Panek D, Pasieka A, Latacz G, Zareba P, Szczech M, Godyn J, Chantegreil F, Nachon F, Brazzolotto X, Skrzypczak-Wiercioch A, Walczak M, Smolik M, Salat K, Hofner G, Wanner K, Wieckowska A, Malawska B (2023)
Discovery of new, highly potent and selective inhibitors of BuChE - Design, synthesis, in vitro and in vivo evaluation and crystallography studies
Eur Journal of Medicinal Chemistry

Godyn J, Zareba P, Stary D, Kaleta M, Kuder KJ, Latacz G, Mogilski S, Reiner-Link D, Frank A, Doroz-Plonka A, Olejarz-Maciej A, Sudol-Talaj S, Nolte T, Handzlik J, Stark H, Wieckowska A, Malawska B, Kiec-Kononowicz K, Lazewska D, Bajda M (2022)
Benzophenone Derivatives with Histamine H(3) Receptor Affinity and Cholinesterase Inhibitory Potency as Multitarget-Directed Ligands for Possible Therapy of Alzheimer's Disease
Molecules 28:

Godyn J, Zareba P, aewska D, Stary D, Reiner-Link D, Frank A, Latacz G, Mogilski S, Kaleta M, Doroz-Plonka A, Lubelska A, Honkisz-Orzechowska E, Olejarz-Maciej A, Handzlik J, Stark H, Kiec-Kononowicz K, Malawska B, Bajda M (2021)
Cyanobiphenyls: Novel H(3) receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease
Bioorg Chem 114: 105129

Jonczyk J, Kukulowicz J, tka K, Malawska B, Jung YS, Musilek K, Bajda M (2021)
Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase
Biomolecules 11:

Lazewska D, Zareba P, Godyn J, Doroz-Plonka A, Frank A, Reiner-Link D, Bajda M, Stary D, Mogilski S, Olejarz-Maciej A, Kaleta M, Stark H, Malawska B, Kiec-Kononowicz K (2021)
Biphenylalkoxyamine Derivatives-Histamine H(3) Receptor Ligands with Butyrylcholinesterase Inhibitory Activity
Molecules 26:

Lee HM, Andrys R, Jonczyk J, Kim K, Vishakantegowda AG, Malinak D, Skarka A, Schmidt M, Vaskova M, Latka K, Bajda M, Jung YS, Malawska B, Musilek K (2021)
Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates
J Enzyme Inhib Med Chem 36: 437

Pasieka A, Panek D, Jonczyk J, Godyn J, Szalaj N, Latacz G, Tabor J, Mezeiova E, Chantegreil F, Dias J, Knez D, Lu J, Pi R, Korabecny J, Brazzolotto X, Gobec S, Hofner G, Wanner K, Wieckowska Q, Malawska B ()
Discovery of multifunctional anti-Alzheimers agents with a unique mechanism of action including inhibition of the enzyme butyrylcholinesterase and gamma-aminobutyric acid transporters
Eur Journal of Medicinal Chemistry 218: 113397

Wichur T, Pasieka A, Godyn J, Panek D, Goral I, Latacz G, Honkisz-Orzechowska E, Bucki A, Siwek A, Gluch-Lutwin M, Knez D, Brazzolotto X, Gobec S, Kolaczkowski M, Sabate R, Malawska B, Wieckowska A (2021)
Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT(6) receptor with anti-aggregation properties against amyloid-beta and tau
Eur Journal of Medicinal Chemistry 225: 113783

Wichur T, Godyn J, Goral I, Latacz G, Bucki A, Siwek A, Gluch-Lutwin M, Mordyl B, Sniecikowska J, Walczak M, Knez D, Jukic M, Salat K, Gobec S, Kolaczkowski M, Malawska B, Brazzolotto X, Wieckowska A (2021)
Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT6R antagonists with beta-amyloid anti-aggregation properties
Eur Journal of Medicinal Chemistry 225: 113792

Jonczyk J, Godyn J, Stawarska E, Morak-Mlodawska B, Jelen M, Pluta K, Malawska B (2020)
Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives-Anticancer and Cholinesterase-Inhibiting Activity
Molecules 25:

Lazewska D, Bajda M, Kaleta M, Zareba P, Doroz-Plonka A, Siwek A, Alachkar A, Mogilski S, Saad A, Kuder K, Olejarz-Maciej A, Godyn J, Stary D, Sudol S, Wiecek M, Latacz G, Walczak M, Handzlik J, Sadek B, Malawska B, Kiec-Kononowicz K (2020)
Rational design of new multitarget histamine H(3) receptor ligands as potential candidates for treatment of Alzheimer's disease
Eur Journal of Medicinal Chemistry 207: 112743

Szalaj N, Godyn J, Jonczyk J, Pasieka A, Panek D, Wichur T, Wieckowski K, Zareba P, Bajda M, Pislar A, Malawska B, Sabate R, Wieckowska A (2020)
Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer's disease
J Enzyme Inhib Med Chem 35: 1944

Bajda M, Lazewska D, Godyn J, Zareba P, Kuder K, Hagenow S, Latka K, Stawarska E, Stark H, Kiec-Kononowicz K, Malawska B (2019)
Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands
Eur Journal of Medicinal Chemistry 185: 111785

Jonczyk J, Lodarski K, Staszewski M, Godyn J, Zareba P, Soukup O, Janockova J, Korabecny J, Salat K, Malikowska-Racia N, Hebda M, Szalaj N, Filipek B, Walczynski K, Malawska B, Bajda M (2019)
Search for multifunctional agents against Alzheimer's disease among non-imidazole histamine H3 receptor ligands. In vitro and in vivo pharmacological evaluation and computational studies of piperazine derivatives
Bioorg Chem 90: 103084

Malek R, Arribas RL, Palomino-Antolin A, Totoson P, Demougeot C, Kobrlova T, Soukup O, Iriepa I, Moraleda I, Diez-Iriepa D, Godyn J, Panek D, Malawska B, Gluch-Lutwin M, Mordyl B, Siwek A, Chabchoub F, Marco-Contelles J, Kiec-Kononowicz K, Egea J, de los Rios C, Ismaili L (2019)
New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition
Journal of Medicinal Chemistry 62: 11416

Wichur T, Wieckowska A, Wieckowski K, Godyn J, Jonczyk J, Valdivieso ADR, Panek D, Pasieka A, Sabate R, Knez D, Gobec S, Malawska B (2019)
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease
Eur Journal of Medicinal Chemistry 187: 111916

Bajda M, Latka K, Hebda M, Jonczyk J, Malawska B (2018)
Novel carbamate derivatives as selective butyrylcholinesterase inhibitors
Bioorg Chem 78: 29

Panek D, Wieckowska A, Pasieka A, Godyn J, Jonczyk J, Bajda M, Knez D, Gobec S, Malawska B (2018)
Design, Synthesis, and Biological Evaluation of 2-(Benzylamino-2-Hydroxyalkyl)Isoindoline-1,3-Diones Derivatives as Potential Disease-Modifying Multifunctional Anti-Alzheimer Agents
Molecules 23:

Panek D, Wieckowska A, Jonczyk J, Godyn J, Bajda M, Wichur T, Pasieka A, Knez D, Pislar A, Korabecny J, Soukup O, Sepsova V, Sabate R, Kos J, Gobec S, Malawska B (2018)
Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents
ACS Chem Neurosci 9: 1074

Wieckowska A, Wichur T, Godyn J, Bucki A, Marcinkowska M, Siwek A, Wieckowski K, Zareba P, Knez D, Gluch-Lutwin M, Kazek G, Latacz G, Mika K, Kolaczkowski M, Korabecny J, Soukup O, Benkova M, Kiec-Kononowicz K, Gobec S, Malawska B (2018)
Novel Multitarget-Directed Ligands Aiming at Symptoms and Causes of Alzheimer's Disease
ACS Chem Neurosci 9: 1195

Czarnecka K, Szymanski P, Girek M, Mikiciuk-Olasik E, Skibinski R, Kabzinski J, Majsterek I, Malawska B, Jonczyk J, Bajda M (2017)
Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment
Bioorg Chem 72: 315

