Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ, Nachon F, Pejchal J, Jarosova M, Hepnarova V, Jun D, Hrabinova M, Dolezal R, Karasova JZ, Mzik M, Kristofikova Z, Misik J, Muckova L, Jost P, Soukup O, Benkova M, Setnicka V, Habartova L, Chvojkova M, Kleteckova L, Vales K, Mezeiova E, Uliassi E, Valis M, Nepovimova E, Bolognesi ML, Kuca K (2019)
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
Eur Journal of Medicinal Chemistry 168: 491

Hepnarova V, Muckova L, Ring A, Pejchal J, Herman D, Misik J, Hrabinova M, Jun D, Soukup O (2019)
Pharmacological and toxicological in vitro and in vivo effect of higher doses of oxime reactivators
Toxicol Appl Pharmacol

Karasova JZ, Soukup O, Korabecny J, Hroch M, Krejciova M, Hrabinova M, Misik J, Novotny L, Hepnarova V, Kuca K (2019)
Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats
Drug & Chemical Toxicology

Muckova L, Vanova N, Misik J, Herman D, Pejchal J, Jun D (2019)
Oxidative stress induced by oxime reactivators of acetylcholinesterase in vitro
Toxicol In Vitro 56: 110

Nepovimova E, Janockova J, Misik J, Kubik S, Stuchlik A, Vales K, Korabecny J, Mezeiova E, Dolezal R, Soukup O, Kobrlova T, Pham NL, Nguyen TD, Konecny J, Kuca K (2019)
Orexin supplementation in narcolepsy treatment: A review
Med Res Rev 39: 961

Misik J, Nepovimova E, Pejchal J, Kassa J, Korabecny J, Soukup O (2018)
Cholinesterase inhibitor 6-chlorotacrine - in vivo toxicological profile and behavioural effects
Curr Alzheimer Res 15: 552

Karasova JZ, Maderycova Z, Tumova M, Jun D, Rehacek V, Kuca K, Misik J (2017)
Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis
Toxicol Lett 277: 24

Kassa J, Misik J, Hatlapatkova J, Karasova JZ (2017)
A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats
Toxicol Mech Methods

Kassa J, Misik J, Hatlapatkova J, Karasova JZ, Sepsova V, Caisberger F, Pejchal J (2017)
The Evaluation of the Reactivating and Neuroprotective Efficacy of Two Newly Prepared Bispyridinium Oximes (K305, K307) in Tabun-Poisoned Rats-A Comparison with Trimedoxime and the Oxime K203
Molecules 22:

Mezeiova E, Korabecny J, Sepsova V, Hrabinova M, Jost P, Muckova L, Kucera T, Dolezal R, Misik J, Spilovska K, Pham NL, Pokrievkova L, Roh J, Jun D, Soukup O, Kaping D, Kuca K (2017)
Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy
Molecules 22:

Caisberger F, Novotny L, Hajek P, Misik J, Kassa J, Pejchal J (2016)
HI-6 treatment does not reactivate sarin inhibited acetylcholinesterase activity in dog brain when administered in human therapeutical dose 30 minutes after the poisoning
Military Medical Science Letters 85: 2

Misik J, Korabecny J, Nepovimova E, Kracmarova A, Kassa J (2016)
Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats-Is there a potential for Alzheimer's disease treatment?
Neuroscience Letters 612: 261

Katalinic M, Macek Hrvat N, Karasova JZ, Misik J, Kovarik Z (2015)
Translation of in vitro to in vivo pyridinium oxime potential in tabun poisoning
Arh Hig Rada Toksikol 66: 291

Misik J, Korabecny J, Nepovimova E, Cabelova P, Kassa J (2015)
The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 159: 547

Kassa J, Misik J, Karasova JZ (2013)
Evaluation of the potency of two novel bispyridinium oximes (K456, K458) in comparison with oxime K203 and trimedoxime to counteract tabun-induced neurotoxicity in rats
Basic Clin Pharmacol Toxicol 113: 201

Misik J, Pavlik M, Novotny L, Pavlikova R, Chilcott RP, Cabal J, Kuca K (2012)
In vivo decontamination of the nerve agent VX using the domestic swine model
Clinical Toxicology (Phila) 50: 807

Trovaslet-Leroy M, Musilova L, Renault F, Brazzolotto X, Misik J, Novotny L, Froment MT, Gillon E, Loiodice M, Verdier L, Masson P, Rochu D, Jun D, Nachon F (2011)
Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents
Toxicol Lett 206: 14

Kassa J, Karasova JZ, Pavlikova R, Misik J, Caisberger F, Bajgar J (2010)
The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice
J Appl Toxicol 30: 120

Musilek K, Holas O, Misik J, Pohanka M, Novotny L, Dohnal V, Opletalova V, Kuca K (2010)
Monooxime-monocarbamoyl Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In vitro and Toxicity Evaluation, and Docking Studies
ChemMedChem 5: 247