Worek F, Eyer P, Thiermann H (2012) <br />Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning<br /><i>Drug Test Anal</i> <b>4</b>: 282<br /><br />Eyer P, Szinicz L (2011) <br />Obituary: In memory of Elsa Reiner<br /><i>Toxicol Lett</i> <b>206</b>: 1<br /><br />Rajapakse BN, Thiermann H, Eyer P, Worek F, Bowe SJ, Dawson AH, Buckley NA (2011) <br />Evaluation of the Test-mate ChE (cholinesterase) field kit in acute organophosphorus poisoning<br /><i>Annals of Emergency Medicine</i> <b>58</b>: 559<br /><br />Thiermann H, Steinritz D, Worek F, Radtke M, Eyer P, Eyer F, Felgenhauer N, Zilker T (2011) <br />Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning<br /><i>Toxicol Lett</i> <b>206</b>: 77<br /><br />Worek F, Aurbek N, Wille T, Eyer P, Thiermann H (2011) <br />Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase<br /><i>Toxicol Lett</i> <b>200</b>: 19<br /><br />Worek F, Aurbek N, Wille T, Eyer P, Thiermann H (2011) <br />Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach<br /><i>J Enzyme Inhib Med Chem</i> <b>26</b>: 303<br /><br />Eyer P, Worek F, Thiermann H, Eddleston M (2010) <br />Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 270<br /><br />Herkert NM, Aurbek N, Eyer P, Thiermann H, Worek F (2010) <br />Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon<br /><i>Toxicol Lett</i> <b>194</b>: 94<br /><br />Moffatt A, Mohammed F, Eddleston M, Azher S, Eyer P, Buckley NA (2010) <br />Hypothermia and Fever after organophosphorus poisoning in humans--a prospective case series<br /><i>J Med Toxicol</i> <b>6</b>: 379<br /><br />Thiermann H, Eyer F, Felgenhauer N, Pfab R, Zilker T, Eyer P, Worek F (2010) <br />Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds<br /><i>Toxicol Lett</i> <b>197</b>: 236<br /><br />Thiermann H, Eyer P, Worek F (2010) <br />Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro<br /><i>Toxicology</i> <b>272</b>: 46<br /><br />Worek F, Aurbek N, Herkert NM, John H, Eddleston M, Eyer P, Thiermann H (2010) <br />Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 259<br /><br />Worek F, Wille T, Aurbek N, Eyer P, Thiermann H (2010) <br />Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach<br /><i>Toxicol Appl Pharmacol</i> <b>249</b>: 231<br /><br />Aurbek N, Thiermann H, Eyer F, Eyer P, Worek F (2009) <br />Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis<br /><i>Toxicology</i> <b>259</b>: 133<br /><br />Eddleston M, Eyer P, Worek F, Juszczak E, Alder N, Mohamed F, Senarathna L, Hittarage A, Azher S, Jeganathan K, Jayamanne S, von Meyer L, Dawson AH, Sheriff MH, Buckley NA (2009) <br />Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial<br /><i>PLoS Med</i> <b>6</b>: e1000104<br /><br />Eddleston M, Gunnell D, von Meyer L, Eyer P (2009) <br />Relationship between blood alcohol concentration on admission and outcome in dimethoate organophosphorus self-poisoning<br /><i>British Journal of Clinical Pharmacology</i> <b>68</b>: 916<br /><br />Eddleston M, Worek F, Eyer P, Thiermann H, von Meyer L, Jeganathan K, Sheriff MH, Dawson AH, Buckley NA (2009) <br />Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos<br /><i>Qjm</i> <b>102</b>: 785<br /><br />Eyer F, Roberts DM, Buckley NA, Eddleston M, Thiermann H, Worek F, Eyer P (2009) <br />Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF)<br /><i>Biochemical Pharmacology</i> <b>78</b>: 531<br /><br />Eyer F, Worek F, Eyer P, Felgenhauer N, Haberkorn M, Zilker T, Thiermann H (2009) <br />Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness<br /><i>Clinical Toxicology (Phila)</i> <b>47</b>: 798<br /><br />Roberts DM, Heilmair R, Buckley NA, Dawson AH, Fahim M, Eddleston M, Eyer P (2009) <br />Clinical outcomes and kinetics of propanil following acute self-poisoning: a prospective case series<br /><i>BMC Clin Pharmacol</i> <b>9</b>: 3<br /><br />Theirmann