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high-fat diet-mediated renal injury by activating PAX2 and AMPK<br /><i>Proc Natl Acad Sci U S A</i> <b>116</b>: 5154<br /><br />Liu JY (2018) <br />Inhibition of Soluble Epoxide Hydrolase for Renal Health<br /><i>Front Pharmacol</i> <b>9</b>: 1551<br /><br />Liu JY, Morisseau C, Huang H, Hammock BD (2016) <br />Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use<br /><i>J Ethnopharmacol</i> <b>194</b>: 475<br /><br />Fako VE, Wu X, Pflug B, Liu JY, Zhang JT (2015) <br />Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase<br /><i>Journal of Medicinal Chemistry</i> <b>58</b>: 778<br /><br />Liu JY, Tsai HJ, Morisseau C, Lango J, Hwang SH, Watanabe T, Kim IH, Hammock BD (2015) <br />In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors<br /><i>Biochemical Pharmacology</i> <b>98</b>: 718<br /><br />Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD (2014) <br />Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy<br /><i>Journal of Medicinal Chemistry</i> <b>57</b>: 7016<br /><br />Yang XQ, Liu JY, Li XC, Chen MH, Zhang YL (2014) <br />Key amino acid associated with acephate detoxification by Cydia pomonella carboxylesterase based on molecular dynamics with alanine scanning and site-directed mutagenesis<br /><i>J Chem Inf Model</i> <b>54</b>: 1356<br /><br />Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu JY, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD (2014) <br />Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis<br /><i>Proc Natl Acad Sci U S A</i> <b>111</b>: 11127<br /><br />Liu JY, Lin YP, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD (2013) <br />Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models<br /><i>Eur J Pharm Sci</i> <b>48</b>: 619<br /><br />Ma BD, Yu HL, Pan J, Liu JY, Ju X, Xu JH (2013) <br />A thermostable and organic-solvent tolerant esterase from Pseudomonas putida ECU1011: catalytic properties and performance in kinetic resolution of alpha-hydroxy acids<br /><i>Bioresour Technol</i> <b>133</b>: 354<br /><br />Ouyang LM, Liu JY, Qiao M, Xu JH (2013) <br />Isolation and biochemical characterization of two novel metagenome-derived esterases<br /><i>Appl Biochem Biotechnol</i> <b>169</b>: 15<br /><br />Hwang SH, Wagner KM, Morisseau C, Liu JY, Dong H, Wecksler AT, Hammock BD (2011) <br />Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase<br /><i>Journal of Medicinal Chemistry</i> <b>54</b>: 3037<br /><br />Kamita SG, Samra AI, Liu JY, Cornel AJ, Hammock BD (2011) <br />Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene<br /><i>PLoS ONE</i> <b>6</b>: e28392<br /><br />Huang SX, Li HY, Liu JY, Morisseau C, Hammock BD, Long YQ (2010) <br />Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties<br /><i>Journal of Medicinal Chemistry</i> <b>53</b>: 8376<br /><br />Liu JY, Yang J, Inceoglu B, Qiu H, Ulu A, Hwang SH, Chiamvimonvat N, Hammock BD (2010) <br />Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model<br /><i>Biochemical Pharmacology</i> <b>79</b>: 880<br 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BD, Weiss RH (2009) <br />Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo<br /><i>Mol Cancer Ther</i> <b>8</b>: 2193<br /><br />Hwang SH, Tsai HJ, Liu JY, Morisseau C, Hammock BD (2007) <br />Orally bioavailable potent soluble epoxide hydrolase inhibitors<br /><i>Journal of Medicinal Chemistry</i> <b>50</b>: 3825<br /><br />Zhu QG, Hu JH, Liu JY, Lu SW, Liu YX, Wang J (2007) <br />Stereoselective characteristics and mechanisms of epidermal carboxylesterase metabolism observed in HaCaT keratinocytes<br /><i>Biol Pharm Bull</i> <b>30</b>: 532<br /><br />