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Computationally Elucidating the Binding Kinetics for Different AChE Inhibitors to Access the Rationale for Improving the Drug Efficacy
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Her L, Shi J, Wang X, He B, Smith L, Jiang H, Zhu HJ (2022)
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms
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Liu L, Li J, Lv J, Jiang H, Chen FE (2022)
Detoxification mechanism of vinegar-processed Kansui revealed by systematic phytochemical analysis using UPLC-DAD-MS/MS, UPLC-HR-MS and in silico drug target identification
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Miao Z, Xiong C, Cao X, Shan T, Jin Q, Jiang H (2022)
Genome-wide identification, classification, and expression profiling of serine esterases and other esterase-related proteins in the tobacco hornworm, Manduca sexta
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Song W, Beigneux AP, Winther AL, Kristensen KK, Gronnemose AL, Yang Y, Tu Y, Munguia P, Morales J, Jung H, de Jong PJ, Jung CJ, Miyashita K, Kimura T, Nakajima K, Murakami M, Birrane G, Jiang H, Tontonoz P, Ploug M, Fong LG, Young SG (2022)
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Xiang L, Wu Q, Sun H, Miao X, Lv Z, Liu H, Chen L, Gu Y, Chen J, Zhou S, Jiang H, Du S, Zhou Y, Dong H, Fan Y, Miao S, Lu Q, Chang L, Wang H, Lu Y, Xu X, Wang W, Huang Z (2022)
SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice
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Ye Z, Gao L, Cai J, Wang Y, Li Y, Tong S, Yan T, Sun Q, Qi Y, Xu Y, Jiang H, Zhang S, Zhao L, Chen Q (2022)
Esterase-responsive and size-optimized prodrug nanoparticles for effective intracranial drug delivery and glioblastoma treatment
Nanomedicine

Young SG, Song W, Yang Y, Birrane G, Jiang H, Beigneux AP, Ploug M, Fong LG (2022)
A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism
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Yuan X, Shayiranbieke A, Xu R, Jiang H, Yang Y, Zhang Y, Yin G, Zhao X (2022)
Site-selective covalently immobilized alpha 1A adrenergic receptor for thermodynamic and extra-thermodynamic study of four ligands binding to the receptor by chromatographic methods
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Yue C, Zhang C, Ying C, Jiang H (2022)
Reduced serum cholinesterase is an independent risk factor for all-cause mortality in the pediatric intensive care unit
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Zhao L, Jiang H (2022)
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Gao K, Wang X, Jiang H, Sun J, Mao X (2021)
Identification of a GDSL lipase from Streptomyces bacillaris and its application in the preparation of free astaxanthin
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Guan L, Peng D, Zhang L, Jia J, Jiang H (2021)
Design, synthesis, and cholinesterase inhibition assay of liquiritigenin derivatives as anti-Alzheimer's activity
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Rahman S, Zhao Z, Umair Sial M, Zhang Y, Jiang H (2021)
Case Study Using Recommended Reference Genes Actin and 18S for Reverse-Transcription Quantitative Real-Time PCR Analysis in Myzus persicae
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Wang L, Ding J, Shi P, Fu L, Pan L, Tian J, Cao D, Jiang H, Ding X (2021)
Ensemble machine learning to evaluate the in vivo acute oral toxicity and in vitro human acetylcholinesterase inhibitory activity of organophosphates
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Xiong F, Ding X, Zhang H, Luo X, Chen K, Jiang H, Luo C, Xu H (2021)
Discovery of novel reversible monoacylglycerol lipase inhibitors via docking-based virtual screening
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Zhou Y, Fu Y, Yin W, Li J, Wang W, Bai F, Xu S, Gong Q, Peng T, Hong Y, Zhang D, Liu Q, Xu Y, Xu HE, Zhang H, Jiang H, Liu H (2021)
Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate
Journal of Medicinal Chemistry 64: 1844

