Mak S, Li W, Fu H, Luo J, Cui W, Hu S, Pang Y, Carlier PR, Tsim KW, Pi R, Han Y (2021) <br />Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget<br /><i>Journal of Neurochemistry</i> <br /><br />Xuan Z, Gu X, Yan S, Xie Y, Zhou Y, Zhang H, Jin H, Hu S, Mak MSH, Zhou D, Tsim KWK, Carlier PR, Han Y, Cui W (2021) <br />Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease<br /><i>ACS Chem Neurosci</i> <b>12</b>: 2462<br /><br />Mutunga JM, Ma M, Chen QH, Hartsel JA, Wong DM, Ding S, Totrov M, Carlier PR, Bloomquist JR (2019) <br />Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates<br /><i>Int J Environ Research Public Health</i> <b>16</b>: <br /><br />Carlier PR, Chen QH, Verma A, Wong DM, Mutunga JM, Muller J, Islam R, Shimozono AM, Tong F, Li J, Totrov M, Bloomquist JR (2018) <br />Select beta- and gamma-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase<br /><i>Pestic Biochem Physiol</i> <b>151</b>: 32<br /><br />Chen H, Wu X, Gu X, Zhou Y, Ye L, Zhang K, Pan H, Wang J, Wei H, Zhu B, Naman CB, Mak SH, Carlier PR, Cui W, Han YF (2018) <br />Tacrine(10)-Hupyridone Prevents Post-operative Cognitive Dysfunction via the Activation of BDNF Pathway and the Inhibition of AChE in Aged Mice<br /><i>Front Cell Neurosci</i> <b>12</b>: 396<br /><br />Cheung J, Mahmood A, Kalathur R, Liu L, Carlier PR (2018) <br />Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance<br /><i>Structure</i> <b>26</b>: 130<br /><br />Han Q, Wong DM, Robinson H, Ding H, Lam PC, Totrov MM, Carlier PR, Li J (2018) <br />Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae<br /><i>Insect Sci</i> <b>25</b>: 721<br /><br />Carlier PR, Bloomquist JR, Totrov M, Li J (2017) <br />Discovery of Species-selective and Resistance-breaking Anticholinesterase Insecticides for the Malaria Mosquito<br /><i>Curr Med Chem</i> <b>24</b>: 2946<br /><br />Camerino E, Wong DM, Tong F, Korber F, Gross AD, Islam R, Viayna E, Mutunga JM, Li J, Totrov MM, Bloomquist JR, Carlier PR (2015) <br />Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>25</b>: 4405<br /><br />Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD (2015) <br />Structural genomics for drug design against the pathogen Coxiella burnetii<br /><i>Proteins</i> <b>83</b>: 2124<br /><br />Hu S, Wang R, Cui W, Zhang Z, Mak SH, Xu D, Choi C, Tsim KWK, Carlier PR, Lee M, Han Y (2015) <br />Inhibiting beta-Amyloid-Associated Alzheimer's Pathogenesis In Vitro and In Vivo by a Multifunctional Dimeric Bis(12)-hupyridone Derived from Its Natural Analogue<br /><i>Journal of Molecular Neuroscience</i> <b>55</b>: 1014<br /><br />Mutunga JM, Anderson TD, Craft DT, Gross AD, Swale DR, Tong F, Wong DM, Carlier PR, Bloomquist JR (2015) <br />Carbamate and pyrethroid resistance in the akron strain of Anopheles gambiae<br /><i>Pestic Biochem Physiol</i> <b>121</b>: 116<br /><br />Swale DR, Carlier PR, Hartsel JA, Ma M, Bloomquist JR (2015) <br />Mosquitocidal carbamates with low toxicity to agricultural pests: an advantageous property for insecticide resistance management<br /><i>Pest Manag Sci</i> <b>71</b>: 1158<br /><br />Verma A, Wong DM, Islam R, Tong F, Ghavami M, Mutunga JM, Slebodnick C, Li J, Viayna E, Lam PC, Totrov MM, Bloomquist JR, Carlier PR (2015) <br />3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae<br /><i>Bioorganic & Medicinal Chemistry</i> <b>23</b>: 1321<br /><br />Temeyer KB, Tong F, Totrov MM, Tuckow AP, Chen QH, Carlier PR, Perez de Leon AA, Bloomquist JR (2014) <br />Acetylcholinesterase of the sand fly, Phlebotomus papatasi (Scopoli): construction, expression and biochemical properties of the G119S orthologous mutant<br /><i>Parasit Vectors</i> <b>7</b>: 577<br /><br />Jiang