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Author Report for: Tunek A

Contact information:

Tunek Anders
Lead Generation DMPK & Physical Chemistry, Lead Generation Computational Chemistry, Discovery DMPK and Bioanalytical Chemistry, AstraZeneca R&D, Molndal, SE-431 88
Sweden
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    Title: Synthesis and enzymatic hydrolysis of esters, constituting simple models of soft drugs
    Graffner-Nordberg M, Sjodin K, Tunek A, Hallberg A
    Ref: Chem Pharm Bull (Tokyo), 46:591, 1998 : PubMed

            

    Title: Reversible fatty acid conjugation of budesonide. Novel mechanism for prolonged retention of topically applied steroid in airway tissue
    Miller-Larsson A, Mattsson H, Hjertberg E, Dahlback M, Tunek A, Brattsand R
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 26:623, 1998 : PubMed

            

    Title: Pharmacologic importance of the reversible fatty acid conjugation of budesonide studied in a rat cell line In vitro
    Wieslander E, Delander EL, Jarkelid L, Hjertberg E, Tunek A, Brattsand R
    Ref: American Journal of Respiratory Cellular & Molecular Biology, 19:477, 1998 : PubMed

            

    Title: Reversible formation of fatty acid esters of budesonide, an antiasthma glucocorticoid, in human lung and liver microsomes
    Tunek A, Sjodin K, Hallstrom G
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 25:1311, 1997 : PubMed

            

    Title: Interactions of bambuterol with human serum cholinesterase of the genotypes EuEu (normal), EaEa (atypical) and EuEa
    Tunek A, Hjertberg E, Mogensen JV
    Ref: Biochemical Pharmacology, 41:345, 1991 : PubMed

            

    Title: Determination of bambuterol, a prodrug of terbutaline, in plasma and urine by gas chromatography/mass spectrometry
    Lindberg C, Jonsson S, Paulson J, Tunek A
    Ref: Biomed Environ Mass Spectrom, 19:218, 1990 : PubMed

            

    Title: Metabolism of bambuterol in rat liver microsomes: identification of hydroxylated and demethylated products by liquid chromatography mass spectrometry
    Lindberg C, Roos C, Tunek A, Svensson LA
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 17:311, 1989 : PubMed

            

    Title: Bambuterol: uptake and metabolism in guinea pig isolated lungs
    Ryrfeldt A, Nilsson E, Tunek A, Svensson LA
    Ref: Pharm Res, 5:151, 1988 : PubMed

            

    Title: The design and bioactivation of presystemically stable prodrugs
    Svensson LA, Tunek A
    Ref: Drug Metabolism Reviews, 19:165, 1988 : PubMed

            

    Title: Hydrolysis of 3H-bambuterol, a carbamate prodrug of terbutaline, in blood from humans and laboratory animals in vitro
    Tunek A, Levin E, Svensson LA
    Ref: Biochemical Pharmacology, 37:3867, 1988 : PubMed

            

    Title: Bambuterol, a carbamate ester prodrug of terbutaline, as inhibitor of cholinesterases in human blood
    Tunek A, Svensson LA
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 16:759, 1988 : PubMed

            

    Title: Poster 65. Bambuterol, a terbulaline carbamate prodrug, as substrate and inhibitor for cholinesterase in human blood
    Tunek A
    Ref: In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases, (Brzin M, Barnard EA, Sket D, Eds) De Gruyter:, 1984 : PubMed

            


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