Matsuo N, Sugisaka Y, Aoyama S, Ihara M, Shinoyama H, Hosokawa M, Kamakura Y, Tanaka D, Tanabe Y, Matsuda K (2023) <br />Creating Pyrethrin Mimetic Phosphonates as Chemical Genetics Tools Targeting the GDSL Esterase/Lipase TcGLIP to Investigate Pyrethrin Biosynthesis<br /><i>Journal of Medicinal Chemistry</i> <br /><br />Alma'abadi A, Behzad H, Alarawi M, Conchouso D, Saito Y, Hosokawa M, Nishikawa Y, Kogawa M, Takeyama H, Mineta K, Gojobori T (2022) <br />Identification of Lipolytic Enzymes Using High-Throughput Single-cell Screening and Sorting of a Metagenomic Library<br /><i>N Biotechnol</i> <br /><br />Takahashi M, Hirota I, Nakano T, Kotani T, Takani D, Shiratori K, Choi Y, Haba M, Hosokawa M (2021) <br />Effects of steric hindrance and electron density of ester prodrugs on controlling the metabolic activation by human carboxylesterase<br /><i>Drug Metab Pharmacokinet</i> <b>38</b>: 100391<br /><br />Takahashi M, Takani D, Haba M, Hosokawa M (2020) <br />Investigation of the chiral recognition ability of human carboxylesterase 1 using indomethacin esters<br /><i>Chirality</i> <b>32</b>: 73<br /><br />Takahashi M, Lee YJ, Kanayama T, Kondo Y, Nishio K, Mukai K, Haba M, Hosokawa M (2020) <br />Design, synthesis and biological evaluation of water-soluble phenytoin prodrugs considering the substrate recognition ability of human carboxylesterase 1<br /><i>Eur J Pharm Sci</i> <br /><br />Mizoi K, Takahashi M, Sakai S, Ogihara T, Haba M, Hosokawa M (2019) <br />Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases<br /><i>Xenobiotica</i> <br /><br />Takahashi M, Uehara T, Nonaka M, Minagawa Y, Yamazaki R, Haba M, Hosokawa M (2019) <br />Synthesis and evaluation of haloperidol ester prodrugs metabolically activated by human carboxylesterase<br /><i>Eur J Pharm Sci</i> <b>132</b>: 125<br /><br />Ishizaki Y, Furihata T, Oyama Y, Ohura K, Imai T, Hosokawa M, Akita H, Chiba K (2018) <br />Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies<br /><i>Biol Pharm Bull</i> <b>41</b>: 697<br /><br />Takahashi M, Ogawa T, Kashiwagi H, Fukushima F, Yoshitsugu M, Haba M, Hosokawa M (2018) <br />Chemical synthesis of an indomethacin ester prodrug and its metabolic activation by human carboxylesterase 1<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>28</b>: 997<br /><br />Uno Y, Igawa Y, Tanaka M, Kayoko O, Hosokawa M, Imai T (2018) <br />Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver<br /><i>Xenobiotica</i> <br /><br />Uno Y, Uehara S, Mahadhi HMD, Ohura K, Hosokawa M, Imai T (2018) <br />Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques<br /><i>J Med Primatol</i> <b>47</b>: 185<br /><br />Kabeya T, Matsumura W, Iwao T, Hosokawa M, Matsunaga T (2017) <br />Functional analysis of carboxylesterase in human induced pluripotent stem cell-derived enterocytes<br /><i>Biochemical & Biophysical Research Communications</i> <b>486</b>: 143<br /><br />Mizoi K, Takahashi M, Haba M, Hosokawa M (2016) <br />Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>26</b>: 921<br /><br />Hosokawa M, Hoshino Y, Nishikawa Y, Hirose T, Yoon DH, Mori T, Sekiguchi T, Shoji S, Takeyama H (2015) <br />Droplet-based microfluidics for high-throughput screening of a metagenomic library for isolation of microbial enzymes<br /><i>Biosensors & Bioelectronics</i> <b>67</b>: 379<br /><br />Uno Y, Hosokawa M, Imai T (2015) <br />Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques<br /><i>J Vet Med Sci</i> <b>77</b>: 721<br /><br />Takatani N, Nakanishi M, Meirelles P, Mino S, Suda W, Oshima K, Hattori M, Ohkuma M, Hosokawa M, Miyashita K, Thompson FL, Niwa A, Sawabe T (2014) <br />Draft Genome Sequences of Marine Flavobacterium Algibacter lectus Strains SS8 and