Ohura K, Nakada Y, Imai T (2023) <br />Bioconversion and P-gp-mediated transport of depot fluphenazine prodrugs after intramuscular injection<br /><i>J Pharm Sci</i> <br /><br />Imai T, Isozaki M, Ohura K (2022) <br />Esterases Involved in the Rapid Bioconversion of Esmolol after Intravenous Injection in Humans<br /><i>Biol Pharm Bull</i> <b>45</b>: 1544<br /><br />Imai T, Bahar FG, Ohura K, Toda A (2020) <br />Effect of Calcium on the Hydrolysis Activity of Human Butyrylcholinesterase<br /><i>J Pharm Sci</i> <b>109</b>: 1417<br /><br />Ohura K, Igawa Y, Tanaka M, Matsumoto K, Kasahara A, Wada N, Kubota K, Uno Y, Imai T (2020) <br />Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>48</b>: 146<br /><br />Imai T, Nakada Y, Ohura K (2019) <br />[Comparative Study of Hydrolase Activity in Skin with Liver and Intestine, and Its Aging Relation of Carboxylesterase Expression in Cynomolgus Monkey and Beagle Dog]<br /><i>Yakugaku Zasshi</i> <b>139</b>: 837<br /><br />Abdel-Daim A, Ohura K, Imai T (2018) <br />A novel quantification method for serine hydrolases in cellular expression system using fluorophosphonate-biotin probe<br /><i>Eur J Pharm Sci</i> <b>114</b>: 267<br /><br />Ishizaki Y, Furihata T, Oyama Y, Ohura K, Imai T, Hosokawa M, Akita H, Chiba K (2018) <br />Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies<br /><i>Biol Pharm Bull</i> <b>41</b>: 697<br /><br />Samir A, Kage A, Kayoko O, Imai T (2018) <br />Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat<br /><i>Xenobiotica</i> <br /><br />Tsukada T, Sato I, Matsuoka N, Imai T, Doi Y, Arai M, Fujii Y, Matsunaga T, Kawakami K (2018) <br />Prescription of Antidementia Drugs and Antipsychotics for Elderly Patients in Japan: A Descriptive Study Using Pharmacy Prescription Data<br /><i>J Geriatr Psychiatry Neurol</i> <br /><br />Uno Y, Igawa Y, Tanaka M, Kayoko O, Hosokawa M, Imai T (2018) <br />Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver<br /><i>Xenobiotica</i> <br /><br />Uno Y, Uehara S, Mahadhi HMD, Ohura K, Hosokawa M, Imai T (2018) <br />Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques<br /><i>J Med Primatol</i> <b>47</b>: 185<br /><br />Fujii M, Ohara R, Matsumi A, Ohura K, Koizumi N, Imai T, Watanabe Y (2017) <br />Effect of alcohol on skin permeation and metabolism of an ester-type prodrug in Yucatan micropig skin<br /><i>Eur J Pharm Sci</i> <b>109</b>: 280<br /><br />Igawa Y, Fujiwara S, Ohura K, Hirokawa T, Nishizawa Y, Uehara S, Uno Y, Imai T (2016) <br />Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes<br /><i>Mol Pharm</i> <b>13</b>: 3176<br /><br />Imai T, Ariyoshi S, Ohura K, Sawada T, Nakada Y (2016) <br />Expression of Carboxylesterase Isozymes and Their Role in the Behavior of a Fexofenadine Prodrug in Rat Skin<br /><i>J Pharm Sci</i> <b>105</b>: 714<br /><br />Ohura K, Nishiyama H, Saco S, Kurokawa K, Imai T (2016) <br />Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>44</b>: 1890<br /><br />Matsusaki M, Hikimoto D, Nishiguchi A, Kadowaki K, Ohura K, Imai T, Akashi M (2015) <br />3D-fibroblast tissues constructed by a cell-coat technology enhance tight-junction formation of human colon epithelial cells<br /><i>Biochemical & Biophysical Research Communications</i> <b>457</b>: 363<br /><br />Ohura K, Nakada Y, Kotani S, Imai T (2015) <br />Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein<br /><i>J Pharm Sci</i> <b>104</b>: 3076<br /><br />Uno Y, Hosokawa M, Imai T (2015) <br />Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques<br /><i>J Vet Med Sci</i> <b>77</b>: 721<br /><br />Ohura K, Tasaka K, Hashimoto M, Imai T (2014) <br />Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>42</b>: 264<br /><br />Suzuki S, Murai H, Imai T, Nagane Y, Masuda M, Tsuda E, Konno S, Oji S, Nakane S, Motomura M, Suzuki N, Utsugisawa K (2014) <br />Quality of life in purely ocular myasthenia in Japan<br /><i>BMC Neurol</i> <b>14</b>: 142<br /><br />Uno Y, Uehara S, Hosokawa M, Imai T (2014) <br />Systematic identification and characterization of carboxylesterases in cynomolgus macaques<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>42</b>: 2002<br /><br />Ustun-Aytekin O, Gurhan ID, Ohura K, Imai