Viayna E, Coquelle N, Cieslikiewicz-Bouet M, Cisternas P, Oliva CA, Sanchez-Lopez E, Ettcheto M, Bartolini M, De Simone A, Ricchini M, Rendina M, Pons M, Firuzi O, Perez B, Saso L, Andrisano V, Nachon F, Brazzolotto X, Garcia ML, Camins A, Silman I, Jean L, Inestrosa NC, Colletier JP, Renard PY, Munoz-Torrero D (2021) <br />Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice<br /><i>Journal of Medicinal Chemistry</i> <b>64</b>: 812<br /><br />Catto M, Pisani L, De la Mora E, Belviso BD, Mangiatordi GF, Pinto A, Palma A, Denora N, Caliandro R, Colletier JP, Silman I, Nicolotti O, Altomare CD (2020) <br />Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor<br /><i>ACS Med Chem Lett</i> <b>11</b>: 869<br /><br />Pajk S, Knez D, Kosak U, Zorovic M, Brazzolotto X, Coquelle N, Nachon F, Colletier JP, Zivin M, Stojan J, Gobec S (2020) <br />Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes<br /><i>J Enzyme Inhib Med Chem</i> <b>35</b>: 498<br /><br />Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY (2019) <br />Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3<br /><i>Eur Journal of Medicinal Chemistry</i> <b>168</b>: 58<br /><br />Galdeano C, Coquelle N, Cieslikiewicz-Bouet M, Bartolini M, Perez B, Clos MV, Silman I, Jean L, Colletier JP, Renard PY, Munoz-Torrero D (2018) <br />Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis<br /><i>Molecules</i> <b>23</b>: <br /><br />Knez D, Coquelle N, Pislar A, Zakelj S, Jukic M, Sova M, Mravljak J, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S (2018) <br />Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities<br /><i>Eur Journal of Medicinal Chemistry</i> <b>156</b>: 598<br /><br />Kosak U, Brus B, Knez D, Zakelj S, Trontelj J, Pislar A, Sink R, Jukic M, Zivin M, Podkowa A, Nachon F, Brazzolotto X, Stojan J, Kos J, Coquelle N, Salat K, Colletier JP, Gobec S (2018) <br />The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity<br /><i>Journal of Medicinal Chemistry</i> <b>61</b>: 119<br /><br />Kosak U, Knez D, Coquelle N, Brus B, Pislar A, Nachon F, Brazzolotto X, Kos J, Colletier JP, Gobec S (2017) <br />N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents<br /><i>Bioorganic & Medicinal Chemistry</i> <b>25</b>: 633<br /><br />Colletier JP, Sliwa M, Gallat FX, Sugahara M, Guillon V, Schiro G, Coquelle N, Woodhouse J, Roux L, Gotthard G, Royant A, Uriarte LM, Ruckebusch C, Joti Y, Byrdin M, Mizohata E, Nango E, Tanaka T, Tono K, Yabashi M, Adam V, Cammarata M, Schlichting I, Bourgeois D, Weik M (2016) <br />Serial Femtosecond Crystallography and Ultrafast Absorption Spectroscopy of the Photoswitchable Fluorescent Protein IrisFP<br /><i>J Phys Chem Lett</i> <b>7</b>: 882<br /><br />Kosak U, Brus B, Knez D, Sink R, Zakelj S, Trontelj J, Pislar A, Slenc J, Gobec M, Zivin M, Tratnjek L, Perse M, Salat K, Podkowa A, Filipek B, Nachon F, Brazzolotto X, Wieckowska A, Malawska B, Stojan J, Rascan IM, Kos J, Coquelle N, Colletier JP, Gobec S (2016) <br />Development of an in-vivo active reversible butyrylcholinesterase inhibitor<br /><i>Sci Rep</i> <b>6</b>: 39495<br /><br />Araoz R, Bouet m, Bartolini M, Coquelle N, Colletier JP, Servent D, Molgo J, Jean L, Renard PY (2015) <br />Poster: Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of alpha7 nicotinic acetylcholine receptor<br /><i>Biochemical Pharmacology</i> <b>97</b>: 621<br /><br />Knez D, Brus B, Coquelle N, Sosic I, Sink R, Brazzolotto X, Mravljak J, Colletier JP, Gobec S (2015) <br />Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents<br /><i>Bioorganic & Medicinal Chemistry</i> <b>23</b>: 4442<br /><br />Brus B, Kosak U, Turk S, Pislar A, Coquelle N, Kos J, Stojan J, Colletier JP, Gobec S (2014) <br />Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 8167<br /><br />Kliachyna M, Santoni G, Nussbaum V, Renou J, Sanson B, Colletier JP, Arboleas M, Loiodice M, Weik M, Jean L, Renard PY, Nachon F, Baati R (2014) <br />Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase<br /><i>Eur Journal of Medicinal Chemistry</i> <b>78C</b>: 455<br /><br />Carletti E, Colletier JP, Schopfer LM, Santoni