD , Soukup O , Jun D , Kuca K , Musilek K , Korabecny J |
| Ref : Military Medical Science Letters , 86 :70 , 2017 |
| Abstract : Psotka_2017_Mil.Med.Sci.Lett_86_70 |
| ESTHER : Psotka_2017_Mil.Med.Sci.Lett_86_70 |
| PubMedSearch : Psotka_2017_Mil.Med.Sci.Lett_86_70 |
| PubMedID: |
| Title : Multi-target-directed therapeutic potential of 7-methoxytacrine-adamantylamine heterodimers in the Alzheimer's disease treatment - Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| Author(s) : Gazova Z , Soukup O , Sepsova V , Siposova K , Drtinova L , Jost P , Spilovska K , Korabecny J , Nepovimova E , Fedunova D , Horak M , Kaniakova M , Wang ZJ , Hamouda AK , Kuca K |
| Ref : Biochimica & Biophysica Acta Mol Basis Dis , 1863 :607 , 2017 |
| Abstract : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| ESTHER : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| PubMedSearch : Gazova_2017_Biochim.Biophys.Acta.Mol.Basis.Dis_1863_607 |
| PubMedID: 27865910 |
| Title : Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors - Babkova_2017_Future.Med.Chem_9_1015 |
| Author(s) : Babkova K , Korabecny J , Soukup O , Nepovimova E , Jun D , Kuca K |
| Ref : Future Med Chem , 9 :1015 , 2017 |
| Abstract : Babkova_2017_Future.Med.Chem_9_1015 |
| ESTHER : Babkova_2017_Future.Med.Chem_9_1015 |
| PubMedSearch : Babkova_2017_Future.Med.Chem_9_1015 |
| PubMedID: 28632451 |
| Title : Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation - Spilovska_2017_Molecules_22_ |
| Author(s) : Spilovska K , Korabecny J , Sepsova V , Jun D , Hrabinova M , Jost P , Muckova L , Soukup O , Janockova J , Kucera T , Dolezal R , Mezeiova E , Kaping D , Kuca K |
| Ref : Molecules , 22 : , 2017 |
| Abstract : Spilovska_2017_Molecules_22_ |
| ESTHER : Spilovska_2017_Molecules_22_ |
| PubMedSearch : Spilovska_2017_Molecules_22_ |
| PubMedID: 28621747 |
| Title : Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases - Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| Author(s) : Bautista-Aguilera OM , Hagenow S , Palomino-Antolin A , Farre-Alins V , Ismaili L , Joffrin PL , Jimeno ML , Soukup O , Janockova J , Kalinowsky L , Proschak E , Iriepa I , Moraleda I , Schwed JS , Romero Martinez A , Lopez-Munoz F , Chioua M , Egea J , Ramsay RR , Marco-Contelles J , Stark H |
| Ref : Angew Chem Int Ed Engl , 56 :12765 , 2017 |
| Abstract : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| ESTHER : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedSearch : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedID: 28861918 |
| Title : Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016) - Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
| Author(s) : Gorecki L , Korabecny J , Musilek K , Nepovimova E , Malinak D , Kucera T , Dolezal R , Jun D , Soukup O , Kuca K |
| Ref : Expert Opin Ther Pat , 27 :971 , 2017 |
| Abstract : Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
| ESTHER : Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
| PubMedSearch : Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
| PubMedID: 28569609 |
| Title : Synthesis, in vitro acetylcholinesterase inhibitory activity and molecular docking of new acridine-coumarin hybrids - Hamulakova_2017_Int.J.Biol.Macromol_104_333 |
| Author(s) : Hamulakova S , Janovec L , Soukup O , Jun D , Kuca K |
