Golitz F, Herbert J, Worek F, Wille T (2023)
AChE reactivation in Precision-cut lung slices following organophosphorus compound poisoning
Toxicol Lett

Elsinghorst PW, Wille T, Baric D, Mertens MD, Baumann M, Kuppers J, Gutschow M (2022)
Aminoalkoxy-substituted coumarins: Synthesis and evaluation for reactivation of inhibited human acetylcholinesterase
Arch Pharm (Weinheim)

Horn G, Kranawetvogl T, John H, Weigel C, Rauen U, Worek F, Wille T (2022)
Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro
Chemico-Biological Interactions

Keuler T, Lemke C, Elsinghorst PW, Iriepa I, Chioua M, Martinez-Grau MA, Beadle CD, Vetman T, Lopez-Munoz F, Wille T, Bartz U, Deuther-Conrad W, Marco-Contelles J, Gutschow M (2022)
The Chemotype of Chromanones as a Privileged Scaffold for Multineurotarget Anti-Alzheimer Agents
ACS Pharmacol Transl Sci 5: 1097

Koller M, Thiermann H, Worek F, Wille T (2021)
Release of protein-bound nerve agents by excess fluoride from whole blood: GC-MS/MS method development, validation, and application to a real-life denatured blood sample
Journal of Chromatography B Analyt Technol Biomed Life Sciences 1179: 122693

Stigler L, Kohler A, Koller M, Job L, Escher B, Potschka H, Thiermann H, Skerra A, Worek F, Wille T (2021)
Post-VX exposure treatment of rats with engineered phosphotriesterases
Archives of Toxicology

Tigges J, Worek F, Thiermann H, Wille T (2021)
Organophosphorus pesticides exhibit compound specific effects in rat precision-cut lung slices (PCLS): mechanisms involved in airway response, cytotoxicity, inflammatory activation and antioxidative defense
Archives of Toxicology

Amend N, Niessen KV, Seeger T, Wille T, Worek F, Thiermann H (2020)
Diagnostics and treatment of nerve agent poisoning-current status and future developments
Annals of the New York Academy of Sciences

Amend N, Langgartner J, Siegert M, Kranawetvogl T, Koller M, John H, Pflugler C, Mogele-Schmid C, Worek F, Thiermann H, Wille T (2020)
A case report of cholinesterase inhibitor poisoning: cholinesterase activities and analytical methods for diagnosis and clinical decision making
Archives of Toxicology

Wille T, Djordjevic S, Worek F, Thiermann H, Vucinic S (2020)
Early diagnosis of nerve agent exposure with a mobile test kit and implications for medical countermeasures: a trigger to react
BMJ Mil Health

Worek F, Thiermann H, Koller M, Wille T (2020)
In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase
Molecules 25:

Worek F, Thiermann H, Wille T (2020)
Organophosphorus compounds and oximes: a critical review
Archives of Toxicology 94: 2275

Amend N, Thiermann H, Worek F, Wille T (2019)
The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM)
Toxicol Lett 308: 1

Herbert J, Thiermann H, Worek F, Wille T (2019)
COPD and asthma therapeutics for supportive treatment in organophosphate poisoning
Clinical Toxicology (Phila)

Lemke C, Christmann J, Yin J, Alonso JM, Serrano E, Chioua M, Ismaili L, Martinez-Grau MA, Beadle CD, Vetman T, Dato FM, Bartz U, Elsinghorst PW, Pietsch M, Muller CE, Iriepa I, Wille T, Marco-Contelles J, Gutschow M (2019)
Chromenones as Multineurotargeting Inhibitors of Human Enzymes
ACS Omega 4: 22161

Marquart K, Prokopchuk O, Wilhelm D, Worek F, Thiermann H, Martignoni ME, Wille T (2019)
Human small bowel as model for poisoning with organophosphorus compounds
Toxicol In Vitro 57: 76

Marquart K, Prokopchuk O, Worek F, Thiermann H, Martignoni ME, Wille T (2018)
Human small bowel as a useful tool to investigate smooth muscle effects of potential therapeutics in organophosphate poisoning
Toxicol Lett 293: 235

Marquart K, Herbert J, Amend N, Thiermann H, Worek F, Wille T (2018)
Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats
Clinical Toxicology (Phila)

Worek F, Thiermann H, Wille T (2018)
The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study
Toxicol Lett 293: 216

Wille T, von der Wellen J, Thiermann H, Worek F (2017)
Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6
Archives of Toxicology 91: 1309

De Koning MC, Joosen MJ, Worek F, Nachon F, van Grol M, Klaassen SD, Alkema DPW, Wille T, de Bruijn HM (2017)
Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase
Journal of Medicinal Chemistry 60: 9376

Bierwisch A, Wille T, Thiermann H, Worek F (2016)
Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds
Toxicol Lett 246: 49

Mertens MD, Bierwisch A, Li T, Gutschow M, Thiermann H, Wille T, Elsinghorst PW (2016)
A novel fluorogenic probe for the investigation of free thiols: Application to kinetic measurements of acetylcholinesterase activity
Toxicol Lett 244: 161

Wille T, Neumaier K, Koller M, Ehinger C, Aggarwal N, Ashani Y, Goldsmith M, Sussman JL, Tawfik DS, Thiermann H, Worek F (2016)
Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection
Toxicol Lett 258: 198

Winter M, Wille T, Musilek K, Kuca K, Thiermann H, Worek F (2016)
Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase
Toxicol Lett 244: 136