Y, Swale D, Carlier PR, Hartsel JA, Ma M, Ekstrom F, Bloomquist JR (2013) <br />Evaluation of novel carbamate insecticides for neurotoxicity to non-target species<br /><i>Pesticide Biochemistry and Physiology</i> <b>106</b>: 156<br /><br />Mutunga JM, Boina DR, Anderson TD, Bloomquist JR, Carlier PR, Wong DM, Lam PC, Totrov MM (2013) <br />Neurotoxicology of bis(n)-Tacrines on Blattella germanica and Drosophila melanogaster acetylcholinesterase<br /><i>Archives of Insect Biochemistry & Physiology</i> <b>83</b>: 180<br /><br />Swale DR, Tong F, Temeyer KB, Li A, Lam PC, Totrov MM, Carlier PR, Perez de Leon AA, Bloomquist JR (2013) <br />Inhibitor profile of (n)-tacrines -methylcarbamates on acetylcholinesterase from Rhipicephalus (Boophilus) microplus and Phlebotomus papatasi<br /><i>Pesticide Biochemistry and Physiology</i> <b>106</b>: <br /><br />Tong F, Islam RM, Carlier PR, Ma M, Ekstrom F, Bloomquist JR (2013) <br />Effects of Anticholinesterases on Catalysis and Induced Conformational Change of the Peripheral Anionic Site of Murine Acetylcholinesterase<br /><i>Pesticide Biochemistry and Physiology</i> <b>106</b>: 79<br /><br />Wong DM, Li J, Lam PC, Hartsel JA, Mutunga JM, Totrov M, Bloomquist JR, Carlier PR (2013) <br />Aryl methylcarbamates: Potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 strain An. gambiae<br /><i>Chemico-Biological Interactions</i> <b>203</b>: 314<br /><br />Hartsel JA, Wong DM, Mutunga JM, Ma M, Anderson TD, Wysinski A, Islam R, Wong EA, Paulson SL, Li J, Lam PC, Totrov MM, Bloomquist JR, Carlier PR (2012) <br />Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>22</b>: 4593<br /><br />Wong DM, Li J, Chen QH, Han Q, Mutunga JM, Wysinski A, Anderson TD, Ding H, Carpenetti TL, Verma A, Islam R, Paulson SL, Lam PC, Totrov M, Bloomquist JR, Carlier PR (2012) <br />Select small core structure carbamates exhibit high contact toxicity to carbamate-resistant strain malaria mosquitoes, Anopheles gambiae (Akron)<br /><i>PLoS ONE</i> <b>7</b>: e46712<br /><br />Cui W, Cui GZ, Li W, Zhang Z, Hu S, Mak SH, Zhang H, Carlier PR, Choi CL, Wong YT, Lee SM, Han YF (2011) <br />Bis(12)-hupyridone, a novel multifunctional dimer, promotes neuronal differentiation more potently than its monomeric natural analog huperzine A possibly through alpha7 nAChR<br /><i>Brain Research</i> <b>1401</b>: 10<br /><br />Cui W, Li W, Zhao Y, Mak SH, Gao Y, Luo J, Zhang H, Liu Y, Carlier PR, Rong J, Han YF (2011) <br />Preventing H(2)O(2)-induced apoptosis in cerebellar granule neurons by regulating the VEGFR-2/Akt signaling pathway using a novel dimeric antiacetylcholinesterase bis(12)-hupyridone<br /><i>Brain Research</i> <b>1394</b>: 14<br /><br />Zhao Y, Dou J, Luo J, Li W, Chan HH, Cui W, Zhang H, Han R, Carlier PR, Zhang X, Han Y (2011) <br />Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets<br /><i>Brain Research</i> <b>1421</b>: 100<br /><br />Carlier PR, Anderson TD, Wong DM, Hsu DC, Hartsel J, Ma M, Wong EA, Choudhury R, Lam PC, Totrov MM, Bloomquist JR (2008) <br />Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 368<br /><br />Yu H, Li WM, Kan KK, Ho JM, Carlier PR, Pang YP, Gu ZM, Zhong Z, Chan K, Wang YT, Han YF (2008) <br />The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine<br /><i>J Pharm Biomed Anal</i> <b>46</b>: 75<br /><br />Li WM, Kan KK, Carlier PR, Pang YP, Han YF (2007) <br />East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A<br /><i>Curr Alzheimer Res</i> <b>4</b>: 386<br /><br />Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL (2006) <br />Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge<br /><i>Journal of Medicinal Chemistry</i> <b>49</b>: 5491<br /><br />Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL (2005) <br />Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase<br /><i>Journal of the American Chemical Society</i> <b>127</b>: 11029<br /><br />Li W, Pi R, Chan HH, Fu H, Lee NT, Tsang HW, Pu Y, Chang DC, Li C, Luo J, Xiong K, Li Z, Xue H, Carlier PR, Pang Y, Tsim KWK, Li M, Han Y (2005) <br />Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors<br /><i>Journal of Biological Chemistry</i> <b>280</b>: 18179<br /><br />Du DM, Carlier PR (2004) <br />Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease<br /><i>Curr Pharm Des</i> <b>10</b>: 3141<br /><br />Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL (2003) <br />Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity<br /><i>J Am Chem Soc</i> <b>125</b>: 363<br /><br />Lewis WG, Green LG, Grynszpan F, Radic Z, Carlier PR, Taylor P, Finn MG, Sharpless KB (2002) <br />Cover picture: angew. Chem. Int. Ed. 6/2002<br /><i>Angew Chem Int Ed Engl</i> <b>41</b>: 875<br /><br />Lewis WG, Green LG, Grynszpan F, Radic Z, Carlier PR, Taylor P, Finn MG, Sharpless KB (2002) <br />Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks<br /><i>Angew Chem Int Ed Engl</i> <b>41</b>: 1053<br /><br />Carlier PR, Du DM, Han YF, Liu J, Perola E, Williams ID, Pang YP (2000) <br />Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product<br /><i>Angew Chem Int Ed Engl</i> <b>39</b>: 1775<br /><br />Lenigk R, Lam E, Lai A, Wang H, Han Y, Carlier PR, Renneberg R (2000) <br />Enzyme biosensor for studying therapeutics of Alzheimer's disease<br /><i>Biosensors & Bioelectronics</i> <b>15</b>: 541<br /><br />Liu J, Ho W, Lee NT, Carlier PR, Pang Y, Han Y (2000) <br />Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats<br /><i>Neuroscience Letters</i> <b>282</b>: 165<br /><br />Wu D, Xiao X, Ng AK, Chen PM, Chung W, Lee NT, Carlier PR, Pang Y, Yu AC, Han Y (2000) <br />Corrigendum to 'Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor'<br /><i>Neuroscience Letters</i> <b>290</b>: 84<br /><br />Wu DC, Xiao XQ, Ng AK, Chen PM, Chung W, Lee NT, Carlier PR, Pang YP, Yu AC, Han YF (2000) <br />Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected]<br /><i>Neuroscience Letters</i> <b>288</b>: 95<br /><br />Xiao XQ, Lee NT, Carlier PR, Pang Y, Han YF (2000) <br />Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine<br /><i>Neuroscience Letters</i> <b>290</b>: 197<br /><br />Carlier PR, Han YF, Chow ES, Li CP, Wang H, Lieu TX, Wong HS, Pang YP (1999) <br />Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis<br /><i>Bioorganic & Medicinal Chemistry</i> <b>7</b>: 351<br /><br />Carlier PR, Chow ES, Han Y, Liu J, El Yazal J, Pang YP (1999) <br />Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions<br /><i>Journal of Medicinal Chemistry</i> <b>42</b>: 4225<br /><br />Carlier PR, Du DM, Han Y, Liu J, Pang YP (1999) <br />Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>9</b>: 2335<br /><br />Han YF, Li CP, Chow E, Wang H, Pang YP, Carlier PR (1999) <br />Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities<br /><i>Bioorganic & Medicinal Chemistry</i> <b>7</b>: 2569<br /><br />Li CY, Wang H, Xue H, Carlier PR, Hui KM, Pang YP, Li ZW, Han YF (1999) <br />Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist<br /><i>Neuroreport</i> <b>10</b>: 795<br /><br />Wang H, Carlier PR, Ho WL, Wu DC, Lee NT, Li CP, Pang YP, Han YF (1999) <br />Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE<br /><i>Neuroreport</i> <b>10</b>: 789<br /><br />Wang H, Carlier PR, Ho WL, Lee NT, Pang YP, Han YF (1999) <br />Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor<br /><i>Zhongguo Yao Li Xue Bao</i> <b>20</b>: 211<br /><br />