Joho Y, Vongsouthi V, Spence MA, Ton J, Gomez C, Tan LL, Kaczmarski JA, Caputo AT, Royan S, Jackson CJ, Ardevol A (2022) <br />Ancestral Sequence Reconstruction Identifies Structural Changes Underlying the Evolution of Ideonella sakaiensis PETase and Variants with Improved Stability and Activity<br /><i>Biochemistry</i> <br /><br />Elias MH, Fraser JS, Kamerlin SCL, Patrick WM, Jackson CJ (2021) <br />Dan Salah Tawfik (1955-2021) A giant of protein evolution<br /><i>EMBO Rep</i> <b>22</b>: e53256<br /><br />Correy GJ, Zaidman D, Harmelin A, Carvalho S, Mabbitt PD, Calaora V, James PJ, Kotze AC, Jackson CJ, London N (2019) <br />Overcoming insecticide resistance through computational inhibitor design<br /><i>Proc Natl Acad Sci U S A</i> <b>116</b>: 21012<br /><br />Hopkins DH, Rane RV, Younus F, Coppin CW, Pandey G, Jackson CJ, Oakeshott JG (2019) <br />The molecular basis for the neofunctionalization of the juvenile hormone esterase duplication in Drosophila<br /><i>Insect Biochemistry & Molecular Biology</i> <b>106</b>: 10<br /><br />Buckler JN, Taher ES, Fraser NJ, Willis AC, Carr PD, Jackson CJ, Banwell MG (2017) <br />The Synthesis of Certain Derivatives and Analogues of (-)- and (+)-Galanthamine and an Assessment of their Capacities to Inhibit Acetylcholine Esterase<br /><i>J Org Chem</i> <b>82</b>: 7869<br /><br />Campbell EC, Correy GJ, Mabbitt PD, Buckle AM, Tokuriki N, Jackson CJ (2017) <br />Laboratory evolution of protein conformational dynamics<br /><i>Current Opinion in Structural Biology</i> <b>50</b>: 49<br /><br />Hopkins DH, Fraser NJ, Mabbitt PD, Carr PD, Oakeshott JG, Jackson CJ (2017) <br />Structure of an Insecticide Sequestering Carboxylesterase from the Disease Vector Culex quinquefasciatus: What Makes an Enzyme a Good Insecticide Sponge?<br /><i>Biochemistry</i> <b>56</b>: 5512<br /><br />Younus F, Fraser NJ, Coppin CW, Liu JW, Correy GJ, Chertemps T, Pandey G, Maibeche M, Jackson CJ, Oakeshott JG (2017) <br />Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila<br /><i>Sci Rep</i> <b>7</b>: 46188<br /><br />Campbell EC, Kaltenbach M, Correy GJ, Carr PD, Porebski BT, Livingstone EK, Afriat-Jurnou L, Buckle AM, Weik M, Hollfelder F, Tokuriki N, Jackson CJ (2016) <br />The role of protein dynamics in the evolution of new enzyme function<br /><i>Nat Chemical Biology</i> <b>12</b>: 944<br /><br />Correy GJ, Carr PD, Meirelles T, Mabbitt PD, Fraser NJ, Weik M, Jackson CJ (2016) <br />Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography<br /><i>Structure</i> <b>24</b>: 977<br /><br />Fraser NJ, Liu JW, Mabbitt PD, Correy GJ, Coppin CW, Lethier M, Perugini MA, Murphy JM, Oakeshott JG, Weik M, Jackson CJ (2016) <br />Evolution of Protein Quaternary Structure in Response to Selective Pressure for Increased Thermostability<br /><i>Journal of Molecular Biology</i> <b>428</b>: 2359<br /><br />Mabbitt PD, Correy GJ, Meirelles T, Fraser NJ, Coote ML, Jackson CJ (2016) <br />Conformational Disorganization within the Active Site of a Recently Evolved Organophosphate Hydrolase Limits Its Catalytic Efficiency<br /><i>Biochemistry</i> <b>55</b>: 1408<br /><br />Yang G, Hong N, Baier F, Jackson CJ, Tokuriki N (2016) <br />Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects<br /><i>Biochemistry</i> <b>55</b>: 4583<br /><br />Sugrue E, Fraser NJ, Hopkins DH, Carr PD, Khurana JL, Oakeshott JG, Scott C, Jackson CJ (2015) <br />Evolutionary expansion of the amidohydrolase superfamily in bacteria in response to the synthetic compounds molinate and diuron<br /><i>Applied Environmental Microbiology</i> <b>81</b>: 2612<br /><br />Jackson CJ, Carville A, Ward J, Mansfield K, Ollis DL, Khurana T, Bird SB (2014) <br />Use of OpdA, an organophosphorus (OP) hydrolase, prevents lethality in an African green monkey model of acute OP poisoning<br /><i>Toxicology</i> <b>317</b>: 1<br /><br />Naqvi T, Warden AC, French N, Sugrue E, Carr PD, Jackson CJ, Scott C (2014) <br />A 5000-fold increase in the specificity of a bacterial phosphotriesterase for malathion through combinatorial active site mutagenesis<br /><i>PLoS ONE</i> <b>9</b>: e94177<br /><br />Jackson CJ, Liu JW, Carr PD, Younus F, Coppin C, Meirelles T, Lethier M, Pandey G, Ollis DL, Russell RJ, Weik M, Oakeshott JG (2013) <br />Structure and function of an insect alpha-carboxylesterase (alphaEsterase7) associated with insecticide resistance<br /><i>Proc Natl Acad Sci U S A</i> <b>110</b>: 10177<br /><br />Afriat-Jurnou L, Jackson CJ, Tawfik DS (2012) <br />Reconstructing a missing link in the evolution of a recently diverged phosphotriesterase by active-site loop remodeling<br /><i>Biochemistry</i> <b>51</b>: 6047<br /><br />Coppin CW, Jackson CJ, Sutherland T, Hart PJ, Devonshire AL, Russell RJ, Oakeshott JG (2012) <br />Testing the evolvability of an insect carboxylesterase for the detoxification of synthetic pyrethroid insecticides<br /><i>Insect Biochemistry & Molecular Biology</i> <b>42</b>: 343<br /><br />Jackson CJ, Scott C, Carville A, Mansfield K, Ollis DL, Bird SB (2010) <br />Pharmacokinetics of OpdA, an organophosphorus hydrolase, in the African green monkey<br /><i>Biochemical Pharmacology</i> <b>80</b>: 1075<br /><br />Khurana JL, Jackson CJ, Scott C, Pandey G, Horne I, Russell RJ, Herlt A, Easton CJ, Oakeshott JG (2009) <br />Characterization of the phenylurea hydrolases A and B: founding members of a novel amidohydrolase subgroup<br /><i>Biochemical Journal</i> <b>418</b>: 431<br /><br />Weston DP, Jackson CJ (2009) <br />Use of engineered enzymes to identify organophosphate and pyrethroid-related toxicity in toxicity identification evaluations<br /><i>Environ Sci Technol</i> <b>43</b>: 5514<br /><br />Biswas S, Russell RJ, Jackson CJ, Vidovic M, Ganeshina O, Oakeshott JG, Claudianos C (2008) <br />Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera<br /><i>PLoS ONE</i> <b>3</b>: e3542<br /><br />Jackson CJ, Foo JL, Kim HK, Carr PD, Liu JW, Salem G, Ollis DL (2008) <br />In crystallo capture of a Michaelis complex and product-binding modes of a bacterial phosphotriesterase<br /><i>Journal of Molecular Biology</i> <b>375</b>: 1189<br /><br />