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| Title : Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer - Wierdl_2016_Br.J.Pharmacol_173_2811 |
| Author(s) : Wierdl M , Tsurkan L , Hatfield MJ , Potter PM |
| Ref : British Journal of Pharmacology , 173 :2811 , 2016 |
| Abstract : Wierdl_2016_Br.J.Pharmacol_173_2811 |
| ESTHER : Wierdl_2016_Br.J.Pharmacol_173_2811 |
| PubMedSearch : Wierdl_2016_Br.J.Pharmacol_173_2811 |
| PubMedID: 27423046 |
| Title : Carboxylesterases: General detoxifying enzymes - Hatfield_2016_Chem.Biol.Interact_259_327 |
| Author(s) : Hatfield MJ , Umans RA , Hyatt JL , Edwards CC , Wierdl M , Tsurkan L , Taylor MR , Potter PM |
| Ref : Chemico-Biological Interactions , 259 :327 , 2016 |
| Abstract : Hatfield_2016_Chem.Biol.Interact_259_327 |
| ESTHER : Hatfield_2016_Chem.Biol.Interact_259_327 |
| PubMedSearch : Hatfield_2016_Chem.Biol.Interact_259_327 |
| PubMedID: 26892220 |
| Title : Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism - Yu_2012_J.Mol.Model_18_2869 |
| Author(s) : Yu X , Sigler SC , Hossain D , Wierdl M , Gwaltney SR , Potter PM , Wadkins RM |
| Ref : J Mol Model , 18 :2869 , 2012 |
| Abstract : Yu_2012_J.Mol.Model_18_2869 |
| ESTHER : Yu_2012_J.Mol.Model_18_2869 |
| PubMedSearch : Yu_2012_J.Mol.Model_18_2869 |
| PubMedID: 22127613 |
| Title : Nerve agent hydrolysis activity designed into a human drug metabolism enzyme - Hemmert_2011_PLoS.One_6_e17441 |
| Author(s) : Hemmert AC , Otto TC , Chica RA , Wierdl M , Edwards JS , Lewis SM , Edwards CC , Tsurkan L , Cadieux CL , Kasten SA , Cashman JR , Mayo SL , Potter PM , Cerasoli DM , Redinbo MR |
| Ref : PLoS ONE , 6 :e17441 , 2011 |
| Abstract : Hemmert_2011_PLoS.One_6_e17441 |
| ESTHER : Hemmert_2011_PLoS.One_6_e17441 |
| PubMedSearch : Hemmert_2011_PLoS.One_6_e17441 |
| PubMedID: 21445272 |
| Gene_locus related to this paper: human-CES1 |
| Title : Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin - Hemmert_2010_Mol.Pharmacol_77_508 |
| Author(s) : Hemmert AC , Otto TC , Wierdl M , Edwards CC , Fleming CD , MacDonald M , Cashman JR , Potter PM , Cerasoli DM , Redinbo MR |
| Ref : Molecular Pharmacology , 77 :508 , 2010 |
| Abstract : Hemmert_2010_Mol.Pharmacol_77_508 |
| ESTHER : Hemmert_2010_Mol.Pharmacol_77_508 |
| PubMedSearch : Hemmert_2010_Mol.Pharmacol_77_508 |
| PubMedID: 20051531 |
| Gene_locus related to this paper: human-CES1 |
| Title : Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibition - Streit_2008_Biol.Chem_389_149 |
| Author(s) : Streit TM , Borazjani A , Lentz SE , Wierdl M , Potter PM , Gwaltney SR , Ross MK |
| Ref : Biol Chem , 389 :149 , 2008 |
| Abstract : Streit_2008_Biol.Chem_389_149 |
| ESTHER : Streit_2008_Biol.Chem_389_149 |
| PubMedSearch : Streit_2008_Biol.Chem_389_149 |
| PubMedID: 18163883 |
| Title : Modifications of human carboxylesterase for improved prodrug activation - Hatfield_2008_Expert.Opin.Drug.Metab.Toxicol_4_1153 |
| Author(s) : Hatfield JM , Wierdl M , Wadkins RM , Potter PM |
| Ref : Expert Opin Drug Metab Toxicol , 4 :1153 , 2008 |
| Abstract : Hatfield_2008_Expert.Opin.Drug.Metab.Toxicol_4_1153 |
| ESTHER : Hatfield_2008_Expert.Opin.Drug.Metab.Toxicol_4_1153 |
| PubMedSearch : Hatfield_2008_Expert.Opin.Drug.Metab.Toxicol_4_1153 |
| PubMedID: 18721110 |
| Title : An improved human carboxylesterase for enzyme\/prodrug therapy with CPT-11 - Wierdl_2008_Cancer.Gene.Ther_15_183 |
| Author(s) : Wierdl M , Tsurkan L , Hyatt JL , Edwards CC , Hatfield MJ , Morton CL , Houghton PJ , Danks MK , Redinbo MR , Potter PM |