Godyn J, Hebda M, Wieckowska A, Wieckowski K, Malawska B, Bajda M (2017)
Lipophilic properties of anti-Alzheimer's agents determined by micellar electrokinetic chromatography and reversed-phase thin-layer chromatography
Electrophoresis 38: 1268

Panek D, Wichur T, Godyn J, Pasieka A, Malawska B (2017)
Advances toward multifunctional cholinesterase and beta-amyloid aggregation inhibitors
Future Med Chem 9: 1835

Dgachi Y, Bautista-Aguilera OM, Benchekroun M, Martin H, Bonet A, Knez D, Godyn J, Malawska B, Gobec S, Chioua M, Janockova J, Soukup O, Chabchoub F, Marco-Contelles J, Ismaili L (2016)
Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease
Molecules 21:

Dgachi Y, Ismaili L, Knez D, Benchekroun M, Martin H, Szalaj N, Wehle S, Bautista-Aguilera OM, Luzet V, Bonnet A, Malawska B, Gobec S, Chioua M, Decker M, Chabchoub F, Marco-Contelles J (2016)
Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Abeta1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy
ChemMedChem 11: 1318

Dgachi Y, Sokolov O, Luzet V, Godyn J, Panek D, Bonet A, Martin H, Iriepa I, Moraleda I, Garcia-Iriepa C, Janockova J, Richert L, Soukup O, Malawska B, Chabchoub F, Marco-Contelles J, Ismaili L (2016)
Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy
Eur Journal of Medicinal Chemistry 126: 576

Godyn J, Jonczyk J, Panek D, Malawska B (2016)
Therapeutic strategies for Alzheimer's disease in clinical trials
Pharmacol Rep 68: 127

Hebda M, Bajda M, Wieckowska A, Szalaj N, Pasieka A, Panek D, Godyn J, Wichur T, Knez D, Gobec S, Malawska B (2016)
Synthesis, Molecular Modelling and Biological Evaluation of Novel Heterodimeric, Multiple Ligands Targeting Cholinesterases and Amyloid Beta
Molecules 21:

Kosak U, Brus B, Knez D, Sink R, Zakelj S, Trontelj J, Pislar A, Slenc J, Gobec M, Zivin M, Tratnjek L, Perse M, Salat K, Podkowa A, Filipek B, Nachon F, Brazzolotto X, Wieckowska A, Malawska B, Stojan J, Rascan IM, Kos J, Coquelle N, Colletier JP, Gobec S (2016)
Development of an in-vivo active reversible butyrylcholinesterase inhibitor
Sci Rep 6: 39495

Lazewska D, Jonczyk J, Bajda M, Szalaj N, Wieckowska A, Panek D, Moore C, Kuder K, Malawska B, Kiec-Kononowicz K (2016)
Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands
Bioorganic & Medicinal Chemistry Lett 26: 4140

Panek D, Wieckowska A, Wichur T, Bajda M, Godyn J, Jonczyk J, Mika K, Janockova J, Soukup O, Knez D, Korabecny J, Gobec S, Malawska B (2016)
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation
Eur Journal of Medicinal Chemistry 125: 676

Wieckowska A, Kolaczkowski M, Bucki A, Godyn J, Marcinkowska M, Wieckowski K, Zareba P, Siwek A, Kazek G, Gluch-Lutwin M, Mierzejewski P, Bienkowski P, Sienkiewicz-Jarosz H, Knez D, Wichur T, Gobec S, Malawska B (2016)
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation
Eur Journal of Medicinal Chemistry 124: 63

Bajda M, Jonczyk J, Malawska B, Czarnecka K, Girek M, Olszewska P, Sikora J, Mikiciuk-Olasik E, Skibinski R, Gumieniczek A, Szymanski P (2015)
Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease
Bioorganic & Medicinal Chemistry 23: 5610

Bajda M, Panek D, Hebda M, Wieckowska A, Guzior N, Malawska B (2015)
SEARCH FOR POTENTIAL CHOLINESTERASE INHIBITORS FROM THE ZINC DATABASE BY VIRTUAL SCREENING METHOD
Acta Pol Pharm 72: 737

