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Author Report for: Weik M

Contact information:

Weik Martin
Institut de Biologie Structurale; 41 rue Jules Horowitz; Grenoble; 38027
Phone : +33 4 38 78 95 80
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    Title: Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model.
    Dighe SN, De la Mora E, Chan S, Kantham S, McColl G, Miles JA, Veliyath SK, Sreenivas BY, Nassar ZD and Ross BP <6 more author(s)>
    Ref: Communications chemistry, 2:35, 2019 : PubMed


    Title: Novel multitarget-directed ligands targeting acetylcholinesterase and sigma1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase
    Lalut J, Santoni G, Karila D, Lecoutey C, Davis A, Nachon F, Silman I, Sussman JL, Weik M and Rochais C <2 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 162:234, 2019 : PubMed


    Title: Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
    Santoni G, de Sousa J, De la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD and Nachon F <2 more author(s)>
    Ref: Journal of Medicinal Chemistry, 61:7630, 2018 : PubMed


    Title: Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration
    Zorbaz T, Braiki A, Marakovic N, Renou J, De la Mora E, Macek Hrvat N, Katalinic M, Silman I, Sussman JL and Renard PY <9 more author(s)>
    Ref: Chemistry, 24:9675, 2018 : PubMed


    Title: The role of protein dynamics in the evolution of new enzyme function
    Campbell EC, Kaltenbach M, Correy GJ, Carr PD, Porebski BT, Livingstone EK, Afriat-Jurnou L, Buckle AM, Weik M and Jackson CJ <2 more author(s)>
    Ref: Nat Chemical Biology, 12:944, 2016 : PubMed


    Title: Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein IrisFP
    Colletier JP, Sliwa M, Gallat FX, Sugahara M, Guillon V, Schiro G, Coquelle N, Woodhouse J, Roux L and Weik M <15 more author(s)>
    Ref: J Phys Chem Lett, 7:882, 2016 : PubMed


    Title: Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography
    Correy GJ, Carr PD, Meirelles T, Mabbitt PD, Fraser NJ, Weik M, Jackson CJ
    Ref: Structure, 24:977, 2016 : PubMed


    Title: Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability
    Fraser NJ, Liu JW, Mabbitt PD, Correy GJ, Coppin CW, Lethier M, Perugini MA, Murphy JM, Oakeshott JG and Jackson CJ <1 more author(s)>
    Ref: Journal of Molecular Biology, 428:2359, 2016 : PubMed


    Title: Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase
    Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboleas M, Loiodice M, Weik M and Baati R <3 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 78C:455, 2014 : PubMed


    Title: Reaction site-driven regioselective synthesis of AChE inhibitors
    Oueis E, Santoni G, Ronco C, Syzgantseva O, Tognetti V, Joubert L, Romieu A, Weik M, Jean L and Renard PY <2 more author(s)>
    Ref: Org Biomol Chem, 12:156, 2014 : PubMed


    Title: Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds
    Trapp M, Tehei M, Trovaslet M, Nachon F, Martinez N, Koza MM, Weik M, Masson P, Peters J
    Ref: J R Soc Interface, 11:, 2014 : PubMed


    Title: Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry
    Carletti E, Colletier JP, Schopfer LM, Santoni G, Masson P, Lockridge O, Nachon F, Weik M
    Ref: Chemical Research in Toxicology, 26:280, 2013 : PubMed


    Title: Structure and function of an insect alpha-carboxylesterase (alphaEsterase7) associated with insecticide resistance
    Jackson CJ, Liu JW, Carr PD, Younus F, Coppin C, Meirelles T, Lethier M, Pandey G, Ollis DL and Oakeshott JG <2 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 110:10177, 2013 : PubMed


    Title: Relation between dynamics, activity and thermal stability within the cholinesterase family
    Trovaslet M, Trapp M, Weik M, Nachon F, Masson P, Tehei M, Peters J
    Ref: Chemico-Biological Interactions, 203:14, 2013 : PubMed


    Title: Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography
    Ronco C, Carletti E, Colletier JP, Weik M, Nachon F, Jean L, Renard PY
    Ref: ChemMedChem, 7:400, 2012 : PubMed


    Title: Energy landscapes of human acetylcholinesterase and its huperzine a-inhibited counterpart
    Trapp M, Trovaslet M, Nachon F, Koza MM, van Eijck L, Hill F, Weik M, Masson P, Tehei M, Peters J
    Ref: J Phys Chem B, 116:14744, 2012 : PubMed


    Title: Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis
    Carletti E, Schopfer LM, Colletier JP, Froment MT, Nachon F, Weik M, Lockridge O, Masson P
    Ref: Chemical Research in Toxicology, 24:797, 2011 : PubMed


    Title: Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations
    Sanson B, Colletier JP, Xu Y, Lang PT, Jiang H, Silman I, Sussman JL, Weik M
    Ref: Protein Science, 20:1114, 2011 : PubMed


