Hepnarova V, Hrabinova M, Muckova L, Kucera T, Schmidt M, Dolezal R, Gorecki L, Hrabcova V, Korabecny J, Mezeiova E, Jun D, Pejchal J (2022)
Non-covalent acetylcholinesterase inhibitors: In vitro screening and molecular modeling for novel selective insecticides
Toxicol In Vitro

Karasova JZ, Kassa J, Hepnarova V, Pejchal J, Junova L, Andrys R, Malinak D, Bzonek P, Kohoutova Z, Musilek K (2022)
Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870
Food & Chemical Toxicology

Gorecki L, Hepnarova V, Karasova JZ, Hrabinova M, Courageux C, Dias J, Kucera T, Kobrlova T, Muckova L, Prchal L, Malinak D, Jun D, Musilek K, Worek F, Nachon F, Soukup O, Korabecny J (2021)
Development of versatile and potent monoquaternary reactivators of acetylcholinesterase
Archives of Toxicology

Gorecki L, Uliassi E, Bartolini M, Janockova J, Hrabinova M, Hepnarova V, Prchal L, Muckova L, Pejchal J, Karasova JZ, Mezeiova E, Benkova M, Kobrlova T, Soukup O, Petralla S, Monti B, Korabecny J, Bolognesi ML (2021)
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer's Disease
ACS Chem Neurosci

Hamulakova S, Kudlickova Z, Janovec L, Mezencev R, Deckner ZJ, Chernoff YO, Janockova J, Ihnatova V, Bzonek P, Novakova N, Hepnarova V, Hrabinova M, Jun D, Korabecny J, Soukup O, Kuca K (2021)
Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease
Future Med Chem

Ismaili L, Monnin J, Etievant A, Arribas RL, Viejo L, Refouvelet B, Soukup O, Janockova J, Hepnarova V, Korabecny J, Kucera T, Jun D, Andrys R, Musilek K, Baguet A, Garcia-Frutos EM, De Simone A, Andrisano V, Bartolini M, de los Rios C, Marco-Contelles J, Haffen E (2021)
(+/-)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3beta Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease
ACS Chem Neurosci

Kaniakova M, Korabecny J, Holubova K, Kleteckova L, Chvojkova M, Hakenova K, Prchal L, Novak M, Dolezal R, Hepnarova V, Svobodova B, Kucera T, Lichnerova K, Krausova B, Horak M, Vales K, Soukup O (2021)
7-phenoxytacrine is a dually acting drug with neuroprotective efficacy in vivo
Biochemical Pharmacology

Kassa J, Hatlapatkova J, arova Karasova J, Hepnarova V, Caisberger F, Pejchal J (2021)
A Comparison of the Neuroprotective and Reactivating Efficacy of a Novel Bispyridinium Oxime K870 with Commonly Used Pralidoxime and the Oxime HI-6 in Tabun-Poisoned Rats
Acta Medica (Hradec Kralove) 64: 145

Mezeiova E, Hrabinova M, Hepnarova V, Jun D, Janockova J, Muckova L, Prchal L, Kristofikova Z, Kucera T, Gorecki L, Chalupova K, Kunes J, Hroudova J, Soukup O, Korabecny J (2021)
Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment
Bioorganic & Medicinal Chemistry Lett

Gorecki L, Andrys R, Schmidt M, Kucera T, Psotka M, Svobodova B, Hrabcova V, Hepnarova V, Bzonek P, Jun D, Kuca K, Korabecny J, Musilek K (2020)
Cysteine-Targeted Insecticides against A. gambiae Acetylcholinesterase Are Neither Selective nor Reversible Inhibitors
ACS Med Chem Lett 11: 65

Malinak D, Dolezal R, Hepnarova V, Hozova M, Andrys R, Bzonek P, Racakova V, Korabecny J, Gorecki L, Mezeiova E, Psotka M, Jun D, Kuca K, Musilek K (2020)
Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators
J Enzyme Inhib Med Chem 35: 478