T, Ongen G (2014) <br />Monitoring of the effects of transfection with baculovirus on Sf9 cell line and expression of human dipeptidyl peptidase IV<br /><i>Cytotechnology</i> <b>66</b>: 159<br /><br />Bahar FG, Imai T (2013) <br />Aspirin hydrolysis in human and experimental animal plasma and the effect of metal cations on hydrolase activities<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>41</b>: 1450<br /><br />Imai T, Takase Y, Iwase H, Hashimoto M (2013) <br />Involvement of Carboxylesterase in Hydrolysis of Propranolol Prodrug during Permeation across Rat Skin<br /><i>Pharmaceutics</i> <b>5</b>: 371<br /><br />Bahar FG, Ohura K, Ogihara T, Imai T (2012) <br />Species difference of esterase expression and hydrolase activity in plasma<br /><i>J Pharm Sci</i> <b>101</b>: 3979<br /><br />Nozawa T, Imai T (2011) <br />Prediction of human intestinal absorption of the prodrug temocapril by in situ single-pass perfusion using rat intestine with modified hydrolase activity<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>39</b>: 1263<br /><br />Ohura K, Nozawa T, Murakami K, Imai T (2011) <br />Evaluation of transport mechanism of prodrugs and parent drugs formed by intracellular metabolism in Caco-2 cells with modified carboxylesterase activity: temocapril as a model case<br /><i>J Pharm Sci</i> <b>100</b>: 3985<br /><br />Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R, Maltais LJ (2010) <br />Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins<br /><i>Mamm Genome</i> <b>21</b>: 427<br /><br />Imai T, Hosokawa M (2010) <br />Prodrug approach using carboxylesterases activity: catalytic properties and gene regulation of carboxylesterase in mammalian tissue<br /><i>Journal of Pesticide Science</i> <b>35</b>: 229<br /><br />Imai T, Ohura K (2010) <br />The role of intestinal carboxylesterase in the oral absorption of prodrugs<br /><i>Curr Drug Metab</i> <b>11</b>: 793<br /><br />Ohura K, Sakamoto H, Ninomiya S, Imai T (2010) <br />Development of a novel system for estimating human intestinal absorption using Caco-2 cells in the absence of esterase activity<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>38</b>: 323<br /><br />Imai T (2009) <br />[Carboxylesterase: from drug metabolism to drug discovery]<br /><i>Nihon Yakurigaku Zasshi</i> <b>134</b>: 281<br /><br />Imai T (2007) <br />[Hydrolysis by carboxylesterase and disposition of prodrug with ester moiety]<br /><i>Yakugaku Zasshi</i> <b>127</b>: 611<br /><br />Kanou Y, Hishinuma A, Tsunekawa K, Seki K, Mizuno Y, Fujisawa H, Imai T, Miura Y, Nagasaka T, Yamada C, Ieiri T, Murakami M, Murata Y (2007) <br />Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity<br /><i>J Clinical Endocrinology Metab</i> <b>92</b>: 1451<br /><br />Taketani M, Shii M, Ohura K, Ninomiya S, Imai T (2007) <br />Carboxylesterase in the liver and small intestine of experimental animals and human<br /><i>Life Sciences</i> <b>81</b>: 924<br /><br />Yokoo K, Hamada A, Watanabe H, Matsuzaki T, Imai T, Fujimoto H, Masa K, Saito H (2007) <br />Involvement of up-regulation of hepatic breast cancer resistance protein in decreased plasma concentration of 7-ethyl-10-hydroxycamptothecin (SN-38) by coadministration of S-1 in rats<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>35</b>: 1511<br /><br />Imai T (2006) <br />Human carboxylesterase isozymes: catalytic properties and rational drug design<br /><i>Drug Metab Pharmacokinet</i> <b>21</b>: 173<br /><br />Imai T, Taketani M, Shii M, Hosokawa M, Chiba K (2006) <br />Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine<br /><i>Drug Metabolism & Disposition: The Biological Fate of Chemicals</i> <b>34</b>: 1734<br /><br />Morioka Y, Nishimura M, Imai T, Suzuki S, Harada M, Satoh T, Naito S (2006) <br />Assessment of induction of cytochrome P450 by NO-1886 (ibrolipim), a lipoprotein lipase-promoting agent, in primary cultures of human hepatocytes and in female rat liver<br /><i>Drug Metab Pharmacokinet</i> <b>21</b>: 19<br /><br />Nishimura M, Imai T, Morioka Y, Kuribayashi S, Kamataki T, Naito S (2004) <br />Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes<br /><i>Drug Metab Pharmacokinet</i> <b>19</b>: 422<br /><br />