H, Worek F, Eyer P (2009) <br />Comments on Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI 6<br /><i>Toxicol Mech Methods</i> <b>19</b>: 334; author reply 335<br /><br />Thiermann H, Worek F, Eyer P, Eyer F, Felgenhauer N, Zilker T (2009) <br />Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships<br /><i>Clinical Toxicology (Phila)</i> <b>47</b>: 807<br /><br />Thiermann H, Zilker T, Eyer F, Felgenhauer N, Eyer P, Worek F (2009) <br />Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients<br /><i>Toxicol Lett</i> <b>191</b>: 297<br /><br />Davies J, Roberts D, Eyer P, Buckley N, Eddleston M (2008) <br />Hypotension in severe dimethoate self-poisoning<br /><i>Clinical Toxicology (Phila)</i> <b>46</b>: 880<br /><br />Eckert S, Eyer P, Herkert N, Bumm R, Weber G, Thiermann H, Worek F (2008) <br />Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity<br /><i>Biochemical Pharmacology</i> <b>75</b>: 698<br /><br />Eckert S, Eyer P, Melzer M, Thiermann H, Worek F (2008) <br />Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods<br /><i>Biochemical Pharmacology</i> <b>75</b>: 1561<br /><br />Eddleston M, Buckley NA, Eyer P, Dawson AH (2008) <br />Management of acute organophosphorus pesticide poisoning<br /><i>Lancet</i> <b>371</b>: 597<br /><br />Eddleston M, Eyer P, Worek F, Sheriff MH, Buckley NA (2008) <br />Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning<br /><i>Qjm</i> <b>101</b>: 467<br /><br />Eyer P, Eddleston M, Thiermann H, Worek F, Buckley NA (2008) <br />Are we using the right dose? - a tale of mole and gram<br /><i>British Journal of Clinical Pharmacology</i> <b>66</b>: 451<br /><br />Eyer P, Radtke M, Worek F (2008) <br />Reactions of isodimethoate with human red cell acetylcholinesterase<br /><i>Biochemical Pharmacology</i> <b>75</b>: 2045<br /><br />Heilmair R, Eyer F, Eyer P (2008) <br />Enzyme-based assay for quantification of chlorpyrifos oxon in human plasma<br /><i>Toxicol Lett</i> <b>181</b>: 19<br /><br />Herkert NM, Eckert S, Eyer P, Bumm R, Weber G, Thiermann H, Worek F (2008) <br />Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors<br /><i>Toxicology</i> <b>246</b>: 188<br /><br />Eckert S, Eyer P, Worek F (2007) <br />Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge<br /><i>Toxicology</i> <b>233</b>: 180<br /><br />Eyer P (2007) <br />In memory of Ilse Hagedorn<br /><i>Toxicology</i> <b>233</b>: 3<br /><br />Eyer P, Szinicz L, Thiermann H, Worek F, Zilker T (2007) <br />Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality<br /><i>Toxicology</i> <b>233</b>: 108<br /><br />Stenzel J, Worek F, Eyer P (2007) <br />Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q)<br /><i>Biochemical Pharmacology</i> <b>74</b>: 1390<br /><br />Szinicz L, Worek F, Thiermann H, Kehe K, Eckert S, Eyer P (2007) <br />Development of antidotes: problems and strategies<br /><i>Toxicology</i> <b>233</b>: 23<br /><br />Thiermann H, Kehe K, Steinritz D, Mikler J, Hill I, Zilker T, Eyer P, Worek F (2007) <br />Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds<br /><i>Arh Hig Rada Toksikol</i> <b>58</b>: 359<br /><br />Thiermann H, Szinicz L, Eyer P, Felgenhauer N, Zilker T, Worek F (2007) <br />Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning<br /><i>Toxicology</i> <b>233</b>: 145<br /><br />Worek F, Aurbek N, Koller M, Becker C, Eyer P, Thiermann H (2007) <br />Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates<br /><i>Biochemical Pharmacology</i> <b>73</b>: 1807<br /><br />Worek F, Eyer P, Aurbek N, Szinicz L, Thiermann H (2007) <br />Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis<br /><i>Toxicol Appl Pharmacol</i> <b>219</b>: 226<br /><br />Worek F, Eyer P, Szinicz L, Thiermann H (2007) <br />Simulation of cholinesterase status at different scenarios of nerve agent exposure<br /><i>Toxicology</i> <b>233</b>: 