| Ref : Int J Biol Macromol , 104 :333 , 2017 |
| Abstract : Hamulakova_2017_Int.J.Biol.Macromol_104_333 |
| ESTHER : Hamulakova_2017_Int.J.Biol.Macromol_104_333 |
| PubMedSearch : Hamulakova_2017_Int.J.Biol.Macromol_104_333 |
| PubMedID: 28601645 |
| Title : Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy - Mezeiova_2017_Molecules_22_ |
| Author(s) : Mezeiova E , Korabecny J , Sepsova V , Hrabinova M , Jost P , Muckova L , Kucera T , Dolezal R , Misik J , Spilovska K , Pham NL , Pokrievkova L , Roh J , Jun D , Soukup O , Kaping D , Kuca K |
| Ref : Molecules , 22 : , 2017 |
| Abstract : Mezeiova_2017_Molecules_22_ |
| ESTHER : Mezeiova_2017_Molecules_22_ |
| PubMedSearch : Mezeiova_2017_Molecules_22_ |
| PubMedID: 28788095 |
| Title : Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment - Soukup_2017_Curr.Neuropharmacol_15_637 |
| Author(s) : Soukup O , Winder M , Killi UK , Wsol V , Jun D , Kuca K , Tobin G |
| Ref : Curr Neuropharmacol , 15 :637 , 2017 |
| Abstract : Soukup_2017_Curr.Neuropharmacol_15_637 |
| ESTHER : Soukup_2017_Curr.Neuropharmacol_15_637 |
| PubMedSearch : Soukup_2017_Curr.Neuropharmacol_15_637 |
| PubMedID: 27281175 |
| Title : Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease - Spilovska_2017_Curr.Top.Med.Chem_17_1006 |
| Author(s) : Spilovska K , Korabecny J , Nepovimova E , Dolezal R , Mezeiova E , Soukup O , Kuca K |
| Ref : Curr Top Med Chem , 17 :1006 , 2017 |
| Abstract : Spilovska_2017_Curr.Top.Med.Chem_17_1006 |
| ESTHER : Spilovska_2017_Curr.Top.Med.Chem_17_1006 |
| PubMedSearch : Spilovska_2017_Curr.Top.Med.Chem_17_1006 |
| PubMedID: 27697055 |
| Title : Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies - Dolezal_2016_Eur.J.Med.Chem_121_699 |
| Author(s) : Dolezal R , Soukup O , Malinak D , Savedra RML , Marek J , Dolezalova M , Pasdiorova M , Salajkova S , Korabecny J , Honegr J , Ramalho TC , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 121 :699 , 2016 |
| Abstract : Dolezal_2016_Eur.J.Med.Chem_121_699 |
| ESTHER : Dolezal_2016_Eur.J.Med.Chem_121_699 |
| PubMedSearch : Dolezal_2016_Eur.J.Med.Chem_121_699 |
| PubMedID: 27341309 |
| Title : SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides - Gorecki_2016_Arch.Toxicol_90_2831 |
| Author(s) : Gorecki L , Korabecny J , Musilek K , Malinak D , Nepovimova E , Dolezal R , Jun D , Soukup O , Kuca K |
| Ref : Archives of Toxicology , 90 :2831 , 2016 |
| Abstract : Gorecki_2016_Arch.Toxicol_90_2831 |
| ESTHER : Gorecki_2016_Arch.Toxicol_90_2831 |
| PubMedSearch : Gorecki_2016_Arch.Toxicol_90_2831 |
| PubMedID: 27582056 |
| Title : Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease - Prati_2016_ChemMedChem_11_1284 |
| Author(s) : Prati F , Bergamini C , Fato R , Soukup O , Korabecny J , Andrisano V , Bartolini M , Bolognesi ML |
| Ref : ChemMedChem , 11 :1284 , 2016 |
| Abstract : Prati_2016_ChemMedChem_11_1284 |
| ESTHER : Prati_2016_ChemMedChem_11_1284 |
| PubMedSearch : Prati_2016_ChemMedChem_11_1284 |
| PubMedID: 26880501 |
| Title : Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1 - Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45 |
| Author(s) : Kristofikova Z , Ricny J , Soukup O , Korabecny J , Nepovimova E , Kuca K , Ripova D |
| Ref : Dementia & Geriatric Cognitive Disorders , 43 :45 , 2016 |
