Li G, Li X, Yang L, Wang S, Dai Y, Fekry B, Veillon L, Tan L, Berdeaux R, Eckel-Mahan K, Lorenzi PL, Zhao Z, Lehner R, Sun K (2022)
Adipose tissue-specific ablation of Ces1d causes metabolic dysregulation in mice
Life Sciences Alliance 5:

Lian J, van der Veen JN, Watts R, Jacobs RL, Lehner R (2021)
Carboxylesterase 1d (Ces1d) does not contribute to cholesteryl ester hydrolysis in the liver
J Lipid Res

Szafran BN, Borazjani A, Seay CN, Carr RL, Lehner R, Kaplan BLF, Ross MK (2021)
Effects of Chlorpyrifos on Serine Hydrolase Activities, Lipid Mediators, and Immune Responses in Lungs of Neonatal and Adult Mice
Chemical Research in Toxicology

Lian J, Watts R, Quiroga AD, Beggs MR, Alexander RT, Lehner R (2019)
Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation
J Lipid Res 60: 880

Lian J, Nelson R, Lehner R (2018)
Carboxylesterases in lipid metabolism: from mouse to human
Protein Cell 9: 178

Lian J, Bahitham W, Panigrahi R, Nelson R, Li L, Watts R, Thiesen A, Lemieux MJ, Lehner R (2018)
Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis
Biochimica & Biophysica Acta 1863: 688

Quiroga AD, Lehner R (2018)
Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly
Biochemical Pharmacology 155: 233

Bahitham W, Watts R, Nelson R, Lian J, Lehner R (2016)
Liver-specific expression of carboxylesterase 1g/esterase-x reduces hepatic steatosis, counteracts dyslipidemia and improves insulin signaling
Biochimica & Biophysica Acta 1861: 482

Lian J, Wei E, Groenendyk J, Das SK, Hermansson M, Li L, Watts R, Thiesen A, Oudit GY, Michalak M, Lehner R (2016)
Ces3/TGH Deficiency Attenuates Steatohepatitis
Sci Rep 6: 25747

Lord CC, Ferguson D, Thomas G, Brown AL, Schugar RC, Burrows A, Gromovsky AD, Betters J, Neumann C, Sacks J, Marshall S, Watts R, Schweiger M, Lee RG, Crooke RM, Graham MJ, Lathia JD, Sakaguchi TF, Lehner R, Haemmerle G, Zechner R, Brown JM (2016)
Regulation of Hepatic Triacylglycerol Metabolism by CGI-58 Does Not Require ATGL Co-activation
Cell Rep 16: 939

Erickson B, Selvan SP, Ko KW, Kelly K, Quiroga AD, Li L, Nelson R, King-Jones K, Jacobs RL, Lehner R (2013)
Endoplasmic reticulum-localized hepatic lipase decreases triacylglycerol storage and VLDL secretion
Biochimica & Biophysica Acta 1831: 1113

Nourbakhsh M, Douglas DN, Pu CH, Lewis JT, Kawahara T, Lisboa LF, Wei E, Asthana S, Quiroga AD, Law LM, Chen C, Addison WR, Nelson R, Houghton M, Lehner R, Kneteman NM (2013)
Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production
Journal of Hepatology 59: 336

Lian J, Quiroga AD, Li L, Lehner R (2012)
Ces3/TGH deficiency improves dyslipidemia and reduces atherosclerosis in Ldlr(-/-) mice
Circulation Research 111: 982

Lian J, Wei E, Wang SP, Quiroga AD, Li L, Pardo AD, van der Veen J, Sipione S, Mitchell GA, Lehner R, Di Pardo A (2012)
Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice
Hepatology 56: 2154

Quiroga AD, Lian J, Lehner R (2012)
Carboxylesterase1/Esterase-x Regulates Chylomicron Production in Mice
PLoS ONE 7: e49515

Quiroga AD, Li L, Trotzmuller M, Nelson R, Proctor SD, Kofeler H, Lehner R (2012)
Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia
Hepatology 56: 2188

Quiroga AD, Lehner R (2012)
Liver triacylglycerol lipases
Biochimica & Biophysica Acta 1821: 762

Quiroga AD, Lehner R (2011)
Role of endoplasmic reticulum neutral lipid hydrolases
Trends Endocrinol Metab 22: 218

Holmes RS, Wright MW, Laulederkind SJ, Cox LA, Hosokawa M, Imai T, Ishibashi S, Lehner R, Miyazaki M, Perkins EJ, Potter PM, Redinbo MR, Robert J, Satoh T, Yamashita T, Yan B, Yokoi T, Zechner R, Maltais LJ (2010)
Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins
Mamm Genome 21: 427

Lo V, Erickson B, Thomason-Hughes M, Ko KW, Dolinsky VW, Nelson R, Lehner R (2010)
Arylacetamide deacetylase attenuates fatty-acid-induced triacylglycerol accumulation in rat hepatoma cells
J Lipid Res 51: 368