NR4<br /><i>Genome Announc</i> <b>2</b>: <br /><br />Uno Y, Uehara S, Hosokawa M, Imai T (2014) <br />Systematic identification and characterization of carboxylesterases in cynomolgus macaques<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>42</b>: 2002<br /><br />Suzaki Y, Uemura N, Takada M, Ohyama T, Itohda A, Morimoto T, Imai H, Hamasaki H, Inano A, Hosokawa M, Tateishi M, Ohashi K (2013) <br />The effect of carboxylesterase 1 (CES1) polymorphisms on the pharmacokinetics of oseltamivir in humans<br /><i>European Journal of Clinical Pharmacology</i> <b>69</b>: 21<br /><br />Hori T, Jin L, Fujii A, Furihata T, Nagahara Y, Chiba K, Hosokawa M (2012) <br />Dexamethasone-mediated transcriptional regulation of rat carboxylesterase 2 gene<br /><i>Xenobiotica</i> <b>42</b>: 614<br /><br />Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R, Maltais LJ (2010) <br />Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins<br /><i>Mamm Genome</i> <b>21</b>: 427<br /><br />Hori T, Hosokawa M (2010) <br />DNA methylation and its involvement in carboxylesterase 1A1 (CES1A1) gene expression<br /><i>Xenobiotica</i> <b>40</b>: 119<br /><br />Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y, Ohta K, Kumagai M, Nishi M, Hosokawa M, Fledelius C, Jacobsen P, Yagyu H, Fukayama M, Nagai R, Kadowaki T, Ohashi K, Ishibashi S (2010) <br />The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages<br /><i>Circulation Research</i> <b>107</b>: 1387<br /><br />Imai T, Hosokawa M (2010) <br />Prodrug approach using carboxylesterases activity: catalytic properties and gene regulation of carboxylesterase in mammalian tissue<br /><i>Journal of Pesticide Science</i> <b>35</b>: 229<br /><br />Sai K, Saito Y, Tatewaki N, Hosokawa M, Kaniwa N, Nishimaki-Mogami T, Naito M, Sawada J, Shirao K, Hamaguchi T, Yamamoto N, Kunitoh H, Tamura T, Yamada Y, Ohe Y, Yoshida T, Minami H, Ohtsu A, Matsumura Y, Saijo N, Okuda H (2010) <br />Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients<br /><i>British Journal of Clinical Pharmacology</i> <b>70</b>: 222<br /><br />Satoh T, Hosokawa M (2010) <br />Carboxylesterases: structure, function and polymorphism in mammals<br /><i>Journal of Pesticide Science</i> <b>35</b>: 218<br /><br />Hosokawa M (2008) <br />Structure and catalytic properties of carboxylesterase isozymes involved in metabolic activation of prodrugs<br /><i>Molecules</i> <b>13</b>: 412<br /><br />Hosokawa M, Furihata T, Yaginuma Y, Yamamoto N, Watanabe N, Tsukada E, Ohhata Y, Kobayashi K, Satoh T, Chiba K (2008) <br />Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes<br /><i>Drug Metab Pharmacokinet</i> <b>23</b>: 73<br /><br />Yoshimura M, Kimura T, Ishii M, Ishii K, Matsuura T, Geshi E, Hosokawa M, Muramatsu M (2008) <br />Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites<br /><i>Biochemical & Biophysical Research Communications</i> <b>369</b>: 939<br /><br />Hosokawa M, Furihata T, Yaginuma Y, Yamamoto N, Koyano N, Fujii A, Nagahara Y, Satoh T, Chiba K (2007) <br />Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes<br /><i>Drug Metabolism Reviews</i> <b>39</b>: 1<br /><br />Furihata T, Hosokawa M, Masuda M, Satoh T, Chiba K (2006) <br />Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver<br /><i>Archives of Biochemistry & Biophysics</i> <b>447</b>: 107<br /><br />Imai T, Taketani M, Shii M, Hosokawa M, Chiba K (2006) <br />Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>34</b>: 1734<br /><br />Miyazaki M, Yamashita T, Hosokawa M, Taira H, Suzuki A (2006) <br />Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase<br /><i>Comparative Biochemistry & Physiology B Biochem Mol Biol</i> <b>145</b>: 270<br /><br />Satoh T, Hosokawa M (2006) <br />Structure, function and regulation of carboxylesterases<br /><i>Chemico-Biological Interactions</i> <b>162</b>: 195<br /><br />Furihata T, Hosokawa M, Fujii A, Derbel M, Satoh T, Chiba K (2005) <br />Dexamethasone-induced methylprednisolone hemisuccinate hydrolase: its identification as a member of the rat carboxylesterase 2 family and its unique existence in plasma<br /><i>Biochemical Pharmacology</i> <b>69</b>: 1287<br /><br />Furihata T, Hosokawa M, Koyano N, Nakamura T, Satoh T, Chiba K (2004) <br />Identification of di-(2-ethylhexyl) phthalate-induced carboxylesterase 1 in C57BL/6 mouse liver microsomes: purification, cDNA cloning, and baculovirus-mediated expression<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>32</b>: 1170<br /><br />Furihata T, Hosokawa M, Nakata F, Satoh T, Chiba K (2003) <br />Purification, molecular cloning, and functional expression of inducible liver acylcarnitine hydrolase in C57BL/6 mouse, belonging to the carboxylesterase multigene family<br /><i>Archives of Biochemistry & Biophysics</i> <b>416</b>: 101<br /><br />Satoh T, Taylor P, Bosron WF, Sanghani SP, Hosokawa M, La Du BN (2002) <br />Current progress on esterases: from molecular structure to function<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>30</b>: 488<br /><br />Hosokawa M, Suzuki K, Takahashi D, Mori M, Satoh T, Chiba K (2001) <br />Purification, molecular cloning, and functional expression of dog liver microsomal acyl-CoA hydrolase: a member of the carboxylesterase multigene family<br /><i>Archives of Biochemistry & Biophysics</i> <b>389</b>: 245<br /><br />Kudo S, Umehara K, Hosokawa M, Miyamoto G, Chiba K, Satoh T (2000) <br />Phenacetin deacetylase activity in human liver microsomes: distribution, kinetics, and chemical inhibition and stimulation<br /><i>Journal of Pharmacology & Experimental Therapeutics</i> <b>294</b>: 80<br /><br />Satoh T, Hosokawa M (2000) <br />Organophosphates and their impact on the global environment<br /><i>Neurotoxicology</i> <b>21</b>: 223<br /><br />Mori M, Hosokawa M, Ogasawara Y, Tsukada E, Chiba K (1999) <br />cDNA cloning, characterization and stable expression of novel human brain carboxylesterase<br /><i>FEBS Letters</i> <b>458</b>: 17<br /><br />Satoh T, Suzuki S, Kawai N, Nakamura T, Hosokawa M (1999) <br />Toxicological significance in the cleavage of esterase-beta-glucuronidase complex in liver microsomes by organophosphorus compounds<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 471<br /><br />Satoh T, Hosokawa M (1998) <br />The mammalian carboxylesterases: from molecules to functions<br /><i>Annual Review of Pharmacology & Toxicology</i> <b>38</b>: 257<br /><br />Takayama H, Watanabe A, Hosokawa M, Chiba K, Satoh T, Aimi N (1998) <br />Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterases<br /><i>Bioorganic & Medicinal Chemistry Lett</i> <b>8</b>: 415<br /><br />Yamada J, Suga K, Furihata T, Kitahara M, Watanabe T, Hosokawa M, Satoh T, Suga T (1998) <br />cDNA cloning and genomic organization of peroxisome proliferator- inducible long-chain acyl-CoA hydrolase from rat liver cytosol.<br /><i>Biochemical & Biophysical Research Communications</i> <b>248</b>: 608<br /><br />Yamada J, Furihata T, Iida N, Watanabe T, Hosokawa M, Satoh T, Someya A, Nagaoka I, Suga T (1997) <br />Molecular cloning and expression of cDNAs encoding rat brain and liver cytosolic long-chain acyl-CoA hydrolases<br /><i>Biochemical & Biophysical Research Communications</i> <b>232</b>: 198<br /><br />Derbel M, Hosokawa M, Satoh T (1996) <br />Differences in the induction of carboxylesterase RL4 in rat liver microsomes by various perfluorinated fatty acids, metabolically inert derivatives of fatty