| Abstract : Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45 |
| ESTHER : Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45 |
| PubMedSearch : Kristofikova_2016_Dement.Geriatr.Cogn.Disord_43_45 |
| PubMedID: 27988521 |
| Title : Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease - Benek_2016_ChemMedChem_11_1264 |
| Author(s) : Benek O , Soukup O , Pasdiorova M , Hroch L , Sepsova V , Jost P , Hrabinova M , Jun D , Kuca K , Zala D , Ramsay RR , Marco-Contelles J , Musilek K |
| Ref : ChemMedChem , 11 :1264 , 2016 |
| Abstract : Benek_2016_ChemMedChem_11_1264 |
| ESTHER : Benek_2016_ChemMedChem_11_1264 |
| PubMedSearch : Benek_2016_ChemMedChem_11_1264 |
| PubMedID: 26427608 |
| Title : Assessment of DNA-binding affinity of cholinesterase reactivators and electrophoretic determination of their effect on topoisomerase I and II activity - Janockova_2016_Mol.Biosyst_12_2910 |
| Author(s) : Janockova J , Zilecka E , Kasparkova J , Brabec V , Soukup O , Kuca K , Kozurkova M |
| Ref : Mol Biosyst , 12 :2910 , 2016 |
| Abstract : Janockova_2016_Mol.Biosyst_12_2910 |
| ESTHER : Janockova_2016_Mol.Biosyst_12_2910 |
| PubMedSearch : Janockova_2016_Mol.Biosyst_12_2910 |
| PubMedID: 27412811 |
| Title : Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease - Jerabek_2016_Eur.J.Med.Chem_127_250 |
| Author(s) : Jerabek J , Uliassi E , Guidotti L , Korabecny J , Soukup O , Sepsova V , Hrabinova M , Kuca K , Bartolini M , Pena-Altamira LE , Petralla S , Monti B , Roberti M , Bolognesi ML |
| Ref : Eur Journal of Medicinal Chemistry , 127 :250 , 2016 |
| Abstract : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| ESTHER : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| PubMedSearch : Jerabek_2016_Eur.J.Med.Chem_127_250 |
| PubMedID: 28064079 |
| Title : Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation - Panek_2016_Eur.J.Med.Chem_125_676 |
| Author(s) : Panek D , Wieckowska A , Wichur T , Bajda M , Godyn J , Jonczyk J , Mika K , Janockova J , Soukup O , Knez D , Korabecny J , Gobec S , Malawska B |
| Ref : Eur Journal of Medicinal Chemistry , 125 :676 , 2016 |
| Abstract : Panek_2016_Eur.J.Med.Chem_125_676 |
| ESTHER : Panek_2016_Eur.J.Med.Chem_125_676 |
| PubMedSearch : Panek_2016_Eur.J.Med.Chem_125_676 |
| PubMedID: 27721153 |
| Title : Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy - Dgachi_2016_Eur.J.Med.Chem_126_576 |
| Author(s) : Dgachi Y , Sokolov O , Luzet V , Godyn J , Panek D , Bonet A , Martin H , Iriepa I , Moraleda I , Garcia-Iriepa C , Janockova J , Richert L , Soukup O , Malawska B , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Eur Journal of Medicinal Chemistry , 126 :576 , 2016 |
| Abstract : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| ESTHER : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| PubMedSearch : Dgachi_2016_Eur.J.Med.Chem_126_576 |
| PubMedID: 27918993 |
| Title : Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules - Hamulakova_2016_J.Inorg.Biochem_161_52 |
| Author(s) : Hamulakova S , Poprac P , Jomova K , Brezova V , Lauro P , Drostinova L , Jun D , Sepsova V , Hrabinova M , Soukup O , Kristian P , Gazova Z , Bednarikova Z , Kuca K , Valko M |
| Ref : J Inorg Biochem , 161 :52 , 2016 |
| Abstract : Hamulakova_2016_J.Inorg.Biochem_161_52 |