| Ref : Cancer Gene Therapy , 15 :183 , 2008 |
| Abstract : Wierdl_2008_Cancer.Gene.Ther_15_183 |
| ESTHER : Wierdl_2008_Cancer.Gene.Ther_15_183 |
| PubMedSearch : Wierdl_2008_Cancer.Gene.Ther_15_183 |
| PubMedID: 18188187 |
| Title : Tumor-targeted enzyme\/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma - Danks_2007_Cancer.Res_67_22 |
| Author(s) : Danks MK , Yoon KJ , Bush RA , Remack JS , Wierdl M , Tsurkan L , Kim SU , Garcia E , Metz MZ , Najbauer J , Potter PM , Aboody KS |
| Ref : Cancer Research , 67 :22 , 2007 |
| Abstract : Danks_2007_Cancer.Res_67_22 |
| ESTHER : Danks_2007_Cancer.Res_67_22 |
| PubMedSearch : Danks_2007_Cancer.Res_67_22 |
| PubMedID: 17210679 |
| Title : Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils - Hicks_2007_Bioorg.Med.Chem_15_3801 |
| Author(s) : Hicks LD , Hyatt JL , Moak T , Edwards CC , Tsurkan L , Wierdl M , Ferreira AM , Wadkins RM , Potter PM |
| Ref : Bioorganic & Medicinal Chemistry , 15 :3801 , 2007 |
| Abstract : Hicks_2007_Bioorg.Med.Chem_15_3801 |
| ESTHER : Hicks_2007_Bioorg.Med.Chem_15_3801 |
| PubMedSearch : Hicks_2007_Bioorg.Med.Chem_15_3801 |
| PubMedID: 17399985 |
| Title : Selective inhibition of carboxylesterases by isatins, indole-2,3-diones - Hyatt_2007_J.Med.Chem_50_1876 |
| Author(s) : Hyatt JL , Moak T , Hatfield MJ , Tsurkan L , Edwards CC , Wierdl M , Danks MK , Wadkins RM , Potter PM |
| Ref : Journal of Medicinal Chemistry , 50 :1876 , 2007 |
| Abstract : Hyatt_2007_J.Med.Chem_50_1876 |
| ESTHER : Hyatt_2007_J.Med.Chem_50_1876 |
| PubMedSearch : Hyatt_2007_J.Med.Chem_50_1876 |
| PubMedID: 17378546 |
| Title : Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity - Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| Author(s) : Hyatt JL , Tsurkan L , Wierdl M , Edwards CC , Danks MK , Potter PM |
| Ref : Mol Cancer Ther , 5 :2281 , 2006 |
| Abstract : Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| ESTHER : Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| PubMedSearch : Hyatt_2006_Mol.Cancer.Ther_5_2281 |
| PubMedID: 16985062 |
| Title : Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety - Hyatt_2005_J.Med.Chem_48_5543 |
| Author(s) : Hyatt JL , Stacy V , Wadkins RM , Yoon KJ , Wierdl M , Edwards CC , Zeller M , Hunter AD , Danks MK , Crundwell G , Potter PM |
| Ref : Journal of Medicinal Chemistry , 48 :5543 , 2005 |
| Abstract : Hyatt_2005_J.Med.Chem_48_5543 |
| ESTHER : Hyatt_2005_J.Med.Chem_48_5543 |
| PubMedSearch : Hyatt_2005_J.Med.Chem_48_5543 |
| PubMedID: 16107154 |
| Title : Update on gene therapy approaches for cancer - Wierdl_2005_Curr.Hematol.Rep_4_294 |
| Author(s) : Wierdl M , Potter PM |
| Ref : Curr Hematol Rep , 4 :294 , 2005 |
| Abstract : Wierdl_2005_Curr.Hematol.Rep_4_294 |
| ESTHER : Wierdl_2005_Curr.Hematol.Rep_4_294 |
| PubMedSearch : Wierdl_2005_Curr.Hematol.Rep_4_294 |
| PubMedID: 16009044 |
| Title : Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases - Wadkins_2005_J.Med.Chem_48_2906 |
| Author(s) : Wadkins RM , Hyatt JL , Wei X , Yoon KJ , Wierdl M , Edwards CC , Morton CL , Obenauer JC , Damodaran K , Beroza P , Danks MK , Potter PM |
| Ref : Journal of Medicinal Chemistry , 48 :2906 , 2005 |
| Abstract : Wadkins_2005_J.Med.Chem_48_2906 |
| ESTHER : Wadkins_2005_J.Med.Chem_48_2906 |
| PubMedSearch : Wadkins_2005_J.Med.Chem_48_2906 |
| PubMedID: 15828829 |
| Title : Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model - Wierdl_2004_Biochemistry_43_1874 |
| Author(s) : Wierdl M , Morton CL , Nguyen NK , Redinbo MR , Potter PM |
