Li M, Patel HV, Cognetta AB, 3rd, Smith TC, 2nd, Mallick I, Cavalier JF, Previti ML, Canaan S, Aldridge BB, Cravatt BF, Seeliger JC (2022)
Identification of cell wall synthesis inhibitors active against Mycobacterium tuberculosis by competitive activity-based protein profiling
Cell Chemical Biology 29: 883
Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB, 3rd, To A, Parsons WH, Simon GM, Desai A, Petrascheck M, Bar-Peled L, Cravatt BF (2019)
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan
Nat Chemical Biology 15: 453
Pentinmikko N, Iqbal S, Mana M, Andersson S, Cognetta AB, 3rd, Suciu RM, Roper J, Luopajarvi K, Markelin E, Gopalakrishnan S, Smolander OP, Naranjo S, Saarinen T, Juuti A, Pietilainen K, Auvinen P, Ristimaki A, Gupta N, Tammela T, Jacks T, Sabatini DM, Cravatt BF, Yilmaz OH, Katajisto P (2019)
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
Nature 571: 398
Suciu RM, Cognetta AB, 3rd, Potter ZE, Cravatt BF (2018)
Selective Irreversible Inhibitors of the Wnt-Deacylating Enzyme NOTUM Developed by Activity-Based Protein Profiling
ACS Med Chem Lett 9: 563
Kornahrens AF, Cognetta AB, 3rd, Brody DM, Matthews ML, Cravatt BF, Boger DL (2017)
Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor
Journal of the American Chemical Society 139: 7052
Tan J, Cognetta AB, 3rd, Diaz DB, Lum KM, Adachi S, Kundu S, Cravatt BF, Yudin AK (2017)
Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
Nat Commun 8: 1760
Touchette MH, Van Vlack ER, Bai L, Kim J, Cognetta AB, 3rd, Previti ML, Backus KM, Martin DW, Cravatt BF, Seeliger JC (2017)
A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A
ACS Infect Dis 3: 336
van Esbroeck ACM, Janssen APA, Cognetta AB, 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allara M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M (2017)
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Science 356: 1084
Parsons WH, Kolar MJ, Kamat SS, Cognetta AB, 3rd, Hulce JJ, Saez E, Kahn BB, Saghatelian A, Cravatt BF (2016)
AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs
Nat Chemical Biology 12: 367
Cognetta AB, 3rd, Niphakis MJ, Lee HC, Martini ML, Hulce JJ, Cravatt BF (2015)
Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases
Chemical Biology 22: 928
Lajkiewicz NJ, Cognetta AB, 3rd, Niphakis MJ, Cravatt BF, Porco JA, Jr. (2014)
Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived beta-lactone
Journal of the American Chemical Society 136: 2659
Chang JW, Cognetta AB, 3rd, Niphakis MJ, Cravatt BF (2013)
Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition
ACS Chemical Biology 8: 1590
Hulce JJ, Cognetta AB, 3rd, Niphakis MJ, Tully SE, Cravatt BF (2013)
Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells
Nat Methods 10: 259
Niphakis MJ, Cognetta AB, 3rd, Chang JW, Buczynski MW, Parsons LH, Byrne F, Burston JJ, Chapman V, Cravatt BF (2013)
Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors
ACS Chem Neurosci 4: 1322
Chang JW, Niphakis MJ, Lum KM, Cognetta AB, 3rd, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH, Cravatt BF (2012)
Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates
Chemical Biology 19: 579