Wang H, Wei E, Quiroga AD, Sun X, Touret N, Lehner R (2010)
Altered lipid droplet dynamics in hepatocytes lacking triacylglycerol hydrolase expression
Mol Biology of the cell 21: 1991

Wei E, Ben Ali Y, Lyon J, Wang H, Nelson R, Dolinsky VW, Dyck JR, Mitchell G, Korbutt GS, Lehner R (2010)
Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure
Cell Metab 11: 183

Ko KW, Erickson B, Lehner R (2009)
Es-x/Ces1 prevents triacylglycerol accumulation in McArdle-RH7777 hepatocytes
Biochimica & Biophysica Acta 1791: 1133

Wang H, Gilham D, Lehner R (2007)
Proteomic and lipid characterization of apolipoprotein B-free luminal lipid droplets from mouse liver microsomes: implications for very low density lipoprotein assembly
Journal of Biological Chemistry 282: 33218

Wei E, Gao W, Lehner R (2007)
Attenuation of adipocyte triacylglycerol hydrolase activity decreases basal fatty acid efflux
Journal of Biological Chemistry 282: 8027

Alam M, Gilham D, Vance DE, Lehner R (2006)
Mutation of F417 but not of L418 or L420 in the lipid binding domain decreases the activity of triacylglycerol hydrolase
J Lipid Res 47: 375

Gilham D, Alam M, Gao W, Vance DE, Lehner R (2005)
Triacylglycerol hydrolase is localized to the endoplasmic reticulum by an unusual retrieval sequence where it participates in VLDL assembly without utilizing VLDL lipids as substrates
Mol Biology of the cell 16: 984

Gilham D, Perreault KR, Holmes CF, Brindley DN, Vance DE, Lehner R (2005)
Insulin, glucagon and fatty acid treatment of hepatocytes does not result in phosphorylation or changes in activity of triacylglycerol hydrolase
Biochimica & Biophysica Acta 1736: 189

Gilham D, Lehner R (2005)
Techniques to measure lipase and esterase activity in vitro
Methods 36: 139

Wei E, Lehner R, Vance DE (2005)
C/EBPalpha activates the transcription of triacylglycerol hydrolase in 3T3-L1 adipocytes
Biochemical Journal 388: 959

Dolinsky VW, Gilham D, Alam M, Vance DE, Lehner R (2004)
Triacylglycerol hydrolase: role in intracellular lipid metabolism
Cell Mol Life Sciences 61: 1633

Dolinsky VW, Douglas DN, Lehner R, Vance DE (2004)
Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone
Biochemical Journal 378: 967

Gilham D, Lehner R (2004)
The physiological role of triacylglycerol hydrolase in lipid metabolism
Rev Endocr Metab Disord 5: 303

Soni KG, Lehner R, Metalnikov P, O'Donnell P, Semache M, Gao W, Ashman K, Pshezhetsky AV, Mitchell GA (2004)
Carboxylesterase 3 (EC is a major adipocyte lipase
Journal of Biological Chemistry 279: 40683

Dolinsky VW, Gilham D, Hatch GM, Agellon LB, Lehner R, Vance DE (2003)
Regulation of triacylglycerol hydrolase expression by dietary fatty acids and peroxisomal proliferator-activated receptors
Biochimica & Biophysica Acta 1635: 20

Gilham D, Ho S, Rasouli M, Martres P, Vance DE, Lehner R (2003)
Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion
FASEB Journal 17: 1685

Alam M, Vance DE, Lehner R (2002)
Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site
Biochemistry 41: 6679

Alam M, Ho S, Vance DE, Lehner R (2002)
Heterologous expression, purification, and characterization of human triacylglycerol hydrolase
Protein Expr Purif 24: 33

Dolinsky VW, Sipione S, Lehner R, Vance DE (2001)
The cloning and expression of a murine triacylglycerol hydrolase cDNA and the structure of its corresponding gene
Biochimica & Biophysica Acta 1532: 162

Douglas DN, Dolinsky VW, Lehner R, Vance DE (2001)
A role for Sp1 in the transcriptional regulation of hepatic triacylglycerol hydrolase in the mouse
Journal of Biological Chemistry 276: 25621

Lehner R, Cui Z, Vance DE (1999)
Subcellullar localization, developmental expression and characterization of a liver triacylglycerol hydrolase
Biochemical Journal 338 ( Pt 3): 761

Lehner R, Vance DE (1999)
Cloning and expression of a cDNA encoding a hepatic microsomal lipase that mobilizes stored triacylglycerol
Biochemical Journal 343 Pt 1: 1

Lehner R, Verger R (1997)
Purification and characterization of a porcine liver microsomal triacylglycerol hydrolase
Biochemistry 36: 1861

Lehner R, Kuksis A (1996)
Biosynthesis of triacylglycerols
Prog Lipid Res 35: 169