de Freitas Silva M, Tardelli Lima E, Pruccoli L, Castro NG, Guimares MJR, F MRdS, Fonseca Nadur N, de Azevedo LL, Kummerle AE, Guedes IA, Dardenne LE, Gontijo VS, Tarozzi A, Viegas C (2020) <br />Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease<br /><i>Molecules</i> <b>25</b>: <br /><br />Dias Viegas FP, de Freitas Silva M, Divino da Rocha M, Castelli MR, Riquiel MM, Machado RP, Vaz SM, Simoes de Lima LM, Mancini KC, Marques de Oliveira PC, Morais EP, Gontijo VS, da Silva FMR, D'Alincourt da Fonseca Pecanha D, Castro NG, Neves GA, Giusti-Paiva A, Vilela FC, Orlandi L, Camps I, Veloso MP, Leomil Coelho LF, Ionta M, Ferreira-Silva GA, Pereira RM, Dardenne LE, Guedes IA, de Oliveira Carneiro Junior W, Quaglio Bellozi PM, Pinheiro de Oliveira AC, Ferreira FF, Pruccoli L, Tarozzi A, Viegas C, Jr. (2018) <br />Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates<br /><i>Eur Journal of Medicinal Chemistry</i> <b>147</b>: 48<br /><br />Dias KS, de Paula CT, Dos Santos T, Souza IN, Boni MS, Guimaraes MJ, da Silva FM, Castro NG, Neves GA, Veloso CC, Coelho MM, de Melo IS, Giusti FC, Giusti-Paiva A, da Silva ML, Dardenne LE, Guedes IA, Pruccoli L, Morroni F, Tarozzi A, Viegas C, Jr. (2017) <br />Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>130</b>: 440<br /><br />Lemes LF, de Andrade Ramos G, de Oliveira AS, da Silva FM, de Castro Couto G, da Silva Boni M, Guimaraes MJ, Souza IN, Bartolini M, Andrisano V, do Nascimento Nogueira PC, Silveira ER, Brand GD, Soukup O, Korabecny J, Romeiro NC, Castro NG, Bolognesi ML, Romeiro LA (2015) <br />Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>108</b>: 687<br /><br />Petronilho EC, Renno MD, Castro NG, da Silva FM, Pinto AD, Figueroa-Villar JD (2015) <br />Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase<br /><i>J Enzyme Inhib Med Chem</i> <br /><br />Diniz LP, Tortelli V, Garcia MN, Araujo AP, Melo HM, Seixas da Silva GS, De Felice FG, Alves-Leon SV, de Souza JM, Romao LF, Castro NG, Gomes FC (2014) <br />Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling<br /><i>Glia</i> <b>62</b>: 1917<br /><br />Tributino JL, Santos ML, Mesquita CM, Lima CK, Silva LL, Maia RC, Duarte CD, Barreiro EJ, Fraga CA, Castro NG, Miranda AL, Guimaraes MZ (2010) <br />LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation<br /><i>British Journal of Pharmacology</i> <b>159</b>: 1716<br /><br />Lima JA, Costa RS, Epifanio RA, Castro NG, Rocha MS, Pinto AC (2009) <br />Geissospermum vellosii stembark: anticholinesterase activity and improvement of scopolamine-induced memory deficits<br /><i>Pharmacol Biochem Behav</i> <b>92</b>: 508<br /><br />de Paula AA, Martins JB, dos Santos ML, Nascente Lde C, Romeiro LA, Areas TF, Vieira KS, Gamboa NF, Castro NG, Gargano R (2009) <br />New potential AChE inhibitor candidates<br /><i>Eur Journal of Medicinal Chemistry</i> <b>44</b>: 3754<br /><br />Castro NG, Costa RS, Pimentel LS, Danuello A, Romeiro NC, Viegas C, Jr., Barreiro EJ, Fraga CA, Bolzani VS, Rocha MS (2008) <br />CNS-selective noncompetitive cholinesterase inhibitors derived from the natural piperidine alkaloid (-)-spectaline<br /><i>European Journal of Pharmacology</i> <b>580</b>: 339<br /><br />Santos HR, Ribeiro HS, Setti-Perdigao P, Albuquerque EX, Castro NG (2006) <br />The magnitude of alpha7 nicotinic