    Title: Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase
    Xu Y, Colletier JP, Weik M, Qin G, Jiang H, Silman I, Sussman JL
    Ref: Biophysical Journal, 99:4003, 2010 : PubMed


    Title: Direct correlation between molecular dynamics and enzymatic stability: a comparative neutron scattering study of native human butyrylcholinesterase and its aged soman conjugate
    Gabel F, Masson P, Froment MT, Doctor BP, Saxena A, Silman I, Zaccai G, Weik M
    Ref: Biophysical Journal, 96:1489, 2009 : PubMed


    Title: Kinetic insight into the mechanism of cholinesterasterase inhibition by aflatoxin B1 to develop biosensors
    Hansmann T, Sanson B, Stojan J, Weik M, Marty JL, Fournier D
    Ref: Biosensors & Bioelectronics, 24:2119, 2009 : PubMed


    Title: Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime
    Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P and Weik M <1 more author(s)>
    Ref: Journal of Medicinal Chemistry, 52:7593, 2009 : PubMed


    Title: Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography
    Colletier JP, Bourgeois D, Sanson B, Fournier D, Sussman JL, Silman I, Weik M
    Ref: Proc Natl Acad Sci U S A, 105:11742, 2008 : PubMed


    Title: Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design
    Xu Y, Colletier JP, Jiang H, Silman I, Sussman JL, Weik M
    Ref: Protein Science, 17:601, 2008 : PubMed


    Title: Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics
    Xu Y, Colletier JP, Weik M, Jiang H, Moult J, Silman I, Sussman JL
    Ref: Biophysical Journal, 95:2500, 2008 : PubMed


    Title: Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography
    Colletier JP, Royant A, Specht A, Sanson B, Nachon F, Masson P, Zaccai G, Sussman JL, Goeldner M and Weik M <2 more author(s)>
    Ref: Acta Crystallographica D Biol Crystallogr, 63:1115, 2007 : PubMed


    Title: [Exploring the conformational energy landscape of acetylcholinesterase by kinetic crystallography]
    Colletier JP, Weik M
    Ref: Ann Pharm Fr, 65:108, 2007 : PubMed


    Title: Mechanisms of cholinesterase inhibition by inorganic mercury
    Frasco MF, Colletier JP, Weik M, Carvalho F, Guilhermino L, Stojan J, Fournier D
    Ref: Febs J, 274:1849, 2007 : PubMed


    Title: Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor
    Colletier JP, Sanson B, Nachon F, Gabellieri E, Fattorusso C, Campiani G, Weik M
    Ref: Journal of the American Chemical Society, 128:4526, 2006 : PubMed


    Title: Structural insights into substrate traffic and inhibition in acetylcholinesterase
    Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M
    Ref: EMBO Journal, 25:2746, 2006 : PubMed


    Title: Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study
    Gabel F, Weik M, Masson P, Renault F, Fournier D, Brochier L, Doctor BP, Saxena A, Silman I, Zaccai G
    Ref: Biophysical Journal, 89:3303, 2005 : PubMed


    Title: Poster (74) Structural studies on torpedo californica acetylcholinesterase in complex with a substrate analogue
    Colletier JP, Fournier D, Greenblatt HM, Sussman JL, Zaccai G, Silman I, Weik M
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:359, 2004 : PubMed


    Title: The influence of solvent composition on global dynamics of human butyrylcholinesterase powders: a neutron-scattering study
    Gabel F, Weik M, Doctor BP, Saxena A, Fournier D, Brochier L, Renault F, Masson P, Silman I, Zaccai G
    Ref: Biophysical Journal, 86:3152, 2004 : PubMed


    Title: Temperature derivative fluorescence spectroscopy as a tool to study dynamical changes in protein crystals
    Weik M, Vernede X, Royant A, Bourgeois D
    Ref: Biophysical Journal, 86:3176, 2004 : PubMed


    Title: Poster (54) Experimental approaches to study the dynamics of cholinesterases.
    Weik M
    Ref: In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects, (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina:349, 2004 : PubMed


    Title: Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation
    Weik M, Berges J, Raves ML, Gros P, McSweeney S, Silman I, Sussman JL, Houee-Levin C, Ravelli RB
    Ref: J Synchrotron Radiat, 9:342, 2002 : PubMed


    Title: Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes
    Weik M, Ravelli RB, Silman I, Sussman JL, Gros P, Kroon J
    Ref: Protein Science, 10:1953, 2001 : PubMed


    Title: Specific chemical and structural damage to proteins produced by synchrotron radiation
    Weik M, Ravelli RB, Kryger G, McSweeney S, Raves ML, Harel M, Gros P, Silman I, Kroon J, Sussman JL
    Ref: Proceedings of the National Academy of Sciences of the United States of America, 97:623, 2000 : PubMed


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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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