G, Masson P, Lockridge O, Nachon F, Weik M (2013) <br />Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry<br /><i>Chemical Research in Toxicology</i> <b>26</b>: 280<br /><br />Ronco C, Carletti E, Colletier JP, Weik M, Nachon F, Jean L, Renard PY (2012) <br />Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography<br /><i>ChemMedChem</i> <b>7</b>: 400<br /><br />Carletti E, Schopfer LM, Colletier JP, Froment MT, Nachon F, Weik M, Lockridge O, Masson P (2011) <br />Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis<br /><i>Chemical Research in Toxicology</i> <b>24</b>: 797<br /><br />Sanson B, Colletier JP, Xu Y, Lang PT, Jiang H, Silman I, Sussman JL, Weik M (2011) <br />Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations<br /><i>Protein Science</i> <b>20</b>: 1114<br /><br />Carletti E, Colletier JP, Dupeux F, Trovaslet M, Masson P, Nachon F (2010) <br />Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation<br /><i>Journal of Medicinal Chemistry</i> <b>53</b>: 4002<br /><br />Xu Y, Colletier JP, Weik M, Qin G, Jiang H, Silman I, Sussman JL (2010) <br />Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase<br /><i>Biophysical Journal</i> <b>99</b>: 4003<br /><br />Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P, Silman I, Weik M (2009) <br />Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 7593<br /><br />Colletier JP, Bourgeois D, Sanson B, Fournier D, Sussman JL, Silman I, Weik M (2008) <br />Shoot-and-Trap: use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography<br /><i>Proc Natl Acad Sci U S A</i> <b>105</b>: 11742<br /><br />Xu Y, Colletier JP, Jiang H, Silman I, Sussman JL, Weik M (2008) <br />Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design<br /><i>Protein Science</i> <b>17</b>: 601<br /><br />Xu Y, Colletier JP, Weik M, Jiang H, Moult J, Silman I, Sussman JL (2008) <br />Flexibility of aromatic residues in the active-site gorge of acetylcholinesterase: X-ray versus molecular dynamics<br /><i>Biophysical Journal</i> <b>95</b>: 2500<br /><br />Colletier JP, Royant A, Specht A, Sanson B, Nachon F, Masson P, Zaccai G, Sussman JL, Goeldner M, Silman I, Bourgeois D, Weik M (2007) <br />Use of a 'caged' analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography<br /><i>Acta Crystallographica D Biol Crystallogr</i> <b>63</b>: 1115<br /><br />Colletier JP, Weik M (2007) <br />[Exploring the conformational energy landscape of acetylcholinesterase by kinetic crystallography]<br /><i>Ann Pharm Fr</i> <b>65</b>: 108<br /><br />Frasco MF, Colletier JP, Weik M, Carvalho F, Guilhermino L, Stojan J, Fournier D (2007) <br />Mechanisms of cholinesterase inhibition by inorganic mercury<br /><i>Febs J</i> <b>274</b>: 1849<br /><br />Colletier JP, Sanson B, Nachon F, Gabellieri E, Fattorusso C, Campiani G, Weik M (2006) <br />Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor<br /><i>Journal of the American Chemical Society</i> <b>128</b>: 4526<br /><br />Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M (2006) <br />Structural insights into substrate traffic and inhibition in acetylcholinesterase<br /><i>EMBO Journal</i> <b>25</b>: 2746<br /><br />Chaize B, Colletier JP, Winterhalter M, Fournier D (2004) <br />Encapsulation of enzymes in liposomes: high encapsulation efficiency and control of substrate permeability<br /><i>Artif Cells Blood Substit Immobil Biotechnol</i> <b>32</b>: 67<br /><br />Colletier JP, Fournier D, Greenblatt HM, Sussman JL, Zaccai G, Silman I, Weik M (2004) <br />Poster (74) Structural studies on torpedo californica acetylcholinesterase in complex with a substrate analogue<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 359<br /><br />Stojan J, Brochier L, Alies C, Colletier JP, Fournier D (2004) <br />Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate<br /><i>European Journal of Biochemistry</i> <b>271</b>: 1364<br /><br />Colletier JP, Chaize B, Winterhalter M, Fournier D (2002) <br />Protein encapsulation in liposomes: efficiency depends on interactions between protein and phospholipid bilayer<br /><i>BMC Biotechnol</i> <b>2</b>: 9<br /><br />