Liu H, Weng XJ, Yao JY, Zheng J, Lv X, Zhou XH, Jiang H, Li ST (2020)
Neuregulin-1beta Protects the Rat Diaphragm during Sepsis against Oxidative Stress and Inflammation by Activating the PI3K/Akt Pathway
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Mao L, Jia W, Zhang L, Zhang Y, Zhu L, Sial MU, Jiang H (2020)
Embryonic development and oxidative stress effects in the larvae and adult fish livers of zebrafish (Danio rerio) exposed to the strobilurin fungicides, kresoxim-methyl and pyraclostrobin
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Miao Z, Cao X, Jiang H (2020)
Digestion-related proteins in the tobacco hornworm, Manduca sexta
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He B, Shi J, Wang X, Jiang H, Zhu HJ (2019)
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Hester KP, Bhattarai K, Jiang H, Agarwal PK, Pope C (2019)
Engineering Dynamic Surface Peptide Networks on ButyrylcholinesteraseG117H for Enhanced Organophosphosphorus Anticholinesterase Catalysis
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Jiang H, Gan T, Zhang J, Ma Q, Liang Y, Zhao Y (2019)
The Structures and Bioactivities of Fatty Acid Synthase Inhibitors
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Li S, Qin C, Cui S, Xu H, Wu F, Wang J, Su M, Fang X, Li D, Jiao Q, Zhang M, Xia C, Zhu L, Wang R, Li J, Jiang H, Zhao Z, Li H (2019)
Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes
Journal of Medicinal Chemistry 62: 2348

Li X, Jiang H, Pu Y, Cao J, Jiang W (2019)
Inhibitory Effect of Condensed Tannins from Banana Pulp on Cholesterol Esterase and Mechanisms of Interaction
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Tantawy AH, Farag SM, Hegazy L, Jiang H, Wang MQ (2019)
The larvicidal activity of natural inspired piperine-based dienehydrazides against Culex pipiens
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Wang F, Song T, Jiang H, Pei C, Huang Q, Xi H (2019)
Bacillus subtilis Spore Surface Display of Haloalkane Dehalogenase DhaA
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Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M (2019)
GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism
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Jia W, Mao L, Zhang L, Zhang Y, Jiang H (2018)
Effects of two strobilurins (azoxystrobin and picoxystrobin) on embryonic development and enzyme activities in juveniles and adult fish livers of zebrafish (Danio rerio)
Chemosphere 207: 573

Zhang X, Jiang H, Li S, Luo A, Zhao Y (2018)
Use of low-dose neostigmine intravenously in the treatment of thyroid storm-induced severe tachycardia in patient during huge pelvic mass resection: A case report and review of literature
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Pan H, Zhang X, Jiang H, Jiang X, Wang L, Qi Q, Bi Y, Wang J, Shi Q, Li R (2017)
Ndrg3 gene regulates DSB repair during meiosis through modulation the ERK signal pathway in the male germ cells
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Xu Y, Cheng S, Sussman JL, Silman I, Jiang H (2017)
Computational Studies on Acetylcholinesterases
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Zhang B, Kandhi S, Yang YM, Le Y, Deng W, Qin J, Jiang H, Froogh G, Sun D, Huang A (2017)
A novel mechanism of ascorbate direct modulation of soluble epoxide hydrolase
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Zhang H, Shi J, Hachet MA, Xue C, Bauer RC, Jiang H, Li W, Tohyama J, Millar J, Billheimer J, Phillips MC, Razani B, Rader DJ, Reilly MP (2017)
CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report
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Li S, Xu H, Cui S, Wu F, Zhang Y, Su M, Gong Y, Qiu S, Jiao Q, Qin C, Shan J, Zhang M, Wang J, Yin Q, Xu M, Liu X, Wang R, Zhu L, Li J, Xu Y, Jiang H, Zhao Z, Li H (2016)
Discovery and Rational Design of Natural-Product-Derived 2-Phenyl-3,4-dihydro-2H-benzo[f]chromen-3-amine Analogs as Novel and Potent Dipeptidyl Peptidase 4 (DPP-4) Inhibitors for the Treatment of Type 2 Diabetes
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Liu H, Liu L, Gao X, Liu Y, Xu W, He W, Jiang H, Tang J, Fan H, Xia X (2016)
Novel ferulic amide derivatives with tertiary amine side chain as acetylcholinesterase and butyrylcholinesterase inhibitors: The influence of carbon spacer length, alkylamine and aromatic group
Eur Journal of Medicinal Chemistry 126: 810

Luo HD, Jin MY, Wu H, Jiang H (2016)
Functions of Type II Thioesterases in Bacterial Polyketide Biosynthesis
Protein Pept Lett 23: 1032

Kandhi S, Qin J, Froogh G, Jiang H, Luo M, Wolin MS, Huang A, Sun D (2015)
EET-dependent potentiation of pulmonary arterial pressure: Sex different regulation of soluble epoxide hydrolase
American Journal of Physiology Lung Cell Mol Physiol