| ESTHER : Hamulakova_2016_J.Inorg.Biochem_161_52 |
| PubMedSearch : Hamulakova_2016_J.Inorg.Biochem_161_52 |
| PubMedID: 27230386 |
| Title : A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication - Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
| Author(s) : Nepovimova E , Korabecny J , Dolezal R , Nguyen TD , Jun D , Soukup O , Pasdiorova M , Jost P , Muckova L , Malinak D , Gorecki L , Musilek K , Kuca K |
| Ref : Toxicol Res (Camb) , 5 :1012 , 2016 |
| Abstract : Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
| ESTHER : Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
| PubMedSearch : Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
| PubMedID: 30090408 |
| Title : The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators - Benchekroun_2016_J.Med.Chem_59_9967 |
| Author(s) : Benchekroun M , Romero A , Egea J , Leon R , Michalska P , Buendia I , Jimeno ML , Jun D , Janockova J , Sepsova V , Soukup O , Bautista-Aguilera OM , Refouvelet B , Ouari O , Marco-Contelles J , Ismaili L |
| Ref : Journal of Medicinal Chemistry , 59 :9967 , 2016 |
| Abstract : Benchekroun_2016_J.Med.Chem_59_9967 |
| ESTHER : Benchekroun_2016_J.Med.Chem_59_9967 |
| PubMedSearch : Benchekroun_2016_J.Med.Chem_59_9967 |
| PubMedID: 27736061 |
| Title : Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease - Dgachi_2016_Molecules_21_ |
| Author(s) : Dgachi Y , Bautista-Aguilera OM , Benchekroun M , Martin H , Bonet A , Knez D , Godyn J , Malawska B , Gobec S , Chioua M , Janockova J , Soukup O , Chabchoub F , Marco-Contelles J , Ismaili L |
| Ref : Molecules , 21 : , 2016 |
| Abstract : Dgachi_2016_Molecules_21_ |
| ESTHER : Dgachi_2016_Molecules_21_ |
| PubMedSearch : Dgachi_2016_Molecules_21_ |
| PubMedID: 27187348 |
| Title : Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE - Kuca_2015_Med.Chem_11_683 |
| Author(s) : Kuca K , Hrabinova M , Jun D , Musilek K , Penhaker M , Krejcar O , Soukup O |
| Ref : Med Chem , 11 :683 , 2015 |
| Abstract : Kuca_2015_Med.Chem_11_683 |
| ESTHER : Kuca_2015_Med.Chem_11_683 |
| PubMedSearch : Kuca_2015_Med.Chem_11_683 |
| PubMedID: 25845909 |
| Title : Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity - Nepovimova_2015_J.Med.Chem_58_8985 |
| Author(s) : Nepovimova E , Korabecny J , Dolezal R , Babkova K , Ondrejicek A , Jun D , Sepsova V , Horova A , Hrabinova M , Soukup O , Bukum N , Jost P , Muckova L , Kassa J , Malinak D , Andrs M , Kuca K |
| Ref : Journal of Medicinal Chemistry , 58 :8985 , 2015 |
| Abstract : Nepovimova_2015_J.Med.Chem_58_8985 |
| ESTHER : Nepovimova_2015_J.Med.Chem_58_8985 |
| PubMedSearch : Nepovimova_2015_J.Med.Chem_58_8985 |
| PubMedID: 26503905 |
| Title : 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment - Korabecny_2015_Molecules_20_22084 |
| Author(s) : Korabecny J , Andrs M , Nepovimova E , Dolezal R , Babkova K , Horova A , Malinak D , Mezeiova E , Gorecki L , Sepsova V , Hrabinova M , Soukup O , Jun D , Kuca K |
| Ref : Molecules , 20 :22084 , 2015 |
| Abstract : Korabecny_2015_Molecules_20_22084 |
| ESTHER : Korabecny_2015_Molecules_20_22084 |
| PubMedSearch : Korabecny_2015_Molecules_20_22084 |
| PubMedID: 26690394 |
| Title : Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease - Lemes_2015_Eur.J.Med.Chem_108_687 |
