Jing L, Wei W, Meng B, Chantegreil F, Nachon F, Martinez A, Wu G, Zhao H, Song Y, Kang D, Brazzolotto X, Zhan P, Liu X (2023) <br />Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies<br /><i>Bioorg Chem</i> <b>134</b>: 106465<br /><br />Perinova R, Maafi N, Korabecny J, Kohelova E, De Simone A, Al Mamun A, Hulcova D, Markova J, Kucera T, Jun D, Safratova M, Marikova J, Andrisano V, Jenco J, Kunes J, Martinez A, Novakova L, Cahlikova L (2020) <br />Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease<br /><i>Bioorg Chem</i> <b>100</b>: 103928<br /><br />de Andrade P, Mantoani SP, Goncalves Nunes PS, Magadan CR, Perez C, Xavier DJ, Hojo ETS, Campillo NE, Martinez A, Carvalho I (2019) <br />Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease<br /><i>Bioorganic & Medicinal Chemistry</i> <b>27</b>: 931<br /><br />Chierrito TPC, Pedersoli-Mantoani S, Roca C, Sebastian-Perez V, Martinez-Gonzalez L, Perez DI, Perez C, Canales A, Canada FJ, Campillo NE, Carvalho I, Martinez A (2018) <br />Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>145</b>: 431<br /><br />Roca C, Requena C, Sebastian-Perez V, Malhotra S, Radoux C, Perez C, Martinez A, Antonio Paez J, Blundell TL, Campillo NE (2018) <br />Identification of new allosteric sites and modulators of AChE through computational and experimental tools<br /><i>J Enzyme Inhib Med Chem</i> <b>33</b>: 1034<br /><br />Chierrito TPC, Mantoani SP, Roca C, Requena C, Sebastian-Perez V, Castillo WO, Moreira NCS, Perez C, Sakamoto-Hojo ET, Takahashi CS, Jimenez-Barbero J, Canada FJ, Campillo NE, Martinez A, Carvalho I (2017) <br />From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>139</b>: 773<br /><br />Mantoani SP, Chierrito TP, Vilela AF, Cardoso CL, Martinez A, Carvalho I (2016) <br />Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors<br /><i>Molecules</i> <b>21</b>: <br /><br />Rodrigues R, Artieda M, Tejedor D, Martinez A, Konstantinova P, Petry H, Meyer C, Corzo D, Sundgreen C, Klor HU, Gouni-Berthold I, Westphal S, Steinhagen-Thiessen E, Julius U, Winkler K, Stroes E, Vogt A, Hardt P, Prophet H, Otte B, Nordestgaard BG, Deeb SS, Brunzell JD (2016) <br />Pathogenic classification of LPL gene variants reported to be associated with LPL deficiency<br /><i>J Clin Lipidol</i> <b>10</b>: 394<br /><br />Perez DI, Martinez A, Gil C, Campillo NE (2015) <br />From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease<br /><i>Curr Med Chem</i> <b>22</b>: 3789<br /><br />Peverly AA, O'Sullivan C, Liu LY, Venier M, Martinez A, Hornbuckle KC, Hites RA (2015) <br />Chicago's Sanitary and Ship Canal sediment: Polycyclic aromatic hydrocarbons, polychlorinated biphenyls, brominated flame retardants, and organophosphate esters<br /><i>Chemosphere</i> <b>134</b>: 380<br /><br />Fernandez-Bachiller MI, Perez C, Campillo NE, Paez JA, Gonzalez-Munoz GC, Usan P, Garcia-Palomero E, Lopez MG, Villarroya M, Garcia AG, Martinez A, Rodriguez-Franco MI (2009) <br />Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties<br /><i>ChemMedChem</i> <b>4</b>: 828<br /><br />Garcia-Palomero E, Munoz P, Usan P, Garcia P, Delgado E, de Austria C, Valenzuela R, Rubio L, Medina M, Martinez A (2008) <br />Potent beta-amyloid modulators<br /><i>Neurodegener Dis</i> <b>5</b>: 153<br /><br />Castro A, Martinez A (2006) <br />Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors<br /><i>Curr Pharm Des</i> <b>12</b>: 4377<br /><br />Martinez A, Castro A (2006) <br />Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease<br /><i>Expert Opin Investig Drugs</i> <b>15</b>: 1<br /><br />del Monte-Millan M, Garcia-Palomero E, Valenzuela R, Usan P, de Austria C, Munoz-Ruiz P, Rubio L, Dorronsoro I, Martinez A, Medina M (2006) <br />Dual binding site acetylcholinesterase inhibitors: potential new disease-modifying agents for AD<br /><i>Journal of Molecular Neuroscience</i> <b>30</b>: 85<br /><br />Alonso D, Dorronsoro I, Rubio L, Munoz P, Garcia-Palomero E, del Monte M, Bidon-Chanal A, Orozco M, Luque FJ, Castro A, Medina M, Martinez A (2005) <br />Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE<br /><i>Bioorganic & Medicinal Chemistry</i> <b>13</b>: 6588<br /><br />Dorronsoro I, Alonso D, Castro A, del Monte M, Garcia-Palomero E, Martinez A (2005) <br />Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors<br /><i>Arch Pharm (Weinheim)</i> <b>338</b>: 18<br /><br />Munoz-Ruiz P, Rubio L, Garcia-Palomero E, Dorronsoro I, del Monte-Millan M, Valenzuela R, Usan P, de Austria C, Bartolini M, Andrisano V, Bidon-Chanal A, Orozco M, Luque FJ, Medina M, Martinez A (2005) <br />Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease<br /><i>Journal of Medicinal Chemistry</i> <b>48</b>: 7223<br /><br />Rodriguez-Franco MI, Fernandez-Bachiller MI, Perez C, Castro A, Martinez A (2005) <br />Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase<br /><i>Bioorganic & Medicinal Chemistry</i> <b>13</b>: 6795<br /><br />Castro A, Martinez A (2001) <br />Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease<br /><i>Mini Rev Med Chem</i> <b>1</b>: 267<br /><br />Martinez A, Soberon-Chavez G (2001) <br />Characterization of the lipA gene encoding the major lipase from Pseudomonas aeruginosa strain IGB83<br /><i>Applied Microbiology & Biotechnology</i> <b>56</b>: 731<br /><br />Martinez A, Lanot C, Perez C, Castro A, Lopez-Serrano P, Conde S (2000) <br />Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives<br /><i>Bioorganic & Medicinal Chemistry</i> <b>8</b>: 731<br /><br />Martinez A, Fernandez E, Castro A, Conde S, Rodriguez-Franco I, Banos JE, Badia A (2000) <br />N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors<br /><i>Eur Journal of Medicinal Chemistry</i> <b>35</b>: 913<br /><br />Rodriguez-Franco MI, Dorronsoro I, Martinez A, Perez C, Badia A, Banos JE (2000) <br />Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties<br /><i>Arch Pharm (Weinheim)</i> <b>333</b>: 118<br /><br />Romero S, Martinez A, Hernandez L, Fernandez C, Espasa A, Candela A, Martin C (2000) <br />Light's criteria revisited: consistency and comparison with new proposed alternative criteria for separating pleural transudates from exudates<br /><i>Respiration</i> <b>67</b>: 18<br /><br />Martinez A, Ostrovsky P, Nunn DN (1999) <br />LipC, a second lipase of Pseudomonas aeruginosa, is LipB and Xcp dependent and is transcriptionally regulated by pilus biogenesis components<br /><i>Molecular Microbiology</i> <b>34</b>: 317<br /><br />Alcalde E, Barat A, Goya P, Martinez A, Ramirez G, Roca T, Rozas I (1997) <br />Molecular modeling of (E)-1-alkyl-4(3)-[2-(1H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase<br /><i>Bioorganic & Medicinal Chemistry</i> <b>5</b>: 949<br /><br />Martinez A, Bownes M (1994) <br />The sequence and expression pattern of the Calliphora erythrocephala yolk protein A and B genes<br /><i>Journal of Molecular Evolution</i> <b>38</b>: 336<br /><br />