Mashimo M, Kawashima K, Fujii T (2022)
Non-neuronal Cholinergic Muscarinic Acetylcholine Receptors in the Regulation of Immune Function
Biol Pharm Bull 45: 675

Mashimo M, Moriwaki Y, Misawa H, Kawashima K, Fujii T (2021)
Regulation of Immune Functions by Non-Neuronal Acetylcholine (ACh) via Muscarinic and Nicotinic ACh Receptors
Int J Mol Sci 22:

Nakagawa Y, Kato H, Maeda K, Noguchi D, Gyoten K, Hayasaki A, Iizawa Y, Fujii T, Tanemura A, Murata Y, Kuriyama N, Kishiwada M, Sakurai H, Isaji S, Mizuno S (2021)
Proximal subtotal pancreatectomy as an alternative to total pancreatectomy for malnourished patients
Surg Today

Fujii T, Mashimo M, Moriwaki Y, Misawa H, Ono S, Horiguchi K, Kawashima K (2017)
Physiological functions of the cholinergic system in immune cells
J Pharmacol Sci 134: 1

Fujii T, Mashimo M, Moriwaki Y, Misawa H, Ono S, Horiguchi K, Kawashima K (2017)
Expression and Function of the Cholinergic System in Immune Cells
Front Immunol 8: 1085

Ichimaru Y, Fujii T, Saito H, Sano M, Uchiyama T, Miyairi S (2017)
5-Bromoindirubin 3'-(O-oxiran-2-ylmethyl)oxime: A long-acting anticancer agent and a suicide inhibitor for epoxide hydrolase
Bioorganic & Medicinal Chemistry 25: 4665

Iwata M, Imaoka T, Nishiyama T, Fujii T (2016)
Re-characterization of mono-2-ethylhexyl phthalate hydrolase belonging to the serine hydrolase family
J Biosci Bioeng 122: 140

Kawashima K, Fujii T, Moriwaki Y, Misawa H, Horiguchi K (2015)
Non-neuronal cholinergic system in regulation of immune function with a focus on alpha7 nAChRs
Int Immunopharmacol 29: 127

Fujii T, Horiguchi K, Sunaga H, Moriwaki Y, Misawa H, Kasahara T, Tsuji S, Kawashima K (2014)
SLURP-1, an endogenous alpha7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205(+) dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity
Journal of Neuroimmunology 267: 43

Suzuki K, Noguchi MT, Shinozaki Y, Koitabashi M, Sameshima-Yamashita Y, Yoshida S, Fujii T, Kitamoto HK (2014)
Purification, characterization, and cloning of the gene for a biodegradable plastic-degrading enzyme from Paraphoma-related fungal strain B47-9
Applied Microbiology & Biotechnology 98: 4457

Watanabe T, Shinozaki Y, Yoshida S, Koitabashi M, Sameshima-Yamashita Y, Fujii T, Fukuoka T, Kitamoto HK (2014)
Xylose induces the phyllosphere yeast Pseudozyma antarctica to produce a cutinase-like enzyme which efficiently degrades biodegradable plastics
J Biosci Bioeng 117: 325

Shinozaki Y, Morita T, Cao XH, Yoshida S, Koitabashi M, Watanabe T, Suzuki K, Sameshima-Yamashita Y, Nakajima-kambe T, Fujii T, Kitamoto HK (2013)
Biodegradable plastic-degrading enzyme from Pseudozyma antarctica: cloning, sequencing, and characterization
Applied Microbiology & Biotechnology 97: 2951

Suzuki K, Sakamoto H, Shinozaki Y, Tabata J, Watanabe T, Mochizuki A, Koitabashi M, Fujii T, Tsushima S, Kitamoto HK (2013)
Affinity purification and characterization of a biodegradable plastic-degrading enzyme from a yeast isolated from the larval midgut of a stag beetle, Aegus laevicollis
Applied Microbiology & Biotechnology 97: 7679

Fujii T, Takada-Takatori Y, Kawashima K (2012)
Regulatory mechanisms of acetylcholine synthesis and release by T cells
Life Sciences 91: 981

Fujii T, Takada-Takatori Y, Horiguchi K, Kawashima K (2012)
Mediatophore regulates acetylcholine release from T cells
Journal of Neuroimmunology 244: 16

