Falach R, Sapoznikov A, Gal Y, Elhanany E, Evgy Y, Shifman O, Aftalion M, Ehrlich S, Lazar S, Sabo T, Kronman C, Mazor O (2020) <br />The low density receptor-related protein 1 plays a significant role in ricin-mediated intoxication of lung cells<br /><i>Sci Rep</i> <b>10</b>: 9007<br /><br />Sabo T, Kronman C, Mazor O (2016) <br />Ricin-Holotoxin-Based Vaccines: Induction of Potent Ricin-Neutralizing Antibodies<br /><i>Methods Mol Biol</i> <b>1403</b>: 683<br /><br />Kronman C, Cohen O, Mazor O, Ordentlich A, Raveh L, Velan B, Shafferman A (2010) <br />Next generation OP-bioscavengers: a circulatory long-lived 4-PEG hypolysine mutant of F338A-HuAChE with optimal pharmacokinetics and pseudo-catalytic characteristics<br /><i>Chemico-Biological Interactions</i> <b>187</b>: 253<br /><br />Mazor O, Cohen O, Kronman C, Raveh L, Stein D, Ordentlich A, Shafferman A (2008) <br />Aging-resistant organophosphate bioscavenger based on polyethylene glycol-conjugated F338A human acetylcholinesterase<br /><i>Molecular Pharmacology</i> <b>74</b>: 755<br /><br />Shafferman A, Barak D, Stein D, Kronman C, Velan B, Greig NH, Ordentlich A (2008) <br />Flexibility versus rigidity of the functional architecture of AChE active center<br /><i>Chemico-Biological Interactions</i> <b>175</b>: 166<br /><br />Cohen O, Kronman C, Lazar A, Velan B, Shafferman A (2007) <br />Controlled concealment of exposed clearance and immunogenic domains by site-specific polyethylene glycol attachment to acetylcholinesterase hypolysine mutants<br /><i>Journal of Biological Chemistry</i> <b>282</b>: 35491<br /><br />Kronman C, Cohen O, Raveh L, Mazor O, Ordentlich A, Shafferman A (2007) <br />Polyethylene-glycol conjugated recombinant human acetylcholinesterase serves as an efficacious bioscavenger against soman intoxication<br /><i>Toxicology</i> <b>233</b>: 40<br /><br />Cohen O, Kronman C, Raveh L, Mazor O, Ordentlich A, Shafferman A (2006) <br />Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds<br /><i>Molecular Pharmacology</i> <b>70</b>: 1121<br /><br />Barak D, Ordentlich A, Kaplan D, Kronman C, Velan B, Shafferman A (2005) <br />Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 219<br /><br />Kronman C, Cohen O, Velan B, Shafferman A (2005) <br />Host-regulated disposition of mammalian AChEs<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 51<br /><br />Ordentlich A, Barak D, Sod-Moriah G, Kaplan D, Mizrahi D, Segall Y, Kronman C, Karton Y, Lazar A, Marcus D, Velan B, Shafferman A (2005) <br />The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 191<br /><br />Shafferman A, Barak D, Kaplan D, Ordentlich A, Kronman C, Velan B (2005) <br />Functional requirements for the optimal catalytic configuration of the AChE active center<br /><i>Chemico-Biological Interactions</i> <b>157-158</b>: 123<br /><br />Chitlaru T, Kronman C, Lazar S, Seliger N, Velan B, Shafferman A (2004) <br />Effect of post-translation modifications of human acetylcholinesterase on its circulatory residence.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Cohen O, Kronman C, Velan B, Shafferman A (2004) <br />Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus macaques (Macaca mulatta)<br /><i>Biochemical Journal</i> <b>378</b>: 117<br /><br />Cohen O, Kronman C, Chitlaru T, Ordentlich A, Velan B, Shafferman A (2004) <br />Generation of pharmacokinetically improved recombinant human acetylcholinesterase by polyethylene glycol modification.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Kaplan D, Barak D, Ordentlich A, Kronman C, Velan B, Shafferman A (2004) <br />Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase?<br /><i>Biochemistry</i> <b>43</b>: 3129<br /><br />Kaplan D, Ordentlich A, Barak D, Ariel N, Kronman C, Baruch V, Shafferman A (2004) <br />Attempts to engineer an enzyme mimic of butyrylcholinesterase by substitution of the six divergent aromatic amino acids in the active center of acetylcholinesterase.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Kronman C, Chitlaru T, Seliger N, Lazar S, Lazar A, Zilberstein L, Velan B, Shafferman A (2004) <br />Some basic rules governing oligosaccharide-dependent circulatory residence of glycoproteins are revealed by MALDI-TOF mapping of the multiple N-glycans associated with recombinant bovine acetylcholinesterase.