Guzior N, Bajda M, Skrok M, Kurpiewska K, Lewinski K, Brus B, Pislar A, Kos J, Gobec S, Malawska B (2015)
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase and beta-amyloid aggregation inhibitors with neuroprotective properties
Eur Journal of Medicinal Chemistry 92C: 738

Guzior N, Wieckowska A, Panek D, Malawska B (2015)
Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
Curr Med Chem 22: 373

Guzior N, Bajda M, Rakoczy J, Brus B, Gobec S, Malawska B (2015)
Isoindoline-1,3-dione derivatives targeting cholinesterases: Design, synthesis and biological evaluation of potential anti-Alzheimer's agents
Bioorganic & Medicinal Chemistry 23: 1629

Lodarski K, Jonczyk J, Guzior N, Bajda M, Gladysz J, Walczyk J, Jelen M, Morak-Mlodawska B, Pluta K, Malawska B (2015)
Discovery of butyrylcholinesterase inhibitors among derivatives of azaphenothiazines
J Enzyme Inhib Med Chem 30: 98

Szalaj N, Bajda M, Dudek K, Brus B, Gobec S, Malawska B (2015)
Multiple Ligands Targeting Cholinesterases and beta-Amyloid: Synthesis, Biological Evaluation of Heterodimeric Compounds with Benzylamine Pharmacophore
Arch Pharm (Weinheim) 348: 556

Wieckowska A, Wieckowski K, Bajda M, Brus B, Salat K, Czerwinska P, Gobec S, Filipek B, Malawska B (2015)
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with beta-amyloid anti-aggregation properties and beneficial effects on memory in vivo
Bioorganic & Medicinal Chemistry 23: 2445

Bajda M, Wieckowska A, Hebda M, Guzior N, Sotriffer CA, Malawska B (2013)
Structure-based search for new inhibitors of cholinesterases
Int J Mol Sci 14: 5608

Szymanski P, Skibinski R, Inglot T, Bajda M, Jonczyk J, Malawska B, Mikiciuk-Olasik E (2013)
New tacrine analogs as acetylcholinesterase inhibitors - theoretical study with chemometric analysis
Molecules 18: 2878

Ignasik M, Bajda M, Guzior N, Prinz M, Holzgrabe U, Malawska B (2012)
Design, synthesis and evaluation of novel 2-(aminoalkyl)-isoindoline-1,3-dione derivatives as dual-binding site acetylcholinesterase inhibitors
Arch Pharm (Weinheim) 345: 509

Szymanski P, Markowicz M, Bajda M, Malawska B, Mikiciuk-Olasik E (2012)
Synthesis, biological activity and molecular modeling of 4-fluoro-N-[omega-(1,2,3,4-tetrahydroacridin-9-ylamino)-alkyl]-benzamide derivatives as cholinesterase inhibitors
Arzneimittelforschung 62: 655

Szymanski P, Laznickova A, Laznicek M, Bajda M, Malawska B, Markowicz M, Mikiciuk-Olasik E (2012)
2,3-dihydro-1H-cyclopenta[b]quinoline derivatives as acetylcholinesterase inhibitors-synthesis, radiolabeling and biodistribution
Int J Mol Sci 13: 10067

Bajda M, Guzior N, Ignasik M, Malawska B (2011)
Multi-target-directed ligands in Alzheimer's disease treatment
Curr Med Chem 18: 4949

Wieckowska A, Bajda M, Guzior N, Malawska B (2010)
Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors
Eur Journal of Medicinal Chemistry 45: 5602

Bajda M, Wieckowska A, Malawska B (2009)
Electrophoretically mediated microanalysis technique as a tool for the rapid screening of novel acetylcholinesterase inhibitors
Acta Pol Pharm 66: 357

Musial A, Bajda M, Malawska B (2007)
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment
Curr Med Chem 14: 2654

Musial A, Malawska B (2004)
Synthesis of novel N-alkyl carbamates of a-substituted amides of g-hydroxybutyric acid as potential acetylcholinesterase inhibitors
Acta Pol Pharm 61 Suppl: 94