155<br /><br />Aurbek N, Thiermann H, Szinicz L, Eyer P, Worek F (2006) <br />Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase<br /><i>Toxicology</i> <b>224</b>: 91<br /><br />Aurbek N, Thiermann H, Szinicz L, Eyer P, Worek F (2006) <br />Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning<br /><i>Toxicology</i> <b>224</b>: 74<br /><br />Eckert S, Eyer P, Muckter H, Worek F (2006) <br />Development of a dynamic model for real-time determination of membrane-bound acetylcholinesterase activity upon perfusion with inhibitors and reactivators<br /><i>Biochemical Pharmacology</i> <b>72</b>: 358<br /><br />Eckert S, Eyer P, Muckter H, Worek F (2006) <br />Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds<br /><i>Biochemical Pharmacology</i> <b>72</b>: 344<br /><br />Eddleston M, Mohamed F, Davies JO, Eyer P, Worek F, Sheriff MH, Buckley NA (2006) <br />Respiratory failure in acute organophosphorus pesticide self-poisoning<br /><i>Qjm</i> <b>99</b>: 513<br /><br />Eyer P, Buckley N (2006) <br />Pralidoxime for organophosphate poisoning<br /><i>Lancet</i> <b>368</b>: 2110<br /><br />Worek F, Eyer P (2006) <br />The liberation of thiocholine from acetylthiocholine (ASCh) by pralidoxime iodide (2=PAM) and other oximes (obidoxime and diacetylmonoxime)<br /><i>Toxicol Lett</i> <b>167</b>: 256<br /><br />Eddleston M, Eyer P, Worek F, Mohamed F, Senarathna L, von Meyer L, Juszczak E, Hittarage A, Azhar S, Dissanayake W, Sheriff MH, Szinicz L, Dawson AH, Buckley NA (2005) <br />Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study<br /><i>Lancet</i> <b>366</b>: 1452<br /><br />Kiderlen D, Eyer P, Worek F (2005) <br />Formation and disposition of diethylphosphoryl-obidoxime, a potent anticholinesterase that is hydrolyzed by human paraoxonase (PON1)<br /><i>Biochemical Pharmacology</i> <b>69</b>: 1853<br /><br />Thiermann H, Eyer P, Worek F, Szinicz L (2005) <br />Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon<br /><i>Toxicology</i> <b>214</b>: 190<br /><br />Thiermann H, Szinicz L, Eyer P, Zilker T, Worek F (2005) <br />Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 345<br /><br />Worek F, Szinicz L, Eyer P, Thiermann H (2005) <br />Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model<br /><i>Toxicol Appl Pharmacol</i> <b>209</b>: 193<br /><br />Worek F, Thiermann H, Szinicz L, Eyer P (2004) <br />Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes<br /><i>Biochemical Pharmacology</i> <b>68</b>: 2237<br /><br />Eyer P, Worek F, Kiderlen D, Sinko G, Stuglin A, Simeon-Rudolf V, Reiner E (2003) <br />Molar absorption coefficients for the reduced Ellman reagent: reassessment<br /><i>Analytical Biochemistry</i> <b>312</b>: 224<br /><br />Eyer F, Meischner V, Kiderlen D, Thiermann H, Worek F, Haberkorn M, Felgenhauer N, Zilker T, Eyer P (2003) <br />Human parathion poisoning. A toxicokinetic analysis<br /><i>Toxicol Rev</i> <b>22</b>: 143<br /><br />Eyer P (2003) <br />The role of oximes in the management of organophosphorus pesticide poisoning<br /><i>Toxicol Rev</i> <b>22</b>: 165<br /><br />Eddleston M, Szinicz L, Eyer P, Buckley N (2002) <br />Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials<br /><i>Qjm</i> <b>95</b>: 275<br /><br />Krummer S, Thiermann H, Worek F, Eyer P (2002) <br />Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI 6 dichloride and HI 6 dimethanesulfonate<br /><i>Archives of Toxicology</i> <b>76</b>: 589<br /><br />Worek F, Reiter G, Eyer P, Szinicz L (2002) <br />Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphates<br /><i>Archives of Toxicology</i> <b>76</b>: 523<br /><br />Felgenhauer N, Zilker T, Worek F, Eyer P (2000) <br />Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss<br /><i>J Toxicol Clinical Toxicology</i> <b>38</b>: 803<br /><br />Kiderlen D, Worek F, Klimmek R, Eyer P (2000) <br />The phosphoryl