Maia J, Iannotti FA, Piscitelli F, Fonseca BM, Braga A, Braga J, Teixeira N, Di Marzo V, Correia-da-Silva G (2023)
The endocannabinoidome in human placenta: Possible contribution to the pathogenesis of preeclampsia
Biofactors

Tortoriello G, Beiersdorf J, Romani S, Williams G, Cameron GA, Mackie K, Williams MJ, Di Marzo V, Keimpema E, Doherty P, Harkany T (2021)
Genetic Manipulation of sn-1-Diacylglycerol Lipase and CB(1) Cannabinoid Receptor Gain-of-Function Uncover Neuronal 2-Linoleoyl Glycerol Signaling in Drosophila melanogaster
Cannabis Cannabinoid Res 6: 119

Dione N, Lacroix S, Taschler U, Deschenes T, Abolghasemi A, Leblanc N, Di Marzo V, Silvestri C (2020)
Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota
Cells 9:

Palomba L, Motta A, Imperatore R, Piscitelli F, Capasso R, Mastroiacovo F, Battaglia G, Bruno V, Cristino L, Di Marzo V (2020)
Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen-Glucose Deprivation-Induced Neuronal Injury
Cells 9:

Montanari S, Mahmoud AM, Pruccoli L, Rabbito A, Naldi M, Petralla S, Moraleda I, Bartolini M, Monti B, Iriepa I, Belluti F, Gobbi S, Di Marzo V, Bisi A, Tarozzi A, Ligresti A, Rampa A (2019)
Discovery of novel benzofuran-based compounds with neuroprotective and immunomodulatory properties for Alzheimer's disease treatment
Eur Journal of Medicinal Chemistry 178: 243

Turcotte C, Dumais E, Archambault AS, Martin C, Blanchet MR, Bissonnette E, Boulet LP, Laviolette M, Di Marzo V, Flamand N (2019)
Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways
J Leukoc Biol 106: 1337

Pagano E, Borrelli F, Orlando P, Romano B, Monti M, Morbidelli L, Aviello G, Imperatore R, Capasso R, Piscitelli F, Buono L, Di Marzo V, Izzo AA (2017)
Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis
Pharmacol Res 119: 227

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, De Petrocellis L, Ullmer C, Rothenhausler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M (2017)
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Nat Commun 8: 13958

van Esbroeck ACM, Janssen APA, Cognetta AB, 3rd, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allara M, Fezza F, Lin Z, van der Wel T, Soethoudt M, Mock ED, den Dulk H, Baak IL, Florea BI, Hendriks G, De Petrocellis L, Overkleeft HS, Hankemeier T, De Zeeuw CI, Di Marzo V, Maccarrone M, Cravatt BF, Kushner SA, van der Stelt M (2017)
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474
Science 356: 1084

Brindisi M, Maramai S, Gemma S, Brogi S, Grillo A, Di Cesare Mannelli L, Gabellieri E, Lamponi S, Saponara S, Gorelli B, Tedesco D, Bonfiglio T, Landry C, Jung KM, Armirotti A, Luongo L, Ligresti A, Piscitelli F, Bertucci C, Dehouck MP, Campiani G, Maione S, Ghelardini C, Pittaluga A, Piomelli D, Di Marzo V, Butini S (2016)
Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain
Journal of Medicinal Chemistry 59: 2612

Montanari S, Scalvini L, Bartolini M, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V, Rivara S, Mor M, Bisi A, Rampa A (2016)
Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents
Journal of Medicinal Chemistry 59: 6387

Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, den Dulk H, Allara M, Florea BI, Di Marzo V, Wadman WJ, Kruse CG, Overkleeft HS, Hankemeier T, Werkman TR, Cravatt BF, van der Stelt M (2015)
Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons
Journal of the American Chemical Society 137: 8851

Bashashati M, Nasser Y, Keenan CM, Ho W, Piscitelli F, Nalli M, Mackie K, Storr MA, Di Marzo V, Sharkey KA (2015)
Inhibiting endocannabinoid biosynthesis: a novel approach to the treatment of constipation
British Journal of Pharmacology 172: 3099

Imperatore R, Morello G, Luongo L, Taschler U, Romano R, De Gregorio D, Belardo C, Maione S, Di Marzo V, Cristino L (2015)
Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB1 R signaling and anxiety-like behavior
Journal of Neurochemistry 135: 799

Galdino G, Romero TR, Silva JF, Aguiar DC, de Paula AM, Cruz JS, Parrella C, Piscitelli F, Duarte ID, Di Marzo V, Perez AC (2014)
The endocannabinoid system mediates aerobic exercise-induced antinociception in rats
Neuropharmacology 77: 313

Janssen FJ, Deng H, Baggelaar MP, Allara M, van der Wel T, den Dulk H, Ligresti A, van Esbroeck AC, McGuire R, Di Marzo V, Overkleeft HS, van der Stelt M (2014)
Discovery of Glycine Sulfonamides as Dual Inhibitors of sn-1-Diacylglycerol Lipase alpha and alpha/beta-Hydrolase Domain 6
Journal of Medicinal Chemistry 57: 6610