Hira D, Toh H, Migita CT, Okubo H, Nishiyama T, Hattori M, Furukawa K, Fujii T (2012)
Anammox organism KSU-1 expresses a NirK-type copper-containing nitrite reductase instead of a NirS-type with cytochrome cd1
FEBS Letters 586: 1658

Hiraoka K, Okamura N, Funaki Y, Hayashi A, Tashiro M, Hisanaga K, Fujii T, Takeda A, Yanai K, Iwata R, Mori E (2012)
Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia
Eur Neurol 68: 137

Kawashima K, Fujii T, Moriwaki Y, Misawa H (2012)
Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function
Life Sciences 91: 1027

Kawashima K, Fujii T, Moriwaki Y, Misawa H, Horiguchi K (2012)
Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function
Annals of the New York Academy of Sciences 1261: 7

Suzuki M, Eda Y, Ohsawa S, Kanesaki Y, Yoshikawa H, Tanaka K, Muramatsu Y, Yoshikawa J, Sato I, Fujii T, Amachi S (2012)
Iodide oxidation by a novel multicopper oxidase from the alphaproteobacterium strain Q-1
Applied Environmental Microbiology 78: 3941

Takada-Takatori Y, Kume T, Izumi Y, Niidome T, Fujii T, Sugimoto H, Akaike A (2010)
Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons
J Pharmacol Sci 112: 265

Fujii T, Masai M, Misawa H, Okuda T, Takada-Takatori Y, Moriwaki Y, Haga T, Kawashima K (2009)
Acetylcholine synthesis and release in NIH3T3 cells coexpressing the high-affinity choline transporter and choline acetyltransferase
Journal of Neuroscience Research 87: 3024

Hiraoka K, Okamura N, Funaki Y, Watanuki S, Tashiro M, Kato M, Hayashi A, Hosokai Y, Yamasaki H, Fujii T, Mori E, Yanai K, Watabe H (2009)
Quantitative analysis of donepezil binding to acetylcholinesterase using positron emission tomography and [5-(11)C-methoxy]donepezil
Neuroimage 46: 616

Takada-Takatori Y, Kume T, Izumi Y, Ohgi Y, Niidome T, Fujii T, Sugimoto H, Akaike A (2009)
Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation
Biol Pharm Bull 32: 318

Fujii T, Takada-Takatori Y, Kawashima K (2008)
Basic and clinical aspects of non-neuronal acetylcholine: expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy
J Pharmacol Sci 106: 186

Kawashima K, Fujii T (2008)
Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological significance
J Pharmacol Sci 106: 167

Takada-Takatori Y, Kume T, Ohgi Y, Fujii T, Niidome T, Sugimoto H, Akaike A (2008)
Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment
European Journal of Pharmacology 590: 150

Takada-Takatori Y, Kume T, Ohgi Y, Izumi Y, Niidome T, Fujii T, Sugimoto H, Akaike A (2008)
Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil
Journal of Neuroscience Research 86: 3575

Xia Q, Wang J, Zhou Z, Li R, Fan W, Cheng D, Cheng T, Qin J, Duana J, Xu H, Li Q, Li N, Wang M, Dai F, Liu C, Lin Y, Zhao P, Zhang H, Liu S, Zha X, Li C, Zhao A, Pan M, Pan G, Shen Y, Gao Z, Wang Z, Wang G, Wu Z, Hou Y, Chai C, Yu Q, He N, Zhang Z, Li S, Yang H, Lu C, Xiang Z, Mita K, Kasahara M, Nakatani Y, Yamamoto K, Abe H, Ahsan B, Daimoni T, Doi K, Fujii T, Fujiwara H, Fujiyama A, Futahashi R, Hashimotol S, Ishibashi J, Iwami M, Kadono-Okuda K, Kanamori H, Kataoka H, Katsuma S, Kawaoka S, Kawasaki H, Kohara Y, Kozaki T, Kuroshu RM, Kuwazaki S, Matsushima K, Minami H, Nagayasu Y, Nakagawa T, Narukawa J, Nohata J, Ohishi K, Ono Y, Osanai-Futahashi M, Ozaki K, Qu W, Roller L, Sasaki S, Sasaki T, Seino A, Shimomura M, Shin-I T, Shinoda T, Shiotsuki T, Suetsugu Y, Sugano S, Suwa M, Suzuki Y, Takiya S, Tamura T, Tanaka H, Tanaka Y, Touhara K, Yamada T, Yamakawa M, Yamanaka N, Yoshikawa H, Zhong YS, Shimada T, Morishita S (2008)
The genome of a lepidopteran model insect, the silkworm Bombyx mori
Insect Biochemistry & Molecular Biology 38: 1036

