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Author Report for: von Geldern TW

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    Title: Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
    Backes BJ, Longenecker K, Hamilton GL, Stewart K, Lai C, Kopecka H, von Geldern TW, Madar DJ, Pei Z and Trevillyan JM <10 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 17:2005, 2007 : PubMed

            

    Title: Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors
    Pei Z, Li X, von Geldern TW, Longenecker K, Pireh D, Stewart KD, Backes BJ, Lai C, Lubben TH and Trevillyan JM <4 more author(s)>
    Ref: Journal of Medicinal Chemistry, 50:1983, 2007 : PubMed

            

    Title: Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
    Kurukulasuriya R, Rohde JJ, Szczepankiewicz BG, Basha F, Lai C, Jae HS, Winn M, Stewart KD, Longenecker KL and von Geldern TW <3 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, 16:6226, 2006 : PubMed

            

    Title: Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors
    Longenecker KL, Stewart KD, Madar DJ, Jakob CG, Fry EH, Wilk S, Lin CW, Ballaron SJ, Stashko MA and Stoll VS <8 more author(s)>
    Ref: Biochemistry, 45:7474, 2006 : PubMed

            

    Title: Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes
    Madar DJ, Kopecka H, Pireh D, Yong H, Pei Z, Li X, Wiedeman PE, Djuric SW, von Geldern TW and Trevillyan JM <21 more author(s)>
    Ref: Journal of Medicinal Chemistry, 49:6416, 2006 : PubMed

            

    Title: Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    Pei Z, Li X, von Geldern TW, Madar DJ, Longenecker K, Yong H, Lubben TH, Stewart KD, Zinker BA and Trevillyan JM <12 more author(s)>
    Ref: Journal of Medicinal Chemistry, 49:6439, 2006 : PubMed

            

    Title: Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors
    Pei Z, Li X, Longenecker K, von Geldern TW, Wiedeman PE, Lubben TH, Zinker BA, Stewart K, Ballaron SJ and Trevillyan JM <16 more author(s)>
    Ref: Journal of Medicinal Chemistry, 49:3520, 2006 : PubMed

            


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