Da Silva O, Probst N, Landry C, Hanak AS, Warnault P, Coisne C, Calas AG, Gosselet F, Courageux C, Gastellier AJ, Trancart M, Baati R, Dehouck MP, Jean L, Nachon F, Renard PY, Dias J (2022)
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning
Journal of Medicinal Chemistry

Francois S, Mondot S, Gerard Q, Bel R, Knoertzer J, Berriche A, Cavallero S, Baati R, Orset C, Dal Bo G, Thibault K (2022)
Long-Term Anxiety-like Behavior and Microbiota Changes Induced in Mice by Sublethal Doses of Acute Sarin Surrogate Exposure
Biomedicines 10:

Angrand L, Takillah S, Malissin I, Berriche A, Cervera C, Bel R, Gerard Q, Knoertzer J, Baati R, Kononchik JP, Megarbane B, Thibault K, Dal Bo G (2021)
Persistent brainwave disruption and cognitive impairment induced by acute sarin surrogate sub-lethal dose exposure
Toxicology

Dubrana LE, Knoll-Gellida A, Bourcier LM, Merce T, Pedemay S, Nachon F, Calas AG, Baati R, Soares M, Babin PJ (2021)
An Antidote Screening System for Organophosphorus Poisoning Using Zebrafish Larvae
ACS Chem Neurosci

Calas AG, Hanak AS, Jaffre N, Nervo A, Dias J, Rousseau C, Courageux C, Brazzolotto X, Villa P, Obrecht A, Goossens JF, Landry C, Hachani J, Gosselet F, Dehouck MP, Yerri J, Kliachyna M, Baati R, Nachon F (2020)
Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime
Biomolecules 10:

Yerri J, Dias J, Nimmakayala MR, Razafindrainibe F, Courageux C, Gastellier AJ, Jegoux J, Coisne C, Landry C, Gosselet F, Hachani J, Goossens JF, Dehouck MP, Nachon F, Baati R (2020)
Chemoselective Hydrogenation of 6-Alkynyl-3-fluoro-2-pyridinaldoximes: Access to First-in-Class 6-Alkyl-3-Fluoro-2-pyridinaldoxime Scaffolds as New Reactivators of Sarin-Inhibited Human Acetylcholinesterase with Increased Blood-Brain Barrier Permeability
Chemistry 26: 15035

Santoni G, de Sousa J, De la Mora E, Dias J, Jean L, Sussman JL, Silman I, Renard PY, Brown RCD, Weik M, Baati R, Nachon F (2018)
Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
Journal of Medicinal Chemistry 61: 7630

Zorbaz T, Braiki A, Marakovic N, Renou J, De la Mora E, Macek Hrvat N, Katalinic M, Silman I, Sussman JL, Mercey G, Gomez C, Mougeot R, Perez B, Baati R, Nachon F, Weik M, Jean L, Kovarik Z, Renard PY (2018)
Potent 3-Hydroxy-2-Pyridine Aldoxime Reactivators of Organophosphate-Inhibited Cholinesterases with Predicted Blood-Brain Barrier Penetration
Chemistry 24: 9675

Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboleas M, Loiodice M, Weik M, Jean L, Renard PY, Nachon F, Baati R (2014)
Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase
Eur Journal of Medicinal Chemistry 78C: 455

Renou J, Loiodice M, Arboleas M, Baati R, Jean L, Nachon F, Renard PY (2014)
Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases
Chem Commun (Camb) 50: 3947

de Sousa J, Brown RCD, Baati R (2014)
Buchwald-Hartwig Amination Approach for the Synthesis of Functionalized 1,2,3,4-Tetrahydroacridine Derivatives
Eur J Org Chem 2014: 3468

Renou J, Mercey G, Verdelet T, Paunescu E, Gillon E, Arboleas M, Loiodice M, Kliachyna M, Baati R, Nachon F, Jean L, Renard PY (2013)
Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents
Chemico-Biological Interactions 203: 81

Mercey G, Renou J, Verdelet T, Kliachyna M, Baati R, Gillon E, Arboleas M, Loiodice M, Nachon F, Jean L, Renard PY (2012)
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase
Journal of Medicinal Chemistry 55: 10791

Mercey G, Verdelet T, Renou J, Kliachyna M, Baati R, Nachon F, Jean L, Renard PY (2012)
Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents
Acc Chem Res 45: 756

Mercey G, Verdelet T, Saint-Andre G, Gillon E, Wagner A, Baati R, Jean L, Nachon F, Renard PY (2011)
First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase
Chem Commun (Camb) 47: 5295

Louise-Leriche L, Paunescu E, Saint-Andre G, Baati R, Romieu A, Wagner A, Renard PY (2010)
A HTS assay for the detection of organophosphorus nerve agent scavengers
Chemistry 16: 3510