Purgatorio R, de Candia M, Catto M, Rullo M, Pisani L, Denora N, Carrieri A, Nevskaya AA, Voskressensky LG, Altomare CD (2021) <br />Evaluation of water-soluble Mannich base prodrugs of 2,3,4,5-tetrahydroazepino[4,3-b]indol-1(6H)-one as multitarget-directed agents for Alzheimer's disease<br /><i>ChemMedChem</i> <b>16</b>: 589<br /><br />Titov AA, Kobzev MS, Catto M, Candia M, Gambacorta N, Denora N, Pisani L, Nicolotti O, Borisova TN, Varlamov AV, Voskressensky LG, Altomare CD (2021) <br />Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents<br /><i>ACS Chem Neurosci</i> <br /><br />Catto M, Pisani L, De la Mora E, Belviso BD, Mangiatordi GF, Pinto A, Palma A, Denora N, Caliandro R, Colletier JP, Silman I, Nicolotti O, Altomare CD (2020) <br />Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor<br /><i>ACS Med Chem Lett</i> <b>11</b>: 869<br /><br />Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M, Pisani L, Denora N, Iacobazzi RM, Silman I, Sussman JL, Buron F, Colletier JP, Jean L, Routier S, Renard PY (2019) <br />Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3<br /><i>Eur Journal of Medicinal Chemistry</i> <b>168</b>: 58<br /><br />Pisani L, Iacobazzi RM, Catto M, Rullo M, Farina R, Denora N, Cellamare S, Altomare CD (2018) <br />Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>161</b>: 292<br /><br />Lee BC, Moon BS, Park HS, Jung JH, Park DD, de Candia M, Denora N, Altomare CD, Kim SE (2017) <br />The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain<br /><i>Eur J Pharm Sci</i> <b>109</b>: 209<br /><br />Pisani L, Farina R, Soto-Otero R, Denora N, Mangiatordi GF, Nicolotti O, Mendez-Alvarez E, Altomare CD, Catto M, Carotti A (2016) <br />Searching for Multi-Targeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif<br /><i>Molecules</i> <b>21</b>: <br /><br />Pisani L, Farina R, Catto M, Iacobazzi RM, Nicolotti O, Cellamare S, Mangiatordi GF, Denora N, Soto-Otero R, Siragusa L, Altomare CD, Carotti A (2016) <br />Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents<br /><i>Journal of Medicinal Chemistry</i> <b>59</b>: 6791<br /><br />de Candia M, Zaetta G, Denora N, Tricarico D, Majellaro M, Cellamare S, Altomare CD (2016) <br />New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity<br /><i>Eur Journal of Medicinal Chemistry</i> <b>125</b>: 288<br /><br />Farina R, Pisani L, Catto M, Nicolotti O, Gadaleta D, Denora N, Soto-Otero R, Mendez-Alvarez E, Passos CS, Muncipinto G, Altomare CD, Nurisso A, Carrupt PA, Carotti A (2015) <br />Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases<br /><i>Journal of Medicinal Chemistry</i> <b>58</b>: 5561<br /><br />Tonelli M, Catto M, Tasso B, Novelli F, Canu C, Iusco G, Pisani L, Stradis AD, Denora N, Sparatore A, Boido V, Carotti A, Sparatore F (2015) <br />Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and beta-Amyloid (Abeta) Aggregation<br /><i>ChemMedChem</i> <b>10</b>: 1040<br /><br />