Greenblatt HM, Otto TC, Kirkpatrick MG, Kovaleva E, Brown S, Buchman G, Cerasoli DM, Sussman JL (2012) <br />Structure of Recombinant Human Carboxylesterase 1 Isolated from Whole Cabbage Looper Larvae<br /><i>Acta Crystallographica Sect F Struct Biol Cryst Commun</i> <b>F68</b>: 269<br /><br />Paz A, Xie Q, Greenblatt HM, Fu W, Tang Y, Silman I, Qiu Z, Sussman JL (2009) <br />The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 2543<br /><br />Sanson B, Nachon F, Colletier JP, Froment MT, Toker L, Greenblatt HM, Sussman JL, Ashani Y, Masson P, Silman I, Weik M (2009) <br />Crystallographic snapshots of nonaged and aged conjugates of soman with acetylcholinesterase, and of a ternary complex of the aged conjugate with pralidoxime<br /><i>Journal of Medicinal Chemistry</i> <b>52</b>: 7593<br /><br />Colletier JP, Fournier D, Greenblatt HM, Stojan J, Sussman JL, Zaccai G, Silman I, Weik M (2006) <br />Structural insights into substrate traffic and inhibition in acetylcholinesterase<br /><i>EMBO Journal</i> <b>25</b>: 2746<br /><br />Rydberg EH, Brumshtein B, Greenblatt HM, Wong DM, Shaya D, Williams LD, Carlier PR, Pang YP, Silman I, Sussman JL (2006) <br />Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge<br /><i>Journal of Medicinal Chemistry</i> <b>49</b>: 5491<br /><br />Haviv H, Wong DM, Greenblatt HM, Carlier PR, Pang YP, Silman I, Sussman JL (2005) <br />Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase<br /><i>Journal of the American Chemical Society</i> <b>127</b>: 11029<br /><br />Colletier JP, Fournier D, Greenblatt HM, Sussman JL, Zaccai G, Silman I, Weik M (2004) <br />Poster (74) Structural studies on torpedo californica acetylcholinesterase in complex with a substrate analogue<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 359<br /><br />Greenblatt HM, Guillou C, Guenard D, Argaman A, Botti SA, Badet B, Thal C, Silman I, Sussman JL (2004) <br />The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design<br /><i>Journal of the American Chemical Society</i> <b>126</b>: 15405<br /><br />Silman I, Greenblatt HM, Zeev-Ben-Mordehai T, Sussman JL (2004) <br />Poster (47) Conformational plasticity of acetylcholinesterase<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 346<br /><br />Greenblatt HM, Dvir H, Silman I, Sussman JL (2003) <br />Acetylcholinesterase: a multifaceted target for structure-based drug design of anticholinesterase agents for the treatment of Alzheimer's disease<br /><i>Journal of Molecular Neuroscience</i> <b>20</b>: 369<br /><br />Wong DM, Greenblatt HM, Dvir H, Carlier PR, Han YF, Pang YP, Silman I, Sussman JL (2003) <br />Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity<br /><i>J Am Chem Soc</i> <b>125</b>: 363<br /><br />Doucet-Personeni C, Bentley PD, Fletcher RJ, Kinkaid A, Kryger G, Pirard B, Taylor A, Taylor R, Taylor J, Viner R, Silman I, Sussman JL, Greenblatt HM, Lewis T (2001) <br />A structure-based design approach to the development of novel, reversible AChE inhibitors<br /><i>Journal of Medicinal Chemistry</i> <b>44</b>: 3203<br /><br />Greenblatt HM, Kryger G, Lewis T, Silman I, Sussman JL (1999) <br />Structure of acetylcholinesterase complexed with (-)-galanthamine at 2.3 A resolution<br /><i>FEBS Letters</i> <b>463</b>: 321<br /><br />Millard CB, Kryger G, Ordentlich A, Greenblatt HM, Harel M, Raves ML, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL (1999) <br />Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level<br /><i>Biochemistry</i> <b>38</b>: 7032<br /><br />Morel N, Bon S, Greenblatt HM, Van Belle D, Wodak SJ, Sussman JL, Massoulie J, Silman I (1999) <br />Effect of mutations within the peripheral anionic site on the stability of acetylcholinesterase<br /><i>Molecular Pharmacology</i> <b>55</b>: 982<br /><br />Silman I, Millard CB, Ordentlich A, Greenblatt HM, Harel M, Barak D, Shafferman A, Sussman JL (1999) <br />A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 43<br /><br />Greenblatt HM, Feinberg H, Tucker PA, Shoham G (1998) <br />Carboxypeptidase A: native, zinc-removed and mercury-replaced forms<br /><i>Acta Crystallographica D Biol Crystallogr</i> <b>54</b>: 289<br /><br />Greenblatt HM, Kryger G, Harel M, Lewis T, Taylor J, Silman I, Sussman JL (1998) <br />Crystal Structures of Complexes of E2020-Related Compounds with Torpedo Californica Acetylcholinesterase<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 371-371<br /><br />Millard CB, Kryger G, Ordentlich A, Harel M, Raves ML, Greenblatt HM, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL (1998) <br />Crystal structure of Aged phosphorylated and phosphonylated Torpedo Californica Acetylcholinesterase<br /><i>In Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 425<br /><br />Millard CB, Kryger G, Ordentlich A, Harel M, Raves ML, Greenblatt HM, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL (1998) <br />Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 425<br /><br />Millard CB, Kryger G, Ordentlich A, Harel M, Raves ML, Greenblatt HM, Segall Y, Barak D, Shafferman A, Silman I, Sussman JL (1998) <br />Crystal Structures of Aged Phosphorylated and Phosphonylated Torpedo Californica Acetylcholinesterase<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 454<br /><br />Raves ML, Greenblatt HM, Kryger G, Nicolas A, Ravelli RB, Harel M, Kroon J, Silman I, Sussman JL (1998) <br />Alternative Crystal Forms of Torpedo Californica Acetylcholinesterase<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 372<br /><br />Greenblatt HM, Almog O, Maras B, Spungin-Bialik A, Barra D, Blumberg S, Shoham G (1997) <br />Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 A resolution<br /><i>Journal of Molecular Biology</i> <b>265</b>: 620<br /><br />Maras B, Greenblatt HM, Shoham G, Spungin-Bialik A, Blumberg S, Barra D (1996) <br />Aminopeptidase from Streptomyces griseus: primary structure and comparison with other zinc-containing aminopeptidases<br /><i>European Journal of Biochemistry</i> <b>236</b>: 843<br /><br />