Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Karasova JZ, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K (2019) <br />Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease<br /><i>Eur Journal of Medicinal Chemistry</i> <b>168</b>: 491<br /><br />Hepnarova V, Muckova L, Ring A, Pejchal J, Herman D, Misik J, Hrabinova M, Jun D, Soukup O (2019) <br />Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators<br /><i>Toxicol Appl Pharmacol</i> <br /><br />Karasova JZ, Soukup O, Korabecny J, Hroch M, Krejciova M, Hrabinova M, Misik J, Novotny L, Hepnarova V, Kuca K (2019) <br />Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats<br /><i>Drug & Chemical Toxicology</i> <br /><br />Muckova L, Vanova N, Misik J, Herman D, Pejchal J, Jun D (2019) <br />Oxidative stress induced by oxime reactivators of acetylcholinesterase in vitro<br /><i>Toxicol In Vitro</i> <b>56</b>: 110<br /><br />Nepovimova E, Janockova J, Misik J, Kubik S, Stuchlik A, Vales K, Korabecny J, Mezeiova E, Dolezal R, Soukup O, Kobrlova T, Pham NL, Nguyen TD, Konecny J, Kuca K (2019) <br />Orexin supplementation in narcolepsy treatment: A review<br /><i>Med Res Rev</i> <b>39</b>: 961<br /><br />Misik J, Nepovimova E, Pejchal J, Kassa J, Korabecny J, Soukup O (2018) <br />Cholinesterase inhibitor 6-chlorotacrine - in vivo toxicological profile and behavioural effects<br /><i>Curr Alzheimer Res</i> <b>15</b>: 552<br /><br />Karasova JZ, Maderycova Z, Tumova M, Jun D, Rehacek V, Kuca K, Misik J (2017) <br />Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis<br /><i>Toxicol Lett</i> <b>277</b>: 24<br /><br />Kassa J, Misik J, Hatlapatkova J, Karasova JZ (2017) <br />A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats<br /><i>Toxicol Mech Methods</i> <br /><br />Kassa J, Misik J, Hatlapatkova J, Karasova JZ, Sepsova V, Caisberger F, Pejchal J (2017) <br />The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203<br /><i>Molecules</i> <b>22</b>: <br /><br />Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J, Spilovska K, Pham NL, Pokrievkova L, Roh J, Jun D, Soukup O, Kaping D, Kuca K (2017) <br />Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy<br /><i>Molecules</i> <b>22</b>: <br /><br />Caisberger F, Novotny L, Hajek P, Misik J, Kassa J, Pejchal J (2016) <br />HI-6 treatment does not reactivate sarin inhibited acetylcholinesterase activity in dog brain when administered in human therapeutical dose 30 minutes after the poisoning<br /><i>Military Medical Science Letters</i> <b>85</b>: 2<br /><br />Misik J, Korabecny J, Nepovimova E, Kracmarova A, Kassa J (2016) <br />Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats-Is there a potential for Alzheimer's disease treatment?<br /><i>Neuroscience Letters</i> <b>612</b>: 261<br /><br />Katalinic M, Macek Hrvat N, Karasova JZ, Misik J, Kovarik Z (2015) <br />Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning<br /><i>Arh Hig Rada Toksikol</i> <b>66</b>: 291<br /><br />Misik J, Korabecny J, Nepovimova E, Cabelova P, Kassa J (2015) <br />The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test<br /><i>Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub</i> <b>159</b>: 547<br /><br />Kassa J, Misik J, Karasova JZ (2013) <br />Evaluation of the potency of two novel bispyridinium oximes (K456, K458) in comparison with oxime K203 and trimedoxime to counteract tabun-induced neurotoxicity in rats<br /><i>Basic Clin Pharmacol Toxicol</i> <b>113</b>: 201<br /><br />Misik J, Pavlik M, Novotny L, Pavlikova R, Chilcott RP, Cabal J, Kuca K (2012) <br />In vivo decontamination of the nerve agent VX using the domestic swine model<br /><i>Clinical Toxicology (Phila)</i> <b>50</b>: 807<br /><br />Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M, Verdier L, Masson P, Rochu D, Jun D, Nachon F (2011) <br />Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents<br /><i>Toxicol Lett</i> <b>206</b>: 14<br /><br />Kassa J, Karasova JZ, Pavlikova R, Misik J, Caisberger F, Bajgar J (2010) <br />The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice<br /><i>J Appl Toxicol</i> <b>30</b>: 120<br /><br />Musilek K, Holas O, Misik J, Pohanka M, Novotny L, Dohnal V, Opletalova V, Kuca K (2010) <br />Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies<br /><i>ChemMedChem</i> <b>5</b>: 247<br /><br />