Fujii T, Takada-Takatori Y, Kawashima K (2007)
Roles played by lymphocyte function-associated antigen-1 in the regulation of lymphocytic cholinergic activity
Life Sciences 80: 2320

Fujii YX, Tashiro A, Arimoto K, Fujigaya H, Moriwaki Y, Misawa H, Fujii T, Matsui M, Kasahara T, Kawashima K (2007)
Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice
Journal of Neuroimmunology 188: 80

Kawashima K, Misawa H, Moriwaki Y, Fujii YX, Fujii T, Horiuchi Y, Yamada T, Imanaka T, Kamekura M (2007)
Ubiquitous expression of acetylcholine and its biological functions in life forms without nervous systems
Life Sciences 80: 2206

Fotovati A, Fujii T, Yamaguchi M, Kage M, Shirouzu K, Oie S, Basaki Y, Ono M, Yamana H, Kuwano M (2006)
17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells
Clin Cancer Research 12: 3010

Fujii T, Masuyama K, Kawashima K (2006)
Simvastatin regulates non-neuronal cholinergic activity in T lymphocytes via CD11a-mediated pathways
Journal of Neuroimmunology 179: 101

Nishioka T, Iwata M, Imaoka T, Mutoh M, Egashira Y, Nishiyama T, Shin T, Fujii T (2006)
A mono-2-ethylhexyl phthalate hydrolase from a Gordonia sp. that is able to dissimilate di-2-ethylhexyl phthalate
Applied Environmental Microbiology 72: 2394

Takada-Takatori Y, Kume T, Sugimoto M, Katsuki H, Niidome T, Sugimoto H, Fujii T, Okabe S, Akaike A (2006)
Neuroprotective effects of galanthamine and tacrine against glutamate neurotoxicity
European Journal of Pharmacology 549: 19

Ema T, Fujii T, Ozaki M, Korenaga T, Sakai T (2005)
Rational control of enantioselectivity of lipase by site-directed mutagenesis based on the mechanism
Chem Commun (Camb)

Mima J, Hayashida M, Fujii T, Narita Y, Hayashi R, Ueda M, Hata Y (2005)
Structure of the carboxypeptidase Y inhibitor IC in complex with the cognate proteinase reveals a novel mode of the proteinase-protein inhibitor interaction
Journal of Molecular Biology 346: 1323

Yamada T, Fujii T, Kanai T, Amo T, Imanaka T, Nishimasu H, Wakagi T, Shoun H, Kamekura M, Kamagata Y, Kato T, Kawashima K (2005)
Expression of acetylcholine (ACh) and ACh-synthesizing activity in Archaea
Life Sciences 77: 1935

Fujii T (2004)
[An independent, non-neuronal cholinergic system in lymphocytes and its roles in regulation of immune function]
Nihon Yakurigaku Zasshi 123: 179

Kawashima K, Fujii T (2004)
Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function
Front Biosci 9: 2063

Mima J, Hayashida M, Fujii T, Hata Y, Hayashi R, Ueda M (2004)
Crystallization and preliminary X-ray analysis of carboxypeptidase Y inhibitor IC complexed with the cognate proteinase
Acta Crystallographica D Biol Crystallogr 60: 1622

Suenaga A, Fujii T, Ogawa H, Maruyama T, Ohuchida S, Katsube N, Obata T, Kawashima K (2004)
Up-regulation of lymphocytic cholinergic activity by ONO-4819, a selective prostaglandin EP4 receptor agonist, in MOLT-3 human leukemic T cells
Vascul Pharmacol 41: 51

Fujii T, Okuda T, Haga T, Kawashima K (2003)
Detection of the high-affinity choline transporter in the MOLT-3 human leukemic T-cell line
Life Sciences 72: 2131

Fujii T, Watanabe Y, Inoue T, Kawashima K (2003)
Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses
Neurochem Res 28: 423

Horikoshi T, Fujii T, Kawashima K, Sakuragawa N (2003)
Acetylcholine increase in amniotic fluid of experimental rats for intrauterine growth retardation
Life Sciences 72: 2145

Horiuchi Y, Fujii T, Kamimura Y, Kawashima K (2003)
The endogenous, immunologically active peptide apelin inhibits lymphocytic cholinergic activity during immunological responses
Journal of Neuroimmunology 144: 46

