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Paper(s) concerning Piperidine-fused-benzimidazole-34

1 reference(s) found.
Listing paper details in reverse chronological order.
We are grateful to Keith Bradnam for improvment of this script

Title: Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors
Edmondson SD, Mastracchio A, Cox JM, Eiermann GJ, He H, Lyons KA, Patel RA, Patel SB, Petrov A and Weber AE <6 more author(s)> Edmondson SD, Mastracchio A, Cox JM, Eiermann GJ, He H, Lyons KA, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Xu S, Zhu B, Thornberry NA, Roy RS, Weber AE (- 6)
Ref: Bioorganic & Medicinal Chemistry Lett, 19:4097, 2009 : PubMed
Abstract


ESTHER: Edmondson_2009_Bioorg.Med.Chem.Lett_19_4097
PubMedSearch: Edmondson 2009 Bioorg.Med.Chem.Lett 19 4097
PubMedID: 19539471
Gene_locus related to this paper: human-DPP4
Inhibitor(s) related to this paper: Piperidine-fused-benzimidazole-25, Piperidine-fused-benzimidazole-34

Abstract

A new series of DPP-4 inhibitors derived from piperidine-fused benzimidazoles and imidazopyridines is described. Optimization of this class of DPP-4 inhibitors led to the discovery of imidazopyridine 34. The potency, selectivity, cross-species DMPK profiles, and in vivo efficacy of 34 is reported.