Qin J, Kandhi S, Froogh G, Jiang H, Meng L, Sun D, Huang A (2015)
Sexually dimorphic phenotype of arteriolar responsiveness to shear stress in soluble epoxide hydrolase-knockout mice
American Journal of Physiology Heart Circ Physiol

Zuo Z, Gong T, Che Y, Liu R, Xu P, Jiang H, Qiao C, Song C, Yang C (2015)
Engineering Pseudomonas putida KT2440 for simultaneous degradation of organophosphates and pyrethroids and its application in bioremediation of soil
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Cheng J, Wang D, Hu S, Jiang H, Lu H, Lei Q, Liu J, Yuan F, Chen R (2014)
The Report of Sustained Low-Efficiency Dialysis (SLED) Treatment in Fifteen Patients of Severe Snakebite
Cell Biochem Biophys 69: 71

Elsik CG, Worley KC, Bennett AK, Beye M, Camara F, Childers CP, de Graaf DC, Debyser G, Deng J, Devreese B, Elhaik E, Evans JD, Foster LJ, Graur D, Guigo R, Hoff KJ, Holder ME, Hudson ME, Hunt GJ, Jiang H, Joshi V, Khetani RS, Kosarev P, Kovar CL, Ma J, Maleszka R, Moritz RF, Munoz-Torres MC, Murphy TD, Muzny DM, Newsham IF, Reese JT, Robertson HM, Robinson GE, Rueppell O, Solovyev V, Stanke M, Stolle E, Tsuruda JM, Vaerenbergh MV, Waterhouse RM, Weaver DB, Whitfield CW, Wu Y, Zdobnov EM, Zhang L, Zhu D, Gibbs RA (2014)
Finding the missing honey bee genes: lessons learned from a genome upgrade
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Goulbourne CN, Gin P, Tatar A, Nobumori C, Hoenger A, Jiang H, Grovenor CR, Adeyo O, Esko JD, Goldberg IJ, Reue K, Tontonoz P, Bensadoun A, Beigneux AP, Young SG, Fong LG (2014)
The GPIHBP1-LPL complex is responsible for the margination of triglyceride-rich lipoproteins in capillaries
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Hu SL, Wang D, Jiang H, Lei QF, Zhu XH, Cheng JZ (2014)
Therapeutic effectiveness of sustained low-efficiency hemodialysis plus hemoperfusion and continuous hemofiltration plus hemoperfusion for acute severe organophosphate poisoning
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Ji X, Su M, Wang J, Deng G, Deng S, Li Z, Tang C, Li J, Zhao L, Jiang H, Liu H (2014)
Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
Eur Journal of Medicinal Chemistry 75C: 111

Ji X, Xia C, Wang J, Su M, Zhang L, Dong T, Li Z, Wan X, Li J, Zhao L, Gao Z, Jiang H, Liu H (2014)
Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
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Zhang L, Zhang C, Wu P, Chen Y, Li M, Jiang H, Wu G (2014)
Global analysis of gene expression profiles in physic nut (Jatropha curcas L.) seedlings exposed to salt stress
PLoS ONE 9: e97878

Bai F, Xu Y, Chen J, Liu Q, Gu J, Wang X, Ma J, Li H, Onuchic JN, Jiang H (2013)
Free energy landscape for the binding process of Huperzine A to acetylcholinesterase
Proc Natl Acad Sci U S A 110: 4273

Dou D, Park JG, Rana S, Madden BJ, Jiang H, Pang YP (2013)
Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases
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Liang M, Fan K, Pan Y, Jiang H, Wang F, Yang D, Lu D, Feng J, Zhao J, Yang L, Yan X (2013)
Fe(3)O(4) magnetic nanoparticle peroxidase mimetic-based colorimetric assay for the rapid detection of organophosphorus pesticide and nerve agent
Analytical Chemistry 85: 308

Zhao P, Wang Y, Jiang H (2013)
Biochemical properties, expression profiles, and tissue localization of orthologous acetylcholinesterase-2 in the mosquito, Anopheles gambiae
Insect Biochemistry & Molecular Biology 43: 260