Baggelaar MP, Janssen FJ, van Esbroeck AC, den Dulk H, Allara M, Hoogendoorn S, McGuire R, Florea BI, Meeuwenoord N, van den Elst H, van der Marel GA, Brouwer J, Di Marzo V, Overkleeft HS, van der Stelt M (2013)
Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-alpha in brain
Angew Chem Int Ed Engl 52: 12081

Bisogno T, Mahadevan A, Coccurello R, Chang JW, Allara M, Chen Y, Giacovazzo G, Lichtman A, Cravatt BF, Moles A, Di Marzo V (2013)
A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects
British Journal of Pharmacology 169: 784

Hashimotodani Y, Ohno-Shosaku T, Tanimura A, Kita Y, Sano Y, Shimizu T, Di Marzo V, Kano M (2013)
Acute inhibition of diacylglycerol lipase blocks endocannabinoid-mediated retrograde signalling: evidence for on-demand biosynthesis of 2-arachidonoylglycerol
The Journal of Physiology 591: 4765

Ortar G, Morera E, De Petrocellis L, Ligresti A, Schiano Moriello A, Morera L, Nalli M, Ragno R, Pirolli A, Di Marzo V (2013)
Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring
Eur Journal of Medicinal Chemistry 63: 118

Valdeolivas S, Pazos MR, Bisogno T, Piscitelli F, Iannotti FA, Allara M, Sagredo O, Di Marzo V, Fernandez-Ruiz J (2013)
The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG
Cell Death Dis 4: e862

Rampa A, Bartolini M, Bisi A, Belluti F, Gobbi S, Andrisano V, Ligresti A, Di Marzo V (2012)
The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?
ACS Med Chem Lett 3: 182

Zhang L, Wang M, Bisogno T, Di Marzo V, Alger BE (2011)
Endocannabinoids generated by Ca2+ or by metabotropic glutamate receptors appear to arise from different pools of diacylglycerol lipase
PLoS ONE 6: e16305

Min R, Testa-Silva G, Heistek TS, Canto CB, Lodder JC, Bisogno T, Di Marzo V, Brussaard AB, Burnashev N, Mansvelder HD (2010)
Diacylglycerol lipase is not involved in depolarization-induced suppression of inhibition at unitary inhibitory connections in mouse hippocampus
Journal of Neuroscience 30: 2710

Min R, Di Marzo V, Mansvelder HD (2010)
DAG lipase involvement in depolarization-induced suppression of inhibition: does endocannabinoid biosynthesis always meet the demand?
Neuroscientist 16: 608

Petrosino S, Di Marzo V (2010)
FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels
Curr Opin Investig Drugs 11: 51

Bisogno T, Ortar G, Petrosino S, Morera E, Palazzo E, Nalli M, Maione S, Di Marzo V (2009)
Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo
Biochimica & Biophysica Acta 1791: 53

Loria F, Petrosino S, Mestre L, Spagnolo A, Correa F, Hernangomez M, Guaza C, Di Marzo V, Docagne F (2008)
Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide
European Journal of Neuroscience 28: 633

Maione S, Morera E, Marabese I, Ligresti A, Luongo L, Ortar G, Di Marzo V (2008)
Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms
British Journal of Pharmacology 155: 775

Ortar G, Bisogno T, Ligresti A, Morera E, Nalli M, Di Marzo V (2008)
Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism
Journal of Medicinal Chemistry 51: 6970

Starowicz KM, Cristino L, Matias I, Capasso R, Racioppi A, Izzo AA, Di Marzo V (2008)
Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet
Obesity (Silver Spring) 16: 553

Bisogno T, Cascio MG, Saha B, Mahadevan A, Urbani P, Minassi A, Appendino G, Saturnino C, Martin B, Razdan R, Di Marzo V (2006)
Development of the first potent and specific inhibitors of endocannabinoid biosynthesis
Biochimica & Biophysica Acta 1761: 205

Ligresti A, Cascio MG, Di Marzo V (2005)
Endocannabinoid metabolic pathways and enzymes
Curr Drug Targets CNS Neurol Disord 4: 615

Valenti M, Vigano D, Casico MG, Rubino T, Steardo L, Parolaro D, Di Marzo V (2004)
Differential diurnal variations of anandamide and 2-arachidonoyl-glycerol levels in rat brain
Cell Mol Life Sciences 61: 945

Bisogno T, Howell F, Williams G, Minassi A, Cascio MG, Ligresti A, Matias I, Schiano-Moriello A, Paul P, Williams EJ, Gangadharan U, Hobbs C, Di Marzo V, Doherty P (2003)
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
Journal of Cell Biology 163: 463

Di Marzo V, Bisogno T, De Petrocellis L, Brandi I, Jefferson RG, Winckler RL, Davis JB, Dasse O, Mahadevan A, Razdan RK, Martin BR (2001)
Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor hybrid ligands
Biochemical & Biophysical Research Communications 281: 444

Martin BR, Beletskaya I, Patrick G, Jefferson R, Winckler R, Deutsch DG, Di Marzo V, Dasse O, Mahadevan A, Razdan RK (2000)
Cannabinoid properties of methylfluorophosphonate analogs
Journal of Pharmacology & Experimental Therapeutics 294: 1209