Aboody KS, Najbauer J, Danks MK (2008)
Stem and progenitor cell-mediated tumor selective gene therapy
Gene Therapy 15: 739

Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM (2008)
An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11
Cancer Gene Therapy 15: 183

Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L, Kim SU, Garcia E, Metz MZ, Najbauer J, Potter PM, Aboody KS (2007)
Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma
Cancer Research 67: 22

Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR, 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM (2007)
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1
Journal of Medicinal Chemistry 50: 5727

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM (2007)
Selective inhibition of carboxylesterases by isatins, indole-2,3-diones
Journal of Medicinal Chemistry 50: 1876

Aboody KS, Bush RA, Garcia E, Metz MZ, Najbauer J, Justus KA, Phelps DA, Remack JS, Yoon KJ, Gillespie S, Kim SU, Glackin CA, Potter PM, Danks MK (2006)
Development of a tumor-selective approach to treat metastatic cancer
PLoS ONE 1: e23

Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM (2006)
Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity
Mol Cancer Ther 5: 2281

Yoon KJ, Qi J, Remack JS, Virga KG, Hatfield MJ, Potter PM, Lee RE, Danks MK (2006)
Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy
Mol Cancer Ther 5: 1577

Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM (2005)
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety
Journal of Medicinal Chemistry 48: 5543

Morton CL, Iacono L, Hyatt JL, Taylor KR, Cheshire PJ, Houghton PJ, Danks MK, Stewart CF, Potter PM (2005)
Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice
Cancer Chemother Pharmacol 56: 629

Tyminski E, Leroy S, Terada K, Finkelstein DM, Hyatt JL, Danks MK, Potter PM, Saeki Y, Chiocca EA (2005)
Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan
Cancer Research 65: 6850

Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM (2005)
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases
Journal of Medicinal Chemistry 48: 2906

Yoon KJ, Potter PM, Danks MK (2005)
Development of prodrugs for enzyme-mediated, tumor-selective therapy
Curr Med Chem Anticancer Agents 5: 107

Danks MK, Potter PM (2004)
Enzyme-prodrug systems: carboxylesterase/CPT-11
Methods Mol Med 90: 247

Wadkins RM, Hyatt JL, Yoon KJ, Morton CL, Lee RE, Damodaran K, Beroza P, Danks MK, Potter PM (2004)
Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity
Molecular Pharmacology 65: 1336

Yoon KJ, Hyatt JL, Morton CL, Lee RE, Potter PM, Danks MK (2004)
Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application
Mol Cancer Ther 3: 903

Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR (2003)
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition
Chemical Biology 10: 341

Stubdal H, Perin N, Lemmon M, Holman P, Bauzon M, Potter PM, Danks MK, Fattaey A, Dubensky T, Johnson L (2003)
A prodrug strategy using ONYX-015-based replicating adenoviruses to deliver rabbit carboxylesterase to tumor cells for conversion of CPT-11 to SN-38
Cancer Research 63: 6900

Wierdl M, Morton CL, Harris LC, Danks MK, Schuetz JD, Potter PM (2003)
p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)
Journal of Pharmacology & Experimental Therapeutics 304: 699

Wierdl M, Wall A, Morton CL, Sampath J, Danks MK, Schuetz JD, Potter PM (2003)
Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance
Molecular Pharmacology 64: 279

Yoon KJ, Krull EJ, Morton CL, Bornmann WG, Lee RE, Potter PM, Danks MK (2003)
Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies
Mol Cancer Ther 2: 1171

Yoon KJ, Morton CL, Potter PM, Danks MK, Lee RE (2003)
Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism
Bioorganic & Medicinal Chemistry 11: 3237

Bencharit S, Morton CL, Howard-Williams EL, Danks MK, Potter PM, Redinbo MR (2002)
Structural insights into CPT-11 activation by mammalian carboxylesterases
Nat Struct Biol 9: 337

Wagner LM, Guichard SM, Burger RA, Morton CL, Straign CM, Ashmun RA, Harris LC, Houghton PJ, Potter PM, Danks MK (2002)
Efficacy and toxicity of a virus-directed enzyme prodrug therapy purging method: preclinical assessment and application to bone marrow samples from neuroblastoma patients
Cancer Research 62: 5001

Iyengar RV, Pawlik CA, Krull EJ, Phelps DA, Burger RA, Harris LC, Potter PM, Danks MK (2001)
Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC- or N-MYC-regulated protein expression
Cancer Research 61: 3045

Meck MM, Wierdl M, Wagner LM, Burger RA, Guichard SM, Krull EJ, Harris LC, Potter PM, Danks MK (2001)
A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11
Cancer Research 61: 5083

Wadkins RM, Morton CL, Weeks JK, Oliver L, Wierdl M, Danks MK, Potter PM (2001)
Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases
Molecular Pharmacology 60: 355

Wierdl M, Morton CL, Weeks JK, Danks MK, Harris LC, Potter PM (2001)
Sensitization of human tumor cells to CPT-11 via adenoviral-mediated delivery of a rabbit liver carboxylesterase
Cancer Research 61: 5078

Khanna R, Morton CL, Danks MK, Potter PM (2000)
Proficient metabolism of irinotecan by a human intestinal carboxylesterase
Cancer Research 60: 4725

Morton CL, Wierdl M, Oliver L, Ma MK, Danks MK, Stewart CF, Eiseman JL, Potter PM (2000)
Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase
Cancer Research 60: 4206

Pawlik CA, Iyengar RV, Krull EJ, Mason SE, Khanna R, Harris LC, Potter PM, Danks MK, Guichard SM (2000)
Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11
Mol Ther 1: 457

Wierdl M, Morton CL, Danks MK, Potter PM (2000)
Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation
Biochemical Pharmacology 59: 773

Danks MK, Morton CL, Krull EJ, Cheshire PJ, Richmond LB, Naeve CW, Pawlik CA, Houghton PJ, Potter PM (1999)
Comparison of activation of CPT-11 by rabbit and human carboxylesterases for use in enzyme/prodrug therapy
Clin Cancer Research 5: 917

Morton CL, Wadkins RM, Danks MK, Potter PM (1999)
The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase
Cancer Research 59: 1458

Danks MK, Morton CL, Pawlik CA, Potter PM (1998)
Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11
Cancer Research 58: 20

Guichard SM, Morton CL, Krull EJ, Stewart CF, Danks MK, Potter PM (1998)
Conversion of the CPT-11 metabolite APC to SN-38 by rabbit liver carboxylesterase
Clin Cancer Research 4: 3089

Potter PM, Wolverton JS, Morton CL, Wierdl M, Danks MK (1998)
Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme
Cancer Research 58: 3627

Potter PM, Pawlik CA, Morton CL, Naeve CW, Danks MK (1998)
Isolation and partial characterization of a cDNA encoding a rabbit liver carboxylesterase that activates the prodrug irinotecan (CPT-11)
Cancer Research 58: 2646

Potter PM, Wolverton JS, Morton CL, Whipple DO, Danks MK (1998)
In situ subcellular localization of epitope-tagged human and rabbit carboxylesterases
Cytometry 32: 223