Lu Y, Park Y, Gao X, Zhang X, Yao J, Pang YP, Jiang H, Zhu KY (2012)
Cholinergic and non-cholinergic functions of two acetylcholinesterase genes revealed by gene-silencing in Tribolium castaneum
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Wu D, Jin F, Lu W, Zhu J, Li C, Wang W, Tang Y, Jiang H, Huang J, Liu G, Li J (2012)
Synthesis, structure-activity relationship, and pharmacophore modeling studies of pyrazole-3-carbohydrazone derivatives as dipeptidyl peptidase IV inhibitors
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Chen L, Kong X, Liang Z, Ye F, Yu K, Dai W, Wu D, Luo C, Jiang H (2011)
Theoretical study of the mechanism of proton transfer in the esterase EstB from Burkholderia gladioli
J Phys Chem B 115: 13019

Jiang H, Quilley J, Doumad AB, Zhu AG, Falck JR, Hammock BD, Stier CT, Jr., Carroll MA (2011)
Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats
American Journal of Physiology Heart Circ Physiol 300: H1990

Jiang H, Wang X, Huang L, Luo Z, Su T, Ding K, Li X (2011)
Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease
Bioorganic & Medicinal Chemistry 19: 7228

Sanson B, Colletier JP, Xu Y, Lang PT, Jiang H, Silman I, Sussman JL, Weik M (2011)
Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations
Protein Science 20: 1114

Xie J, Jiang H, Wan YH, Du AY, Guo KJ, Liu T, Ye WY, Niu X, Wu J, Dong XQ, Zhang XJ (2011)
Induction of a 55 kDa acetylcholinesterase protein during apoptosis and its negative regulation by the Akt pathway
J Molecular & Cellular Biology 3: 250

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Functional and evolutionary insights from the genomes of three parasitoid Nasonia species
Science 327: 343

Xu Y, Colletier JP, Weik M, Qin G, Jiang H, Silman I, Sussman JL (2010)
Long route or shortcut? A molecular dynamics study of traffic of thiocholine within the active-site gorge of acetylcholinesterase
Biophysical Journal 99: 4003

Zhao P, Zhu KY, Jiang H (2010)
Heterologous expression, purification, and biochemical characterization of a greenbug (Schizaphis graminum) acetylcholinesterase encoded by a paralogous gene (ace-1)
J Biochem Mol Toxicol 24: 51

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The genome sequence of taurine cattle: a window to ruminant biology and evolution
Science 324: 522

Jiang H, Liu S, Zhao P, Pope C (2009)
Recombinant expression and biochemical characterization of the catalytic domain of acetylcholinesterase-1 from the African malaria mosquito, Anopheles gambiae
Insect Biochemistry & Molecular Biology 39: 646

Li W, Mak M, Jiang H, Wang Q, Pang Y, Chen K, Han Y (2009)
Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets
Neurotherapeutics 6: 187

Shu Z, Lin R, Jiang H, Zhang Y, Wang M, Huang J (2009)
A rapid and efficient method for directed screening of lipase-producing Burkholderia cepacia complex strains with organic solvent tolerance from rhizosphere
J Biosci Bioeng 107: 658

Bourgogne A, Garsin DA, Qin X, Singh KV, Sillanpaa J, Yerrapragada S, Ding Y, Dugan-Rocha S, Buhay C, Shen H, Chen G, Williams G, Muzny D, Maadani A, Fox KA, Gioia J, Chen L, Shang Y, Arias CA, Nallapareddy SR, Zhao M, Prakash VP, Chowdhury S, Jiang H, Gibbs RA, Murray BE, Highlander SK, Weinstock GM (2008)
Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF
Genome Biol 9: R110

Jiang H, Zhu AG, Mamczur M, Morisseau C, Hammock BD, Falck JR, McGiff JC (2008)
Hydrolysis of cis- and trans-epoxyeicosatrienoic acids by rat red blood cells
Journal of Pharmacology & Experimental Therapeutics 326: 330

Jiang H, Zhang XJ (2008)
Acetylcholinesterase and apoptosis. A novel perspective for an old enzyme
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Li H, Jiang H, Gao X, Wang X, Qu W, Lin R, Chen J (2008)
Acute toxicity of the pesticide methomyl on the topmouth gudgeon (Pseudorasbora parva): mortality and effects on four biomarkers
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The genome of the model beetle and pest Tribolium castaneum
Nature 452: 949

Xu Y, Colletier JP, Jiang H, Silman I, Sussman JL, Weik M (2008)
Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design
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Zhang JY, Jiang H, Gao W, Wu J, Peng K, Shi YF, Zhang XJ (2008)
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He XC, Feng S, Wang ZF, Shi Y, Zheng S, Xia Y, Jiang H, Tang XC, Bai D (2007)
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Bioorganic & Medicinal Chemistry 15: 1394