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Ordentlich A, Barak D, Ariel N, Kronman C, Kaplan D, Velan B, Shafferman A (2004) <br />Surprising findings from the functional analysis of human acetylcholinesterase adducts of Alzheimer?s disease drugs.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Ordentlich A, Kronman C, Barak D, Ariel N, Kaplan D, Velan B, Shafferman A (2004) <br />Poster (21) Analysis of acetylcholinesterase adducts of alzheimer's drugs<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 332<br /><br />Ordentlich A, Barak D, Sod-Moriah G, Kaplan D, Mizrahi D, Segall Y, Kronman C, Karton Y, Lazar A, Marcus D, Velan B, Shafferman A (2004) <br />Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE<br /><i>Biochemistry</i> <b>43</b>: 11255<br /><br />Shafferman A, Chitlaru T, Ordentlich A, Velan B, Kronman C (2004) <br />A complex array of post-translation modifications determines the circulatory longevity of acetylcholinesterase in a hierarchical manner.<br /><i>Cholinergic Mechanisms, CRC Press</i> <br /><br />Velan B, Kronman C, Chitlaru T, Cohen O, Ordentlich A, Shafferman A (2004) <br />Poster (35) The hierarchy of post-translation modifications determining circulatory longevity of acetylcholinesterase.<br /><i>In: Cholinesterases in the Second Millennium: Biomolecular and Pathological Aspects</i> <b> (Inestrosa NC, Campos EO) P. Universidad Catolica de Chile-FONDAP Biomedicina</b>: 339<br /><br />Chitlaru T, Kronman C, Velan B, Shafferman A (2002) <br />Overloading and removal of N-glycosylation targets on human acetylcholinesterase: effects on glycan composition and circulatory residence time<br /><i>Biochemical Journal</i> <b>363</b>: 619<br /><br />Chitlaru T, Kronman C, Velan B, Shafferman A (2001) <br />Effect of human acetylcholinesterase subunit assembly on its circulatory residence<br /><i>Biochemical Journal</i> <b>354</b>: 613<br /><br />Cohen O, Kronman C, Chitlaru T, Ordentlich A, Velan B, Shafferman A (2001) <br />Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity<br /><i>Biochemical Journal</i> <b>357</b>: 795<br /><br />Kaplan D, Ordentlich A, Barak D, Ariel N, Kronman C, Velan B, Shafferman A (2001) <br />Does butyrylization of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase?<br /><i>Biochemistry</i> <b>40</b>: 7433<br /><br />Barak D, Ordentlich A, Kaplan D, Barak R, Mizrahi D, Kronman C, Segall Y, Velan B, Shafferman A (2000) <br />Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase<br /><i>Biochemistry</i> <b>39</b>: 1156<br /><br />Cohen S, Mendelson I, Altboum Z, Kobiler D, Elhanany E, Bino T, Leitner M, Inbar I, Rosenberg H, Gozes Y, Barak R, Fisher M, Kronman C, Velan B, Shafferman A (2000) <br />Attenuated nontoxinogenic and nonencapsulated recombinant Bacillus anthracis spore vaccines protect against anthrax<br /><i>Infect Immun</i> <b>68</b>: 4549<br /><br />Kronman C, Chitlaru T, Elhanany E, Velan B, Shafferman A (2000) <br />Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>275</b>: 29488<br /><br />Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL (2000) <br />Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II<br /><i>Acta Crystallographica D Biol Crystallogr</i> <b>56</b>: 1385<br /><br />Malany S, Baker NA, Verweyst M, Medhekar R, Quinn DM, Velan B, Kronman C, Shafferman A (1999) <br />Theoretical and experimental investigations of electrostatic effects on acetylcholinesterase catalysis and inhibition<br /><i>Chemico-Biological Interactions</i> <b>119-120</b>: 99<br /><br />Ordentlich A, Barak D, Kronman C, Benschop HP, De Jong LP, Ariel N, Barak R, Segall Y, Velan B, Shafferman A (1999) <br />Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers<br /><i>Biochemistry</i> <b>38</b>: 3055<br /><br />Chitlaru T, Kronman C, Zeevi M, Kam M, Harel A, Ordentlich A, Velan B, Shafferman A (1998) <br />Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels<br /><i>Biochemical Journal</i> <b>336</b>: 647<br /><br />Kryger G, Giles K, Harel M, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL (1998) <br />3D Structure at 2.7  Resolution of Native and E202Q Mutant Human Acetylcholinesterase Complexed with Fasciculin-II<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 323<br /><br />Kryger G, Giles K, Harel M, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL (1998) <br />3D Structure of a Complex of Human Acetylcholinesterase with Fasciculin-II at 2.7  Resolution<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 370<br /><br />Malany S, Taylor P, Quinn DM, Sawai M, Shafferman A, Velan B, Kronman C (1998) <br />Correlation of Isotope and Viscosity Effects<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 232<br /><br />Mendelson I, Kronman C, Zeliger N, Seri T, Ordentlich A, Shafferman A, Velan B (1998) <br />Bovine Acetylcholinestrase  Cloning, Expression and Characterization of the Recombinant Enzyme<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 148<br /><br />Mendelson I, Kronman C, Ariel N, Shafferman A, Velan B (1998) <br />Bovine acetylcholinesterase: cloning, expression and characterization<br /><i>Biochemical Journal</i> <b>334</b>: 251<br /><br />Ordentlich A, Barak D, Stein D, Berman D, Kronman C, Ariel N, Velan B, Shafferman A (1998) <br />Does Electrostatic Attraction or Steering by Charged Residues within the Gorge Contribute to the Reactivity of AChE?<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 234<br /><br />Ordentlich A, Barak D, Kronman C, Ariel N, Segall Y, Velan B, Shafferman A (1998) <br />Functional characteristics of the oxyanion hole in human acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>273</b>: 19509<br /><br />Shafferman A, Ordentlich A, Barak D, Kronman C, Ariel N, Velan B (1998) <br />Contribution of the Active Center Functional Architecture to AChE Reactivity Toward Substrates and Inhibitors<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 203<br /><br />Velan B, Kronman C, Chitlaru T, Mendelson I, Ordentlich A, Shafferman A (1998) <br />Contribution of Primary Sequence and Post-Translation Modification to the Pharmacokinetics of Human and Bovine Acetylcholinesterases<br /><i>In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases</i> <b>(Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp.</b>: 291<br /><br />Ordentlich A, Barak D, Kronman C, Ariel N, Segall Y, Velan B, Shafferman A (1996) <br />The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors<br /><i>Journal of Biological Chemistry</i> <b>271</b>: 11953<br /><br />Barak D, Ordentlich A, Kronman C, Ber R, Bino T, Ariel N, Osman R, Velan B, Shafferman A (1995) <br />Electrostatic Attraction by Surface Charge does not Contribute to the Catalytic Efficiency of Acetylcholinesterase<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 223<br /><br />Barak D, Ordentlich A, Bromberg A, Kronman C, Marcus D, Lazar A, Ariel N, Velan B, Shafferman A (1995) <br />Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite<br /><i>Biochemistry</i> <b>34</b>: 15444<br /><br />Kronman C, Flashner Y, Shafferman A, Velan B (1995) <br />Signal-Mediated Cellular Retention and Subunit Assembly of Human Acetylcholinesterase<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 293<br /><br />Kronman C, Velan B, Marcus D, Ordentlich A, Reuveny S, Shafferman A (1995) <br />Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation<br /><i>Biochemical Journal</i> <b>311</b>: 959<br /><br />Ordentlich A, Kronman C, Stein D, Ariel N, Reuveny S, Marcus D, Segall Y, Barak D, Velan B, Shafferman A (1995) <br />Amino Acids Determining Specificity to OP-Agents and Facilitating the Aging Process in Human Acetylcholinesterase<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 221<br /><br />Ordentlich A, Barak D, Kronman C, Ariel N, Segall Y, Velan B, Shafferman A (1995) <br />Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>270</b>: 2082<br /><br />Shafferman A, Ordentlich A, Barak D, Kronman C, Ariel N, Leitner M, Segall Y, Bromberg A, Reuveny S, Marcus D, Bino T, Lazar A, Cohen S, Velan B (1995) <br />Molecular Aspects of Catalysis and of Allosteric Regulation of Aceytlcholinesterases<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 189<br /><br />Shafferman A, Kronman C, Ordentlich A (1995) <br />Compilation of Evaluated Mutants of Cholinesterases<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 481<br /><br />Velan B, Kronman C, Ordentlich A, Flashner Y, Ber R (1995) <br />Post-Translation Processing of Acetylcholinesterase<br /><i>In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases</i> <b>(Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp.