Spatz P, Steinmuller SAM, Tutov A, Poeta E, Morilleau A, Carles A, Deventer MH, Hofmann J, Stove CP, Monti B, Maurice T, Decker M (2023)
Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model
Journal of Medicinal Chemistry

Hofmann J, Spatz P, Walther R, Gutmann M, Maurice T, Decker M (2022)
Synthesis and Biological Evaluation of Flavonoid-Cinnamic Acid Amide Hybrids with Distinct Activity against Neurodegeneration in Vitro and in Vivo

Scheiner M, Sink A, Hoffmann M, Vrigneau C, Endres E, Carles A, Sotriffer C, Maurice T, Decker M (2022)
Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition in Vitro and Enable Restoration of Cognition in an Alzheimer's Disease Mouse Model upon Irradiation
Journal of the American Chemical Society

Spatz P, Zimmermann T, Steinmuller S, Hofmann J, Maurice T, Decker M (2022)
Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model
RSC Med Chem 13: 944

Gentzsch C, Hoffmann M, Ohshima Y, Nose N, Chen X, Higuchi T, Decker M (2021)
Synthesis and Initial Characterization of a Selective, Pseudo-irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer

Gentzsch C, Chen X, Spatz P, Kosak U, Knez D, Nose N, Gobec S, Higuchi T, Decker M (2021)
Synthesis and Initial Characterization of a Reversible, Selective (18)F-Labeled Radiotracer for Human Butyrylcholinesterase
Mol Imaging Biol

Hofmann J, Ginex T, Espargaro A, Scheiner M, Gunesch S, Arago M, Stigloher C, Sabate R, Luque FJ, Decker M (2021)
Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation
Chemistry 27: 6015

Pont C, Ginex T, Grinan-Ferre C, Scheiner M, Mattellone A, Martinez N, Arce EM, Soriano-Fernandez Y, Naldi M, De Simone A, Barenys M, Gomez-Catalan J, Perez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallas M, Luque FJ, Munoz-Torrero D (2021)
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
Eur Journal of Medicinal Chemistry 225: 113779

Scheiner M, Hoffmann M, He F, Poeta E, Chatonnet A, Monti B, Maurice T, Decker M (2021)
Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer's Disease Mouse Model
Journal of Medicinal Chemistry 64(13):: 9302

Scheiner M, Sink A, Spatz P, Endres E, Decker M (2021)
Photopharmacology on Acetylcholinesterase: Novel Photoswitchable Inhibitors with Improved Pharmacological Profiles
ChemPhotoChem 5: 149

Basagni F, Rosini M, Decker M (2020)
Functionalized Cannabinoid Subtype 2 Receptor Ligands: Fluorescent, PET, Photochromic and Covalent Molecular Probes
ChemMedChem 15: 1374

Gunesch S, Hoffmann M, Kiermeier C, Fischer W, Pinto AFM, Maurice T, Maher P, Decker M (2020)
7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo
Redox Biol 29: 101378

Hofmann J, Fayez S, Scheiner M, Hoffmann M, Oerter S, Appelt-Menzel A, Maher P, Maurice T, Bringmann G, Decker M (2020)
Sterubin: Enantioresolution and Configurational Stability, Enantiomeric Purity in Nature, and Neuroprotective Activity in Vitro and in Vivo
Chemistry 26: 7299

Marques CS, Lopez O, Bagetta D, Carreiro EP, Petralla S, Bartolini M, Hoffmann M, Alcaro S, Monti B, Bolognesi ML, Decker M, Fernandez-Bolanos JG, Burke AJ (2020)
N-1,2,3-triazole-isatin derivatives for cholinesterase and beta-amyloid aggregation inhibition: A comprehensive bioassay study
Bioorg Chem 98: 103753

Hoffmann M, Stiller C, Endres E, Scheiner M, Gunesch S, Sotriffer C, Maurice T, Decker M (2019)
Highly Selective Butyrylcholinesterase Inhibitors with Tunable Duration of Action by Chemical Modification of Transferable Carbamate Units Exhibit Pronounced Neuroprotective Effect in an Alzheimer's Disease Mouse Model
Journal of Medicinal Chemistry 62: 9116

