Porzio E, Bettazzi F, Mandrich L, Del Giudice I, Restaino OF, Laschi S, Febbraio F, De Luca V, Borzacchiello MG, Carusone TM, Worek F, Pisanti A, Porcaro P, Schiraldi C, De Rosa M, Palchetti I, Manco G (2018)
Innovative Biocatalysts as Tools to Detect and Inactivate Nerve Agents
Sci Rep 8: 13773

Del Giudice I, Coppolecchia R, Merone L, Porzio E, Carusone TM, Mandrich L, Worek F, Manco G (2016)
An efficient thermostable organophosphate hydrolase and its application in pesticide decontamination
Biotechnol Bioeng 113: 724

Pennacchio A, Mandrich L, Manco G, Trincone A (2015)
Enlarging the substrate portfolio of the thermophilic esterase EST2 from Alicyclobacillus acidocaldarius
Extremophiles 19: 1001

Mandrich L, Di Gennaro S, Palma A, Manco G (2013)
A Further Biochemical Characterization of DrPLL the Thermophilic Lactonase from Deinococcus radiodurans
Protein Pept Lett 20: 36

Pezzullo M, Del Vecchio P, Mandrich L, Nucci R, Rossi M, Manco G (2013)
Comprehensive analysis of surface charged residues involved in thermal stability in Alicyclobacillus acidocaldarius esterase 2
Protein Engineering Des Sel 26: 47

Manco G, Merone L, Porzio E, Feng Y, Mandrich L (2012)
Enzyme Promiscuity in the Hormone-Sensitive Lipase Family of Proteins
Protein Pept Lett 19: 144

De Santi C, Tutino ML, Mandrich L, Giuliani M, Parrilli E, Del Vecchio P, de Pascale D (2010)
The hormone-sensitive lipase from Psychrobacter sp. TA144: new insight in the structural/functional characterization
Biochimie 92: 949

Mandrich L, Merone L, Manco G (2010)
Hyperthermophilic phosphotriesterases/lactonases for the environment and human health
Environ Technol 31: 1115

Merone L, Mandrich L, Porzio E, Rossi M, Muller S, Reiter G, Worek F, Manco G (2010)
Improving the promiscuous nerve agent hydrolase activity of a thermostable archaeal lactonase
Bioresour Technol 101: 9204

Mandrich L, Manco G (2009)
Evolution in the amidohydrolase superfamily: substrate-assisted gain of function in the E183K mutant of a phosphotriesterase-like metal-carboxylesterase
Biochemistry 48: 5602

Mandrich L, Merone L, Manco G (2009)
Structural and kinetic overview of the carboxylesterase EST2 from alicyclobacillus acidocaldarius: a comparison with the other members of the HSL family
Protein Pept Lett 16: 1189

Elias M, Dupuy J, Merone L, Mandrich L, Porzio E, Moniot S, Rochu D, Lecomte C, Rossi M, Masson P, Manco G, Chabriere E (2008)
Structural basis for natural lactonase and promiscuous phosphotriesterase activities
Journal of Molecular Biology 379: 1017

Febbraio F, D'Andrea SE, Mandrich L, Merone L, Rossi M, Nucci R, Manco G (2008)
Irreversible inhibition of the thermophilic esterase EST2 from Alicyclobacillus acidocaldarius
Extremophiles 12: 719

Mandrich L, Menchise V, Alterio V, De Simone G, Pedone C, Rossi M, Manco G (2008)
Functional and structural features of the oxyanion hole in a thermophilic esterase from Alicyclobacillus acidocaldarius
Proteins 71: 1721

Mandrich L, Pezzullo M, Rossi M, Manco G (2007)
SSoNDelta and SSoNDeltalong: two thermostable esterases from the same ORF in the archaeon Sulfolobus solfataricus?
Archaea 2: 109

Porzio E, Merone L, Mandrich L, Rossi M, Manco G (2007)
A new phosphotriesterase from Sulfolobus acidocaldarius and its comparison with the homologue from Sulfolobus solfataricus
Biochimie 89: 625

Ben Ali Y, Chahinian H, Petry S, Muller G, Lebrun R, Verger R, Carriere F, Mandrich L, Rossi M, Manco G, Sarda L, Abousalham A (2006)
Use of an inhibitor to identify members of the hormone-sensitive lipase family
Biochemistry 45: 14183

Mandrich L, Manco G, Rossi M, Floris E, Jansen-van den Bosch T, Smit G, Wouters JA (2006)
Alicyclobacillus acidocaldarius thermophilic esterase EST2's activity in milk and cheese models
Applied Environmental Microbiology 72: 3191

Chahinian H, Ben Ali Y, Abousalham A, Petry S, Mandrich L, Manco G, Canaan S, Sarda L (2005)
Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases
Biochimica & Biophysica Acta 1738: 29

Mandrich L, Merone L, Pezzullo M, Cipolla L, Nicotra F, Rossi M, Manco G (2005)
Role of the N terminus in enzyme activity, stability and specificity in thermophilic esterases belonging to the HSL family
Journal of Molecular Biology 345: 501

De Simone G, Mandrich L, Menchise V, Giordano V, Febbraio F, Rossi M, Pedone C, Manco G (2004)
A substrate-induced switch in the reaction mechanism of a thermophilic esterase: kinetic evidences and structural basis
Journal of Biological Chemistry 279: 6815

De Simone G, Menchise V, Alterio V, Mandrich L, Rossi M, Manco G, Pedone C (2004)
The crystal structure of an EST2 mutant unveils structural insights on the H group of the carboxylesterase/lipase family
Journal of Molecular Biology 343: 137

Mandrich L, Pezzullo M, Del Vecchio P, Barone G, Rossi M, Manco G (2004)
Analysis of thermal adaptation in the HSL enzyme family
Journal of Molecular Biology 335: 357

Del Vecchio P, Graziano G, Granata V, Barone G, Mandrich L, Rossi M, Manco G (2003)
Effect of trifluoroethanol on the conformational stability of a hyperthermophilic esterase: a CD study
Biophysical Chemistry 104: 407

Sorrentino N, De Simone G, Menchise V, Mandrich L, Rossi M, Manco G, Pedone C (2003)
Crystallization and preliminary X-ray diffraction studies of Aes acetyl-esterase from Escherichia coli
Acta Crystallographica D Biol Crystallogr 59: 1846

Mandrich L, Caputo E, Martin BM, Rossi M, Manco G (2002)
The Aes protein and the monomeric alpha-galactosidase from Escherichia coli form a non-covalent complex. Implications for the regulation of carbohydrate metabolism
Journal of Biological Chemistry 277: 48241

De Simone G, Menchise V, Manco G, Mandrich L, Sorrentino N, Lang D, Rossi M, Pedone C (2001)
The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus
Journal of Molecular Biology 314: 507

Manco G, Mandrich L, Rossi M (2001)
Residues at the active site of the esterase 2 from Alicyclobacillus acidocaldarius involved in substrate specificity and catalytic activity at high temperature
Journal of Biological Chemistry 276: 37482