acids<br /><i>Biol Pharm Bull</i> <b>19</b>: 765<br /><br />Hosokawa M, Endo T, Fujisawa M, Hara S, Iwata N, Sato Y, Satoh T (1995) <br />Interindividual variation in carboxylesterase levels in human liver microsomes<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>23</b>: 1022<br /><br />Satoh T, Hosokawa M (1995) <br />Molecular aspects of carboxylesterase isoforms in comparison with other esterases<br /><i>Toxicol Lett</i> <b>82-83</b>: 439<br /><br />Yamada T, Kawaguchi N, Hosokawa M, Satoh T (1995) <br />Localization of an isoform of carboxylesterase in rat brain differs from that in human brain<br /><i>Brain Research</i> <b>674</b>: 175<br /><br />Hosokawa M, Hirata K, Nakata F, Suga T, Satoh T (1994) <br />Species differences in the induction of hepatic microsomal carboxylesterases caused by dietary exposure to di(2-ethylhexyl)phthalate, a peroxisome proliferator<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>22</b>: 889<br /><br />Satoh T, Hosokawa M, Atsumi R, Suzuki W, Hakusui H, Nagai E (1994) <br />Metabolic activation of CPT-11, 7-ethyl-10-[4-(1-piperidino)-1- piperidino]carbonyloxycamptothecin, a novel antitumor agent, by carboxylesterase<br /><i>Biol Pharm Bull</i> <b>17</b>: 662<br /><br />Yamada T, Hosokawa M, Satoh T, Moroo I, Takahashi M, Akatsu H, Yamamoto T (1994) <br />Immunohistochemistry with an antibody to human liver carboxylesterase in human brain tissues<br /><i>Brain Research</i> <b>658</b>: 163<br /><br />Hosokawa M, Hattori K, Satoh T (1993) <br />Differential responses of rat hepatic microsomal carboxylesterase isozymes to glucocorticoids and pregnenolone 16 alpha-carbonitrile<br /><i>Biochemical Pharmacology</i> <b>45</b>: 2317<br /><br />Hosokawa M, Satoh T (1993) <br />Differences in the induction of carboxylesterase isozymes in rat liver microsomes by perfluorinated fatty acids<br /><i>Xenobiotica</i> <b>23</b>: 1125<br /><br />Maki T, Hosokawa M, Satoh T, Sato K (1991) <br />Changes in carboxylesterase isoenzymes of rat liver microsomes during hepatocarcinogenesis<br /><i>Jpn J Cancer Research</i> <b>82</b>: 800<br /><br />Hosokawa M, Maki T, Satoh T (1990) <br />Characterization of molecular species of liver microsomal carboxylesterases of several animal species and humans<br /><i>Archives of Biochemistry & Biophysics</i> <b>277</b>: 219<br /><br />Hosokawa M, Maki T, Satoh T (1988) <br />Differences in the induction of carboxylesterase isozymes in rat liver microsomes by xenobiotics<br /><i>Biochemical Pharmacology</i> <b>37</b>: 2708<br /><br />Hosokawa M, Satoh T (1988) <br />Effects of hypophysectomy and pituitary hormones on hepatic microsomal carboxylesterase isozymes in male rats<br /><i>Res Commun Chem Pathol Pharmacol</i> <b>62</b>: 279<br /><br />Hosokawa M, Maki T, Satoh T (1987) <br />Multiplicity and regulation of hepatic microsomal carboxylesterases in rats<br /><i>Molecular Pharmacology</i> <b>31</b>: 579<br /><br />Hosokawa M, Satoh T, Ohkawara S, Ohmori S, Igarashi T, Ueno K, Kitagawa H (1985) <br />Effects of adrenalectomy on gonadal hormone-induced changes in hepatic microsomal carboxylesterase activities in rats<br /><i>Res Commun Chem Pathol Pharmacol</i> <b>47</b>: 285<br /><br />Sugiyama S, Hosokawa M, Igarashi T, Ueno K, Satoh T, Kitagawa H (1985) <br />Enhancement of the binding of O-ethyl O-p-nitrophenyl phenylphosphonate (EPNoxon) to microsomal carboxylesterase by NAD in vitro<br /><i>Japanese Journal of Pharmacology</i> <b>37</b>: 39<br /><br />Hosokawa M, Satoh T, Ohkawara S, Ohmori S, Igarashi T, Ueno K, Kitagawa H (1984) <br />Gonadal hormone-induced changes in hepatic microsomal carboxylesterase in rats<br /><i>Res Commun Chem Pathol Pharmacol</i> <b>46</b>: 245<br /><br />