Worek F, Schilha M, Neumaier K, Aurbek N, Wille T, Thiermann H, Kehe K (2016)
On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit-Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds
Toxicol Lett 249: 22

Worek F, Thiermann H, Wille T (2016)
Oximes in organophosphate poisoning: 60 years of hope and despair
Chemico-Biological Interactions 259: 93

Worek F, Koller M, Thiermann H, Wille T (2016)
Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics
Toxicology 350-352: 25

Worek F, Seeger T, Neumaier K, Wille T, Thiermann H (2016)
Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study
Toxicol Lett 262: 12

Worek F, Thiermann H, Wille T (2016)
Catalytic bioscavengers in nerve agent poisoning: A promising approach?
Toxicol Lett 244: 143

von der Wellen J, Bierwisch A, Worek F, Thiermann H, Wille T (2016)
Kinetics of pesticide degradation by human fresh frozen plasma (FFP) in vitro
Toxicol Lett 244: 124

Horn G, Wille T, Musilek K, Kuca K, Thiermann H, Worek F (2015)
Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase
Archives of Toxicology 89: 405

Worek F, Herkert NM, Koller M, Thiermann H, Wille T (2015)
Application of a dynamic in vitro model with real-time determination of acetylcholinesterase activity for the investigation of tabun analogues and oximes
Toxicol In Vitro 30: 514

Wille T, Thiermann H, Worek F (2014)
In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP)
Archives of Toxicology 88: 301

Worek F, Seeger T, Zengerle M, Kubik S, Thiermann H, Wille T (2014)
Effectiveness of a substituted beta-cyclodextrin to prevent cyclosarin toxicity in vivo
Toxicol Lett 226: 222

Worek F, Seeger T, Goldsmith M, Ashani Y, Leader H, Sussman JL, Tawfik DS, Thiermann H, Wille T (2014)
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro
Archives of Toxicology 88: 1257

Worek F, Horn G, Wille T, Thiermann H (2014)
Adaptation of a dynamic in vitro model with real-time determination of butyrylcholinesterase activity in the presence of cyclosarin and an oxime
Toxicol In Vitro 29: 162

Estour F, Letort S, Muller S, Kalakuntla RK, Le Provost R, Wille T, Reiter G, Worek F, Lafont O, Gouhier G (2013)
Functionalized cyclodextrins bearing an alpha nucleophile - A promising way to degrade nerve agents
Chemico-Biological Interactions 203: 202

Kalakuntla RK, Wille T, Le Provost R, Letort S, Reiter G, Muller S, Thiermann H, Worek F, Gouhier G, Lafont O, Estour F (2013)
New modified beta-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: Evaluation of the detoxification using a half-quantitative enzymatic assay
Toxicol Lett 216: 200

von der Wellen J, Worek F, Thiermann H, Wille T (2013)
Investigations of kinetic interactions between lipid emulsions, hydroxyethyl starch or dextran and organophosphorus compounds
Clinical Toxicology (Phila) 51: 918

Wille T, Kaltenbach L, Thiermann H, Worek F (2013)
Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates
Chemico-Biological Interactions 206: 569

Wille T, Worek F, Thiermann H (2013)
Fourteenth International Medical Chemical Defence Conference 2013 Translation of experimental research for improved treatment of chemical warfare agents
Chemico-Biological Interactions 206: 433

Worek F, Wille T, Koller M, Thiermann H (2013)
Structural requirements for effective oximes - Evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes
Chemico-Biological Interactions 203: 125

Worek F, Wille T, Koller M, Thiermann H (2012)
Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships
Biochemical Pharmacology 83: 1700

Herkert NM, Schulz S, Wille T, Thiermann H, Hatz RA, Worek F (2011)
Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro
Toxicol Appl Pharmacol 253: 7

Le Provost R, Wille T, Louise L, Masurier N, Muller S, Reiter G, Renard PY, Lafont O, Worek F, Estour F (2011)
Optimized strategies to synthesize beta-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers
Org Biomol Chem 9: 3026

Muller S, Koller M, Le Provost R, Lafont O, Estour F, Wille T, Thiermann H, Worek F, Reiter G (2011)
In vitro detoxification of cyclosarin (GF) by modified cyclodextrins
Toxicol Lett 200: 53

Wille T, Thiermann H, Worek F (2011)
In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases
Chemico-Biological Interactions 190: 79

Wille T, Thiermann H, Worek F (2011)
In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases - Response to the letter to the editor
Chemico-Biological Interactions 193: 108

Wille T, Thiermann H, Worek F (2011)
Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species
Toxicol Mech Methods 21: 533

Worek F, Aurbek N, Wille T, Eyer P, Thiermann H (2011)
Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase
Toxicol Lett 200: 19

Worek F, Aurbek N, Wille T, Eyer P, Thiermann H (2011)
Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach
J Enzyme Inhib Med Chem 26: 303

Wille T, Thiermann H, Worek F (2010)
Development of a high-throughput screening for nerve agent detoxifying materials using a fully-automated robot-assisted biological assay
Toxicol In Vitro 24: 1026

Wille T, Ekstrom F, Lee JC, Pang YP, Thiermann H, Worek F (2010)
Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds
Biochemical Pharmacology 80: 941

Worek F, Wille T, Aurbek N, Eyer P, Thiermann H (2010)
Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach
Toxicol Appl Pharmacol 249: 231

Wille T, Tenberken O, Reiter G, Muller S, Le Provost R, Lafont O, Estour F, Thiermann H, Worek F (2009)
Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay
Toxicology 265: 96