Highlander SK, Hulten KG, Qin X, Jiang H, Yerrapragada S, Mason EO, Jr., Shang Y, Williams TM, Fortunov RM, Liu Y, Igboeli O, Petrosino J, Tirumalai M, Uzman A, Fox GE, Cardenas AM, Muzny DM, Hemphill L, Ding Y, Dugan S, Blyth PR, Buhay CJ, Dinh HH, Hawes AC, Holder M, Kovar CL, Lee SL, Liu W, Nazareth LV, Wang Q, Zhou J, Kaplan SL, Weinstock GM (2007)
Subtle genetic changes enhance virulence of methicillin resistant and sensitive Staphylococcus aureus
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Jiang H, Zhang J, Zhu H, Li H, Zhang X (2007)
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Zeng J, Liu G, Tang Y, Jiang H (2007)
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Calcineurin mediates acetylcholinesterase expression during calcium ionophore A23187-induced HeLa cell apoptosis
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Cong J, Lan WS, Jiang H, Jiang SR, Qiao CL (2006)
Detoxication of pyrethroid insecticides by recombinant carboxylesterase from peach-potato aphid (Myzus persicae)
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Gioia J, Qin X, Jiang H, Clinkenbeard K, Lo R, Liu Y, Fox GE, Yerrapragada S, McLeod MP, McNeill TZ, Hemphill L, Sodergren E, Wang Q, Muzny DM, Homsi FJ, Weinstock GM, Highlander SK (2006)
The genome sequence of Mannheimia haemolytica A1: insights into virulence, natural competence, and Pasteurellaceae phylogeny
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Petrosino JF, Xiang Q, Karpathy SE, Jiang H, Yerrapragada S, Liu Y, Gioia J, Hemphill L, Gonzalez A, Raghavan TM, Uzman A, Fox GE, Highlander S, Reichard M, Morton RJ, Clinkenbeard KD, Weinstock GM (2006)
Chromosome rearrangement and diversification of Francisella tularensis revealed by the type B (OSU18) genome sequence
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Feng S, Wang Z, He X, Zheng S, Xia Y, Jiang H, Tang X, Bai D (2005)
Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors
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Lan WS, Cong J, Jiang H, Gu BG, Qiao Ch L (2005)
Biodegradation of pesticide pollutants by two kinds of enzymes coexpressed in genetically engineered bacteria
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Niu C, Xu Y, Luo X, Duan W, Silman I, Sussman JL, Zhu W, Chen K, Shen J, Jiang H (2005)
Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation
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Ranalletta M, Jiang H, Li J, Tsao TS, Stenbit AE, Yokoyama M, Katz EB, Charron MJ (2005)
Altered hepatic and muscle substrate utilization provoked by GLUT4 ablation
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Poster (79) X-ray structures of TcAChE complexed with (+)-huperzine a and (-)-huperzine b: structural evidence for an active-site rearrangement
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Complete genome sequence of Rickettsia typhi and comparison with sequences of other rickettsiae
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Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression
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Zhang J, Lan W, Qiao C, Jiang H, Mulchandani A, Chen W (2004)
Bioremediation of organophosphorus pesticides by surface-expressed carboxylesterase from mosquito on Escherichia coli
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Jiang H, Luo X, Bai D (2003)
Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional chinese medicine origin for the treatment of Alzheimer's disease
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Synthesis and docking studies of alkylene-linked dimers of (-)-huperzine A
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Xu Y, Shen J, Luo X, Silman I, Sussman JL, Chen K, Jiang H (2003)
How does huperzine A enter and leave the binding gorge of acetylcholinesterase? Steered molecular dynamics simulations
Journal of the American Chemical Society 125: 11340

Dvir H, Jiang H, Wong DM, Harel M, Chetrit M, He XC, Jin GY, Yu GL, Tang XC, Silman I, Bai DL, Sussman JL (2002)
X-ray Structures of Torpedo californica Acetylcholinesterase Complexed with (+)-Huperzine A and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement
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Jin QH, Shi YF, He HY, Ng KK, Jiang H, Yang L, Jiang ZQ, Zhang XJ (2002)
Isolation of acetylcholinesterase from apoptotic human lung fibroblast cells by antibody affinity chromatography
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Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound
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Analysis of electronic structures of physostigmine analogs
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Synthesis and acetylcholinesterase inhibitory activity of (+/-)-14- fluorohuperzine A
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