Gorecki L, Soukup O, Korabecny J (2022)
Countermeasures in organophosphorus intoxication: pitfalls and prospects
Trends in Pharmacological Sciences

Hepnarova V, Hrabinova M, Muckova L, Kucera T, Schmidt M, Dolezal R, Gorecki L, Hrabcova V, Korabecny J, Mezeiova E, Jun D, Pejchal J (2022)
Non-covalent acetylcholinesterase inhibitors: In vitro screening and molecular modeling for novel selective insecticides
Toxicol In Vitro

Gorecki L, Hepnarova V, Karasova JZ, Hrabinova M, Courageux C, Dias J, Kucera T, Kobrlova T, Muckova L, Prchal L, Malinak D, Jun D, Musilek K, Worek F, Nachon F, Soukup O, Korabecny J (2021)
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
Archives of Toxicology

Gorecki L, Uliassi E, Bartolini M, Janockova J, Hrabinova M, Hepnarova V, Prchal L, Muckova L, Pejchal J, Karasova JZ, Mezeiova E, Benkova M, Kobrlova T, Soukup O, Petralla S, Monti B, Korabecny J, Bolognesi ML (2021)
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease
ACS Chem Neurosci

Gorecki L, Misiachna A, Damborsky J, Dolezal R, Korabecny J, Cejkova L, Hakenova K, Chvojkova M, Karasova JZ, Prchal L, Novak M, Kolcheva M, Kortus S, Vales K, Horak M, Soukup O (2021)
Structure-activity relationships of dually-acting acetylcholinesterase inhibitors derived from tacrine on N-methyl-d-Aspartate receptors
Eur Journal of Medicinal Chemistry 219: 113434

Hroudova J, Novakova T, Korabecny J, Malinak D, Gorecki L, Fisar Z (2021)
Effects of Novel Tacrine Derivatives on Mitochondrial Energy Metabolism and Monoamine Oxidase Activity-In Vitro Study
Molecular Neurobiology 58: 1102

Mezeiova E, Hrabinova M, Hepnarova V, Jun D, Janockova J, Muckova L, Prchal L, Kristofikova Z, Kucera T, Gorecki L, Chalupova K, Kunes J, Hroudova J, Soukup O, Korabecny J (2021)
Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment
Bioorganic & Medicinal Chemistry Lett

Gorecki L, Andrys R, Schmidt M, Kucera T, Psotka M, Svobodova B, Hrabcova V, Hepnarova V, Bzonek P, Jun D, Kuca K, Korabecny J, Musilek K (2020)
Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors
ACS Med Chem Lett 11: 65

Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal DK, Taylor P, Ballatore C, Kovalevsky A, Radic Z (2020)
Rational design, synthesis and evaluation of uncharged, smart bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase
Journal of Biological Chemistry 295: 4079

Malinak D, Dolezal R, Hepnarova V, Hozova M, Andrys R, Bzonek P, Racakova V, Korabecny J, Gorecki L, Mezeiova E, Psotka M, Jun D, Kuca K, Musilek K (2020)
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators
J Enzyme Inhib Med Chem 35: 478

Gorecki L, Soukup O, Kucera T, Malinak D, Jun D, Kuca K, Musilek K, Korabecny J (2019)
Oxime K203: a drug candidate for the treatment of tabun intoxication
Archives of Toxicology 93: 673

Gorecki L, Junova L, Kucera T, Hepnarova V, Prchal L, Kobrlova T, Muckova L, Soukup O, Korabecny J (2019)
Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase
Future Med Chem 11: 2625

Mezeiova E, Chalupova K, Nepovimova E, Gorecki L, Prchal L, Malinak D, Kuca K, Soukup O, Korabecny J (2019)
Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease
Curr Alzheimer Res 16: 772

Mezeiova E, Spilovska K, Nepovimova E, Gorecki L, Soukup O, Dolezal R, Malinak D, Janockova J, Jun D, Kuca K, Korabecny J (2018)
Profiling donepezil template into multipotent hybrids with antioxidant properties
J Enzyme Inhib Med Chem 33: 583

Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K (2018)
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Med Chem 14: 281

Gorecki L, Korabecny J, Musilek K, Nepovimova E, Malinak D, Kucera T, Dolezal R, Jun D, Soukup O, Kuca K (2017)
Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016)
Expert Opin Ther Pat 27: 971

Psotka M, Malinak D, Gorecki L, Nguyen TD, Soukup O, Jun D, Kuca K, Musilek K, Korabecny J (2017)
HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication
Military Medical Science Letters 86: 70

Gorecki L, Korabecny J, Musilek K, Malinak D, Nepovimova E, Dolezal R, Jun D, Soukup O, Kuca K (2016)
SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides
Archives of Toxicology 90: 2831

Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L, Malinak D, Gorecki L, Musilek K, Kuca K (2016)
A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication
Toxicol Res (Camb) 5: 1012

Korabecny J, Andrs M, Nepovimova E, Dolezal R, Babkova K, Horova A, Malinak D, Mezeiova E, Gorecki L, Sepsova V, Hrabinova M, Soukup O, Jun D, Kuca K (2015)
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
Molecules 20: 22084