oxime-destroying activity of human plasma<br /><i>Archives of Toxicology</i> <b>74</b>: 27<br /><br />Worek F, Eyer P, Kiderlen D, Thiermann H, Szinicz L (2000) <br />Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase<br /><i>Archives of Toxicology</i> <b>74</b>: 21<br /><br />Thiermann H, Szinicz L, Eyer F, Worek F, Eyer P, Felgenhauer N, Zilker T (1999) <br />Modern strategies in therapy of organophosphate poisoning<br /><i>Toxicol Lett</i> <b>107</b>: 233<br /><br />Worek F, Diepold C, Eyer P (1999) <br />Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics<br /><i>Archives of Toxicology</i> <b>73</b>: 7<br /><br />Worek F, Mast U, Kiderlen D, Diepold C, Eyer P (1999) <br />Improved determination of acetylcholinesterase activity in human whole blood<br /><i>Clinica Chimica Acta</i> <b>288</b>: 73<br /><br />Eyer F, Eyer P (1998) <br />Enzyme-based assay for quantification of paraoxon in blood of parathion poisoned patients<br /><i>Hum Exp Toxicol</i> <b>17</b>: 645<br /><br />Szinicz L, Thiermann H, Worek F, Eyer P (1998) <br />Acetylcholinesterase, a Versatile Protein<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 269<br /><br />Worek F, Eyer P, Szinicz L (1998) <br />Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases<br /><i>Archives of Toxicology</i> <b>72</b>: 580<br /><br />Thiermann H, Mast U, Klimmek R, Eyer P, Hibler A, Pfab R, Felgenhauer N, Zilker T (1997) <br />Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients<br /><i>Hum Exp Toxicol</i> <b>16</b>: 473<br /><br />Worek F, Backer M, Thiermann H, Szinicz L, Mast U, Klimmek R, Eyer P (1997) <br />Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning<br /><i>Hum Exp Toxicol</i> <b>16</b>: 466<br /><br />Zilker T, Felgenhauer N, Hibler A, Pfab R, Thiermann H, Worek F, Eyer P (1997) <br />Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning [editorial]<br /><i>Przegl Lek</i> <b>54</b>: 662<br /><br />Thiermann H, Radtke M, Spohrer U, Klimmek R, Eyer P (1996) <br />Pharmacokinetics of atropine in dogs after i.m. injection with newly developed dry/wet combination autoinjectors containing HI 6 or HLo 7<br /><i>Archives of Toxicology</i> <b>70</b>: 293<br /><br />Eyer P (1995) <br />Neuropsychopathological changes by organophosphorus compounds--a review.<br /><i>Hum Exp Toxicol</i> <b>14</b>: 857<br /><br />Spohrer U, Thiermann H, Klimmek R, Eyer P (1994) <br />Pharmacokinetics of the oximes HI 6 and HLo 7 in dogs after i.m. injection with newly developed dry/wet autoinjectors<br /><i>Archives of Toxicology</i> <b>68</b>: 480<br /><br />Eyer P, Hagedorn I, Klimmek R, Lippstreu P, Loffler M, Oldiges H, Spohrer U, Steidl I, Szinicz L, Worek F (1992) <br />HLo 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases<br /><i>Archives of Toxicology</i> <b>66</b>: 603<br /><br />Eyer P, Ladstetter B, Schafer W, Sonnenbichler J (1989) <br />Studies on the stability and decomposition of the Hagedorn-oxime HLo 7 in aqueous solution<br /><i>Archives of Toxicology</i> <b>63</b>: 59<br /><br />Eyer P, Hagedorn I, Ladstetter B (1988) <br />Study on the stability of the oxime HI 6 in aqueous solution<br /><i>Archives of Toxicology</i> <b>62</b>: 224<br /><br />Eyer P, Kawan A, Ladstetter B (1987) <br />Formation of cyanide after i.v. administration of the oxime HI 6 to dogs<br /><i>Archives of Toxicology</i> <b>61</b>: 63<br /><br />Eyer P, Hell W, Kawan A, Klehr H (1986) <br />Studies on the decomposition of the oxime HI 6 in aqueous solution<br /><i>Archives of Toxicology</i> <b>59</b>: 266<br /><br />Klimmek R, Eyer P (1986) <br />Pharmacokinetics and pharmacodynamics of the oxime HI6 in dogs<br /><i>Archives of Toxicology</i> <b>59</b>: 272<br /><br />Klimmek R, Eyer P (1985) <br />Pharmacokinetics and toxicity of the oxime HGG 12 in dogs<br /><i>Archives of Toxicology</i> <b>57</b>: 237<br /><br />