Mak S, Li W, Fu H, Luo J, Cui W, Hu S, Pang Y, Carlier PR, Tsim KW, Pi R, Han Y (2021)
Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget
Journal of Neurochemistry

Xuan Z, Gu X, Yan S, Xie Y, Zhou Y, Zhang H, Jin H, Hu S, Mak MSH, Zhou D, Tsim KWK, Carlier PR, Han Y, Cui W (2021)
Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease
ACS Chem Neurosci 12: 2462

Mutunga JM, Ma M, Chen QH, Hartsel JA, Wong DM, Ding S, Totrov M, Carlier PR, Bloomquist JR (2019)
Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates
Int J Environ Research Public Health 16:

Carlier PR, Chen QH, Verma A, Wong DM, Mutunga JM, Muller J, Islam R, Shimozono AM, Tong F, Li J, Totrov M, Bloomquist JR (2018)
Select beta- and gamma-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase
Pestic Biochem Physiol 151: 32

Chen H, Wu X, Gu X, Zhou Y, Ye L, Zhang K, Pan H, Wang J, Wei H, Zhu B, Naman CB, Mak SH, Carlier PR, Cui W, Han YF (2018)
Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice
Front Cell Neurosci 12: 396

Cheung J, Mahmood A, Kalathur R, Liu L, Carlier PR (2018)
Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance
Structure 26: 130

Han Q, Wong DM, Robinson H, Ding H, Lam PC, Totrov MM, Carlier PR, Li J (2018)
Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae
Insect Sci 25: 721

Carlier PR, Bloomquist JR, Totrov M, Li J (2017)
Discovery of Species-selective and Resistance-breaking Anticholinesterase Insecticides for the Malaria Mosquito
Curr Med Chem 24: 2946

Camerino E, Wong DM, Tong F, Korber F, Gross AD, Islam R, Viayna E, Mutunga JM, Li J, Totrov MM, Bloomquist JR, Carlier PR (2015)
Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett 25: 4405

Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD (2015)
Structural genomics for drug design against the pathogen Coxiella burnetii
Proteins 83: 2124

Hu S, Wang R, Cui W, Zhang Z, Mak SH, Xu D, Choi C, Tsim KWK, Carlier PR, Lee M, Han Y (2015)
Inhibiting beta-Amyloid-Associated Alzheimer's Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue
Journal of Molecular Neuroscience 55: 1014

Mutunga JM, Anderson TD, Craft DT, Gross AD, Swale DR, Tong F, Wong DM, Carlier PR, Bloomquist JR (2015)
Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae
Pestic Biochem Physiol 121: 116

Swale DR, Carlier PR, Hartsel JA, Ma M, Bloomquist JR (2015)
Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance management
Pest Manag Sci 71: 1158

Verma A, Wong DM, Islam R, Tong F, Ghavami M, Mutunga JM, Slebodnick C, Li J, Viayna E, Lam PC, Totrov MM, Bloomquist JR, Carlier PR (2015)
3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae
Bioorganic & Medicinal Chemistry 23: 1321

Temeyer KB, Tong F, Totrov MM, Tuckow AP, Chen QH, Carlier PR, Perez de Leon AA, Bloomquist JR (2014)
Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant
Parasit Vectors 7: 577

Jiang Y, Swale D, Carlier PR, Hartsel JA, Ma M, Ekstrom F, Bloomquist JR (2013)
Evaluation of novel carbamate insecticides for neurotoxicity to non-target species
Pesticide Biochemistry and Physiology 106: 156

Mutunga JM, Boina DR, Anderson TD, Bloomquist JR, Carlier PR, Wong DM, Lam PC, Totrov MM (2013)
Neurotoxicology of bis(n)-Tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase
Archives of Insect Biochemistry & Physiology 83: 180

Swale DR, Tong F, Temeyer KB, Li A, Lam PC, Totrov MM, Carlier PR, Perez de Leon AA, Bloomquist JR (2013)
Inhibitor profile of (n)-tacrines -methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi
Pesticide Biochemistry and Physiology 106:

Tong F, Islam RM, Carlier PR, Ma M, Ekstrom F, Bloomquist JR (2013)
Effects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine Acetylcholinesterase
Pesticide Biochemistry and Physiology 106: 79

Wong DM, Li J, Lam PC, Hartsel JA, Mutunga JM, Totrov M, Bloomquist JR, Carlier PR (2013)
Aryl methylcarbamates: Potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae
Chemico-Biological Interactions 203: 314

Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL, Li J, Lam PC, Totrov MM, Bloomquist JR, Carlier PR (2012)
Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase
Bioorganic & Medicinal Chemistry Lett 22: 4593

