Deng BQ, Li MY, Fu X, Luo Y, Qiao Q, Liu JY (2022)
Targeted Metabolomics Study of Human Plasma Revealed Activation of the Cytochrome P450 Epoxygenase/Epoxide Hydrolase Axis in Patients with IgA Nephropathy
J Proteome Res

Zhang HX, Lin HH, Su D, Yang DC, Liu JY (2022)
Enzyme-Activated Multifunctional Prodrug Combining Site-Specific Chemotherapy with Light-Triggered Photodynamic Therapy
Mol Pharm

Singh N, Barnych B, Morisseau C, Wagner KM, Wan D, Takeshita A, Pham H, Xu T, Dandekar A, Liu JY, Hammock BD (2020)
N-Benzyl-linoleamide, a Constituent of Lepidium meyenii (Maca), Is an Orally Bioavailable Soluble Epoxide Hydrolase Inhibitor That Alleviates Inflammatory Pain
Journal of Natural Products 83: 3689

Luo Y, Wu MY, Deng BQ, Huang J, Hwang SH, Li MY, Zhou CY, Zhang QY, Yu HB, Zhao DK, Zhang G, Qin L, Peng A, Hammock BD, Liu JY (2019)
Inhibition of soluble epoxide hydrolase attenuates a high-fat diet-mediated renal injury by activating PAX2 and AMPK
Proc Natl Acad Sci U S A 116: 5154

Liu JY (2018)
Inhibition of Soluble Epoxide Hydrolase for Renal Health
Front Pharmacol 9: 1551

Liu JY, Morisseau C, Huang H, Hammock BD (2016)
Screening of soluble epoxide hydrolase inhibitory ingredients from traditional Chinese medicines for anti-inflammatory use
J Ethnopharmacol 194: 475

Fako VE, Wu X, Pflug B, Liu JY, Zhang JT (2015)
Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase
Journal of Medicinal Chemistry 58: 778

Liu JY, Tsai HJ, Morisseau C, Lango J, Hwang SH, Watanabe T, Kim IH, Hammock BD (2015)
In vitro and in vivo metabolism of N-adamantyl substituted urea-based soluble epoxide hydrolase inhibitors
Biochemical Pharmacology 98: 718

Lee KS, Liu JY, Wagner KM, Pakhomova S, Dong H, Morisseau C, Fu SH, Yang J, Wang P, Ulu A, Mate CA, Nguyen LV, Hwang SH, Edin ML, Mara AA, Wulff H, Newcomer ME, Zeldin DC, Hammock BD (2014)
Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy
Journal of Medicinal Chemistry 57: 7016

Yang XQ, Liu JY, Li XC, Chen MH, Zhang YL (2014)
Key amino acid associated with acephate detoxification by Cydia pomonella carboxylesterase based on molecular dynamics with alanine scanning and site-directed mutagenesis
J Chem Inf Model 54: 1356

Zhang G, Panigrahy D, Hwang SH, Yang J, Mahakian LM, Wettersten HI, Liu JY, Wang Y, Ingham ES, Tam S, Kieran MW, Weiss RH, Ferrara KW, Hammock BD (2014)
Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis
Proc Natl Acad Sci U S A 111: 11127

Liu JY, Lin YP, Qiu H, Morisseau C, Rose TE, Hwang SH, Chiamvimonvat N, Hammock BD (2013)
Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models
Eur J Pharm Sci 48: 619

Ma BD, Yu HL, Pan J, Liu JY, Ju X, Xu JH (2013)
A thermostable and organic-solvent tolerant esterase from Pseudomonas putida ECU1011: catalytic properties and performance in kinetic resolution of alpha-hydroxy acids
Bioresour Technol 133: 354

Ouyang LM, Liu JY, Qiao M, Xu JH (2013)
Isolation and biochemical characterization of two novel metagenome-derived esterases
Appl Biochem Biotechnol 169: 15

Hwang SH, Wagner KM, Morisseau C, Liu JY, Dong H, Wecksler AT, Hammock BD (2011)
Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase
Journal of Medicinal Chemistry 54: 3037

Kamita SG, Samra AI, Liu JY, Cornel AJ, Hammock BD (2011)
Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene
PLoS ONE 6: e28392

Huang SX, Li HY, Liu JY, Morisseau C, Hammock BD, Long YQ (2010)
Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties
Journal of Medicinal Chemistry 53: 8376

Liu JY, Yang J, Inceoglu B, Qiu H, Ulu A, Hwang SH, Chiamvimonvat N, Hammock BD (2010)
Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model
Biochemical Pharmacology 79: 880

Rose TE, Morisseau C, Liu JY, Inceoglu B, Jones PD, Sanborn JR, Hammock BD (2010)
1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain
Journal of Medicinal Chemistry 53: 7067

Li N, Liu JY, Timofeyev V, Qiu H, Hwang SH, Tuteja D, Lu L, Yang J, Mochida H, Low R, Hammock BD, Chiamvimonvat N (2009)
Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches
Journal of Molecular & Cellular Cardiology 47: 835

Liu JY, Tsai HJ, Hwang SH, Jones PD, Morisseau C, Hammock BD (2009)
Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation
British Journal of Pharmacology 156: 284

Liu JY, Park SH, Morisseau C, Hwang SH, Hammock BD, Weiss RH (2009)
Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo
Mol Cancer Ther 8: 2193

Hwang SH, Tsai HJ, Liu JY, Morisseau C, Hammock BD (2007)
Orally bioavailable potent soluble epoxide hydrolase inhibitors
Journal of Medicinal Chemistry 50: 3825

Zhu QG, Hu JH, Liu JY, Lu SW, Liu YX, Wang J (2007)
Stereoselective characteristics and mechanisms of epidermal carboxylesterase metabolism observed in HaCaT keratinocytes
Biol Pharm Bull 30: 532