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Author Report for: Xu JH

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    Title: Reprogramming Epoxide Hydrolase to Improve Enantioconvergence in Hydrolysis of Styrene Oxide Scaffolds
    Li FL, Qiu YY, Zheng YC, Chen FF, Kong XD, Xu JH, Yu HL
    Ref: Adv Synth Catal, 362:4699, 2021 : PubMed

            

    Title: A High-Throughput Screening Method for the Directed Evolution of Hydroxynitrile Lyase towards Cyanohydrin Synthesis
    Zheng YC, Ding LY, Jia Q, Lin Z, Hong R, Yu HL, Xu JH
    Ref: Chembiochem, 22:996, 2021 : PubMed

            

    Title: Structural investigation of the enantioselectivity and thermostability mechanisms of esterase RhEst1
    Chen Q, Yu HL, Cheng X, Xu JH
    Ref: J Mol Graph Model, 85:182, 2018 : PubMed

            

    Title: Regioselectivity Engineering of Epoxide Hydrolase: Near-Perfect Enantioconvergence through a Single Site Mutation
    Li FL, Kong XD, Chen Q, Zheng YC, Xu Q, Chen FF, Fan LQ, Lin GQ, Zhou J and Xu JH <1 more author(s)>
    Ref: ACS Catal, 8:8314, 2018 : PubMed

            

    Title: Catalytic Promiscuity of Ancestral Esterases and Hydroxynitrile Lyases
    Devamani T, Rauwerdink AM, Lunzer M, Jones BJ, Mooney JL, Tan MA, Zhang ZJ, Xu JH, Dean AM, Kazlauskas RJ
    Ref: Journal of the American Chemical Society, 138:1046, 2016 : PubMed

            

    Title: Rational selection of circular permutation sites in characteristic regions of the alpha/beta-hydrolase fold enzyme RhEst1
    Li FL, Luan ZJ, Chen Q, Xu JH, Yu HL
    Ref: J Mol Catal B Enzym, 125:75, 2016 : PubMed

            

    Title: Dramatically Improved Performance of an Esterase for Cilastatin Synthesis by Cap Domain Engineering
    Luan ZJ, Yu HL, Ma BD, Qi YK, Chen Q, Xu JH
    Ref: Ind. Eng. Chem. Res, 55:12167, 2016 : PubMed

            

    Title: Evolution of a Catalytic Mechanism
    Rauwerdink A, Lunzer M, Devamani T, Jones B, Mooney J, Zhang ZJ, Xu JH, Kazlauskas RJ, Dean AM
    Ref: Molecular Biology Evolution, 33:971, 2016 : PubMed

            

    Title: Molecular dynamics investigation of the substrate binding mechanism in carboxylesterase
    Chen Q, Luan ZJ, Cheng X, Xu JH
    Ref: Biochemistry, 54:1841, 2015 : PubMed

            

    Title: Rational design of a carboxylic esterase RhEst1 based on computational analysis of substrate binding
    Chen Q, Luan ZJ, Yu HL, Cheng X, Xu JH
    Ref: J Mol Graph Model, 62:319, 2015 : PubMed

            

    Title: Substrate channel evolution of an esterase for the synthesis of cilastatin
    Luan ZJ, Li FL, Dou S, Chen Q, Kong XD, Zhou J, Yu HL, Xu JH
    Ref: Catal Sci Technol, 5:2622, 2015 : PubMed

            

    Title: Cloning and Characterization of an Enantioselective l-Menthyl Benzoate Hydrolase from Acinetobacter sp. ECU2040
    Yin JG, Xu GC, Zheng GW, Xu JH
    Ref: Appl Biochem Biotechnol, 176:1102, 2015 : PubMed

            

    Title: Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition
    Dou S, Kong XD, Ma BD, Chen Q, Zhang J, Zhou J, Xu JH
    Ref: Biochemical & Biophysical Research Communications, 446:1145, 2014 : PubMed

            

    Title: A Smart Library of Epoxide Hydrolase Variants and the Top Hits for Synthesis of (S)-beta-Blocker Precursors
    Kong XD, Ma Q, Zhou J, Zeng BB, Xu JH
    Ref: Angew Chem Int Ed Engl, 53:6641, 2014 : PubMed

            

    Title: Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates
    Kong XD, Yuan S, Li L, Chen S, Xu JH, Zhou J
    Ref: Proc Natl Acad Sci U S A, 111:15717, 2014 : PubMed

            

    Title: Essential Role of Gly33 in a Novel Organic Solvent-Tolerant Lipase from Serratia marcescens ECU1010 as Determined by Site-Directed Mutagenesis
    Li SX, Ma Q, Lin K, Wu JJ, Wu YX, Xu JH
    Ref: Appl Biochem Biotechnol, 172:2945, 2014 : PubMed

            

    Title: Increased Catalyst Productivity in alpha-Hydroxy Acids Resolution by Esterase Mutation and Substrate Modification
    Ma BD, Kong XD, Yu HL, Zhang ZJ, Dou S, Xu YP, Ni Y, Xu JH
    Ref: ACS Catal, 4:1026, 2014 : PubMed

            

    Title: Newly Identified Thermostable Esterase from Sulfobacillus acidophilus: Properties and Performance in Phthalate Ester Degradation
    Zhang XY, Fan X, Qiu YJ, Li CY, Xing S, Zheng YT, Xu JH
    Ref: Applied Environmental Microbiology, 80:6870, 2014 : PubMed