Wong DM, Li J, Chen QH, Han Q, Mutunga JM, Wysinski A, Anderson TD, Ding H, Carpenetti TL, Verma A, Islam R, Paulson SL, Lam PC, Totrov M, Bloomquist JR, Carlier PR (2012)
Select small core structure carbamates exhibit high contact toxicity to carbamate-resistant strain malaria mosquitoes, Anopheles gambiae (Akron)
PLoS ONE 7: e46712

Cui W, Cui GZ, Li W, Zhang Z, Hu S, Mak SH, Zhang H, Carlier PR, Choi CL, Wong YT, Lee SM, Han YF (2011)
Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR
Brain Research 1401: 10

Cui W, Li W, Zhao Y, Mak SH, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han YF (2011)
Preventing H(2)O(2)-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone
Brain Research 1394: 14

Zhao Y, Dou J, Luo J, Li W, Chan HH, Cui W, Zhang H, Han R, Carlier PR, Zhang X, Han Y (2011)
Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets
Brain Research 1421: 100

Carlier PR, Anderson TD, Wong DM, Hsu DC, Hartsel J, Ma M, Wong EA, Choudhury R, Lam PC, Totrov MM, Bloomquist JR (2008)
Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae
Chemico-Biological Interactions 175: 368

Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF (2008)
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine
J Pharm Biomed Anal 46: 75

Li WM, Kan KK, Carlier PR, Pang YP, Han YF (2007)
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A
Curr Alzheimer Res 4: 386

Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL (2006)
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge
Journal of Medicinal Chemistry 49: 5491

Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL (2005)
Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase
Journal of the American Chemical Society 127: 11029

Li W, Pi R, Chan HH, Fu H, Lee NT, Tsang HW, Pu Y, Chang DC, Li C, Luo J, Xiong K, Li Z, Xue H, Carlier PR, Pang Y, Tsim KWK, Li M, Han Y (2005)
Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors
Journal of Biological Chemistry 280: 18179

Du DM, Carlier PR (2004)
Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease
Curr Pharm Des 10: 3141

Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL (2003)
Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity
J Am Chem Soc 125: 363

Lewis WG, Green LG, Grynszpan F, Radic Z, Carlier PR, Taylor P, Finn MG, Sharpless KB (2002)
Cover picture: angew. Chem. Int. Ed. 6/2002
Angew Chem Int Ed Engl 41: 875

Lewis WG, Green LG, Grynszpan F, Radic Z, Carlier PR, Taylor P, Finn MG, Sharpless KB (2002)
Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks
Angew Chem Int Ed Engl 41: 1053

Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP (2000)
Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product
Angew Chem Int Ed Engl 39: 1775

Lenigk R, Lam E, Lai A, Wang H, Han Y, Carlier PR, Renneberg R (2000)
Enzyme biosensor for studying therapeutics of Alzheimer's disease
Biosensors & Bioelectronics 15: 541

Liu J, Ho W, Lee NT, Carlier PR, Pang Y, Han Y (2000)
Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats
Neuroscience Letters 282: 165

Wu D, Xiao X, Ng AK, Chen PM, Chung W, Lee NT, Carlier PR, Pang Y, Yu AC, Han Y (2000)
Corrigendum to 'Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor'
Neuroscience Letters 290: 84

Wu DC, Xiao XQ, Ng AK, Chen PM, Chung W, Lee NT, Carlier PR, Pang YP, Yu AC, Han YF (2000)
Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected]
Neuroscience Letters 288: 95

Xiao XQ, Lee NT, Carlier PR, Pang Y, Han YF (2000)
Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine
Neuroscience Letters 290: 197

Carlier PR, Han YF, Chow ES, Li CP, Wang H, Lieu TX, Wong HS, Pang YP (1999)
Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis
Bioorganic & Medicinal Chemistry 7: 351

Carlier PR, Chow ES, Han Y, Liu J, El Yazal J, Pang YP (1999)
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions
Journal of Medicinal Chemistry 42: 4225

Carlier PR, Du DM, Han Y, Liu J, Pang YP (1999)
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett 9: 2335

Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR (1999)
Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities
Bioorganic & Medicinal Chemistry 7: 2569

Li CY, Wang H, Xue H, Carlier PR, Hui KM, Pang YP, Li ZW, Han YF (1999)
Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist
Neuroreport 10: 795

Wang H, Carlier PR, Ho WL, Wu DC, Lee NT, Li CP, Pang YP, Han YF (1999)
Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE
Neuroreport 10: 789

Wang H, Carlier PR, Ho WL, Lee NT, Pang YP, Han YF (1999)
Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor
Zhongguo Yao Li Xue Bao 20: 211