Horiuchi Y, Kimura R, Kato N, Fujii T, Seki M, Endo T, Kato T, Kawashima K (2003)
Evolutional study on acetylcholine expression
Life Sciences 72: 1745

Kamimura Y, Fujii T, Kojima H, Nagano T, Kawashima K (2003)
Nitric oxide (NO) synthase mRNA expression and NO production via muscarinic acetylcholine receptor-mediated pathways in the CEM, human leukemic T-cell line
Life Sciences 72: 2151

Kawashima K, Fujii T (2003)
The lymphocytic cholinergic system and its contribution to the regulation of immune activity
Life Sciences 74: 675

Kawashima K, Fujii T (2003)
The lymphocytic cholinergic system and its biological function
Life Sciences 72: 2101

Kimura R, Ushiyama N, Fujii T, Kawashima K (2003)
Nicotine-induced Ca2+ signaling and down-regulation of nicotinic acetylcholine receptor subunit expression in the CEM human leukemic T-cell line
Life Sciences 72: 2155

Ogawa H, Fujii T, Watanabe Y, Kawashima K (2003)
Expression of multiple mRNA species for choline acetyltransferase in human T-lymphocytes
Life Sciences 72: 2127

Fujii T, Ushiyama N, Hosonuma K, Suenaga A, Kawashima K (2002)
Effects of human antithymocyte globulin on acetylcholine synthesis, its release and choline acetyltransferase transcription in a human leukemic T-cell line
Journal of Neuroimmunology 128: 1

Fujii T, Kawashima K (2001)
An independent non-neuronal cholinergic system in lymphocytes
Japanese Journal of Pharmacology 85: 11

Fujimoto K, Matsui M, Fujii T, Kawashima K (2001)
Decreased acetylcholine content and choline acetyltransferase mRNA expression in circulating mononuclear leukocytes and lymphoid organs of the spontaneously hypertensive rat
Life Sciences 69: 1629

Sakuragawa N, Elwan MA, Uchida S, Fujii T, Kawashima K (2001)
Non-neuronal neurotransmitters and neurotrophic factors in amniotic epithelial cells: expression and function in humans and monkey
Japanese Journal of Pharmacology 85: 20

Fujii T, Nakai K, Nakajima Y, Kawashima K (2000)
Enhancement of hippocampal cholinergic neurotransmission through 5-HT1A receptor-mediated pathways by repeated lithium treatment in rats
Canadian Journal of Physiology & Pharmacology 78: 392

Fujii T, Harada H, Koyama T, Nakajima Y, Kawashima K (2000)
Effects of physostigmine and calcium on acetylcholine efflux from the hippocampus of freely moving rats as determined by in vivo microdialysis and a radioimmunoassay
Neuroscience Letters 289: 181

Fujii T, Kawashima K (2000)
Ca2+ oscillation and c-fos gene expression induced via muscarinic acetylcholine receptor in human T- and B-cell lines
Naunyn Schmiedebergs Arch Pharmacol 362: 14

Fujii T, Kawashima K (2000)
Calcium signaling and c-Fos gene expression via M3 muscarinic acetylcholine receptors in human T- and B-cells
Japanese Journal of Pharmacology 84: 124

Fujii T, Kawashima K (2000)
YM905, a novel M3 antagonist, inhibits Ca2+ signaling and c-fos gene expression mediated via muscarinic receptors in human T cells
General Pharmacology 35: 71

Harada H, Hosonuma K, Fujii T, Kawashima K (2000)
Enhancement of cerebral cortical acetylcholine release by intraperitoneal acetic acid and its suppression by analgesics in freely moving rats
Neuroscience Letters 284: 163

Kawashima K, Fujii T (2000)
Extraneuronal cholinergic system in lymphocytes
Pharmacol Ther 86: 29

Fujii T, Ohba S, Nakai K, Fujimoto K, Suzuki T, Kawashima K (1999)
Enhancement of the serotonin-mediated acetylcholine release by repeated desmethylimipramine treatment in the hippocampus of freely moving rats
Japanese Journal of Pharmacology 80: 303

Fujii T, Tajima S, Yamada S, Watanabe Y, Sato KZ, Matsui M, Misawa H, Kasahara T, Kawashima K (1999)
Constitutive expression of mRNA for the same choline acetyltransferase as that in the nervous system, an acetylcholine-synthesizing enzyme, in human leukemic T-cell lines
Neuroscience Letters 259: 71