Rodriguez-Soacha DA, Scheiner M, Decker M (2019)
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands
Eur Journal of Medicinal Chemistry 180: 690

Scheiner M, Dolles D, Gunesch S, Hoffmann M, Nabissi M, Marinelli O, Naldi M, Bartolini M, Petralla S, Poeta E, Monti B, Falkeis C, Vieth M, Hubner H, Gmeiner P, Maitra R, Maurice T, Decker M (2019)
Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo
Journal of Medicinal Chemistry 62: 9078

Dolles D, Hoffmann M, Gunesch S, Marinelli O, Moller J, Santoni G, Chatonnet A, Lohse MJ, Wittmann HJ, Strasser A, Nabissi M, Maurice T, Decker M (2018)
Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles
Journal of Medicinal Chemistry 61: 1646

Holzgrabe U, Decker M (2017)
Bitopic muscarinic agonists and antagonists and uses thereof: a patent evaluation of US20160136145A1
Expert Opin Ther Pat 27: 121

Decker M, Munoz-Torrero D (2016)
Special Issue: Molecules against Alzheimer
Molecules 21:

Dgachi Y, Ismaili L, Knez D, Benchekroun M, Martin H, Szalaj N, Wehle S, Bautista-Aguilera OM, Luzet V, Bonnet A, Malawska B, Gobec S, Chioua M, Decker M, Chabchoub F, Marco-Contelles J (2016)
Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Abeta1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy
ChemMedChem 11: 1318

Dolles D, Nimczick M, Scheiner M, Ramler J, Stadtmuller P, Sawatzky E, Drakopoulos A, Sotriffer C, Wittmann HJ, Strasser A, Decker M (2016)
Aminobenzimidazoles and Structural Isomers as Templates for Dual-Acting Butyrylcholinesterase Inhibitors and hCB2 R Ligands To Combat Neurodegenerative Disorders
ChemMedChem 11: 1270

Sadek B, Khan N, Darras FH, Pockes S, Decker M (2016)
The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats
Physiol Behav 165: 383

Sawatzky E, Wehle S, Kling B, Wendrich J, Bringmann G, Sotriffer CA, Heilmann J, Decker M (2016)
Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode
Journal of Medicinal Chemistry 59: 2067

Sawatzky E, Al-Momani E, Kobayashi R, Higuchi T, Samnick S, Decker M (2016)
A Novel Way To Radiolabel Human Butyrylcholinesterase for Positron Emission Tomography through Irreversible Transfer of the Radiolabeled Moiety
ChemMedChem 11: 1540

Sawatzky E, Drakopoulos A, Rolz M, Sotriffer C, Engels B, Decker M (2016)
Experimental and theoretical investigations into the stability of cyclic aminals
Beilstein J Org Chem 12: 2280

Benchekroun M, Bartolini M, Egea J, Romero A, Soriano E, Pudlo M, Luzet V, Andrisano V, Jimeno ML, Lopez MG, Wehle S, Gharbi T, Refouvelet B, de Andres L, Herrera-Arozamena C, Monti B, Bolognesi ML, Rodriguez-Franco MI, Decker M, Marco-Contelles J, Ismaili L (2015)
Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids
ChemMedChem 10: 523

Khan N, Saad A, Nurulain SM, Darras FH, Decker M, Sadek B (2015)
The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats
Behavioural Brain Research 297: 155

Chen X, Wehle S, Kuzmanovic N, Merget B, Holzgrabe U, Konig B, Sotriffer CA, Decker M (2014)
Acetylcholinesterase inhibitors with photoswitchable inhibition of beta-amyloid aggregation
ACS Chem Neurosci 5: 377

Darras FH, Pockes S, Huang G, Wehle S, Strasser A, Wittmann HJ, Nimczick M, Sotriffer CA, Decker M (2014)
Synthesis, Biological Evaluation, and Computational Studies of Tri- and Tetracyclic Nitrogen-Bridgehead Compounds as Potent Dual-Acting AChE Inhibitors and hH3 Receptor Antagonists
ACS Chem Neurosci 5: 225

