Joho Y, Vongsouthi V, Spence MA, Ton J, Gomez C, Tan LL, Kaczmarski JA, Caputo AT, Royan S, Jackson CJ, Ardevol A (2022)
Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of Ideonella sakaiensis PETase and Variants with Improved Stability and Activity

Elias MH, Fraser JS, Kamerlin SCL, Patrick WM, Jackson CJ (2021)
Dan Salah Tawfik (1955-2021) A giant of protein evolution
EMBO Rep 22: e53256

Correy GJ, Zaidman D, Harmelin A, Carvalho S, Mabbitt PD, Calaora V, James PJ, Kotze AC, Jackson CJ, London N (2019)
Overcoming insecticide resistance through computational inhibitor design
Proc Natl Acad Sci U S A 116: 21012

Hopkins DH, Rane RV, Younus F, Coppin CW, Pandey G, Jackson CJ, Oakeshott JG (2019)
The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila
Insect Biochemistry & Molecular Biology 106: 10

Buckler JN, Taher ES, Fraser NJ, Willis AC, Carr PD, Jackson CJ, Banwell MG (2017)
The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase
J Org Chem 82: 7869

Campbell EC, Correy GJ, Mabbitt PD, Buckle AM, Tokuriki N, Jackson CJ (2017)
Laboratory evolution of protein conformational dynamics
Current Opinion in Structural Biology 50: 49

Hopkins DH, Fraser NJ, Mabbitt PD, Carr PD, Oakeshott JG, Jackson CJ (2017)
Structure of an Insecticide Sequestering Carboxylesterase from the Disease Vector Culex quinquefasciatus: What Makes an Enzyme a Good Insecticide Sponge?
Biochemistry 56: 5512

Younus F, Fraser NJ, Coppin CW, Liu JW, Correy GJ, Chertemps T, Pandey G, Maibeche M, Jackson CJ, Oakeshott JG (2017)
Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila
Sci Rep 7: 46188

Campbell EC, Kaltenbach M, Correy GJ, Carr PD, Porebski BT, Livingstone EK, Afriat-Jurnou L, Buckle AM, Weik M, Hollfelder F, Tokuriki N, Jackson CJ (2016)
The role of protein dynamics in the evolution of new enzyme function
Nat Chemical Biology 12: 944

Correy GJ, Carr PD, Meirelles T, Mabbitt PD, Fraser NJ, Weik M, Jackson CJ (2016)
Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography
Structure 24: 977

Fraser NJ, Liu JW, Mabbitt PD, Correy GJ, Coppin CW, Lethier M, Perugini MA, Murphy JM, Oakeshott JG, Weik M, Jackson CJ (2016)
Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability
Journal of Molecular Biology 428: 2359

Mabbitt PD, Correy GJ, Meirelles T, Fraser NJ, Coote ML, Jackson CJ (2016)
Conformational Disorganization within the Active Site of a Recently Evolved Organophosphate Hydrolase Limits Its Catalytic Efficiency
Biochemistry 55: 1408

Yang G, Hong N, Baier F, Jackson CJ, Tokuriki N (2016)
Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects
Biochemistry 55: 4583

Sugrue E, Fraser NJ, Hopkins DH, Carr PD, Khurana JL, Oakeshott JG, Scott C, Jackson CJ (2015)
Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron
Applied Environmental Microbiology 81: 2612

Jackson CJ, Carville A, Ward J, Mansfield K, Ollis DL, Khurana T, Bird SB (2014)
Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning
Toxicology 317: 1

Naqvi T, Warden AC, French N, Sugrue E, Carr PD, Jackson CJ, Scott C (2014)
A 5000-fold increase in the specificity of a bacterial phosphotriesterase for malathion through combinatorial active site mutagenesis
PLoS ONE 9: e94177

Jackson CJ, Liu JW, Carr PD, Younus F, Coppin C, Meirelles T, Lethier M, Pandey G, Ollis DL, Russell RJ, Weik M, Oakeshott JG (2013)
Structure and function of an insect alpha-carboxylesterase (alphaEsterase7) associated with insecticide resistance
Proc Natl Acad Sci U S A 110: 10177

Afriat-Jurnou L, Jackson CJ, Tawfik DS (2012)
Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling
Biochemistry 51: 6047

Coppin CW, Jackson CJ, Sutherland T, Hart PJ, Devonshire AL, Russell RJ, Oakeshott JG (2012)
Testing the evolvability of an insect carboxylesterase for the detoxification of synthetic pyrethroid insecticides
Insect Biochemistry & Molecular Biology 42: 343

Jackson CJ, Scott C, Carville A, Mansfield K, Ollis DL, Bird SB (2010)
Pharmacokinetics of OpdA, an organophosphorus hydrolase, in the African green monkey
Biochemical Pharmacology 80: 1075

Khurana JL, Jackson CJ, Scott C, Pandey G, Horne I, Russell RJ, Herlt A, Easton CJ, Oakeshott JG (2009)
Characterization of the phenylurea hydrolases A and B: founding members of a novel amidohydrolase subgroup
Biochemical Journal 418: 431

Weston DP, Jackson CJ (2009)
Use of engineered enzymes to identify organophosphate and pyrethroid-related toxicity in toxicity identification evaluations
Environ Sci Technol 43: 5514

Biswas S, Russell RJ, Jackson CJ, Vidovic M, Ganeshina O, Oakeshott JG, Claudianos C (2008)
Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera
PLoS ONE 3: e3542

Jackson CJ, Foo JL, Kim HK, Carr PD, Liu JW, Salem G, Ollis DL (2008)
In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase
Journal of Molecular Biology 375: 1189