receptor currents in rat hippocampal neurons is dependent upon GABAergic activity and depolarization<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>319</b>: 376<br /><br />Pessoa RF, Castro NG, Noel F (2005) <br />Binding of [3H]MK-801 in subcellular fractions of Schistosoma mansoni: evidence for interaction with nicotinic receptors<br /><i>Biochemical Pharmacology</i> <b>69</b>: 1509<br /><br />Viegas C, Jr., Bolzani VS, Pimentel LS, Castro NG, Cabral RF, Costa RS, Floyd C, Rocha MS, Young MC, Barreiro EJ, Fraga CA (2005) <br />New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids<br /><i>Bioorganic & Medicinal Chemistry</i> <b>13</b>: 4184<br /><br />Santos HR, Cintra WM, Aracava Y, Maciel CM, Castro NG, Albuquerque EX (2004) <br />Spine density and dendritic branching pattern of hippocampal CA1 pyramidal neurons in neonatal rats chronically exposed to the organophosphate paraoxon<br /><i>Neurotoxicology</i> <b>25</b>: 481<br /><br />Barreiro EJ, Camara CA, Verli H, Brazil-Mas L, Castro NG, Cintra WM, Aracava Y, Rodrigues CR, Fraga CA (2003) <br />Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors<br /><i>Journal of Medicinal Chemistry</i> <b>46</b>: 1144<br /><br />Santos MD, Pereira EF, Aracava Y, Castro NG, Fawcett WP, Randall WR, Albuquerque EX (2003) <br />Low concentrations of pyridostigmine prevent soman-induced inhibition of GABAergic transmission in the central nervous system: involvement of muscarinic receptors<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>304</b>: 254<br /><br />Gonzalez-Serratos H, Chang R, Pereira EF, Castro NG, Aracava Y, Melo PA, Lima PC, Fraga CA, Barreiro EJ, Albuquerque EX (2001) <br />A novel thienylhydrazone, (2-thienylidene)3,4-methylenedioxybenzoylhydrazine, increases inotropism and decreases fatigue of skeletal muscle<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>299</b>: 558<br /><br />Mike A, Castro NG, Albuquerque EX (2000) <br />Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons<br /><i>Brain Research</i> <b>882</b>: 155<br /><br />Albuquerque EX, Alkondon M, Pereira EF, Castro NG, Schrattenholz A, Barbosa CT, Bonfante-Cabarcas R, Aracava Y, Eisenberg HM, Maelicke A (1997) <br />Properties of neuronal nicotinic acetylcholine receptors: pharmacological characterization and modulation of synaptic function<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>280</b>: 1117<br /><br />Albuquerque EX, Pereira EF, Castro NG, Alkondon M, Reinhardt S, Schroder H, Maelicke A (1995) <br />Nicotinic receptor function in the mammalian central nervous system<br /><i>Annals of the New York Academy of Sciences</i> <b>757</b>: 48<br /><br />Castro NG, Albuquerque EX (1995) <br />alpha-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability<br /><i>Biophysical Journal</i> <b>68</b>: 516<br /><br />Castro NG, Albuquerque EX (1993) <br />Brief-lifetime, fast-inactivating ion channels account for the alpha-bungarotoxin-sensitive nicotinic response in hippocampal neurons<br /><i>Neuroscience Letters</i> <b>164</b>: 137<br /><br />Pereira EF, Alkondon M, Tano T, Castro NG, Froes-Ferrao MM, Rozental R, Aronstam RS, Schrattenholz A, Maelicke A, Albuquerque EX (1993) <br />A novel agonist binding site on nicotinic acetylcholine receptors<br /><i>J Recept Res</i> <b>13</b>: 413<br /><br />