Darras FH, Kling B, Sawatzky E, Heilmann J, Decker M (2014)
Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase
Bioorganic & Medicinal Chemistry 22: 5020

Darras FH, Wehle S, Huang G, Sotriffer CA, Decker M (2014)
Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode
Bioorganic & Medicinal Chemistry 22: 4867

Huang G, Kling B, Darras FH, Heilmann J, Decker M (2014)
Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine
Eur Journal of Medicinal Chemistry 81C: 15

Chen X, Zenger K, Lupp A, Kling B, Heilmann J, Fleck C, Kraus B, Decker M (2012)
Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo
Journal of Medicinal Chemistry 55: 5231

Darras FH, Kling B, Heilmann J, Decker M (2012)
Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer
ACS Med Chem Lett 3: 914

Decker M, Adamska M, Cronin A, Di Giallonardo F, Burgener J, Marowsky A, Falck JR, Morisseau C, Hammock BD, Gruzdev A, Zeldin DC, Arand M (2012)
EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides
J Lipid Res 53: 2038

Chen X, Tikhonova IG, Decker M (2011)
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry 19: 1222

Cronin A, Decker M, Arand M (2011)
Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase
J Lipid Res 52: 712

Macabeo AP, Vidar WS, Chen X, Decker M, Heilmann J, Wan B, Franzblau SG, Galvez EV, Aguinaldo MA, Cordell GA (2011)
Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa
Eur Journal of Medicinal Chemistry 46: 3118

Fang L, Jumpertz S, Zhang Y, Appenroth D, Fleck C, Mohr K, Trankle C, Decker M (2010)
Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors
Journal of Medicinal Chemistry 53: 2094

Schulze M, Siol O, Decker M, Lehmann J (2010)
Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: novel heterocyclic templates for butyrylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett 20: 2946

Decker M, Arand M, Cronin A (2009)
Mammalian epoxide hydrolases in xenobiotic metabolism and signalling
Archives of Toxicology 83: 297

Elenes S, Decker M, Cymes GD, Grosman C (2009)
Decremental response to high-frequency trains of acetylcholine pulses but unaltered fractional Ca2+ currents in a panel of slow-channel syndrome nicotinic receptor mutants
Journal of General Physiology 133: 151

Decker M, Kraus B, Heilmann J (2008)
Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties
Bioorganic & Medicinal Chemistry 16: 4252

Fang L, Appenroth D, Decker M, Kiehntopf M, Lupp A, Peng S, Fleck C, Zhang Y, Lehmann J (2008)
NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity
Journal of Medicinal Chemistry 51: 7666

Fang L, Appenroth D, Decker M, Kiehntopf M, Roegler C, Deufel T, Fleck C, Peng S, Zhang Y, Lehmann J (2008)
Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates
Journal of Medicinal Chemistry 51: 713

Fang L, Kraus B, Lehmann J, Heilmann J, Zhang Y, Decker M (2008)
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates
Bioorganic & Medicinal Chemistry Lett 18: 2905

Fleck C, Appenroth D, Decker M, Lehmann J (2008)
A new way of data interpretation for cognition tests in rats used to characterise six choline esterase inhibitors with heterocyclic nitrogen bridgehead structure. Application in Alzheimer therapy
Arzneimittelforschung 58: 543

Decker M (2007)
Recent advances in the development of hybrid molecules/designed multiple compounds with antiamnesic properties
Mini Rev Med Chem 7: 221

Decker M, Krauth F, Lehmann J (2006)
Novel tricyclic quinazolinimines and related tetracyclic nitrogen bridgehead compounds as cholinesterase inhibitors with selectivity towards butyrylcholinesterase
Bioorganic & Medicinal Chemistry 14: 1966

Decker M (2006)
Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase
Journal of Medicinal Chemistry 49: 5411

Schott Y, Decker M, Rommelspacher H, Lehmann J (2006)
6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry Lett 16: 5840

Decker M (2005)
Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpine
Eur Journal of Medicinal Chemistry 40: 305