Nepovimova E, Svobodova L, Dolezal R, Hepnarova V, Junova L, Jun D, Korabecny J, Kucera T, Gazova Z, Motykova K, Kubackova J, Bednarikova Z, Janockova J, Jesus C, Cortes L, Pina J, Rostohar D, Serpa C, Soukup O, Aitken L, Hughes RE, Musilek K, Muckova L, Jost P, Chvojkova M, Vales K, Valis M, Chrienova Z, Chalupova K, Kuca K (2020)
Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimes drugs dealing with cholinergic, amyloid and mitochondrial systems
Bioorg Chem 107: 104596

Sobolova K, Hrabinova M, Hepnarova V, Kucera T, Kobrlova T, Benkova M, Janockova J, Dolezal R, Prchal L, Benek O, Mezeiova E, Jun D, Soukup O, Korabecny J (2020)
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
Eur Journal of Medicinal Chemistry 203: 112593

Zdarova Karasova J, Hepnarova V, Andrys R, Lisa M, Jost P, Muckova L, Pejchal J, Herman D, Jun D, Kassa J, Kuca K (2020)
Encapsulation of oxime K027 into cucurbit[7]uril: In vivo evaluation of safety, absorption, brain distribution and reactivation effectiveness
Toxicol Lett 320: 64

Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Zdarova Karasova J, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K (2019)
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
Eur Journal of Medicinal Chemistry 168: 491

Gorecki L, Junova L, Kucera T, Hepnarova V, Prchal L, Kobrlova T, Muckova L, Soukup O, Korabecny J (2019)
Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase
Future Med Chem 11: 2625

Hepnarova V, Muckova L, Ring A, Pejchal J, Herman D, Misik J, Hrabinova M, Jun D, Soukup O (2019)
Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators
Toxicol Appl Pharmacol

Kaniakova M, Nepovimova E, Kleteckova L, Skrenkova K, Holubova K, Chrienova Z, Hepnarova V, Kucera T, Kobrlova T, Vales K, Korabecny J, Soukup O, Horak M (2019)
Combination of Memantine and 6-Chlorotacrine as Novel Multi-Target Compound against Alzheimer's Disease
Curr Alzheimer Res 16: 821

Nepovimova E, Korabecny J, Hepnarova V, Jun D, Dolezal R, Muckova L, Jost P, Soukup O, Janockova J, Pham NL, Nguyen TD, Valis M, Kuca K (2019)
N-alkylated Tacrine Derivatives as Potential Agents in Alzheimer's Disease Therapy
Curr Alzheimer Res 16: 333

Svobodova B, Mezeiova E, Hepnarova V, Hrabinova M, Muckova L, Kobrlova T, Jun D, Soukup O, Jimeno ML, Marco-Contelles J, Korabecny J (2019)
Exploring Structure-Activity Relationship in Tacrine-Squaramide Derivatives as Potent Cholinesterase Inhibitors
Biomolecules 9:

Zdarova Karasova J, Soukup O, Korabecny J, Hroch M, Krejciova M, Hrabinova M, Misik J, Novotny L, Hepnarova V, Kuca K (2019)
Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats
Drug & Chemical Toxicology

Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T, Dolezal R, Nepovimova E, Spilovska K, Mezeiova E, Pham NL, Jun D, Staud F, Kaping D, Kuca K, Soukup O (2018)
The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
Eur Journal of Medicinal Chemistry 150: 292

Janockova J, Dolezal R, Nepovimova E, Kobrlova T, Benkova M, Kuca K, Konecny J, Mezeiova E, Melikova M, Hepnarova V, Ring A, Soukup O, Korabecny J (2018)
Investigation of New Orexin 2 Receptor Modulators Using In Silico and In Vitro Methods
Molecules 23:

Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K (2018)
In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?
Med Chem 14: 281