Jing L, Wei W, Meng B, Chantegreil F, Nachon F, Martinez A, Wu G, Zhao H, Song Y, Kang D, Brazzolotto X, Zhan P, Liu X (2023)
Rapid discovery and crystallography study of highly potent and selective butylcholinesterase inhibitors based on oxime-containing libraries and conformational restriction strategies
Bioorg Chem 134: 106465

Perinova R, Maafi N, Korabecny J, Kohelova E, De Simone A, Al Mamun A, Hulcova D, Markova J, Kucera T, Jun D, Safratova M, Marikova J, Andrisano V, Jenco J, Kunes J, Martinez A, Novakova L, Cahlikova L (2020)
Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer's disease
Bioorg Chem 100: 103928

de Andrade P, Mantoani SP, Goncalves Nunes PS, Magadan CR, Perez C, Xavier DJ, Hojo ETS, Campillo NE, Martinez A, Carvalho I (2019)
Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease
Bioorganic & Medicinal Chemistry 27: 931

Chierrito TPC, Pedersoli-Mantoani S, Roca C, Sebastian-Perez V, Martinez-Gonzalez L, Perez DI, Perez C, Canales A, Canada FJ, Campillo NE, Carvalho I, Martinez A (2018)
Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors
Eur Journal of Medicinal Chemistry 145: 431

Roca C, Requena C, Sebastian-Perez V, Malhotra S, Radoux C, Perez C, Martinez A, Antonio Paez J, Blundell TL, Campillo NE (2018)
Identification of new allosteric sites and modulators of AChE through computational and experimental tools
J Enzyme Inhib Med Chem 33: 1034

Chierrito TPC, Mantoani SP, Roca C, Requena C, Sebastian-Perez V, Castillo WO, Moreira NCS, Perez C, Sakamoto-Hojo ET, Takahashi CS, Jimenez-Barbero J, Canada FJ, Campillo NE, Martinez A, Carvalho I (2017)
From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease
Eur Journal of Medicinal Chemistry 139: 773

Mantoani SP, Chierrito TP, Vilela AF, Cardoso CL, Martinez A, Carvalho I (2016)
Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors
Molecules 21:

Rodrigues R, Artieda M, Tejedor D, Martinez A, Konstantinova P, Petry H, Meyer C, Corzo D, Sundgreen C, Klor HU, Gouni-Berthold I, Westphal S, Steinhagen-Thiessen E, Julius U, Winkler K, Stroes E, Vogt A, Hardt P, Prophet H, Otte B, Nordestgaard BG, Deeb SS, Brunzell JD (2016)
Pathogenic classification of LPL gene variants reported to be associated with LPL deficiency
J Clin Lipidol 10: 394

Perez DI, Martinez A, Gil C, Campillo NE (2015)
From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease
Curr Med Chem 22: 3789

Peverly AA, O'Sullivan C, Liu LY, Venier M, Martinez A, Hornbuckle KC, Hites RA (2015)
Chicago's Sanitary and Ship Canal sediment: Polycyclic aromatic hydrocarbons, polychlorinated biphenyls, brominated flame retardants, and organophosphate esters
Chemosphere 134: 380

Fernandez-Bachiller MI, Perez C, Campillo NE, Paez JA, Gonzalez-Munoz GC, Usan P, Garcia-Palomero E, Lopez MG, Villarroya M, Garcia AG, Martinez A, Rodriguez-Franco MI (2009)
Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties
ChemMedChem 4: 828

Garcia-Palomero E, Munoz P, Usan P, Garcia P, Delgado E, de Austria C, Valenzuela R, Rubio L, Medina M, Martinez A (2008)
Potent beta-amyloid modulators
Neurodegener Dis 5: 153

Castro A, Martinez A (2006)
Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors
Curr Pharm Des 12: 4377

Martinez A, Castro A (2006)
Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease
Expert Opin Investig Drugs 15: 1

del Monte-Millan M, Garcia-Palomero E, Valenzuela R, Usan P, de Austria C, Munoz-Ruiz P, Rubio L, Dorronsoro I, Martinez A, Medina M (2006)
Dual binding site acetylcholinesterase inhibitors: potential new disease-modifying agents for AD
Journal of Molecular Neuroscience 30: 85

Alonso D, Dorronsoro I, Rubio L, Munoz P, Garcia-Palomero E, del Monte M, Bidon-Chanal A, Orozco M, Luque FJ, Castro A, Medina M, Martinez A (2005)
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE
Bioorganic & Medicinal Chemistry 13: 6588

Dorronsoro I, Alonso D, Castro A, del Monte M, Garcia-Palomero E, Martinez A (2005)
Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors
Arch Pharm (Weinheim) 338: 18

Munoz-Ruiz P, Rubio L, Garcia-Palomero E, Dorronsoro I, del Monte-Millan M, Valenzuela R, Usan P, de Austria C, Bartolini M, Andrisano V, Bidon-Chanal A, Orozco M, Luque FJ, Medina M, Martinez A (2005)
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease
Journal of Medicinal Chemistry 48: 7223

Rodriguez-Franco MI, Fernandez-Bachiller MI, Perez C, Castro A, Martinez A (2005)
Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase
Bioorganic & Medicinal Chemistry 13: 6795

Castro A, Martinez A (2001)
Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease
Mini Rev Med Chem 1: 267

Martinez A, Soberon-Chavez G (2001)
Characterization of the lipA gene encoding the major lipase from Pseudomonas aeruginosa strain IGB83
Applied Microbiology & Biotechnology 56: 731

Martinez A, Lanot C, Perez C, Castro A, Lopez-Serrano P, Conde S (2000)
Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives
Bioorganic & Medicinal Chemistry 8: 731

Martinez A, Fernandez E, Castro A, Conde S, Rodriguez-Franco I, Banos JE, Badia A (2000)
N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors
Eur Journal of Medicinal Chemistry 35: 913

Rodriguez-Franco MI, Dorronsoro I, Martinez A, Perez C, Badia A, Banos JE (2000)
Synthesis of new N-(4-pyridyl)-1-aminopyrazoles and their muscarinic and adrenergic properties
Arch Pharm (Weinheim) 333: 118

Romero S, Martinez A, Hernandez L, Fernandez C, Espasa A, Candela A, Martin C (2000)
Light's criteria revisited: consistency and comparison with new proposed alternative criteria for separating pleural transudates from exudates
Respiration 67: 18

Martinez A, Ostrovsky P, Nunn DN (1999)
LipC, a second lipase of Pseudomonas aeruginosa, is LipB and Xcp dependent and is transcriptionally regulated by pilus biogenesis components
Molecular Microbiology 34: 317

Alcalde E, Barat A, Goya P, Martinez A, Ramirez G, Roca T, Rozas I (1997)
Molecular modeling of (E)-1-alkyl-4(3)-[2-(1H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase
Bioorganic & Medicinal Chemistry 5: 949

Martinez A, Bownes M (1994)
The sequence and expression pattern of the Calliphora erythrocephala yolk protein A and B genes
Journal of Molecular Evolution 38: 336