Amitai G, Plotnikov A, Chapman S, Lazar S, Gez R, Loewenthal D, Shurrush KA, Cohen G, Solmesky LJ, Barr H, Russell AJ (2021)
Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
Commun Biol 4: 573
Zhang L, Baker SL, Murata H, Harris N, Ji W, Amitai G, Matyjaszewski K, Russell AJ (2020)
Tuning Butyrylcholinesterase Inactivation and Reactivation by Polymer-Based Protein Engineering
Adv Sci (Weinh) 7: 1901904
Zhang L, Murata H, Amitai G, Smith PN, Matyjaszewski K, Russell AJ (2020)
Catalytic Detoxification of Organophosphorus Nerve Agents by Butyrylcholinesterase-Polymer-Oxime Bioscavengers
Biomacromolecules 21: 3867
Amitai G, Gez R, Raveh L, Bar-Ner N, Grauer E, Chapman S (2016)
Novel bifunctional hybrid small molecule scavengers for mitigating nerve agents toxicity
Chemico-Biological Interactions 259: 187
Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radic Z (2014)
Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification
Journal of Medicinal Chemistry 57: 1378
Radic Z, Dale T, Kovarik Z, Zunec S, Garcia E, Zhang LM, Amitai G, Green C, Radic B, Duggan BM, Ajami D, Rebek J, Taylor P (2013)
Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes
Biochemical Journal 450: 231
Radic Z, Sit RK, Garcia E, Zhang LM, Zunec S, Kovarik Z, Amitai G, Fokin VV, Sharpless KB, Taylor P (2013)
Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates
Chemico-Biological Interactions 203: 67
Radic Z, Sit RK, Kovarik Z, Zunec S, Garcia E, Zhang L, Amitai G, Green C, Radic B, Fokin VV, Sharpless KB, Taylor P (2012)
Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases
Journal of Biological Chemistry 287: 11798
Cochran R, Kalisiak J, Kucukkilinc TT, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P (2011)
Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging
Journal of Biological Chemistry 286: 29718
Sit RK, Radic Z, Gerardi V, Zhang L, Garcia E, Katalinic M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P (2011)
New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases
Journal of Biological Chemistry 286: 19422
Amitai G, Murata H, Andersen JD, Koepsel RR, Russell AJ (2010)
Decontamination of chemical and biological warfare agents with a single multi-functional material
Biomaterials 31: 4417
Kucukkilinc TT, Cochran R, Kalisiak J, Garcia E, Valle A, Amitai G, Radic Z, Taylor P (2010)
Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation
Chemico-Biological Interactions 187: 238
Amitai G, Adani R, Limanovich O, Teitlboim S, Yishay S, Tveria L, Yacov G, Meshulam H, Raveh L (2008)
Characterization of asymmetric fluorogenic phosphonates as probes for developing organophosphorus hydrolases with broader stereoselectivity
Chemico-Biological Interactions 175: 249
Amitai G, Adani R, Yacov G, Yishay S, Teitlboim S, Tveria L, Limanovich O, Kushnir M, Meshulam H (2007)
Asymmetric fluorogenic organophosphates for the development of active organophosphate hydrolases with reversed stereoselectivity
Toxicology 233: 187
Nizri E, Irony-Tur-Sinai M, Lavon I, Meshulam H, Amitai G, Brenner T (2007)
IBU-octyl-cytisine, a novel bifunctional compound eliciting anti-inflammatory and cholinergic activity, ameliorates CNS inflammation by inhibition of T-cell activity
Int Immunopharmacol 7: 1129
Amitai G, Adani R, Fishbein E, Meshulam H, Laish I, Dachir S (2006)
Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning
J Appl Toxicol 26: 81
Amitai G, Gaidukov L, Adani R, Yishay S, Yacov G, Kushnir M, Teitlboim S, Lindenbaum M, Bel P, Khersonsky O, Tawfik DS, Meshulam H (2006)
Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase
Febs J 273: 1906
Lundy PM, Raveh L, Amitai G (2006)
Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning
Toxicol Rev 25: 231
Miller OJ, Bernath K, Agresti JJ, Amitai G, Kelly BT, Mastrobattista E, Taly V, Magdassi S, Tawfik DS, Griffiths AD (2006)
Directed evolution by in vitro compartmentalization
Nat Methods 3: 561
Aharoni A, Amitai G, Bernath K, Magdassi S, Tawfik DS (2005)
High-throughput screening of enzyme libraries: thiolactonases evolved by fluorescence-activated sorting of single cells in emulsion compartments
Chemical Biology 12: 1281
Farias GG, Godoy JA, Vazquez MC, Adani R, Meshulam H, Avila J, Amitai G, Inestrosa NC (2005)
The anti-inflammatory and cholinesterase inhibitor bifunctional compound IBU-PO protects from beta-amyloid neurotoxicity by acting on Wnt signaling components
Neurobiol Dis 18: 176
Nizri E, Adani R, Meshulam H, Amitai G, Brenner T (2005)
Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for neuroinflammatory impairments
Neuroscience Letters 376: 46
Salmon A, Erb C, Meshorer E, Ginzberg D, Adani Y, Rabinovitz I, Amitai G, Soreq H (2005)
Muscarinic modulations of neuronal anticholinesterase responses
Chemico-Biological Interactions 157-158: 105
Amitai G, Adani R, Rabinovitz I, Beit-Yanai E, Shohami E, Sod-Moriah G, Meshulam H (2004)
Bifunctional compounds eliciting both anti-inflammatory and cholinergic activity as potential drugs for CNS disorders.