            

    Title: Cloning and Characterization of a Novel Esterase from Rhodococcus sp. for Highly Enantioselective Synthesis of a Chiral Cilastatin Precursor
    Zhang Y, Pan J, Luan ZJ, Xu GC, Park S, Xu JH
    Ref: Applied Environmental Microbiology, 80:7348, 2014 : PubMed

            

    Title: Heterologous overexpression of Vigna radiata epoxide hydrolase in Escherichia coli and its catalytic performance in enantioconvergent hydrolysis of p-nitrostyrene oxide into (R)-p-nitrophenyl glycol
    Zhu QQ, He WH, Kong XD, Fan LQ, Zhao J, Li SX, Xu JH
    Ref: Applied Microbiology & Biotechnology, 98:207, 2014 : PubMed

            

    Title: Enzymatic production of Cilastatin intermediate via highly enantioselective hydrolysis of methyl (+/-)-2,2-dimethylcyclopropane carboxylate using newly isolated Rhodococcus sp. ECU1013
    Liu CH, Pan J, Ye Q, Xu JH
    Ref: Applied Microbiology & Biotechnology, 97:7659, 2013 : PubMed

            

    Title: A thermostable and organic-solvent tolerant esterase from Pseudomonas putida ECU1011: catalytic properties and performance in kinetic resolution of alpha-hydroxy acids
    Ma BD, Yu HL, Pan J, Liu JY, Ju X, Xu JH
    Ref: Bioresour Technol, 133:354, 2013 : PubMed

            

    Title: Isolation and biochemical characterization of two novel metagenome-derived esterases
    Ouyang LM, Liu JY, Qiao M, Xu JH
    Ref: Appl Biochem Biotechnol, 169:15, 2013 : PubMed

            

    Title: Target-oriented discovery of a new esterase-producing strain Enterobacter sp. ECU1107 for whole cell-catalyzed production of (2S,3R)-3-phenylglycidate as a chiral synthon of Taxol
    Zhou DJ, Pan J, Yu HL, Zheng GW, Xu JH
    Ref: Applied Microbiology & Biotechnology, 97:6293, 2013 : PubMed

            

    Title: Expression and characterization of a novel lipase from Aspergillus fumigatus with high specific activity
    Shangguan JJ, Liu YQ, Wang FJ, Zhao J, Fan LQ, Li SX, Xu JH
    Ref: Appl Biochem Biotechnol, 165:949, 2011 : PubMed

            

    Title: Bioproduction of chiral mandelate by enantioselective deacylation of alpha-acetoxyphenylacetic acid using whole cells of newly isolated Pseudomonas sp. ECU1011
    Ju X, Yu HL, Pan J, Wei DZ, Xu JH
    Ref: Applied Microbiology & Biotechnology, 86:83, 2010 : PubMed

            

    Title: Efficient production of (S)-naproxen with (R)-substrate recycling using an overexpressed carboxylesterase BsE-NP01
    Liu X, Xu JH, Pan J, Zhao J
    Ref: Appl Biochem Biotechnol, 162:1574, 2010 : PubMed

            

    Title: Significantly improved expression and biochemical properties of recombinant Serratia marcescens lipase as robust biocatalyst for kinetic resolution of chiral ester
    Wang Y, Zhao J, Xu JH, Fan LQ, Li SX, Zhao LL, Mao XB
    Ref: Appl Biochem Biotechnol, 162:2387, 2010 : PubMed

            

    Title: Synthesis of novel salidroside esters by lipase-mediated acylation with various functional acyl groups
    Yu HL, Xu JH, Su JH, Lu WY, Lin GQ
    Ref: J Biosci Bioeng, 106:65, 2008 : PubMed

            

    Title: Overexpression of Serratia marcescens lipase in Escherichia coli for efficient bioresolution of racemic ketoprofen
    Long ZD, Xu JH, Zhao LL, Pan J, Yang S, Hua L
    Ref: J Mol Catal B Enzym, 47:105, 2007 : PubMed

            

    Title: Significant improvement of Serratia marcescens lipase fermentation, by optimizing medium, induction, and oxygen supply
    Long ZD, Xu JH, Pan J
    Ref: Appl Biochem Biotechnol, 142:148, 2007 : PubMed

            

    Title: Optimization of Serratia marcescens lipase production for enantioselective hydrolysis of 3-phenylglycidic acid ester
    Gao L, Xu JH, Li XJ, Liu ZZ
    Ref: J Ind Microbiol Biotechnol, 31:525, 2004 : PubMed

            

    Title: Integration of purification with immobilization of Candida rugosa lipase for kinetic resolution of racemic ketoprofen
    Liu YY, Xu JH, Wu HY, Shen D
    Ref: J Biotechnol, 110:209, 2004 : PubMed

            

    Title: Biocatalytic resolution of glycidyl aryl ethers by Trichosporon loubierii : cell/substrate ratio influences the optical purity of (R) - epoxides
    Xu Y, Xu JH, Pan J, Tang YF
    Ref: Biotechnol Lett, 26:1217, 2004 : PubMed

            

    Title: Improved catalytic performance of Bacillus megaterium epoxide hydrolase in a medium containing Tween-80
    Gong PF, Xu JH, Tang YF, Wu HY
    Ref: Biotechnol Prog, 19:652, 2003 : PubMed

            


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