</b>: 269<br /><br />Ashani Y, Grunwald J, Kronman C, Velan B, Shafferman A (1994) <br />Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase<br /><i>Molecular Pharmacology</i> <b>45</b>: 555<br /><br />Barak D, Kronman C, Ordentlich A, Ariel N, Bromberg A, Marcus D, Lazar A, Velan B, Shafferman A (1994) <br />Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core<br /><i>Journal of Biological Chemistry</i> <b>269</b>: 6296<br /><br />Kronman C, Ordentlich A, Barak D, Velan B, Shafferman A (1994) <br />The back door hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis<br /><i>Journal of Biological Chemistry</i> <b>269</b>: 27819<br /><br />Shafferman A, Ordentlich A, Barak D, Kronman C, Ber R, Bino T, Ariel N, Osman R, Velan B (1994) <br />Electrostatic attraction by surface charge does not contribute to the catalytic efficiency of acetylcholinesterase<br /><i>EMBO Journal</i> <b>13</b>: 3448<br /><br />Velan B, Kronman C, Flashner Y, Shafferman A (1994) <br />Reversal of signal-mediated cellular retention by subunit assembly of human acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>269</b>: 22719<br /><br />Kerem A, Kronman C, Bar-Nun S, Shafferman A, Velan B (1993) <br />Interrelations between assembly and secretion of recombinant human acetylcholinesterase<br /><i>Journal of Biological Chemistry</i> <b>268</b>: 180<br /><br />Lazar A, Reuveny S, Kronman C, Velan B, Shafferman A (1993) <br />Evaluation of anchorage-dependent cell propagation systems for production of human acetylcholinesterase by recombinant 293 cells<br /><i>Cytotechnology</i> <b>13</b>: 115<br /><br />Ordentlich A, Barak D, Kronman C, Flashner Y, Leitner M, Segall Y, Ariel N, Cohen S, Velan B, Shafferman A (1993) <br />Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket<br /><i>Journal of Biological Chemistry</i> <b>268</b>: 17083<br /><br />Ordentlich A, Kronman C, Barak D, Stein D, Ariel N, Marcus D, Velan B, Shafferman A (1993) <br />Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center<br /><i>FEBS Letters</i> <b>334</b>: 215<br /><br />Shafferman A, Velan B, Barak D, Kronman C, Ordentlich A, Flashner Y, Leitner M, Segal Y, Grosfeld H, Stein D, Ariel N (1993) <br />Recombinant human acetylcholinesterase - Enzyme engineering<br /><i>Medical Defense Bioscience Review</i> <b>3</b>: 1097<br /><br />Velan B, Kronman C, Ordentlich A, Flashner Y, Leitner M, Cohen S, Shafferman A (1993) <br />N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis<br /><i>Biochemical Journal</i> <b>296</b>: 649<br /><br />Kronman C, Velan B, Gozes Y, Leitner M, Flashner Y, Lazar A, Marcus D, Sery T, Papier Y, Grosfeld H, Cohen S, Shafferman A (1992) <br />Production and secretion of high levels of recombinant human acetylcholinesterase in cultured cell lines: microheterogeneity of the catalytic subunit<br /><i>Gene</i> <b>121</b>: 295<br /><br />Shafferman A, Kronman C, Flashner Y, Leitner M, Grosfeld H, Ordentlich A, Gozes Y, Cohen S, Ariel N, Barak D, Harel M, Silman I, Sussman JL, Velan B (1992) <br />Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding<br /><i>Journal of Biological Chemistry</i> <b>267</b>: 17640<br /><br />Shafferman A, Velan B, Ordentlich A, Kronman C, Grosfeld H, Leitner M, Flashner Y, Cohen S, Barak D, Ariel N (1992) <br />Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center<br /><i>EMBO Journal</i> <b>11</b>: 3561<br /><br />Velan B, Kronman C, Leitner M (1992) <br />Molecular Organization of Recombinant Human Acetylcholinesterase<br /><i>In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases</i> <b>(Shafferman, A. and Velan, B., Eds) Plenum Press, New York</b>: 39<br /><br />Velan B, Grosfeld H, Kronman C, Leitner M, Gozes Y, Lazar A, Flashner Y, Marcus D, Cohen S, Shafferman A (1991) <br />The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant<br /><i>Journal of Biological Chemistry</i> <b>266</b>: 23977<br /><br />Velan B, Kronman C, Grosfeld H, Leitner M, Gozes Y, Flashner Y, Sery T, Cohen S, Ben-Aziz R, Seidman S, Shafferman A, Soreq H (1991) <br />Recombinant human acetylcholinesterase is secreted from transiently transfected 293 cells as a soluble globular enzyme<br /><i>Cellular Molecular Neurobiology</i> <b>11</b>: 143<br /><br />