| Ref : Biochemistry , 43 :1874 , 2004 |
| Abstract : Wierdl_2004_Biochemistry_43_1874 |
| ESTHER : Wierdl_2004_Biochemistry_43_1874 |
| PubMedSearch : Wierdl_2004_Biochemistry_43_1874 |
| PubMedID: 14967028 |
| Title : p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) - Wierdl_2003_J.Pharmacol.Exp.Ther_304_699 |
| Author(s) : Wierdl M , Morton CL , Harris LC , Danks MK , Schuetz JD , Potter PM |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 304 :699 , 2003 |
| Abstract : Wierdl_2003_J.Pharmacol.Exp.Ther_304_699 |
| ESTHER : Wierdl_2003_J.Pharmacol.Exp.Ther_304_699 |
| PubMedSearch : Wierdl_2003_J.Pharmacol.Exp.Ther_304_699 |
| PubMedID: 12538824 |
| Title : Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance - Wierdl_2003_Mol.Pharmacol_64_279 |
| Author(s) : Wierdl M , Wall A , Morton CL , Sampath J , Danks MK , Schuetz JD , Potter PM |
| Ref : Molecular Pharmacology , 64 :279 , 2003 |
| Abstract : Wierdl_2003_Mol.Pharmacol_64_279 |
| ESTHER : Wierdl_2003_Mol.Pharmacol_64_279 |
| PubMedSearch : Wierdl_2003_Mol.Pharmacol_64_279 |
| PubMedID: 12869632 |
| Title : Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases - Wadkins_2001_Mol.Pharmacol_60_355 |
| Author(s) : Wadkins RM , Morton CL , Weeks JK , Oliver L , Wierdl M , Danks MK , Potter PM |
| Ref : Molecular Pharmacology , 60 :355 , 2001 |
| Abstract : Wadkins_2001_Mol.Pharmacol_60_355 |
| ESTHER : Wadkins_2001_Mol.Pharmacol_60_355 |
| PubMedSearch : Wadkins_2001_Mol.Pharmacol_60_355 |
| PubMedID: 11455023 |
| Title : Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase - Wierdl_2001_Cancer.Res_61_5078 |
| Author(s) : Wierdl M , Morton CL , Weeks JK , Danks MK , Harris LC , Potter PM |
| Ref : Cancer Research , 61 :5078 , 2001 |
| Abstract : Wierdl_2001_Cancer.Res_61_5078 |
| ESTHER : Wierdl_2001_Cancer.Res_61_5078 |
| PubMedSearch : Wierdl_2001_Cancer.Res_61_5078 |
| PubMedID: 11431344 |
| Title : A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11 - Meck_2001_Cancer.Res_61_5083 |
| Author(s) : Meck MM , Wierdl M , Wagner LM , Burger RA , Guichard SM , Krull EJ , Harris LC , Potter PM , Danks MK |
| Ref : Cancer Research , 61 :5083 , 2001 |
| Abstract : Meck_2001_Cancer.Res_61_5083 |
| ESTHER : Meck_2001_Cancer.Res_61_5083 |
| PubMedSearch : Meck_2001_Cancer.Res_61_5083 |
| PubMedID: 11431345 |
| Title : Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase - Morton_2000_Cancer.Res_60_4206 |
| Author(s) : Morton CL , Wierdl M , Oliver L , Ma MK , Danks MK , Stewart CF , Eiseman JL , Potter PM |
| Ref : Cancer Research , 60 :4206 , 2000 |
| Abstract : Morton_2000_Cancer.Res_60_4206 |
| ESTHER : Morton_2000_Cancer.Res_60_4206 |
| PubMedSearch : Morton_2000_Cancer.Res_60_4206 |
| PubMedID: 10945631 |
| Title : Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation - Wierdl_2000_Biochem.Pharmacol_59_773 |
| Author(s) : Wierdl M , Morton CL , Danks MK , Potter PM |
| Ref : Biochemical Pharmacology , 59 :773 , 2000 |
| Abstract : Wierdl_2000_Biochem.Pharmacol_59_773 |
| ESTHER : Wierdl_2000_Biochem.Pharmacol_59_773 |
| PubMedSearch : Wierdl_2000_Biochem.Pharmacol_59_773 |
| PubMedID: 10718335 |
| Gene_locus related to this paper: horse-BCHE |
| Title : Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme - Potter_1998_Cancer.Res_58_3627 |
| Author(s) : Potter PM , Wolverton JS , Morton CL , Wierdl M , Danks MK |
| Ref : Cancer Research , 58 :3627 , 1998 |
| Abstract : Potter_1998_Cancer.Res_58_3627 |
| ESTHER : Potter_1998_Cancer.Res_58_3627 |
| PubMedSearch : Potter_1998_Cancer.Res_58_3627 |
| PubMedID: 9721871 |