| Author(s) : Lemes LF , de Andrade Ramos G , de Oliveira AS , da Silva FM , de Castro Couto G , da Silva Boni M , Guimaraes MJ , Souza IN , Bartolini M , Andrisano V , do Nascimento Nogueira PC , Silveira ER , Brand GD , Soukup O , Korabecny J , Romeiro NC , Castro NG , Bolognesi ML , Romeiro LA |
| Ref : Eur Journal of Medicinal Chemistry , 108 :687 , 2015 |
| Abstract : Lemes_2015_Eur.J.Med.Chem_108_687 |
| ESTHER : Lemes_2015_Eur.J.Med.Chem_108_687 |
| PubMedSearch : Lemes_2015_Eur.J.Med.Chem_108_687 |
| PubMedID: 26735910 |
| Title : Cholinergic properties of new 7-methoxytacrine-donepezil derivatives - Sepsova_2015_Gen.Physiol.Biophys_34_189 |
| Author(s) : Sepsova V , Karasova JZ , Tobin G , Jun D , Korabecny J , Cabelova P , Janska K , Krusek J , Skrenkova K , Kuca K , Soukup O |
| Ref : Gen Physiol Biophys , 34 :189 , 2015 |
| Abstract : Sepsova_2015_Gen.Physiol.Biophys_34_189 |
| ESTHER : Sepsova_2015_Gen.Physiol.Biophys_34_189 |
| PubMedSearch : Sepsova_2015_Gen.Physiol.Biophys_34_189 |
| PubMedID: 25504063 |
| Title : In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat - Killi_2014_Clin.Exp.Pharmacol.Physiol_41_139 |
| Author(s) : Killi UK , Wsol V , Soukup O , Kuca K , Winder M , Tobin G |
| Ref : Clinical & Experimental Pharmacology & Physiology , 41 :139 , 2014 |
| Abstract : Killi_2014_Clin.Exp.Pharmacol.Physiol_41_139 |
| ESTHER : Killi_2014_Clin.Exp.Pharmacol.Physiol_41_139 |
| PubMedSearch : Killi_2014_Clin.Exp.Pharmacol.Physiol_41_139 |
| PubMedID: 24341923 |
| Title : From Pyridinium-based to Centrally Active Acetylcholinesterase Reactivators - Korabecny_2014_Mini.Rev.Med.Chem_14_215 |
| Author(s) : Korabecny J , Soukup O , Dolezal R , Spilovska K , Nepovimova E , Andrs M , Nguyen TD , Jun D , Musilek K , Kucerova-Chlupacova M , Kuca K |
| Ref : Mini Rev Med Chem , 14 :215 , 2014 |
| Abstract : Korabecny_2014_Mini.Rev.Med.Chem_14_215 |
| ESTHER : Korabecny_2014_Mini.Rev.Med.Chem_14_215 |
| PubMedSearch : Korabecny_2014_Mini.Rev.Med.Chem_14_215 |
| PubMedID: 24552265 |
| Title : The interaction of quaternary reversible acetylcholinesterase inhibitors with the nicotinic receptor - Sepsova_2014_Physiol.Res_63_771 |
| Author(s) : Sepsova V , Krusek J , Karasova JZ , Zemek F , Musilek K , Kuca K , Soukup O |
| Ref : Physiol Res , 63 :771 , 2014 |
| Abstract : Sepsova_2014_Physiol.Res_63_771 |
| ESTHER : Sepsova_2014_Physiol.Res_63_771 |
| PubMedSearch : Sepsova_2014_Physiol.Res_63_771 |
| PubMedID: 25157661 |
| Title : Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX - Kuca_2013_Med.Chem_9_689 |
| Author(s) : Kuca K , Musilek K , Jun D , Karasova J , Soukup O , Pejchal J , Hrabinova M |
| Ref : Med Chem , 9 :689 , 2013 |
| Abstract : Kuca_2013_Med.Chem_9_689 |
| ESTHER : Kuca_2013_Med.Chem_9_689 |
| PubMedSearch : Kuca_2013_Med.Chem_9_689 |
| PubMedID: 22779796 |
| Title : 7-methoxytacrine-adamantylamine heterodimers as cholinesterase inhibitors in alzheimer's disease treatment, synthesis, biological evaluation and molecular modeling studies - Spilovska_2013_Molecules_18_2397 |
| Author(s) : Spilovska K , Korabecny J , Kral J , Horova A , Musilek K , Soukup O , Drtinova L , Gazova Z , Siposova K , Kuca K |
| Ref : Molecules , 18 :2397 , 2013 |
| Abstract : Spilovska_2013_Molecules_18_2397 |
| ESTHER : Spilovska_2013_Molecules_18_2397 |
| PubMedSearch : Spilovska_2013_Molecules_18_2397 |
