Hatfield MJ, Umans RA, Hyatt JL, Edwards CC, Wierdl M, Tsurkan L, Taylor MR, Potter PM (2016) <br />Carboxylesterases: General detoxifying enzymes<br /><i>Chemico-Biological Interactions</i> <b>259</b>: 327<br /><br />Hatfield MJ, Tsurkan LG, Hyatt JL, Edwards CC, Lemoff A, Jeffries C, Yan B, Potter PM (2013) <br />Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza (Danshen)<br /><i>Journal of Natural Products</i> <b>76</b>: 36<br /><br />Tsurkan LG, Hatfield MJ, Edwards CC, Hyatt JL, Potter PM (2013) <br />Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors<br /><i>Chemico-Biological Interactions</i> <b>203</b>: 226<br /><br />Edwards JS, Kumbhar A, Roberts A, Hemmert AC, Edwards CC, Potter PM, Redinbo MR (2011) <br />Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles<br /><i>Biotechnol Prog</i> <b>27</b>: 863<br /><br />Hatfield MJ, Tsurkan L, Garrett M, Shaver TM, Hyatt JL, Edwards CC, Hicks LD, Potter PM (2011) <br />Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11<br /><i>Biochemical Pharmacology</i> <b>81</b>: 24<br /><br />Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR (2011) <br />Nerve agent hydrolysis activity designed into a human drug metabolism enzyme<br /><i>PLoS ONE</i> <b>6</b>: e17441<br /><br />Parkinson EI, Hatfield MJ, Tsurkan L, Hyatt JL, Edwards CC, Hicks LD, Yan B, Potter PM (2011) <br />Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones<br /><i>Bioorganic & Medicinal Chemistry</i> <b>19</b>: 4635<br /><br />Hatfield MJ, Tsurkan LG, Hyatt JL, Yu X, Edwards CC, Hicks LD, Wadkins RM, Potter PM (2010) <br />Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin<br /><i>British Journal of Pharmacology</i> <b>160</b>: 1916<br /><br />Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR (2010) <br />Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin<br /><i>Molecular Pharmacology</i> <b>77</b>: 508<br /><br />Xie S, Borazjani A, Hatfield MJ, Edwards CC, Potter PM, Ross MK (2010) <br />Inactivation of lipid glyceryl ester metabolism in human THP1 monocytes/macrophages by activated organophosphorus insecticides: role of carboxylesterases 1 and 2<br /><i>Chemical Research in Toxicology</i> <b>23</b>: 1890<br /><br />Hicks LD, Hyatt JL, Stoddard S, Tsurkan L, Edwards CC, Wadkins RM, Potter PM (2009) <br />Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 3742<br /><br />Barthel BL, Torres RC, Hyatt JL, Edwards CC, Hatfield MJ, Potter PM, Koch TH (2008) <br />Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug<br /><i>Journal of Medicinal Chemistry</i> <b>51</b>: 298<br /><br />Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM (2008) <br />An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11<br /><i>Cancer Gene Therapy</i> <b>15</b>: 183<br /><br />Fleming CD, Edwards CC, Kirby SD, Maxwell DM, Potter PM, Cerasoli DM, Redinbo MR (2007) <br />Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun<br /><i>Biochemistry</i> <b>46</b>: 5063<br /><br />Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM (2007) <br />Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils<br /><i>Bioorganic & Medicinal Chemistry</i> <b>15</b>: 3801<br /><br />Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR, 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM (2007) <br />Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 5727<br /><br />Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM (2007) <br />Selective inhibition of carboxylesterases by isatins, indole-2,3-diones<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 1876<br /><br />Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM (2007) <br />Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds<br /><i>Molecular Pharmacology</i> <b>71</b>: 713<br /><br />Bencharit S, Edwards CC, Morton CL, Howard-Williams EL, Kuhn P, Potter PM, Redinbo MR (2006) <br />Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1<br /><i>Journal of Molecular Biology</i> <b>363</b>: 201<br /><br />Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM (2006) <br />Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity<br /><i>Mol Cancer Ther</i> <b>5</b>: 2281<br /><br />Ross MK, Borazjani A, Edwards CC, Potter PM (2006) <br />Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases<br /><i>Biochemical Pharmacology</i> <b>71</b>: 657<br /><br />Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR (2005) <br />Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil<br /><i>Journal of Molecular Biology</i> <b>352</b>: 165<br /><br />Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM (2005) <br />Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 5543<br /><br />Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM (2005) <br />Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 2906<br /><br />