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Author Report for: Wierdl M

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    Title: Carboxylesterases: General detoxifying enzymes
    Hatfield MJ, Umans RA, Hyatt JL, Edwards CC, Wierdl M, Tsurkan L, Taylor MR, Potter PM
    Ref: Chemico-Biological Interactions, 259:327, 2016 : PubMed

            

    Title: Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer
    Wierdl M, Tsurkan L, Hatfield MJ, Potter PM
    Ref: British Journal of Pharmacology, 173:2811, 2016 : PubMed

            

    Title: Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism
    Yu X, Sigler SC, Hossain D, Wierdl M, Gwaltney SR, Potter PM, Wadkins RM
    Ref: J Mol Model, 18:2869, 2012 : PubMed

            

    Title: Nerve agent hydrolysis activity designed into a human drug metabolism enzyme
    Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL and Redinbo MR <5 more author(s)>
    Ref: PLoS ONE, 6:e17441, 2011 : PubMed

            

    Title: Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin
    Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR
    Ref: Molecular Pharmacology, 77:508, 2010 : PubMed

            

    Title: Modifications of human carboxylesterase for improved prodrug activation
    Hatfield JM, Wierdl M, Wadkins RM, Potter PM
    Ref: Expert Opin Drug Metab Toxicol, 4:1153, 2008 : PubMed

            

    Title: Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibition
    Streit TM, Borazjani A, Lentz SE, Wierdl M, Potter PM, Gwaltney SR, Ross MK
    Ref: Biol Chem, 389:149, 2008 : PubMed

            

    Title: An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11
    Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM
    Ref: Cancer Gene Therapy, 15:183, 2008 : PubMed

            

    Title: Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma
    Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L, Kim SU, Garcia E, Metz MZ and Aboody KS <2 more author(s)>
    Ref: Cancer Research, 67:22, 2007 : PubMed

            

    Title: Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils
    Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM
    Ref: Bioorganic & Medicinal Chemistry, 15:3801, 2007 : PubMed

            

    Title: Selective inhibition of carboxylesterases by isatins, indole-2,3-diones
    Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM
    Ref: Journal of Medicinal Chemistry, 50:1876, 2007 : PubMed

            

    Title: Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity
    Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM
    Ref: Mol Cancer Ther, 5:2281, 2006 : PubMed

            

    Title: Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety
    Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK and Potter PM <1 more author(s)>
    Ref: Journal of Medicinal Chemistry, 48:5543, 2005 : PubMed

            

    Title: Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases
    Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K and Potter PM <2 more author(s)>
    Ref: Journal of Medicinal Chemistry, 48:2906, 2005 : PubMed

            

    Title: Update on gene therapy approaches for cancer
    Wierdl M, Potter PM
    Ref: Curr Hematol Rep, 4:294, 2005 : PubMed

            

    Title: Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model
    Wierdl M, Morton CL, Nguyen NK, Redinbo MR, Potter PM
    Ref: Biochemistry, 43:1874, 2004 : PubMed

            

    Title: p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)
    Wierdl M, Morton CL, Harris LC, Danks MK, Schuetz JD, Potter PM
    Ref: Journal of Pharmacology & Experimental Therapeutics, 304:699, 2003 : PubMed

            

    Title: Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance
    Wierdl M, Wall A, Morton CL, Sampath J, Danks MK, Schuetz JD, Potter PM
    Ref: Molecular Pharmacology, 64:279, 2003 : PubMed

            

    Title: A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11
    Meck MM, Wierdl M, Wagner LM, Burger RA, Guichard SM, Krull EJ, Harris LC, Potter PM, Danks MK
    Ref: Cancer Research, 61:5083, 2001 : PubMed

            

    Title: Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases
    Wadkins RM, Morton CL, Weeks JK, Oliver L, Wierdl M, Danks MK, Potter PM
    Ref: Molecular Pharmacology, 60:355, 2001 : PubMed

            

    Title: Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase
    Wierdl M, Morton CL, Weeks JK, Danks MK, Harris LC, Potter PM
    Ref: Cancer Research, 61:5078, 2001 : PubMed

            

    Title: Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase
    Morton CL, Wierdl M, Oliver L, Ma MK, Danks MK, Stewart CF, Eiseman JL, Potter PM
    Ref: Cancer Research, 60:4206, 2000 : PubMed

            

    Title: Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation
    Wierdl M, Morton CL, Danks MK, Potter PM
    Ref: Biochemical Pharmacology, 59:773, 2000 : PubMed

            

    Title: Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme
    Potter PM, Wolverton JS, Morton CL, Wierdl M, Danks MK
    Ref: Cancer Research, 58:3627, 1998 : PubMed

            


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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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