Cholinergic Mechanisms, CRC Press
Amitai G, Adani R, Rabinovitz I, Shohami E, Sod-Moriah G, Meshulam H (2004)
Poster (56) The bifunctional compound IBU-PO elicits prolonged anti-inflammatory and cholinesterase inhibition in vivo
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 350
Amitai G, Adani R, Hershkovitz M, Bel P, Rabinovitz I, Meshulam H (2004)
Poster (64) Chloroperoxidases catalyzes the degradation of VX and sulfur mustard.
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 354
Godoy JA, Adani R, Meshulam H, Inestrosa NC, Amitai G (2004)
The anti-inflammatory bifunctional compound IBU-PO protects rat hippocampal neurons from A-beta-induced cytotoxicity and beta-catenin depletion
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 135
Godoy JA, Adani R, Meshulam H, Inestrosa NC, Amitai G (2004)
Poster (80) The anti-inflammatory-cholinergic bifunctional compound ibu-po protects at sub-micromolar levels rat hippocampal cells from a beta-induced apoptosis and beta-catenin depletion
In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina: 363
Gilat E, Goldman M, Lahat E, Levy A, Rabinovitz I, Cohen G, Brandeis R, Amitai G, Alkalai D, Eshel G (2003)
Nasal midazolam as a novel anticonvulsive treatment against organophosphate-induced seizure activity in the guinea pig
Archives of Toxicology 77: 167
Chen R, Raveh L, Zomber G, Rabinovitz I, Cohen G, Adani R, Amitai G (2001)
Determination of therapeutic doses of bisquaternary oximes in large animals
J Appl Toxicol 21: 285
Amitai G, Adani R, Rabinovitz I, Sod-Moriah G, Brandeis R, Rachaman E, Heldman E (1998)
Quaternary-Lipophilic Carbamates with Blood Brain Barrier Permeability as Potential Drugs for the Treatment of Diseases Associated with Cholinergic Deficiency
In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.: 277
Amitai G, Moorad DR, Adani R, Doctor BP (1998)
Inhibition of acetylcholinesterase and butyrylcholinesterase by chlorpyrifos-oxon
Biochemical Pharmacology 56: 293
Amitai G, Adani R, Sod-Moriah G, Rabinovitz I, Vincze A, Leader H, Chefetz B, Leibovitz-Persky L, Friesem D, Hadar Y (1998)
Oxidative biodegradation of phosphorothiolates by fungal laccase
FEBS Letters 438: 195
Amitai G, Rabinovitz I, Zomber G, Chen R, Cohen G, Adani R, Raveh L (1995)
Bisquaternary Oximes as Antidotes against Tabun and Soman Poisoning
In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.: 345
Amitai G, Taylor P (1991)
Poster: Characterization of peripheral anionic site peptides of AChE by photoaffinity labeling with monoazidopropidium (MAP)
In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC: 285
Friboulet A, Rieger F, Goudou D, Amitai G, Taylor P (1990)
Interaction of an organophosphate with a peripheral site on acetylcholinesterase
Biochemistry 29: 914
Amitai G, Herz JM, Bruckstein R, Luz-Chapman S (1987)
The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor
Molecular Pharmacology 32: 678
Amitai G, Brown RD, Taylor P (1984)
The relationship between alpha 1-adrenergic receptor occupation and the mobilization of intracellular calcium
Journal of Biological Chemistry 259: 12519
Taylor P, Camp S, Lee SL, Amitai G, Taylor SS, Doctor BP (1984)
Molecular aspects of the biosynthesis and disposition of multiple forms of acetylcholinesterase
In: Cholinesterases, fundamental and applied aspects : proceedings of the Second International Meeting on Cholinesterases (Brzin M, Barnard EA, Sket D, Eds) De Gruyter: 145
Avissar S, Amitai G, Sokolovsky M (1983)
Oligomeric structure of muscarinic receptors is shown by photoaffinity labeling: subunit assembly may explain high- and low-affinity agonist states
Proc Natl Acad Sci U S A 80: 156
Amitai G, Avissar S, Balderman D, Sokolovsky M (1982)
Affinity labeling of muscarinic receptors in rat cerebral cortex with a photolabile antagonist
Proc Natl Acad Sci U S A 79: 243
Amitai G, Ashani Y, Gafni A, Silman I (1982)
Novel pyrene-containing organophosphates as fluorescent probes for studying aging-induced conformational changes in organophosphate-inhibited acetylcholinesterase
Biochemistry 21: 2060
Amitai G, Ashani Y, Gafni A, Silman I (1980)
New fluorescent organophosphates as probes for studying aging-induced conformational changes in inhibited acetylcholinesterase
Neurochem Int 2C: 199
Amitai G, Kloog Y, Balderman D, Sokolovsky M (1980)
The interaction of bis-pyridinium oximes with mouse brain muscarinic receptor
Biochemical Pharmacology 29: 483
Amitai G, Ashani Y, Shahar A, Gafni A, Silman I (1980)
Fluorescent organophosphates: novel probes for studying aging-induced conformational changes in inhibited acetylcholinesterase and for localization of cholinesterase in nervous tissue
Monographs in Neural Sciences 7: 70