| PubMedID: 23429378 |
| Title : A Resurrection of 7-MEOTA: A Comparison with Tacrine - Soukup_2013_Curr.Alzheimer.Res_10_893 |
| Author(s) : Soukup O , Jun D , Karasova JZ , Patocka J , Musilek K , Korabecny J , Krusek J , Kaniakova M , Sepsova V , Mandikova J , Trejtnar F , Pohanka M , Drtinova L , Pavlik M , Tobin G , Kuca K |
| Ref : Curr Alzheimer Res , 10 :893 , 2013 |
| Abstract : Soukup_2013_Curr.Alzheimer.Res_10_893 |
| ESTHER : Soukup_2013_Curr.Alzheimer.Res_10_893 |
| PubMedSearch : Soukup_2013_Curr.Alzheimer.Res_10_893 |
| PubMedID: 24093535 |
| Title : The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors - Soukup_2013_Arch.Toxicol_87_711 |
| Author(s) : Soukup O , Jun D , Tobin G , Kuca K |
| Ref : Archives of Toxicology , 87 :711 , 2013 |
| Abstract : Soukup_2013_Arch.Toxicol_87_711 |
| ESTHER : Soukup_2013_Arch.Toxicol_87_711 |
| PubMedSearch : Soukup_2013_Arch.Toxicol_87_711 |
| PubMedID: 23179755 |
| Title : Prophylaxis and Post-exposure Treatment of Intoxications Caused by Nerve Agents and Organophosphorus Pesticides - Kuca_2013_Mini.Rev.Med.Chem_13_2102 |
| Author(s) : Kuca K , Jun D , Musilek K , Pohanka M , Karasova JZ , Soukup O |
| Ref : Mini Rev Med Chem , 13 :2102 , 2013 |
| Abstract : Kuca_2013_Mini.Rev.Med.Chem_13_2102 |
| ESTHER : Kuca_2013_Mini.Rev.Med.Chem_13_2102 |
| PubMedSearch : Kuca_2013_Mini.Rev.Med.Chem_13_2102 |
| PubMedID: 24195661 |
| Title : The interaction of standard oxime reactivators with hemicholinium-3 sensitive choline carriers - Soukup_2012_Toxicol.Lett_212_315 |
| Author(s) : Soukup O , Kristofikova Z , Jun D , Tambor V , Ripova D , Kuca K |
| Ref : Toxicol Lett , 212 :315 , 2012 |
| Abstract : Soukup_2012_Toxicol.Lett_212_315 |
| ESTHER : Soukup_2012_Toxicol.Lett_212_315 |
| PubMedSearch : Soukup_2012_Toxicol.Lett_212_315 |
| PubMedID: 22683831 |
| Title : [Tacrine and its derivatives in the therapy of Alzheimers disease] - Korabecny_2012_Ceska.Slov.Farm_61_210 |
| Author(s) : Korabecny J , Spilovska K , Benek O , Musilek K , Soukup O , Kuca K |
| Ref : Ceska a Slovenska Farmacie , 61 :210 , 2012 |
| Abstract : Korabecny_2012_Ceska.Slov.Farm_61_210 |
| ESTHER : Korabecny_2012_Ceska.Slov.Farm_61_210 |
| PubMedSearch : Korabecny_2012_Ceska.Slov.Farm_61_210 |
| PubMedID: 23256654 |
| Title : On the universality of oxime Hl-7 - antidote for case of the nerve agent poisoning - Kuca_2011_Mil.Med.Sci.Lett_80_80 |
| Author(s) : Kuca K , Musilek K , Karasova J , Jun D , Soukup O , Pohanka M , Ghosh KK , Hrabinova M |
| Ref : Military Medical Science Letters , 80 :80 , 2011 |
| Abstract : Kuca_2011_Mil.Med.Sci.Lett_80_80 |
| ESTHER : Kuca_2011_Mil.Med.Sci.Lett_80_80 |
| PubMedSearch : Kuca_2011_Mil.Med.Sci.Lett_80_80 |
| PubMedID: |
| Title : The effect of oxime reactivators on muscarinic receptors: functional and binding examinations - Soukup_2011_Environ.Toxicol.Pharmacol_31_364 |
| Author(s) : Soukup O , Kumar UK , Proska J , Bratova L , Adem A , Jun D , Fusek J , Kuca K , Tobin G |
| Ref : Environ Toxicol Pharmacol , 31 :364 , 2011 |
| Abstract : Soukup_2011_Environ.Toxicol.Pharmacol_31_364 |
| ESTHER : Soukup_2011_Environ.Toxicol.Pharmacol_31_364 |
| PubMedSearch : Soukup_2011_Environ.Toxicol.Pharmacol_31_364 |
| PubMedID: 21787706 |