Koyama T, Nakajima Y, Fujii T, Kawashima K (1999)
Enhancement of cortical and hippocampal cholinergic neurotransmission through 5-HT1A receptor-mediated pathways by BAY x 3702 in freely moving rats
Neuroscience Letters 265: 33

Oosawa H, Fujii T, Kawashima K (1999)
Nerve growth factor increases the synthesis and release of acetylcholine and the expression of vesicular acetylcholine transporter in primary cultured rat embryonic septal cells
Journal of Neuroscience Research 57: 381

Sakuragawa N, Elwan MA, Fujii T, Kawashima K (1999)
Possible dynamic neurotransmitter metabolism surrounding the fetus
Journal of Child Neurology 14: 265

Sato KZ, Fujii T, Watanabe Y, Yamada S, Ando T, Kazuko F, Kawashima K (1999)
Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines
Neuroscience Letters 266: 17

Fujii T, Yamada S, Watanabe Y, Misawa H, Tajima S, Fujimoto K, Kasahara T, Kawashima K (1998)
Induction of choline acetyltransferase mRNA in human mononuclear leukocytes stimulated by phytohemagglutinin, a T-cell activator
Journal of Neuroimmunology 82: 101

Kawashima K, Fujii T, Watanabe Y, Misawa H (1998)
Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes
Life Sciences 62: 1701

Nakai K, Fujii T, Fujimoto K, Suzuki T, Kawashima K (1998)
Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenylalanine-treated rats as measured by in vivo microdialysis
Neurosci Res 31: 23

Takeo M, Fujii T, Takenaka K, Maeda Y (1998)
Cloning and sequencing of a gene cluster for the meta-cleavage pathway of aniline degradation in Acinetobacter sp. strain YAA
J.Ferment.Bioeng 85: 514

Fujii T, Takeo M, Maeda Y (1997)
Plasmid-encoded genes specifying aniline oxidation from Acinetobacter sp. strain YAA
Microbiology 143: 93

Fujii T, Mori Y, Tominaga T, Hayasaka I, Kawashima K (1997)
Maintenance of constant blood acetylcholine content before and after feeding in young chimpanzees
Neuroscience Letters 227: 21

Fujii T, Yoshizawa M, Nakai K, Fujimoto K, Suzuki T, Kawashima K (1997)
Demonstration of the facilitatory role of 8-OH-DPAT on cholinergic transmission in the rat hippocampus using in vivo microdialysis
Brain Research 761: 244

Fujino Y, Fujii T (1997)
Low sensitivity of adrenal chromaffin cells to acetylcholine, neostigmine and oxotremorine in 21-day-old rats
Japanese Journal of Pharmacology 75: 145

Suzuki T, Nakajima K, Fujimoto K, Fujii T, Kawashima K (1997)
Nitric oxide increases stimulation-evoked acetylcholine release from rat hippocampal slices by a cyclic GMP-independent mechanism
Brain Research 760: 158

Yamada S, Fujii T, Kawashima K (1997)
Oral administration of KW-5092, a novel gastroprokinetic agent with acetylcholinesterase inhibitory and acetylcholine release enhancing activities, causes a dose-dependent increase in the blood acetylcholine content of beagle dogs
Neuroscience Letters 225: 25

Fujii T, Tsuchiya T, Yamada S, Fujimoto K, Suzuki T, Kasahara T, Kawashima K (1996)
Localization and synthesis of acetylcholine in human leukemic T cell lines
Journal of Neuroscience Research 44: 66

Hisano T, Hata Y, Fujii T, Liu JQ, Kurihara T, Esaki N, Soda K (1996)
Crystal structure of L-2-haloacid dehalogenase from Pseudomonas sp. YL. An alpha/beta hydrolase structure that is different from the alpha/beta hydrolase fold
Journal of Biological Chemistry 271: 20322

Fujii T, Yamada S, Yamaguchi N, Fujimoto K, Suzuki T, Kawashima K (1995)
Species differences in the concentration of acetylcholine, a neurotransmitter, in whole blood and plasma
Neuroscience Letters 201: 207

Kawashima K, Sato A, Yoshizawa M, Fujii T, Fujimoto K, Suzuki T (1994)
Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats
Naunyn Schmiedebergs Arch Pharmacol 350: 523