| Title : Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors - Soukup_2011_Physiol.Res_60_679 |
| Author(s) : Soukup O , Krusek J , Kaniakova M , Kumar UK , Oz M , Jun D , Fusek J , Kuca K , Tobin G |
| Ref : Physiol Res , 60 :679 , 2011 |
| Abstract : Soukup_2011_Physiol.Res_60_679 |
| ESTHER : Soukup_2011_Physiol.Res_60_679 |
| PubMedSearch : Soukup_2011_Physiol.Res_60_679 |
| PubMedID: 21574759 |
| Title : Novel acetylcholinesterase reactivator K112 and its cholinergic properties - Soukup_2010_Biomed.Pharmacother_64_541 |
| Author(s) : Soukup O , Kristofikova Z , Proska J , Tobin G , Patocka J , Marek J , Jun D , Fusek J , Ripova D , Kuca K |
| Ref : Biomed Pharmacother , 64 :541 , 2010 |
| Abstract : Soukup_2010_Biomed.Pharmacother_64_541 |
| ESTHER : Soukup_2010_Biomed.Pharmacother_64_541 |
| PubMedSearch : Soukup_2010_Biomed.Pharmacother_64_541 |
| PubMedID: 20634031 |
| Title : Interaction of nerve agent antidotes with cholinergic systems - Soukup_2010_Curr.Med.Chem_17_1708 |
| Author(s) : Soukup O , Tobin G , Kumar UK , Binder J , Proska J , Jun D , Fusek J , Kuca K |
| Ref : Curr Med Chem , 17 :1708 , 2010 |
| Abstract : Soukup_2010_Curr.Med.Chem_17_1708 |
| ESTHER : Soukup_2010_Curr.Med.Chem_17_1708 |
| PubMedSearch : Soukup_2010_Curr.Med.Chem_17_1708 |
| PubMedID: 20345348 |
| Title : Pralidoxime--the gold standard of acetylcholinesterase reactivators--reactivation in vitro efficacy - Kuca_2010_Bratisl.Lek.Listy_111_502 |
| Author(s) : Kuca K , Hrabinova M , Soukup O , Tobin G , Karasova J , Pohanka M |
| Ref : Bratislavske Lekarske Listy , 111 :502 , 2010 |
| Abstract : Kuca_2010_Bratisl.Lek.Listy_111_502 |
| ESTHER : Kuca_2010_Bratisl.Lek.Listy_111_502 |
| PubMedSearch : Kuca_2010_Bratisl.Lek.Listy_111_502 |
| PubMedID: 21180265 |
| Title : Characterization of the anticholinergic properties of obidoxime\; functional examinations of the rat atria and the urinary bladder - Soukup_2010_Toxicol.Mech.Methods_20_428 |
| Author(s) : Soukup O , Tobin G , Kumar UK , Jun D , Fusek J , Kuca K |
| Ref : Toxicol Mech Methods , 20 :428 , 2010 |
| Abstract : Soukup_2010_Toxicol.Mech.Methods_20_428 |
| ESTHER : Soukup_2010_Toxicol.Mech.Methods_20_428 |
| PubMedSearch : Soukup_2010_Toxicol.Mech.Methods_20_428 |
| PubMedID: 20602545 |
| Title : Reactivation of human brain homogenate cholinesterases inhibited by Tabun using newly developed oximes K117 and K127 - Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
| Author(s) : Kuca K , Cabal J , Jung YS , Musilek K , Soukup O , Jun D , Pohanka M , Musilova L , Karasova J , Novotny L , Hrabinova M |
| Ref : Basic Clin Pharmacol Toxicol , 105 :207 , 2009 |
| Abstract : Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
| ESTHER : Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
| PubMedSearch : Kuca_2009_Basic.Clin.Pharmacol.Toxicol_105_207 |
| PubMedID: 19473310 |
| Title : The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder - Soukup_2008_Neuro.Endocrinol.Lett_29_759 |
| Author(s) : Soukup O , Pohanka M , Tobin G , Jun D , Fusek J , Musilek K , Marek J , Kassa J , Kuca K |
| Ref : Neuro Endocrinol Lett , 29 :759 , 2008 |
| Abstract : Soukup_2008_Neuro.Endocrinol.Lett_29_759 |
| ESTHER : Soukup_2008_Neuro.Endocrinol.Lett_29_759 |
| PubMedSearch : Soukup_2008_Neuro.Endocrinol.Lett_29_759 |
| PubMedID: 18987577 |